European Journal of Oral Sciences最新文献

Microbial dysbiosis and tumor biomarker expression in oral leukoplakia and oral squamous cell carcinoma: A quantitative polymerase chain reaction-based immunohistochemical study. 口腔白斑和口腔鳞状细胞癌中微生物生态失调和肿瘤生物标志物表达：一项基于定量聚合酶链反应的免疫组织化学研究。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-01 DOI: 10.1111/eos.70137

Ajay Kumar Verma, Anjali Narwal, Mala Kamboj, Anju Devi, Shikha Tewari, Gopikrishnan Vijayakumar

{"title":"Microbial dysbiosis and tumor biomarker expression in oral leukoplakia and oral squamous cell carcinoma: A quantitative polymerase chain reaction-based immunohistochemical study.","authors":"Ajay Kumar Verma, Anjali Narwal, Mala Kamboj, Anju Devi, Shikha Tewari, Gopikrishnan Vijayakumar","doi":"10.1111/eos.70137","DOIUrl":"https://doi.org/10.1111/eos.70137","url":null,"abstract":"Porphyromonas gingivalis is a major periodontal pathogen increasingly associated with oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) due to its role in microbial dysbiosis and carcinogenesis. This study aimed to evaluate the relative abundance of P. gingivalis in healthy controls, OL, and OSCC patients and to correlate the bacterial load with immunohistochemical (IHC) markers. A total of 48 oral swab samples were collected from three study groups: (1) healthy, (2) OL, and (3) OSCC. Quantitative PCR was performed to assess the relative abundance of P. gingivalis in these groups. Immunohistochemistry was done to analyze the expression of Ki-67, Bcl-2, and β-catenin in 32 formalin-fixed paraffin-embedded tissue of OL and OSCC. The mean cycle threshold value of P. gingivalis was 23.82, 23.57, and 22.05 in healthy, OL, and OSCC, respectively, indicating a higher abundance of the bacterium in OSCC. IHC analysis revealed increased Ki-67 and Bcl-2 expression in OSCC. Additionally, β-catenin exhibited a shift from membranous in OL to cytoplasmic/nuclear localization in OSCC, suggesting its role in cancer progression. No significant correlation was observed between bacterial abundance and IHC marker expression. This study highlights the significant presence of P. gingivalis in OSCC, suggesting its potential role in oral carcinogenesis.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70137"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet concentrates in sinus augmentation: The impact of platelet dose and biological characteristics-A systematic review and meta-analysis. 静脉窦增强术中血小板浓缩：血小板剂量和生物学特性的影响——系统回顾和荟萃分析。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-08-29 DOI: 10.1111/eos.70136

Olav Kansgar Straum, Hans Thomas Brox, Juliane Hesse, Andreas Jörn Schmalfuss, Erlend Bugge

{"title":"Platelet concentrates in sinus augmentation: The impact of platelet dose and biological characteristics-A systematic review and meta-analysis.","authors":"Olav Kansgar Straum, Hans Thomas Brox, Juliane Hesse, Andreas Jörn Schmalfuss, Erlend Bugge","doi":"10.1111/eos.70136","DOIUrl":"https://doi.org/10.1111/eos.70136","url":null,"abstract":"This systematic review investigated the osteogenic effects of platelet concentrate (PRF/PRP) when combined with non-autogenous graft materials in sinus lift procedures. Key characteristics assessed included platelet concentration, total platelet dose, leukocyte content, and fibrin-network structure. A comprehensive search of EMBASE OvidSP, PubMed, and the Cochrane Library was conducted in April 2026, resulting in the inclusion of 25 articles. Studies were broadly categorized according to whether they reported enhanced osteogenic outcomes or not: positive studies (n = 15) and negative studies (n = 10). A key finding is that positive studies used a higher total platelet dose than negative studies (8.02 × 109 vs. 3.67 × 109). A subgroup meta-analysis of eight randomized controlled trials (RCTs) found that the five high-dose studies, using approx. ≥10 × 109 platelets, demonstrated a significant increase in new bone formation (effect size: 1.04; p < 0.01). In contrast, the three low-dose studies showed a modest but nonsignificant effect (effect size: 0.49; p = 0.355). However, the difference between the two subgroups was not statistically significant. Available evidence suggests that higher platelet doses, particularly around ≥10 × 109 platelets, may be associated with more favorable osteogenic outcomes. However, this dose should not be interpreted as a clinically validated threshold.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70136"},"PeriodicalIF":2.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of organic solvents on the depth-of-cure determination of conventional and bulk-fill resin composites. 有机溶剂对常规和填充型树脂复合材料固化深度测定的影响。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-08-17 DOI: 10.1111/eos.70130

Beatriz de Cássia Romano, Frederick Allen Rueggeberg, Jorge Soto-Montero, Carolina Bosso Andre, Marcelo Giannini

{"title":"Effects of organic solvents on the depth-of-cure determination of conventional and bulk-fill resin composites.","authors":"Beatriz de Cássia Romano, Frederick Allen Rueggeberg, Jorge Soto-Montero, Carolina Bosso Andre, Marcelo Giannini","doi":"10.1111/eos.70130","DOIUrl":"https://doi.org/10.1111/eos.70130","url":null,"abstract":"This study investigated the influence of organic solvents on the depth of cure (DOC) of resin composites. Two conventional (Filtek Universal [FU] and Beautifil II [BE]) and two bulk-fill (Filtek One Bulk Fill [FO] and Beautifil-Bulk [BB]) composites were evaluated. Cylindrical specimens were fabricated using polyvinylsiloxane molds, light-cured according to the manufacturers' recommendations, and immersed in one of four solvents: acetone, chloroform, ethanol (ETH), or tetrahydrofuran, for 48 h at 22°C (n = 10/composite/solvent). Specimens were imaged under a digital microscope, and the thicknesses of the \"solvent-resistant\" and \"solvent-affected\" zones, as well as the percentage of solvent-affected area, were measured with imagej. Knoop microhardness was measured at the top and at 1-mm intervals down to 5 mm (conventional) or 7 mm (bulk-fill). The \"solvent-resistant\" zone ranged from 3.1 to 4.3 mm for conventional and from 4.9 to 6.9 mm for bulk-fill composites. ETH produced the smallest solvent-affected area for all composites. The 80% bottom-to-top microhardness ratio was reached at 2.6-3.4 mm for conventional, 3.6-4.2 mm for FO, and 2.9-3.3 mm for BB. The resin composite and the organic solvent influenced the determination of DOC, and ETH was the least effective solvent.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70130"},"PeriodicalIF":2.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD73 is associated with glycolysis-related metabolic features in head and neck squamous cell carcinoma. CD73与头颈部鳞状细胞癌中糖酵解相关的代谢特征相关。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-08-17 DOI: 10.1111/eos.70129

Hanwen Zhang, Chang Gao, Feifei Xue, Weihua Shao, Leqi Zhang, Yi Fan, Hua Yuan

{"title":"CD73 is associated with glycolysis-related metabolic features in head and neck squamous cell carcinoma.","authors":"Hanwen Zhang, Chang Gao, Feifei Xue, Weihua Shao, Leqi Zhang, Yi Fan, Hua Yuan","doi":"10.1111/eos.70129","DOIUrl":"https://doi.org/10.1111/eos.70129","url":null,"abstract":"CD73, encoded by NT5E, is an ecto-5'-nucleotidase implicated in tumour progression, but its association with glycolysis-related metabolic features in head and neck squamous cell carcinoma (HNSCC) remains unclear. In this study, we combined public transcriptomic analyses with in vitro and in vivo experiments to investigate the relationship between NT5E/CD73 and these features in HNSCC. NT5E expression was positively associated with glycolysis-related signatures, and a high glycolysis score was associated with poorer overall survival in an exploratory analysis. In CAL27 cells, NT5E knockdown reduced extracellular acidification rate and oxygen consumption rate and decreased the expression of glucose transporter 3 (GLUT3), lactate dehydrogenase A (LDHA) and pyruvate kinase M2 (PKM2), indicating a broader reduction in metabolic activity. In a xenograft model, NT5E depletion suppressed tumour growth and reduced GLUT3, LDHA and PKM2 expression. ADORA2B was upregulated in HNSCC, and its silencing decreased glycolysis-related gene expression, whereas pharmacological activation of A2B partially restored glycolysis-related protein expression and migratory capacity after NT5E knockdown. These findings support an association between NT5E/CD73 and glycolysis-related metabolic features in HNSCC and suggest that A2B signalling may contribute, at least in part, to the associated metabolic and migratory changes.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70129"},"PeriodicalIF":2.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glass gradation of 4Y-PSZ zirconia: Future perspectives on mechanical and optical performance. 4Y-PSZ氧化锆的玻璃级配：机械和光学性能的未来展望。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-08-12 DOI: 10.1111/eos.70131

Shaik Mohammed Yaseen, David Livingstone, Raj Kumar E, Josephine Flora

引用次数: 0

Optimizing diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide concentration and post-curing time to balance mechanical properties and color stability in a three-dimensional-printed restorative resin. 优化二苯基（2,4,6-三甲基苯甲酰）氧化膦的浓度和固化后时间，以平衡三维打印修复树脂的力学性能和颜色稳定性。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-08-10 DOI: 10.1111/eos.70125

Eloah Nunes de Almeida, Vinicius da Nóbrega Marques, Ido Luiz de Azevedo Feiten, André Luis Faria-E-Silva, Larissa Maria Cavalcante, Luis Felipe Schneider

{"title":"Optimizing diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide concentration and post-curing time to balance mechanical properties and color stability in a three-dimensional-printed restorative resin.","authors":"Eloah Nunes de Almeida, Vinicius da Nóbrega Marques, Ido Luiz de Azevedo Feiten, André Luis Faria-E-Silva, Larissa Maria Cavalcante, Luis Felipe Schneider","doi":"10.1111/eos.70125","DOIUrl":"https://doi.org/10.1111/eos.70125","url":null,"abstract":"Three-dimensional (3D) printing is widely used in dental restorations; however, optimization of photoinitiator concentration and post-curing protocols remains critical to achieve a balance between mechanical and esthetic performance. This study evaluated the combined effect of diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) concentration and post-curing time on mechanical properties and color stability of a 3D-printed restorative resin. A commercial photoinitiator-free resin (BioPrint Prov, Horus 3D) was supplemented with TPO at 0.5, 1.0, and 1.5 wt% and fabricated using a digital light processing printer. Specimens were post-cured for 30, 45, or 60 min under UV light, while non-post-cured (NoPC) samples served as controls. Flexural strength and elastic modulus were evaluated using a three-point bending test. Color stability and translucency were assessed using spectrophotometry (CIELab/ΔE00) under storage conditions, including dry storage, water immersion, and coffee aging. Data were analyzed using two-way anova and Tukey's test. The 1.0% TPO and 30 min post-curing combination provided best performance, with highest flexural strength and lowest color change after staining. Higher TPO concentration and prolonged post-curing increased color alteration and yellowness. NoPC specimens showed inferior mechanical properties and greater discoloration. Translucency remained more stable in post-curing groups. These findings indicate optimized photoinitiator concentration and controlled post-curing time improve mechanical and esthetic outcomes in 3D-printed restorative resins.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70125"},"PeriodicalIF":2.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene oxide-modified fluoridated varnish promotes mineral recovery in demineralized bovine enamel: An in vitro study. 氧化石墨烯修饰的氟化清漆促进脱矿牛牙釉质中的矿物质恢复：一项体外研究。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-08-07 DOI: 10.1111/eos.70126

Mariana Souza Rodrigues, Guilherme José Drigo, Sofia Furlanete Raymundo, Nair Cristina Brondino, Salvatore Sauro, Marilia Mattar de Amoêdo Campos Velo

{"title":"Graphene oxide-modified fluoridated varnish promotes mineral recovery in demineralized bovine enamel: An in vitro study.","authors":"Mariana Souza Rodrigues, Guilherme José Drigo, Sofia Furlanete Raymundo, Nair Cristina Brondino, Salvatore Sauro, Marilia Mattar de Amoêdo Campos Velo","doi":"10.1111/eos.70126","DOIUrl":"10.1111/eos.70126","url":null,"abstract":"This in vitro study evaluated the efficacy of an experimental fluoridated varnish modified with graphene oxide (GO) nanoparticles in arresting initial caries lesion progression and promoting mineral recovery in demineralized bovine enamel. Enamel blocks (6 × 4 × 2 mm) were artificially demineralized and treated with one of five varnish formulations: CTRL (experimental varnish), 10% GO (CTRL + 10% GO), 20% GO (CTRL + 20% GO), NaF/CaF2 (CTRL + NaF + CaF2), or NaF (Duraphat; Colgate-Palmolive). Following varnish application, specimens were stored in artificial saliva (37°C, 24 h) and subjected to a 7-d pH-cycling regimen. Surface hardness outcomes (%SHL, %SHR, and ΔSH) were determined using six specimens per group. Additional specimens were prepared for transverse microradiography (n = 3 per group) to determine integrated mineral loss (ΔZ) and lesion depth was measured, and the specimens were examined using field-emission scanning electron microscopy (FEG-SEM) coupled with energy-dispersive X-ray spectroscopy (EDS). (n = 9 per group) to evaluate surface morphology, Ca, P, and the Ca/P ratio. Data were analyzed using appropriate parametric or non-parametric tests (α = 0.05). Overall, the 10% GO group exhibited significantly lower %SHL and higher %SHR than the other experimental groups, whereas higher Ca/P ratios were observed in the 10% GO and NaF groups.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70126"},"PeriodicalIF":2.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of adhesive strategies for direct posterior composite restorations in permanent teeth: A systematic review and network meta-analysis. 粘接策略在恒牙直接后牙复合修复中的有效性：一项系统综述和网络荟萃分析。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-08-07 DOI: 10.1111/eos.70127

Pablo Felipe Gutiérrez Da Venezia, David Osvaldo Rodríguez Chaparro, Meylin Santiesteban Velázquez, Jorge J Menendez, Alain Manuel Chaple Gil

{"title":"Effectiveness of adhesive strategies for direct posterior composite restorations in permanent teeth: A systematic review and network meta-analysis.","authors":"Pablo Felipe Gutiérrez Da Venezia, David Osvaldo Rodríguez Chaparro, Meylin Santiesteban Velázquez, Jorge J Menendez, Alain Manuel Chaple Gil","doi":"10.1111/eos.70127","DOIUrl":"10.1111/eos.70127","url":null,"abstract":"This systematic review and network meta-analysis (NMA) compared the clinical performance of adhesive strategies used in direct posterior composite restorations in permanent teeth. Randomized controlled trials were retrieved from PubMed, Scopus, Embase, Web of Science, and the Cochrane Library. Studies reporting dichotomous clinical outcomes assessed with USPHS or FDI criteria were included. A frequentist random-effects NMA estimated relative treatment effects as odds ratios with 95% confidence intervals; treatments were ranked using P-scores, and evidence certainty was assessed with the Confidence in Network Meta-Analysis (CINeMA) framework. Nine studies were identified, of which six contributed to the 12-month NMA. Multiple adhesive strategies combining different etching approaches and adhesive systems were evaluated. No significant differences were found for marginal adaptation or retention loss. Although etch-and-rinse and universal adhesives showed higher P-scores, these findings were uncertain. CINeMA indicated moderate confidence in the evidence, with imprecision as the main limitation. At 12 months, no statistically significant differences were detected among contemporary adhesive strategies for marginal adaptation or retention loss; however, the estimates were imprecise, so these results indicate a lack of demonstrated differences rather than proven equivalence between strategies.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70127"},"PeriodicalIF":2.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental resin composites generate microparticles and impact on gingival keratinocytes-In vitro study. 牙用树脂复合材料对牙龈角质形成细胞的影响研究。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-08-05 DOI: 10.1111/eos.70124

Ella Pullinen, Saara V Sirkiä, Johan Nyman, Pekka K Vallittu, Vuokko Loimaranta

{"title":"Dental resin composites generate microparticles and impact on gingival keratinocytes-In vitro study.","authors":"Ella Pullinen, Saara V Sirkiä, Johan Nyman, Pekka K Vallittu, Vuokko Loimaranta","doi":"10.1111/eos.70124","DOIUrl":"https://doi.org/10.1111/eos.70124","url":null,"abstract":"Along with our increased understanding of the spread of microplastic pollution, the awareness of microparticle release from medical and dental materials has increased. Still, their effects on human health are largely unknown. As the use of resin composite materials in dentistry continues to increase, it is essential to understand the formation and biological activities of microparticles generated during material fabrication and use. This study investigated the type and size of microparticles formed from two commonly used restorative resin composite materials, ground with two different dental burs, and their effects on cultured spontaneously immortalized human gingival keratinocytes. Scanning electron microscopy and laser diffraction were used to examine particle morphology and size distribution. Flow cytometry was used to analyze microparticle adhesion to the cell surface and cell viability, and cytokine release was measured. From the two composite materials, microparticles ranging from approximately 4.50 to 137 µm were released. The particles adhered to gingival keratinocytes and induced IL-8 expression of the cells but did not affect the cell viability. The grinding method and the material affected the size of released particles. Further investigation is needed to understand the impact of cellular responses and the dose dependence of the reactions.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70124"},"PeriodicalIF":2.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamate, its relation to periodontitis, diabetes and cognition before and after scaling and root planing. 谷氨酸与牙周炎、糖尿病及认知的关系。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-07-29 DOI: 10.1111/eos.70128

Munishwar Rama, Nichani Ashish S, Pai B S Jagadish

{"title":"Glutamate, its relation to periodontitis, diabetes and cognition before and after scaling and root planing.","authors":"Munishwar Rama, Nichani Ashish S, Pai B S Jagadish","doi":"10.1111/eos.70128","DOIUrl":"https://doi.org/10.1111/eos.70128","url":null,"abstract":"This study aimed to correlate levels of salivary and serum glutamate in patients with/without generalized periodontitis and Type 2 diabetes mellitus (T2DM) and to evaluate the effect of scaling and root planing (SRP) on glutamate and cognition. We hypothesized that periodontitis and T2DM are associated with altered glutamate levels and poorer cognitive performance and explored whether SRP-related changes in glutamate relate to cognitive performance. Eighty patients aged 45-70-yr were allocated into four groups: healthy, periodontitis, T2DM and periodontitis with T2DM (n = 20 each). Periodontal parameters, Trail Making Tests (TMT-A and TMT-B) and salivary and serum glutamate levels were recorded at baseline and 1-month post-SRP. Diabetic patients showed higher glutamate levels, poorer periodontal status and prolonged TMT times than non-diabetics at baseline. Glutamate levels decreased significantly after SRP, whereas TMT completion times showed only small reductions. Serum glutamate levels showed a significant, moderate positive correlation with TMT-B scores. Fasting plasma glucose and glutamate were significant predictors of periodontitis. Glutamate was altered but did not mediate the periodontitis-TMT association. In T2DM and non-T2DM patients, serum glutamate was the most accurate marker to differentiate periodontitis. SRP improved periodontal status, reduced glutamate levels and was associated with improved executive function and processing speed.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70128"},"PeriodicalIF":2.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0