European Journal of Oral Sciences最新文献_第10页

Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation 牙釉质上皮瞬时受体电位美拉他汀7的条件敲除:对牙釉质形成的影响

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-02-16 DOI: 10.1111/eos.12920

Masashi Shin, Aya Matsushima, Hiroshi Kajiya, Fujio Okamoto, Kayoko Ogata, Kyoko Oka, Hayato Ohshima, John D. Bartlett, Koji Okabe

{"title":"Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation","authors":"Masashi Shin, Aya Matsushima, Hiroshi Kajiya, Fujio Okamoto, Kayoko Ogata, Kyoko Oka, Hayato Ohshima, John D. Bartlett, Koji Okabe","doi":"10.1111/eos.12920","DOIUrl":"10.1111/eos.12920","url":null,"abstract":"Transient receptor potential melastatin 7 (TRPM7) is a unique ion channel connected to a kinase domain. We previously demonstrated that Trpm7 expression is high in mouse ameloblasts and odontoblasts, and that amelogenesis is impaired in TRPM7 kinase-dead mice. Here, we analyzed TRPM7 function during amelogenesis in Keratin 14-Cre;Trpm7fl/fl conditional knockout (cKO) mice and Trpm7 knockdown cell lines. cKO mice showed lesser tooth pigmentation than control mice and broken incisor tips. Enamel calcification and microhardness were lower in cKO mice. Electron probe microanalysis (EPMA) showed that the calcium and phosphorus contents in the enamel were lower in cKO mouse than in control mice. The ameloblast layer in cKO mice showed ameloblast dysplasia at the maturation stage. The morphological defects were observed in rat SF2 cells with Trpm7 knockdown. Compared with mock transfectants, the Trpm7 knockdown cell lines showed lower levels of calcification with Alizarin Red-positive staining and an impaired intercellular adhesion structures. These findings suggest that TRPM7 is a critical ion channel in enamel calcification for the effective morphogenesis of ameloblasts during amelogenesis.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9173043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Citrus reticulata peel nano-encapsulated essential oil and in vitro assessment of its biological properties 柑桔皮纳米胶囊精油的制备及其体外生物学性能评价

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-02-16 DOI: 10.1111/eos.12924

Maryam Torshabi, Zahra MoadabShoar, Maryam Negahban

{"title":"Preparation of Citrus reticulata peel nano-encapsulated essential oil and in vitro assessment of its biological properties","authors":"Maryam Torshabi, Zahra MoadabShoar, Maryam Negahban","doi":"10.1111/eos.12924","DOIUrl":"10.1111/eos.12924","url":null,"abstract":"Dental caries is the most common biofilm-dependent oral disease. Streptococcus mutans is among the main microorganisms responsible for the development of dental caries. Nano-suspension of Citrus reticulata (tangerine) peel essential oil in 0.5% (v/v) concentration was prepared and its antibacterial effect on S. mutans in planktonic and biofilm forms as well as its cytotoxic and antioxidant effects were assessed and compared with chlorhexidine (CHX). The minimum inhibitory concentration (MIC) of free essential oil, nano-encapsulated essential oil, and CHX was 5.6% (v/v), 0.0005% (v/v), and 0.0002% (w/v), respectively. The percentage of biofilm inhibition by the free essential oil, nano-encapsulated essential oil, and CHX at half-MIC was 67.3%, 24%, and 90.6%, respectively. The nano-encapsulated essential oil had no cytotoxicity and showed significant antioxidant effects in different concentrations. Nano-encapsulation of tangerine peel essential oil significantly enhanced its biological activities in much lower concentrations than the free essential oil (11,000 times diluted). It also showed lower cytotoxicity and higher antibiofilm effects in sub-MICs compared with CHX, indicating the optimal potential of tangerine nano-encapsulated essential oil for incorporation in the composition of organic antibacterial and antioxidant mouth rinses.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9225498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cortactin expression in a Norwegian cohort of human papilloma virus negative oral squamous cell carcinomas of the mobile tongue 挪威人乳头状瘤病毒阴性口腔鳞状细胞癌患者中皮层蛋白的表达

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-02-15 DOI: 10.1111/eos.12925

B. Sengüven Toközlü, D. Sapkota, E. M. Vallenari, O. Schreurs, T. M. Søland

{"title":"Cortactin expression in a Norwegian cohort of human papilloma virus negative oral squamous cell carcinomas of the mobile tongue","authors":"B. Sengüven Toközlü, D. Sapkota, E. M. Vallenari, O. Schreurs, T. M. Søland","doi":"10.1111/eos.12925","DOIUrl":"10.1111/eos.12925","url":null,"abstract":"Oral squamous cell carcinoma of the tongue (OTSCC) is the most common malignancy among oral squamous cell carcinomas and is frequently associated with an unfavorable prognosis. Local spread and distant metastasis are important causes of poor prognosis in OTSCC. Cortactin amplification and overexpression, a common molecular alteration in oral squamous cell carcinomas, have been linked to invasion and metastasis of tumor cells. However, the intra-tumor expression pattern and prognostic significance of cortactin in human papillomavirus (HPV) negative OTSCC is not fully investigated. Immunohistochemical analysis using tissue microarray consisting of formalin-fixed and paraffin-embedded HPV negative OTSCC (n = 123) specimens showed overexpression of cortactin at tissue cores from invading fronts as compared to the corresponding center cores. High overall cortactin expression was found to be associated with advanced (larger) tumor size and the occurrence of distance metastasis. Kaplan-Meier survival analysis showed that patients with high overall cortactin expression were associated with reduced 5-year survival. Multivariate Cox regression analysis identified high cortactin expression to be an independent prognostic factor in OTSCC. Additionally, siRNA-mediated silencing of cortactin was found to suppress the proliferative and invasive abilities of OTSCC cells in an organotypic co-culture model. Overexpression of cortactin is a promising prognostic marker in HPV-negative OTSCC.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9225491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four-point flexural strength and microtensile bond strength of digitally and conventionally veneered zirconia 四点弯曲强度和微拉伸结合强度的数字和传统贴面氧化锆

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-02-15 DOI: 10.1111/eos.12926

M. Utar, Z. Demirtağ

{"title":"Four-point flexural strength and microtensile bond strength of digitally and conventionally veneered zirconia","authors":"M. Utar, Z. Demirtağ","doi":"10.1111/eos.12926","DOIUrl":"10.1111/eos.12926","url":null,"abstract":"This study intended to evaluate the effect of digital veneering on four-point flexural strength (FS) and microtensile bond strength (μTBS) of veneered zirconia. Two different zirconia blocks, a lithium disilicate and a feldspathic ceramic block, and two different layering ceramics were used. IPS e.max Zir CAD (ZC) and Vita In-Ceram YZ (YZ) with yttria stabilized tetragonal zirconia polycrystals (3Y-TZP) were used as substructures. IPS e.max CAD (LD), Vita Mark II (VMII), IPS e.max Ceram (EC) and Vita VM9 (VM9) were used for veneering. Resin cement and fusion ceramic were placed between veneer and zirconia substructure for digital veneering. A total of one hundred and fifty specimens in five groups (n = 30) were prepared for FS and tested in universal machine at 1.0 mm/min. One hundred specimens in five groups (n = 20) were obtained for the μTBS and tested at 1.0 mm/min. Statistical analysis was made by one way ANOVA and Tukey HSD. Conventional veneering showed statistically significant FS. ZC veneered with EC had the highest mean FS and the lowest was obtained in groups veneered through resin cement. YZ layered with VM9 had the highest mean μTBS. ZC veneered through fusion ceramic and YZ veneered through resin cement showed significantly lower and similar μTBS.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9225496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of cathepsin D induced by Porphyromonas gingivalis lipopolysaccharide in periodontitis 牙龈卟啉单胞菌脂多糖诱导组织蛋白酶D在牙周炎中的作用

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-02-14 DOI: 10.1111/eos.12923

Hyun Woong Jeong, Dong Sik Chang, June Soo Kim, Young Sun Hwang

{"title":"Role of cathepsin D induced by Porphyromonas gingivalis lipopolysaccharide in periodontitis","authors":"Hyun Woong Jeong, Dong Sik Chang, June Soo Kim, Young Sun Hwang","doi":"10.1111/eos.12923","DOIUrl":"10.1111/eos.12923","url":null,"abstract":"Periodontitis is an inflammatory disease of tooth-supporting tissues caused by oral bacteria. Periodontal ligament loss and alveolar bone destruction occur in progressive periodontitis. Since gingival crevicular fluids (GCF) reflects the inflammatory environment of the periodontal pocket, it is a very important specimen for developing targets for periodontitis diagnosis. An antibody array was performed using GCF collected from healthy participants and patients with periodontitis to identify the proteolytic enzymes involved in periodontitis. Of 21 targets on the antibody array membrane, kallikrein 6 (KLK6), kallikrein 10 (KLK10), cathepsin A (CathA), and cathepsin D (CathD) showed higher levels in periodontitis GCF than in GCF from healthy participants. Lipopolysaccharide stimulation of Porphyromonas gingivalis (PG-LPS) in immortalized gingival fibroblasts only increased CathD protein levels among the four targets. The substrate cleavage activity of CathD was increased in PG-LPS-treated immortalized gingival fibroblast extract. The PG-LPS-induced substrate cleavage effect was abolished by the CathD inhibitor pepstatin A. Osteoclast formation was promoted by treatment with conditioned media from PG-LPS- treated immortalized gingival fibroblasts but inhibited by the CathD inhibitor pepstatin A. These results suggest that PG-LPS affected the osteoclast formation process by increasing CathD expression in cells around the alveolar bone, thereby participating in periodontitis progression.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9523777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface smoothness of resin composites after polishing—A systematic review and network meta-analysis of in vitro studies 树脂复合材料抛光后的表面光滑度——体外研究的系统综述和网络荟萃分析

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-02-13 DOI: 10.1111/eos.12921

Ananda Gomes de Oliveira, Rafael Santos Rocha, Manuela da Silva Spinola, Graziela Ribeiro Batista, Eduardo Bresciani, Taciana Marco Ferraz Caneppele

{"title":"Surface smoothness of resin composites after polishing—A systematic review and network meta-analysis of in vitro studies","authors":"Ananda Gomes de Oliveira, Rafael Santos Rocha, Manuela da Silva Spinola, Graziela Ribeiro Batista, Eduardo Bresciani, Taciana Marco Ferraz Caneppele","doi":"10.1111/eos.12921","DOIUrl":"10.1111/eos.12921","url":null,"abstract":"A systematic review and network meta-analysis was performed to provide evidence for the best polishing protocol for different types of resin composites to minimize surface roughness. A search was performed in PubMed, Scopus, Web of Science, LILACS, BBO, EMBASE, and Cochrane Library on July 2, 2019 (updated in December, 2020). In vitro studies that included at least two systems for polishing resin composites and analyzed surface roughness were included. The risk of bias was evaluated. A random-effects Bayesian-mixed treatment comparison model was used to compare surface roughness in resin composites with the different types of polishers. Surface under the cumulative ranking curve (SUCRA) analysis was performed to rank the probability for the best polishing system. After removal of duplicates, title and abstract screening yielded 34 studies. Network meta-analysis was not possible for hybrid and microhybrid composites. SUCRA analysis showed that abrasive paper discs allowed greater surface smoothness for nanohybrid and nanofill composites to a probability of between 83% and 91.6%. Silicon carbide brush had a 78.2% probability of being the best system for microfill composites. The use of abrasive paper disc polishers showed a favorable result in nanofill and nanohybrid resin composites. Silicon carbide brush has a greater chance of promoting a smoother surface for microfill resin composites.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9539633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of local administration of eicosapentaenoic acid on the jaw-opening reflex in rats 局部给药二十碳五烯酸对大鼠开颚反射的影响

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-02-07 DOI: 10.1111/eos.12917

Hibiki Osaki, Mina Mori, Katsuo Oshima, Yoshihito Shimazu, Mamoru Takeda

{"title":"Effect of local administration of eicosapentaenoic acid on the jaw-opening reflex in rats","authors":"Hibiki Osaki, Mina Mori, Katsuo Oshima, Yoshihito Shimazu, Mamoru Takeda","doi":"10.1111/eos.12917","DOIUrl":"10.1111/eos.12917","url":null,"abstract":"Although eicosapentaenoic acid (EPA) application in vitro inhibits voltage-gated Na+ (Nav) channels in excitable tissues, the acute local effect of EPA on the jaw-opening reflex in vivo remains unknown. The aim of the present study was to determine whether local administration of EPA to adult male Wistar rats could attenuate the excitability of the jaw-opening reflex in vivo, including nociception. The jaw-opening reflex evoked by electrical stimulation of the tongue was recorded by a digastric muscle electromyogram (dEMG) in pentobarbital-anesthetized rats. The amplitude of the dEMG response was significantly increased in proportion to the electrical stimulation intensity (1×–5× threshold). At 3×, local administration of EPA dose-dependently inhibited the dEMG response, lasting 60 min, with maximum inhibition observed within approximately 10 min. The mean magnitude of dEMG signal inhibition by EPA was almost equal to that observed with a local anesthetic, 1% lidocaine, and with a half dose of lidocaine plus a half dose of EPA. These findings suggest that EPA attenuates the jaw-opening reflex, possibly by blocking Nav channels of primary nerve terminals, and strongly support the idea that EPA is a potential therapeutic agent and complementary alternative medicine for the prevention of acute trigeminal nociception.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9172560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel bioactive glass/graphene oxide composite coating for a polyether ether ketone-based dental implant 一种新型生物活性玻璃/氧化石墨烯复合涂层用于聚醚醚酮基牙科种植体

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-01-27 DOI: 10.1111/eos.12915

Ahmed Al-Noaman, Simon Charles Fielding Rawlinson

{"title":"A novel bioactive glass/graphene oxide composite coating for a polyether ether ketone-based dental implant","authors":"Ahmed Al-Noaman, Simon Charles Fielding Rawlinson","doi":"10.1111/eos.12915","DOIUrl":"10.1111/eos.12915","url":null,"abstract":"Polyether ether ketone (PEEK) is a biocompatible material that lacks antimicrobial activity and bioactivity; therefore, is not appropriate for use as a dental implant. To overcome these deficiencies, a novel composite coating of bioactive glass and graphene oxide was prepared. PEEK discs were polished, cleaned, and the surface treated with sulfuric acid for 15 min. The composite coating consisted of bioactive glass produced by the sol-gel route and doped with 0.75 wt% graphene oxide. X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy-energy dispersive spectroscopy analyses were employed to characterize the composite coating, and the coating adhesion strength quantified using a pull-off test. Cytotoxicity was assessed using osteoblast-like cells and gingival fibroblasts. The wettability of the coated and non-coated samples was determined by optical contact angle assessment, and bioactivity was assessed by immersion in simulated body fluid. The results revealed that the bioactive glass/graphene oxide composite coating, approximately 7 μm thick, was transparent, homogenous with few microcracks and microporosities, but adhered strongly and was not cytotoxic to either osteoblast-like cells or gingival fibroblasts. The wettability of the PEEK sample was increased to <20° after coating with the composite, and apatite formation was detectable after 14 days of immersion in simulated body fluid.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9165248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Reviewers 2022 2022年评审员

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-01-27 DOI: 10.1111/eos.12918

引用次数: 0

Association between genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment 关键维生素d途径基因的遗传变异与正畸治疗相关的外根尖吸收之间的关系

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-01-22 DOI: 10.1111/eos.12916

G. Marañón-Vásquez, EC. Küchler, S. Hermann, E Paddenberg, A. Schröder, F. Baratto-Filho, C. Flores-Mir, P. Proff, C. Kirschneck

{"title":"Association between genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment","authors":"G. Marañón-Vásquez, EC. Küchler, S. Hermann, E Paddenberg, A. Schröder, F. Baratto-Filho, C. Flores-Mir, P. Proff, C. Kirschneck","doi":"10.1111/eos.12916","DOIUrl":"10.1111/eos.12916","url":null,"abstract":"This study evaluated the association between single-nucleotide polymorphisms (SNPs) in vitamin-D-related genes and the amount of external apical root resorption linked to orthodontic treatment. One hundred and forty-three individuals were assessed. The amount of external apical root resorption of upper central incisors (EARRinc) and lower first molars (EARRmol) were evaluated in radiographs. Seven SNPs were genotyped across four genes including the vitamin D receptor [VDR], group-specific component [GC], cytochrome P450 family 27 subfamily B member 1 [CYP27B1], and cytochrome P450 family 24 subfamily A member 1 [CYP24A1]. Linear regressions were implemented to determine allele-effects on external apical root resorption. Individuals carrying the AA genotype in VDR rs2228570 had a 21% higher EARRmol than those having AG and GG genotypes (95% CI: 1.03,1.40). EARRmol in heterozygous rs2228570, was 12% lower than for homozygotes (95%CI: 0.78,0.99). Participants with the CCG haplotype (rs1544410-rs7975232-rs731236) in VDR had an EARRmol 16% lower than those who did not carry this haplotype. Regarding CYP27B1 rs4646536, EARRinc in participants who had at least one G allele was 42% lower than for homozygotes AA (95%CI: 0.37,0.93). Although these results did not remain significant after multiple testing adjustment, potential associations may still be suggested. Further replication studies are needed to confirm or refute these findings.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12916","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9172553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0