{"title":"Clinical benefits of autologous platelet concentrate in periodontal intrabony defects: A network meta-analysis of randomized controlled trials","authors":"Yue Cui, Yuhe Mai, Xuewei Liu, Hong Mu","doi":"10.1111/eos.12978","DOIUrl":"10.1111/eos.12978","url":null,"abstract":"<p>This study aimed to compare clinical benefits of autologous platelet concentrate with other periodontal regenerative approaches in intrabony defects. An electronic and hand search of studies up to December 2022 was conducted. Randomized controlled trials with at least 6 months of follow-up were identified to compare autologous platelet concentrates with enamel matrix derivative, bone graft, guided tissue regeneration, and open-flap debridement. All approaches involved papilla preservation flap surgery. The outcomes included probing depth reduction, clinical attachment level gain, linear bone fill, and safety. A network meta-analysis and meta-regression were performed. Fifty-seven studies were included in five network meta-analyses. Autologous platelets concentrate and its adjunct treatments achieved significantly greater clinical and radiographic parameters than did open-flap debridement, and had comparable or better performance than other regenerative treatments. Platelet-rich fibrin showed superiority over platelet-rich plasma in probing depth reduction at 6-month follow-up. Minimal pain and improved wound healing were observed in the treatments with autologous platelet concentrate. Meta-regression showed that deeper baseline intrabony defects resulted in larger probing depth reductions, while smoking impaired the effectiveness of regenerative surgeries. Minimal invasive flap designs led to less effect of regenerative materials. Autologous platelet concentrate is a promising biomaterial in periodontal regeneration due to its convenience, safety, and biocompatibility characteristics.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Feldmann, Gustavo Eidt, Sandra Liana Henz, Rodrigo Alex Arthur
{"title":"Probiotics-containing beverages and dental caries: A systematic review and meta-analysis","authors":"Alexandra Feldmann, Gustavo Eidt, Sandra Liana Henz, Rodrigo Alex Arthur","doi":"10.1111/eos.12980","DOIUrl":"10.1111/eos.12980","url":null,"abstract":"<p>The aim was to evaluate the effect of probiotics-containing beverages on dental caries development by a systematic review and meta-analysis (PROSPERO CRD42021258010). PubMed, Embase, and Web of Science databases were assessed (up to October 2023) for randomized placebo-controlled trials that evaluated the consumption of probiotics-containing beverages having dental caries as endpoint. Risk of bias assessment (Cochrane Handbook) was performed for all studies. Risk ratio (RR), standardized mean difference (SMD) and 95% confidence interval (CI), were calculated for caries prevalence and caries increment, respectively. Meta-analysis was performed. Qualitative analysis of more than 2000 individuals aged from 1 to 84 years (9 studies) showed inconsistent effects of these probiotics-containing beverages. Synthesis of more than 1000 children and adolescents did not demonstrate a statistically significant difference in the proportion of individuals with cavitated lesions (RR 0.60 [95 % CI 0.34 to 1.08]; <i>n</i> = 2), but a significantly smaller increment of both cavitated and non-cavitated carious lesions (SMD −0.23 [95 % CI −0.39 to −0.08]; <i>n</i> = 4) was related to the consumption of probiotics-containing beverages. Certainty of evidence for caries prevalence and caries increment were moderate and low, respectively. Current evidence is not substantial to strengthen the impact of these beverages on caries development.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of occlusal appliances on the masticatory muscle function in individuals with sleep bruxism: A systematic review and meta-analysis","authors":"Guilherme Fantini Ferreira, Talita Malini Carletti, Lorena Tavares Gama, Marcela Baraúna Magno, Lucianne Cople Maia, Renata Cunha Matheus Rodrigues Garcia","doi":"10.1111/eos.12979","DOIUrl":"10.1111/eos.12979","url":null,"abstract":"<p>This systematic review answers the question: “Does occlusal appliance use influence masticatory muscle function of dentate individuals with sleep bruxism?”. The literature search included six databases, grey literature, and manual search for articles. Randomized and non-randomized clinical trials were included comparing muscle function of sleep bruxers before and after receiving occlusal appliances. Risk of bias was assessed with risk of bias assessment for randomized and non-randomized clinical trials tool. Twelve studies, three represent randomized clinical trials, were included. Risk of bias was considered low, moderate, or serious. Meta-analyses indicated that soft and hard appliances did not influence muscle activity and bite force of bruxers. Qualitative analysis showed that occlusal appliance use did not influence masticatory performance and muscle volume. However, it was effective in reducing tongue force. Certainty of evidence was considered very low for muscle activity when evaluated with hard appliances, and for bite force evaluated with both appliance materials. Low certainty of evidence was observed for muscle activity with soft appliances. Based on the findings of this meta-analysis, occlusal appliances do not affect masticatory muscle function of sleep bruxers. Regardless of appliance material, the activity of masseter and temporal, and bite force of sleep bruxers was not influenced.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria G. Balta, Olav Schreurs, Inger Johanne Schytte Blix, Karl Schenck
{"title":"The effect of resolvin D1n-3 DPA on primary oral epithelial cell migration in vitro","authors":"Maria G. Balta, Olav Schreurs, Inger Johanne Schytte Blix, Karl Schenck","doi":"10.1111/eos.12981","DOIUrl":"10.1111/eos.12981","url":null,"abstract":"<p>Specialized pro-resolving lipid mediators (SPMs) are known for their anti-inflammatory and pro-resolving actions. The aim of the present study was to find new functions of the SPM resolvin D1<sub>n-3 DPA</sub> (RvD1<sub>n-3 DPA</sub>) on oral epithelial cells. As a starting point, we used a dataset obtained by RNA high-throughput sequencing of oral epithelial cells exposed to TNF-α and RvD1<sub>n-3 DPA</sub> versus TNF-α alone. <i>GOrilla</i> enrichment analysis showed that the actin cytoskeleton was significantly overrepresented after adjustment for multiple hypothesis testing. As actin, amongst others, is closely related to cell migration, we then explored whether RvD1<sub>n-3 DPA</sub> can modulate oral epithelial cell migration. To this end, we used an in vitro cell migration model, including TNF-α treatment, to mimic an inflammatory cell state. The analysis revealed that RvD1<sub>n-3 DPA</sub> increased oral epithelial cell migration in the presence but not in the absence of TNF-α. Addition of RvD1<sub>n-3 DPA</sub> also induced F actin accumulation around the cell nucleus, indicating that RvD1<sub>n-3 DPA</sub> potentially can mediate processes of intracellular transport. This indicates that this lipid mediator may be a promising therapeutic candidate in oral mucosal wound healing.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christoph Matthias Schoppmeier, Malin Janson, Karolin Höfer, Isabelle Graf, Michael Jochen Wicht, Anna Greta Barbe
{"title":"Use of the modified Schirmer test to measure salivary gland hypofunction/hyposalivation: Systematic review and meta-analysis","authors":"Christoph Matthias Schoppmeier, Malin Janson, Karolin Höfer, Isabelle Graf, Michael Jochen Wicht, Anna Greta Barbe","doi":"10.1111/eos.12977","DOIUrl":"10.1111/eos.12977","url":null,"abstract":"<p>Although dry mouth is a relatively common condition, salivary flow is not routinely measured in dental clinical practice. Moreover, existing data regarding the use of the modified Schirmer test (MST) for the screening of dry mouth has not been summarized. This systematic review and meta-analysis, conducted in accordance with the PRISMA guidelines, aimed to determine whether the modified Schirmer test can be used to identify dry mouth. The databases of PubMed, Scopus, ScienceDirect, and CENTRAL (CRD42023393843) were systematically searched to retrieve articles published until 9th November 2023. Among the 343 original articles retrieved, six met the inclusion criteria. A total of 1150 patients, comprising 710 (61.7%) women and 440 (38.3%) men (mean age, 47.1 ± 7.3 years), were included. The meta-analysis revealed a weak correlation coefficient of <math>\u0000 <semantics>\u0000 <mover>\u0000 <mi>r</mi>\u0000 <mo>¯</mo>\u0000 </mover>\u0000 <annotation>$bar{r}$</annotation>\u0000 </semantics></math> = 0.42 (95% Cl: 0.29–0.55) between MST and the unstimulated salivary flow rate. Therefore, while the MST might offer a simple and accessible alternative for initial screening in the future, especially in non-specialized settings, its variability in sensitivity and specificity, along with an actual lack of standardization, necessitates cautious interpretation. Further studies are necessary before recommending the test in clinical routine.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12977","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mika Ogawa, Akihiro Saito, Max Karukivi, Satu Lahti
{"title":"Associations of sensory sensitivity, pain catastrophizing, and alexithymia with dental anxiety","authors":"Mika Ogawa, Akihiro Saito, Max Karukivi, Satu Lahti","doi":"10.1111/eos.12973","DOIUrl":"10.1111/eos.12973","url":null,"abstract":"<p>We aimed to reveal interrelationships between alexithymia, catastrophic thinking, sensory processing patterns, and dental anxiety among 460 participants who were registrants of a Japanese research company. Measures used were the Modified Dental Anxiety Scale, the Adult Sensory Profile, the Pain Catastrophizing Scale, and the 20-item Toronto Alexithymia Scale. The interrelationships among the constructs were analyzed using structural equation modeling, adjusting for age, gender, and negative dental treatment experience. Data from 428 participants were used in the analyses. Sensory sensitivity and pain catastrophizing were independently associated with anticipatory and treatment-related dental anxiety, while difficulty identifying feelings was not. In the mediation model, sensory sensitivity and pain catastrophizing served as full mediators between difficulty identifying feelings and the dimensions of dental anxiety (indirect effects were between 0.13 and 0.15). The strength of the associations was 0.55 from difficulty identifying feelings to both pain catastrophizing and sensory sensitivity, and between 0.24 and 0.26 to anticipatory and treatment-related dental anxiety. The association between trait-like phenomena, such as alexithymia, and dental anxiety may be mediated by neurophysiological and cognitive factors such as sensory sensitivity and pain catastrophizing. These findings could be crucial for new and innovative interventions for managing dental anxiety.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differences in anxiety, depression, and oral health-related quality of life among dental anxiety patients with and without reported abuse experience","authors":"Vilde Aardal, Tiril Willumsen, Kjersti Berge Evensen","doi":"10.1111/eos.12976","DOIUrl":"10.1111/eos.12976","url":null,"abstract":"<p>This study aimed to explore the differences in anxiety, depression, and oral health-related quality of life between people with dental anxiety who reported abuse experience (<i>n</i> = 60) and people with dental anxiety who did not report abuse experience (<i>n</i> = 97). Both groups attended a dental service focused on the treatment of dental anxiety intended for people with a history of physiological or psychological trauma, or odontophobia. The participants responded to a questionnaire that included the Hospital Anxiety and Depression Scale (HADS), Oral Impacts on Daily Performance (OIDP), and the Index of Dental Anxiety and Fear (IDAF-4C<sup>+</sup>). The differences between groups were tested for statistical significance using Welch's <i>T</i>-tests, and linear regression was used to adjust for gender. The participants with reported abuse experience expressed greater psychological symptoms of anxiety and poorer oral health-related quality of life. The participants with reported abuse experience also expressed a higher fear of losing control, as well as feeling shame and disgust. This study shows that individuals with dental anxiety and a history of abuse may face more complex challenges than those with dental anxiety and no history of abuse.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139665137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathrine Høyvik Bergum, Vibeke Hervik Bull, Linda Maria Stein, Kjersti Berge Evensen
{"title":"Prisoners’ perceived oral and general health and their experience with accessing, understanding and assessing health information: A qualitative study","authors":"Kathrine Høyvik Bergum, Vibeke Hervik Bull, Linda Maria Stein, Kjersti Berge Evensen","doi":"10.1111/eos.12972","DOIUrl":"10.1111/eos.12972","url":null,"abstract":"<p>Prisoners’ oral health and general health are closely connected and generally poorer than that of the wider population. Moreover, knowledge of prisoners’ health literacy is scarce. This study aimed to explore prisoners’ perceived oral and general health and how they accessed, understood and assessed health information to gain insight into their health literacy. Twelve prisoners in a high-security prison and a halfway house participated in individual semi-structured interviews. Data was analysed through thematic analysis, which identified five themes: inconsistent self-reporting of general and oral health; autonomous health behaviour through utilizing personal resources; preference for personalized adapted health information; psychological and physical proximity; and barriers. The prisoners perceived their oral and general health as good despite several health problems. They expressed scepticism towards health information from public authorities and made their own health-related choices based on previous experiences, their own ‘common sense’ and the experiences of people they trusted. Health information was considered useful when adjusted to their needs. Obtaining health-related information through physical encounters was considered more accessible than through online platforms. Adapting the communication to prisoners’ expressed needs and their health literacy can enhance the accessibility to improve their oral and general health. In-person encounters would be preferable.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139502068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stress analysis of horizontal mid-root fracture managed with different intraradicular fixation protocols: A 3D-finite element study","authors":"Neha Jasrasaria, Saumya Johri, Ramesh Bharti, Aseem Prakash Tikku","doi":"10.1111/eos.12971","DOIUrl":"10.1111/eos.12971","url":null,"abstract":"<p>The current study evaluated the stress distribution in a maxillary central incisor with mid-root fracture after splinting with different intra-radicular posts using 3D-finite element analysis (FEA). Five 3D-FEA models were constructed. Model 1 was an intact tooth with no fracture, Model 2: A tooth with a horizontal mid-root fracture, with no treatment. Model 3: Same as model 2, and intraradicular splinting using fiber post. Model 4: Same as model 2 and intra-radicular splinting using Protaper Gold file F3. Model 5: Same as model 2, and with intraradicular splinting with Ribbond. The FEA of all models was done to obtain the maximum Von-Mises stress in the root canal space, the dentin, the periodontal ligament, and the bone. The highest Von Mises stresses for the root canal space and the dentin were found in Model 3, followed by models 4, 5, and 2, and least in Model 1. The Von Mises stress of the periodontal ligament was the least in model 1. The Von Mises stress of bone was higher in all experimental models than in the baseline model. The results suggest that in cases where intra-radicular splinting is indicated, fiber posts and Ribbond are better alternatives to endodontic files due to the lower stresses exerted.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}