{"title":"Proteomic profile of the acquired enamel pellicle of children with early childhood caries and caries-free children","authors":"Bethania Paludo Oliveira, Marília Afonso Rabelo Buzalaf, Natália Caldeira Silva, Talita Mendes Oliveira Ventura, Júlia Toniolo, Jonas Almeida Rodrigues","doi":"10.1111/eos.12944","DOIUrl":"10.1111/eos.12944","url":null,"abstract":"<p>Acquired enamel pellicle plays an important role in the pathogenesis of early childhood caries (ECC), working as a protective interface between the tooth and the oral cavity. The aim of this cross-sectional in vivo proteomic study was to compare the acquired enamel pellicle protein profile of 3–5-year-old children with ECC (<i>n</i> = 10) and caries-free children (<i>n</i> = 10). Acquired enamel pellicle samples were collected and processed for proteomic analysis (nLC-ESI-MS/MS). In total, 241 proteins were identified. Basic salivary proline-rich protein 1 and 2, Cystatin-B, and SA were found only in the caries free group. When comparing caries free and ECC groups, lower protein levels were found in the caries free group for hemoglobin subunit beta, delta, epsilon, gamma-2, globin domain-containing protein and gamma-1, neutrophil defensin 3, serum albumin, protein S100-A8, and S100-A9. The proteins histatin-1, statherin, salivary acidic proline-rich phosphoprotein ½, proline-rich protein 4, submaxillary gland androgen-regulated protein 3B, alpha-amylase 1 and 2B were found at higher levels in the caries free group. The exclusive and the proteins found at higher levels in the caries free group might have protective functions that play a role in the prevention of caries, besides providing important insights to be evaluated in future studies for the possible development of new therapeutic strategies for ECC.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10233510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreas Koutroulis, Håkon Valen, Dag Ørstavik, Vasileios Kapralos, Josette Camilleri, Pia Titterud Sunde
{"title":"Effect of exposure conditions on chemical properties of materials for surgical endodontic procedures","authors":"Andreas Koutroulis, Håkon Valen, Dag Ørstavik, Vasileios Kapralos, Josette Camilleri, Pia Titterud Sunde","doi":"10.1111/eos.12943","DOIUrl":"10.1111/eos.12943","url":null,"abstract":"This study investigated the role of aging and changes in environmental conditions on selected properties of a prototype radiopacified calcium silicate-based cement (TZ-base) with or without incorporation of silver nanoparticles or bioactive glass, and two commercial materials, Biodentine and intermediate restorative material. Materials were immersed in ultrapure water or fetal bovine serum for 28 days and were characterized with scanning electron microscopy and energy dispersive x-ray analysis. Immersion media were either replaced weekly or not replenished at all and were assessed for alkalinity and calcium release after 1, 7, 14, 21, and 28 days; antibacterial effect against 2-day monospecies biofilms; and cytotoxicity by the 3-(4,5 dimethylthiazolyl-2-yl)-2,5-diphenyl tetrazolium bromide assay after 1, 7, or 28 days. Alkalinity, calcium release, antibacterial activity, and cell cytotoxicity increased over time when the medium was not changed but decreased with medium replenishment. Immersion in fetal bovine serum resulted in lower alkalinity, less bactericidal properties, and lower cytotoxicity of prototype cements and Biodentine than did water immersion. Biodentine and 20% bioactive glass-containing cement had overall lower alkalinity, calcium release, and antibacterial activity than TZ-base, and Biodentine was less cytotoxic than TZ-base. In conclusion, exposure conditions and cement modifications significantly affected materials' leaching properties. Exposure conditions warrant consideration when evaluating cements' clinical properties.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9856716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of stress contagion on anxiogenic- and orofacial inflammatory pain-like behaviors with brain activation in mice","authors":"Kajita Piriyaprasath, Mana Hasegawa, Yoshito Kakihara, Yuya Iwamoto, Rantaro Kamimura, Isao Saito, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto","doi":"10.1111/eos.12942","DOIUrl":"10.1111/eos.12942","url":null,"abstract":"<p>The conditions of stress contagion are induced in bystanders without direct experiences of stressful events. This study determined the effects of stress contagion on masseter muscle nociception in mice. Stress contagion was developed in the bystanders after cohabitating with a conspecific mouse subjected to social defeat stress for 10 days. On Day 11, stress contagion increased anxiety- and orofacial inflammatory pain-like behaviors. The c-Fos and FosB immunoreactivities evoked by masseter muscle stimulation were increased in the upper cervical spinal cord, while c-Fos expressions were increased in the rostral ventromedial medulla, including the lateral paragigantocellular reticular nucleus and nucleus raphe magnus in stress contagion mice. The level of serotonin in the rostral ventromedial medulla was increased under stress contagion, while the number of serotonin positive cells was increased in the lateral paragigantocellular reticular nucleus. Stress contagion increased c-Fos and FosB expressions in the anterior cingulate cortex and insular cortex, both of which were positively correlated with orofacial inflammatory pain-like behaviors. The level of brain-derived neurotrophic factor was increased in the insular cortex under stress contagion. These results indicate that stress contagion can cause neural changes in the brain, resulting in increased masseter muscle nociception, as seen in social defeat stress mice.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10214037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard Huynh, Christine I. Peters, Sobia Zafar, Ove A. Peters
{"title":"Evaluating the stress of root canal treatment in patients and dentists compared to other dental treatments: A systematic review and meta-analysis","authors":"Richard Huynh, Christine I. Peters, Sobia Zafar, Ove A. Peters","doi":"10.1111/eos.12941","DOIUrl":"10.1111/eos.12941","url":null,"abstract":"<p>This systematic review aimed to investigate whether root canal treatment caused greater stress than other dental treatments for patients and dentists. All peer-reviewed literature published in English between January 1990 and January 2023 was included. This included randomized/non-randomized control trials, cohort studies, case-control studies, and cross-sectional studies. An electronic search used PubMed, Scopus, Medline, Cochrane Collaboration, and Embase. Hand searching supplemented the screening pool. Studies examining physiological or psychological stress measures within patients or providers of dental treatment (dentists, dental specialists, and dental students) were eligible. The study must have reported on the stress outcome for root canal treatment and at least one other dental procedure. After screening 3639 eligible records, there were 23 studies included, varying from very-low to low certainty of evidence. This review found that root canal treatment was more psychologically stressful for patients than routine restorative or cleaning procedures. However, the stress of root canal treatment relative to other dental procedures, especially extractions, was inconclusive for both dental patients and providers. Since patients regard root canal treatment as more stress-evoking than other routine dental procedures, providers should endeavour to minimise their own bias toward root canal treatment when providing adequate information for an informed treatment choice.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12941","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9910073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Filip Blasko, Bohuslav Novak, Karolina Gyonyorova, Boris Mravec
{"title":"Effect of long-term intake of liquid nutrition on the development and maintenance of the weight and size of the skull, mandible, and teeth in rats","authors":"Filip Blasko, Bohuslav Novak, Karolina Gyonyorova, Boris Mravec","doi":"10.1111/eos.12940","DOIUrl":"10.1111/eos.12940","url":null,"abstract":"<p>The consistency of the diet may affect the development and maintenance of the muscular and bony parts of the masticatory apparatus. Therefore, we investigated the effect of chronic intake of liquid nutrition (Fresubin) on the growth and maintenance of the weight and size of the skull, mandible, and teeth in Wistar rats fed with liquid nutrition during different developmental periods: (i) from weaning to adulthood, (ii) only in the juvenile period, or (iii) only in adulthood. We found that in all groups of rats fed with liquid nutrition, the skull and the mandible were significantly lighter in weight than those of control rats fed exclusively with pelleted chow from weaning to adulthood. In addition, in rats fed with liquid nutrition, the length of the mandible was significantly increased, whereas the height of the mandible and the length of the upper incisors were reduced. Our data indicate that food consistency may profoundly affect the growth pattern and the maintenance of the mass and size of skull bones and teeth during different periods of life. The extent of the effect was found to depend on the period during which liquid nutrition is provided and on the duration of its intake. In conclusion, the findings indicate that prolonged intake of liquid nutrition can significantly affect the development of the bone part of the masticatory apparatus.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9856266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. de Melo Alencar, J. Ferrari Zaniboni, J. Felipe Besegato, A. Patricia Oliveira Barros, M. Bena Gélio, L Garcia Belizário, E. Maximiliano Fernandez Godoy, M. Carlos Kuga
{"title":"Effect of irrigation acid solutions on cleaning and bond strength to post-space dentin","authors":"C. de Melo Alencar, J. Ferrari Zaniboni, J. Felipe Besegato, A. Patricia Oliveira Barros, M. Bena Gélio, L Garcia Belizário, E. Maximiliano Fernandez Godoy, M. Carlos Kuga","doi":"10.1111/eos.12939","DOIUrl":"10.1111/eos.12939","url":null,"abstract":"<p>This study evaluated the effects of irrigating solutions containing 5% boric acid + 1% citric acid or 1% peracetic acid + high concentration hydrogen peroxide on root cleaning and bond strength of cementation systems after 24 h and 6 months of glass fiber post cementation. One hundred and twenty roots were endodontically treated. The specimens were randomized into one of four treatments (<i>n</i> = 10): DW (distilled water); NaOCl<sub>2.5%</sub> + EDTA<sub>17%</sub> (2.5% sodium hypochlorite solution + 17% EDTA); PA<sub>1%</sub> + HP (1% peracetic acid solution + high concentration of hydrogen peroxide); BA<sub>5%</sub> + CA<sub>1%</sub> (5% boric acid associated with 1% citric acid). The cleaning efficacy in the cervical, middle, and apical thirds of the post-space, and the push-out bond strength at 24 h and 6 months after post cementation were evaluated by Kruskal-Wallis and two-way ANOVA tests, respectively. BA<sub>5%</sub> + CA<sub>1%</sub> showed statistically significantly superior cleaning efficacy compared to the other solutions. This irrigation protocol also resulted in higher bond strength at 24 h and 6 months, regardless of the root third considered, and this was statistically significantly higher than those seen for DW and PA<sub>1%</sub> + HP. For BA<sub>5%</sub> + CA<sub>1%</sub> irrigation protocol, type 1 adhesive failure was the most prevalent. Post-space irrigation with BA<sub>5%</sub> + CA<sub>1%</sub> provided both higher cleaning efficacy and better bond strength.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10226434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guilherme Pauletto, Israel Bangel Carlotto, Lucas Saldanha da Rosa, Natália de Freitas Daudt, Gabriel Kalil Rocha Pereira, Carlos Alexandre Souza Bier
{"title":"Effect of calcium hypochlorite and sodium thiosulfate on the bond strength to pulp chamber dentin: A laboratory investigation","authors":"Guilherme Pauletto, Israel Bangel Carlotto, Lucas Saldanha da Rosa, Natália de Freitas Daudt, Gabriel Kalil Rocha Pereira, Carlos Alexandre Souza Bier","doi":"10.1111/eos.12938","DOIUrl":"10.1111/eos.12938","url":null,"abstract":"<p>This study aimed to compare the effect of sodium hypochlorite (NaOCl) and calcium hypochlorite [Ca(OCl)<sub>2</sub>] on the bond strength to pulp chamber dentin when followed or not by the use of sodium thiosulfate (Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub>). The pulp chamber of fifty human molars were divided into five groups (<i>n</i> = 10) according to the immersion protocol: 2.5% NaOCl; 2.5% NaOCl + 5% Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub>; 2.5% Ca(OCl)<sub>2</sub>; 2.5% Ca(OCl)<sub>2</sub> + 5% Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub>; and 0.9% sodium chloride (NaCl; control). Subsequently, the samples were restored with resin composite. Three sticks each were obtained and subjected to microtensile testing. SEM/EDS analyses of the pulp chamber roof (<i>n</i> = 8) were carried out for mineral quantification. Elemental analysis data were investigated via one-way ANOVA and Tukey's post hoc, and bond strength data by post hoc pairwise comparisons using the Kruskal–Wallis test. Use of 2.5% NaOCl was associated with the lowest value of bond strength, while 2.5% Ca(OCl)<sub>2</sub> had similar bond strength to that of the 0.9% NaCl control. Using 5% Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub> was able to increase the bond strength after 2.5% NaOCl, but not after 2.5% Ca(OCl)<sub>2</sub>. The group treated only with 2.5% Ca(OCl)<sub>2</sub> had a higher Ca/P ratio on the dentin surface. Dentin treated with Ca(OCl)<sub>2</sub> was not affected by Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub> and showed bond strength similar to the 0.9% NaCl.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9854976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda Barchesi Zanelatto, Willians Fernando Vieira, Catarine Massucato Nishijima, César Renato Sartori, Carlos Amilcar Parada, Claudia Herrera Tambeli
{"title":"Effect of sound-induced repeated stress on the development of pain and inflammation in the temporomandibular joint of female and male rats","authors":"Fernanda Barchesi Zanelatto, Willians Fernando Vieira, Catarine Massucato Nishijima, César Renato Sartori, Carlos Amilcar Parada, Claudia Herrera Tambeli","doi":"10.1111/eos.12936","DOIUrl":"10.1111/eos.12936","url":null,"abstract":"<p>Temporomandibular disorder (TMD) is a common painful condition of the temporomandibular joint (TMJ) and associated structures. Stress is a significant risk factor for developing this painful condition that predominantly affects women. This study aimed to test the hypothesis that stress increases the risk of developing TMJ pain by facilitating inflammatory mechanisms in female and male rats. To test this hypothesis, we evaluated TMJ carrageenan-induced expression of pro-inflammatory cytokines and migration of inflammatory cells and TMJ formalin-induced nociception in female and male rats submitted to a repeated stress protocol induced by sound. We found that sound-induced repeated stress facilitates TMJ inflammation and contributes to TMJ nociception development equally in females and males. We conclude that stress is a risk factor for developing painful TMJ conditions in males and females, at least in part, by favoring the inflammatory process similarly in both sexes.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9852569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karla Regina Nogueira da Silva, Lucas Novaes Teixeira, Marcelo Lucchesi Teixeira, Guilherme Bovi Ambrosano, Elizabeth Ferreira Martinez
{"title":"Short implants: Influence of different diameters, torques, and transmucosal heights of straight prosthetic abutments on screw preload loss after cycling","authors":"Karla Regina Nogueira da Silva, Lucas Novaes Teixeira, Marcelo Lucchesi Teixeira, Guilherme Bovi Ambrosano, Elizabeth Ferreira Martinez","doi":"10.1111/eos.12937","DOIUrl":"10.1111/eos.12937","url":null,"abstract":"<p>This study evaluated the influence of different implant diameters, insertion torques, and transmucosal heights on the loosening of abutments installed on short implants, after mechanical cycling. The Morse taper connection implants (<i>n</i> = 96) tested were 5 mm high, divided according to the platform diameter: 4 or 6 mm. A universal abutment was coupled to each implant (with different transmucosal heights: 1 or 5 mm). The sets were subdivided into 20- and 32-Ncm torque. After the cycle fatigue test, the detorque values were measured with a digital torque indicator. After mechanical cycling, the mean detorque values obtained for the abutment with 20-Ncm insertion torque were lower than for implants with 32-Ncm insertion torque, regardless of the platform diameter or transmucosal height. In the 20-Ncm torque group, there was no statistically significant difference in the detorque values between platform diameters or transmucosal heights. Otherwise, for 32-Ncm sets, a smaller platform diameter (4 mm), and a longer transmucosal height (5 mm) showed the lowest detorque values. In conclusion, implants placed with 32-Ncm insertion torque and abutments with 1 mm transmucosal height and a 6 mm implant diameter demonstrated the highest detorque values.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10212969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Meza-Mauricio, Elisa Ribeiro Sá Tscherbakowski Mourão, Kelson Oliveira Marinho, Andrea Vergara-Buenaventura, Gerardo Mendoza-Azpur, Francisco Wilker Mustafa Gomes Muniz, Mauro Pedrine Santamaria, Marcelo Faveri
{"title":"Effect of collagen sponge and flowable resin composite on pain management after free gingival graft harvesting: A randomized controlled clinical trial","authors":"Jonathan Meza-Mauricio, Elisa Ribeiro Sá Tscherbakowski Mourão, Kelson Oliveira Marinho, Andrea Vergara-Buenaventura, Gerardo Mendoza-Azpur, Francisco Wilker Mustafa Gomes Muniz, Mauro Pedrine Santamaria, Marcelo Faveri","doi":"10.1111/eos.12935","DOIUrl":"10.1111/eos.12935","url":null,"abstract":"<p>The aim of this study was to compare the effect of the application of a flowable resin composite coating, over a collagen sponge stabilized with suture, on postoperative pain after free gingival graft harvesting. Thirty-two free gingival grafts were harvested from the palate in 32 patients, who were subsequently randomized to have only a collagen sponge stabilized with sutures applied to the palatal wound (control), or to have the collagen sponge coated with a flowable resin composite (test). Patients were observed for 14 days, and the pain level was evaluated by using a numerical rating scale. The consumption of analgesics during the postoperative period and the characteristic of the graft were also analyzed. The patients in the test group reported having experienced significantly less pain statistically than the patients in the control group throughout the study. The consumption of analgesics was lower in the test group. The dimensions of harvested grafts in the control and test groups showed no significant differences in height, width, and thickness. In conclusion, the addition of flowable resin composite coating to the hemostatic collagen sponge on the palatal wound following free gingival graft harvesting helped to minimize postoperative pain.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9525052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}