European Journal of Oral Sciences最新文献_第8页

Evaluation of salivary α-amylase and immunoglobulin A responses after endurance exercise in adolescent males and females with similar aerobic fitness 评估耐力运动后唾液α-淀粉酶和免疫球蛋白A对有氧运动能力相似的青少年男性和女性的反应。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-12-22 DOI: 10.1111/eos.12968

Nobuo Yasuda, Toshihiro Tanioka, Kimitaka Nakazawa

{"title":"Evaluation of salivary α-amylase and immunoglobulin A responses after endurance exercise in adolescent males and females with similar aerobic fitness","authors":"Nobuo Yasuda, Toshihiro Tanioka, Kimitaka Nakazawa","doi":"10.1111/eos.12968","DOIUrl":"10.1111/eos.12968","url":null,"abstract":"The objective of this study was to clarify whether there are sex-specific differences in salivary α-amylase and immunoglobulin A responses following acute endurance exercise in adolescent males and females with equivalent cardiorespiratory fitness levels. Twenty-six aerobically trained adolescent males and females with similar training status were enrolled in this study. Each individual executed a 1-h prolonged cycling exercise corresponding to a constant power output at 65% of peak oxygen uptake. Unstimulated whole salivary samples were taken with the passive drooling method at the 10-min period before and after exercise for the determination of salivary responses [α-amylase, immunoglobulin A, total protein and flow rate]. Salivary α-amylase activity, immunoglobulin A concentration and total protein concentration were significantly augmented immediately after acute endurance exercise. Regarding sex differences, only the salivary flow rate was significantly lower in females than in males. The findings of the present study imply that adolescent males and females appear to have similar salivary responses after acute endurance exercise, as represented by salivary α-amylase activity and immunoglobulin A concentration in connection with total protein concentration and salivary flow rate, when they are matched for peak oxygen uptake relative to fat-free body mass.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138884752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of alpha-tocopherol antioxidant on fracture strength and adhesion of endodontically treated teeth restored after dental bleaching α-生育酚抗氧化剂对牙髓治疗后牙齿漂白修复后的断裂强度和附着力的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-12-20 DOI: 10.1111/eos.12965

Natália Marcomini, Maria Carolina da Costa Albaricci, Joatan Lucas de Sousa Gomes Costa, João Felipe Besegato, Eduardo Fernández Godoy, Andréa Abi Rached Dantas, Milton Carlos Kuga

{"title":"Effects of alpha-tocopherol antioxidant on fracture strength and adhesion of endodontically treated teeth restored after dental bleaching","authors":"Natália Marcomini, Maria Carolina da Costa Albaricci, Joatan Lucas de Sousa Gomes Costa, João Felipe Besegato, Eduardo Fernández Godoy, Andréa Abi Rached Dantas, Milton Carlos Kuga","doi":"10.1111/eos.12965","DOIUrl":"10.1111/eos.12965","url":null,"abstract":"This study evaluated the effect of different concentrations of alpha-tocopherol in gel form on fracture strength, hybrid layer formation, and microtensile bond strength of endodontically treated teeth bleached with 40% hydrogen peroxide (H2O2). Sixty bovine incisors were randomized into one of six groups (n = 10 incisors per group) defined by the interventions carried out after endodontic treatment. In the control group, no additional intervention was carried out, while all teeth in the five intervention groups were bleached with 40% H2O2 and subsequently treated with alpha-tocopherol at concentrations of 15% (15AT), 20% (20AT), or 25% (25AT), with 10% sodium ascorbate (10SA), or with nothing (40HP). Fracture strength was evaluated in a mechanical testing machine, hybrid layer formation was assessed using scanning electron microscopy, and bond strength was determined using microtensile bond-strength testing. Data were analyzed using Kruskal–Wallis and Dunn's tests. No statistically significant difference regarding fracture strength was observed among groups. Hybrid layer formation was greater in the 15AT group than in groups 40HP and 10SA. Teeth in groups 15AT, 20AT, and 25AT demonstrated higher bond strength than teeth in groups 40HP and 10SA. Alpha-tocopherol, preferably at 15%, effectively reverses the deleterious effects, of bleaching, on hybrid layer formation and bond strength to dentin.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of erosion and abrasion on resin-matrix ceramic CAD/CAM materials: An in vitro investigation 侵蚀和磨损对树脂基质陶瓷 CAD/CAM 材料的影响：体外研究

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-12-17 DOI: 10.1111/eos.12967

Cosima Reidelbach, Michael Swoboda, Mathias Spraul, Kirstin Vach, Sebastian B. M. Patzelt, Elmar Hellwig, Olga Polydorou

{"title":"Effects of erosion and abrasion on resin-matrix ceramic CAD/CAM materials: An in vitro investigation","authors":"Cosima Reidelbach, Michael Swoboda, Mathias Spraul, Kirstin Vach, Sebastian B. M. Patzelt, Elmar Hellwig, Olga Polydorou","doi":"10.1111/eos.12967","DOIUrl":"10.1111/eos.12967","url":null,"abstract":"The aim of the study was to evaluate the effects of erosion and abrasion on resin-matrix ceramic CAD/CAM materials [CERASMART (GC); VITA ENAMIC (VITA Zahnfabrik); Lava Ultimate (3 M)] in comparison to feldspar ceramic (VITABLOCS Mark II, VITA Zahnfabrik) and resin composite materials (ceram.x universal, Dentsply Sirona). Daily brushing and acid exposure were simulated using a brushing apparatus and a solution of 0.5 vol% citric acid. Microhardness, surface roughness, and substance loss were measured at baseline and after simulation of 1 and 3 years of function. All materials showed a decrease in microhardness after 3 years and an increase in surface roughness (Ra) after 1 and 3 years. The Ra increase was statistically significantly lower for the resin-matrix ceramics than for feldspar ceramic and similar to composite material. After 3 years, only feldspar ceramic showed no significant substance loss. In conclusion, resin-matrix ceramics demonstrate reduced roughening compared to feldspar ceramics, potentially improving restoration longevity by preventing plaque buildup, but differences in abrasion resistance suggest the need for further material-specific research. Future research should aim to replicate clinical conditions closely and to transition to in vivo trials.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138717596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical effects of graphene addition on adhesives for orthodontic lingual retainers 添加石墨烯对正畸舌侧保持器粘合剂的光学效应

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-12-07 DOI: 10.1111/eos.12966

Shiyao Liu, Ahmed El-Angbawi, Ruidong Ji, Vinicius Rosa, Nick Silikas

{"title":"Optical effects of graphene addition on adhesives for orthodontic lingual retainers","authors":"Shiyao Liu, Ahmed El-Angbawi, Ruidong Ji, Vinicius Rosa, Nick Silikas","doi":"10.1111/eos.12966","DOIUrl":"10.1111/eos.12966","url":null,"abstract":"The objective of this study was to determine the effects on the colour of adding increasing concentrations of graphene to orthodontic fixed retainer adhesives and to evaluate changes in optical transmission during light curing and the resultant degree of conversion. Two different types of adhesives commonly used for fixed retainers were investigated: A packable composite (Transbond) and a flowable composite (Transbond Supreme). Graphene was added to the adhesives in three different concentrations (0.01, 0.05, and 0.1 wt%). Adhesives without graphene addition were set as control groups. A Minolta colourimeter was used to measure the colour and translucency parameters. Irradiance transmitted during curing was quantified using MARC Light Collector. Fourier-transform infrared spectroscopy was used to record degree of conversion. Data were statistically analysed with the Student's t-test and one-way ANOVA with Tukey's tests (α = 0.05). The findings showed that incorporating graphene darkened the adhesive colour significantly and reduced translucency. As the graphene concentration reached 0.1 wt%, samples became opaque; yet, no adverse effect on degree of conversion was observed. The addition of graphene reduces optical transmission of lingual retainer adhesives; the effect increases with graphene concentration.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138560568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finishing technique effect on strength of zirconia-reinforced lithium silicate ceramic 抛光技术对氧化锆增强硅酸锂陶瓷强度的影响

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-12-07 DOI: 10.1111/eos.12964

Ernesto Byron Benalcazar-Jalkh, Verena Souza Cunha, Edmara Tatiely Pedroso Bergamo, Larissa Marcia Martins Alves, Raphaelle Santos de Monteiro-Sousa, Tiago Moreira Bastos Campos, Ricardo Tanaka, Giovana de Assis Marcolino, Felipe Machado de Souza, Estevam Augusto Bonfante

{"title":"Finishing technique effect on strength of zirconia-reinforced lithium silicate ceramic","authors":"Ernesto Byron Benalcazar-Jalkh, Verena Souza Cunha, Edmara Tatiely Pedroso Bergamo, Larissa Marcia Martins Alves, Raphaelle Santos de Monteiro-Sousa, Tiago Moreira Bastos Campos, Ricardo Tanaka, Giovana de Assis Marcolino, Felipe Machado de Souza, Estevam Augusto Bonfante","doi":"10.1111/eos.12964","DOIUrl":"10.1111/eos.12964","url":null,"abstract":"The aim of this study was to evaluate the effect of two finishing techniques, glazing or polishing, in comparison with the as-cut condition, on the biaxial-flexural-strength (BFS) of a zirconia-reinforced lithium silicate ceramic (ZLS). Cylinders were milled from CAD/CAM blocks and sliced to obtain disc-shaped specimens (ISO6872:2015). Polished and glazed specimens were processed following the manufacturer's instructions. Thirty-three specimens were obtained for each condition and microstructural and BFS/fractographic characterizations were performed. BFS and roughness data were analyzed using Weibull statistics and ANOVA one-way with Tukey post-hoc test, respectively. While a rougher surface was observed for as-cut specimens, smoother surfaces were observed for polished and glazed ZLS at microscopical evaluation and confirmed through surface-roughness evaluation. X-ray spectra depicted a glass phase for all groups and characteristic metasilicate, lithium disilicate, and lithium phosphate peaks for the as-cut and polished specimens. Glazed specimens showed higher characteristic strength than polished and as-cut specimens, which did not differ significantly. While higher Weibull-modulus was observed for the polished than for the as-cut specimens, no statistically significant differences were noted between glazed and polished, and between glazed and as-cut specimens. ZLS presents higher strength when glazed, and polishing increases the structural reliability of the material relative to the as-cut condition. Both finishing techniques reduced surface roughness similarly.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138560579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degree of cure of orthodontic composite attachments underneath aligners 正畸矫正器下复合附着体的治愈程度。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-12-01 DOI: 10.1111/eos.12963

Sandrine Janine Lasance, Despina Koletsi, George Eliades, Theodore Eliades

{"title":"Degree of cure of orthodontic composite attachments underneath aligners","authors":"Sandrine Janine Lasance, Despina Koletsi, George Eliades, Theodore Eliades","doi":"10.1111/eos.12963","DOIUrl":"10.1111/eos.12963","url":null,"abstract":"The aim of this study was to assess the percentage degree of cure (DC%) of 2-mm-thick resin composite attachments used for aligner treatment. Three types of aligner – two thermoformed aligners (Clear Aligner [CLA], polyethylene terephthalate glycol modified; and Invisalign [INV], polyester urethane) and a three-dimensional-printed aligner (Graphy TC-85DAC [GRP], an acrylate-methacrylate copolymer) – were selected, along with two universal resin composites (3M Filtek Universal [FTU] and Charisma Topaz ONE [CTO]). Samples of each composite were placed under each aligner, and the degree of cure of each composite was evaluated on the top (facing the aligner) and the bottom (facing the substrate) attachment surfaces after curing. Five specimens were used per combination of aligner and composite, and an additional group of composites irradiated without aligners served as the control. The DC% measurements were performed using attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. The DC% across the aligners were (median values) 33.8%–44.8% for CLA, 33.6%–40.8% for INV, 32.8%–40.6% for GRP, and 40.0%–51.7% for the control group. The DC% values of the attachments cured under any aligner were significantly lower than that of the corresponding control, with the values recorded on the top surfaces being 6% higher than those on the bottom surfaces after adjusting for aligner group and composite type.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case study evaluating the effect of clustering, publication bias, and heterogeneity on the meta-analysis estimates in implant dentistry 一个评估聚类、发表偏倚和异质性对种植牙科meta分析估计影响的案例研究。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-11-29 DOI: 10.1111/eos.12962

Clovis Mariano Faggion Jr, Momen A. Atieh, Michail Tsagris, Jadbinder Seehra, Nikolaos Pandis

{"title":"A case study evaluating the effect of clustering, publication bias, and heterogeneity on the meta-analysis estimates in implant dentistry","authors":"Clovis Mariano Faggion Jr, Momen A. Atieh, Michail Tsagris, Jadbinder Seehra, Nikolaos Pandis","doi":"10.1111/eos.12962","DOIUrl":"10.1111/eos.12962","url":null,"abstract":"Meta-analyses may provide imprecise estimates when important meta-analysis parameters are not considered during the synthesis. The aim of this case study was to highlight the influence of meta-analysis parameters that can affect reported estimates using as an example pre-existing meta-analyses on the association between implant survival and sinus membrane perforation. PubMed was searched on 7 July 2021 for meta-analyses comparing implant failure in perforated and non-perforated sinus membranes. Primary studies identified in these meta-analyses were combined in a new random-effects model with odds ratios (ORs), confidence intervals (CIs), and prediction intervals reported. Using this new meta-analysis, further meta-analyses were then undertaken considering the clinical, methodological, and statistical heterogeneity of the primary studies, publication bias, and clustering effects. The meta-analyses with the greatest number and more homogeneous studies provided lower odds of implant failure in non-perforated sites (OR 0.49, 95 % CI = [0.26, 0.92]). However, when considering heterogeneity, publication bias, and clustering (number of implants), the confidence in these results was reduced. Interpretation of estimates reported in systematic reviews can vary depending on the assumptions made in the meta-analysis. Users of these analyses need to carefully consider the impact of heterogeneity, publication bias, and clustering, which can affect the size, direction, and interpretation of the reported estimates.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12962","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of theanine on the hyperexcitability of trigeminal secondary nociceptive neurons following orofacial inflammation in rats 茶氨酸对大鼠口面部炎症后三叉神经次级痛觉神经元高兴奋性的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-11-20 DOI: 10.1111/eos.12961

Yui Watanuki, Sora Yajima, Yukito Sashide, Mamoru Takeda

{"title":"Effect of theanine on the hyperexcitability of trigeminal secondary nociceptive neurons following orofacial inflammation in rats","authors":"Yui Watanuki, Sora Yajima, Yukito Sashide, Mamoru Takeda","doi":"10.1111/eos.12961","DOIUrl":"10.1111/eos.12961","url":null,"abstract":"The present in vivo study investigated whether systemic administration of theanine attenuates the inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons associated with hyperalgesia. Complete Freund's adjuvant (CFA) was injected into the whisker pads of 24 rats to induce inflammation, and then mechanical stimulation was applied to the orofacial area to assess the threshold of escape. The mechanical threshold was statistically significantly lower in CFA-inflamed rats compared to uninjected naïve rats, and this lowered threshold returned to control levels after 2 days of theanine administration. The mean discharge frequency of SpVc wide-dynamic range (WDR) neurons to mechanical stimuli in anesthetized CFA-inflamed rats was statistically significantly lower after two days of theanine administration. In addition, the increased mean spontaneous discharge of SpVc WDR neurons in CFA-inflamed rats statistically significantly decreased after theanine administration. Similarly, theanine restored the expanded mean receptive field size in CFA-inflamed rats to control levels. Taken together, these results suggest that administration of theanine attenuates inflammatory hyperalgesia associated with hyperexcitability of nociceptive SpVc WDR neurons. These findings support the potential of theanine as a therapeutic agent in complementary alternative medicine strategies to prevent inflammatory hyperalgesia.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138175971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between malocclusion and health-related quality of life in adolescents: A mediation analysis 青少年错牙合与健康相关生活质量之间的关系：一项中介分析。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-11-09 DOI: 10.1111/eos.12960

Sarah Debora Camardella Leite, Fernando José Herkrath, Mario Vianna Vettore, Maria Augusta Bessa Rebelo, Adriana Corrêa de Queiroz, Juliana Vianna Pereira, Ana Paula Corrêa de Queiroz de Herkrath

{"title":"The association between malocclusion and health-related quality of life in adolescents: A mediation analysis","authors":"Sarah Debora Camardella Leite, Fernando José Herkrath, Mario Vianna Vettore, Maria Augusta Bessa Rebelo, Adriana Corrêa de Queiroz, Juliana Vianna Pereira, Ana Paula Corrêa de Queiroz de Herkrath","doi":"10.1111/eos.12960","DOIUrl":"10.1111/eos.12960","url":null,"abstract":"This study investigated the role of oral health-related functional limitations and social well-being, self-perceived health, psychosocial factors, and social support in mediating the impact of malocclusion on health-related quality of life (HRQoL). A school-based 6-month cohort study was conducted with 376 12-year-old deprived adolescents. Measures at baseline included malocclusion (DAI score), dental caries, sociodemographic characteristics, psychosocial traits (self-esteem, sense of coherence, oral health beliefs), and social support. The oral health-related functional limitations and symptoms (social well-being) domains of the CPQ11-14, self-perceived health, and HRQoL (Kiddo-KINDL) were evaluated at the 6-month follow-up. Associations between observed and latent variables (social support, psychosocial factors, and HRQoL) were evaluated using structural equation modelling, according to the Wilson and Cleary theoretical model. Malocclusion was indirectly associated with worse HRQoL, mediated by functional limitations, social well-being, and self-perceived health. Better psychosocial status was directly associated with better HRQoL, and higher social support was indirectly associated with better HRQoL via psychosocial factors. Dental caries experience, female sex, and lower family income were indirectly associated with worse HRQoL. The impact of malocclusion on HRQoL was mediated by oral health-related functional limitations, social well-being, and self-perceived health. Sociodemographic and psychosocial factors, and social support also impacted HRQoL.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of propranolol on temporomandibular joint pain in repeatedly stressed rats 普萘洛尔对反复应激大鼠颞下颌关节疼痛的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-10-31 DOI: 10.1111/eos.12957

Fernanda Barchesi Zanelatto, Willians Fernando Vieira, Catarine Massucato Nishijima, Tamires Marques Zanotto, Silviane Fernandes de Magalhães, César Renato Sartori, Carlos Amilcar Parada, Claudia Herrera Tambeli

{"title":"Effect of propranolol on temporomandibular joint pain in repeatedly stressed rats","authors":"Fernanda Barchesi Zanelatto, Willians Fernando Vieira, Catarine Massucato Nishijima, Tamires Marques Zanotto, Silviane Fernandes de Magalhães, César Renato Sartori, Carlos Amilcar Parada, Claudia Herrera Tambeli","doi":"10.1111/eos.12957","DOIUrl":"10.1111/eos.12957","url":null,"abstract":"Stress substantially increases the risk of developing painful temporomandibular disorders (TMDs) by influencing the release of endogenous catecholamines. Propranolol, an antagonist of β-adrenergic receptors, has shown potential in alleviating TMD-associated pain, particularly when the level of catecholamines is elevated. The aim of this study was to explore whether intra-articular propranolol administration is effective in diminishing temporomandibular joint (TMJ) pain during repeated stress situations. Additionally, we investigated the effect of repeated stress on the expression of genes encoding β-adrenoceptors in the trigeminal ganglion. In the present study, rats were exposed to a stress protocol induced by sound, then to the administration of formalin in the TMJ (to elicit a nociceptive response), followed immediately afterward by different doses of propranolol, after which the analgesic response to propranolol was evaluated. We also assessed the levels of beta-1 and beta-2 adrenergic receptor mRNAs (Adrb1 and Adrb2, respectively) using reverse transcription–quantitative PCR (RT-qPCR). Our findings revealed that propranolol administration reduces formalin-induced TMJ nociception more effectively in stressed rats than in non-stressed rats. Furthermore, repeated stress decreases the expression of the Adrb2 gene within the trigeminal ganglion. The findings of this study are noteworthy as they suggest that individuals with a chronic stress history might find potential benefits from β-blockers in TMD treatment.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0