European Journal of Oral Sciences最新文献

Response to letter to the editor.

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-09 DOI: 10.1111/eos.13035

Bahram Ranjkesh

引用次数: 0

Effect of changing the internal structure on the mechanical properties of three-dimensional-printed custom tray material: An in vitro study.

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-08 DOI: 10.1111/eos.13033

Cafer Anıl Erdem, Selin Çelik Öge, Orhun Ekren

{"title":"Effect of changing the internal structure on the mechanical properties of three-dimensional-printed custom tray material: An in vitro study.","authors":"Cafer Anıl Erdem, Selin Çelik Öge, Orhun Ekren","doi":"10.1111/eos.13033","DOIUrl":"https://doi.org/10.1111/eos.13033","url":null,"abstract":"The main challenges to the widespread clinical application of three-dimensional (3D)-printed customized trays include cost and time limitations. This study examined how changing the internal structure of 3D-printed materials used for customized trays affects flexural strength (FS), flexural modulus (FM), manufacturing time, and material weight. Specimens (64 × 10 × 3.3 mm) were printed using a light-sensitive liquid resin. The internal structures of control specimens were completely filled, whereas the internal structures of test groups comprised vertical bars spaced 1 mm (Test 1) or 2 mm (Test 2) apart. Specimens were weighed and then subjected to a three-point bending test to evaluate their FS and FM. Data were analyzed using one-way ANOVA and Tukey's test, with Weibull analysis applied to FS values. Control specimens had the highest FS (106 ± 4 MPa), while Test 2 specimens demonstrated the highest FM (6101 ± 1407 MPa). No significant differences were found between Test 1 and Test 2 specimens in FS or FM. Test 2 specimens had the lowest mean weight (1440 ± 42 mg). Manufacturing times were 80 min for control and Test 1 specimens and 60 min for Test 2 specimens. Including spaces in the internal structure of 3D-printed custom tray material saves material and manufacturing time while maintaining mechanical properties.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e13033"},"PeriodicalIF":1.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of metformin and verteporfin treatment alone or in combination in a murine head and neck cancer xenograft model.

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-08 DOI: 10.1111/eos.13034

Aung Phyo Shan, Khin Swe Hlaing, Asada Leelahavanichkul, Panomwat Amornphimoltham

{"title":"Efficacy of metformin and verteporfin treatment alone or in combination in a murine head and neck cancer xenograft model.","authors":"Aung Phyo Shan, Khin Swe Hlaing, Asada Leelahavanichkul, Panomwat Amornphimoltham","doi":"10.1111/eos.13034","DOIUrl":"https://doi.org/10.1111/eos.13034","url":null,"abstract":"Despite treatment advances, head and neck squamous cell carcinoma (HNSCC) still poses a significant global health challenge. Combination therapies have emerged as more effective strategies than traditional chemotherapy in clinical practice by improving tumor response rates and patient survival while minimizing treatment-related toxicity. This study investigates the anticancer effects of metformin and verteporfin (Yes-associated protein 1 [YAP1] inhibitor) alone or in combination in HNSCC using vitro and in vivo approaches. Quantitative RT-PCR analysis of HNSCC cell lines reveals upregulation of YAP1 and related genes in the Hippo signaling pathway. Cell viability assays demonstrate a beneficial synergistic effect between metformin and verteporfin in inhibiting HNSCC tumor growth. In male BALB/cAJcl-nu/nu mice harboring HNSCC tumor xenografts, intraperitoneal administration of metformin and verteporfin enhances the inhibitory effect on tumor growth and suppresses YAP1 nuclear translocation when compared to vehicle or monotherapies. Furthermore, combination of these drugs reduces tumor cell proliferation (marked by Ki-67) and inhibits phosphoS6 ribosomal protein, as observed through immunofluorescent and immunohistochemical (IHC) analyses. The in vivo study underscores the therapeutic potential of the dual targeting approach with metformin and verteporfin in treating HNSCC, with minimal toxicity.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e13034"},"PeriodicalIF":1.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of thyme honey in the management of oral aphthous ulcers: A randomized controlled clinical trial.

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-12-26 DOI: 10.1111/eos.13032

Dalia Ghalwash, Ayman El-Gawish, Ahmed Ammar, Asmaa Abou-Bakr

{"title":"Efficacy of thyme honey in the management of oral aphthous ulcers: A randomized controlled clinical trial.","authors":"Dalia Ghalwash, Ayman El-Gawish, Ahmed Ammar, Asmaa Abou-Bakr","doi":"10.1111/eos.13032","DOIUrl":"https://doi.org/10.1111/eos.13032","url":null,"abstract":"The current study aimed to assess the effect of thyme honey on pain relief in patients with minor aphthous ulcers as a primary objective, its healing effect on ulcer size reduction, and the Oral Health Impact Profile (OHIP-14). In this randomized clinical trial, 30 patients (15 in each group) having minor aphthous ulcers at the oral diagnostic clinic at the British University in Egypt were treated with either thyme honey or triamcinolone acetonide in orabase. Different clinical parameters were recorded for both groups at various intervals, such as pain intensity using the Visual Analog Scale (VAS), size of ulcers in mm, and OHIP-14. Thyme honey intervention showed more significant ulcer size reduction than the triamcinolone acetonide group on days 5, and 7, and a more substantial decrease in pain intensity on days 3, 5, and 7. Additionally, the thyme honey group showed significantly lower OHIP values than the triamcinolone acetonide group after 7 days. The current clinical trial furnished evidence of the effectiveness of thyme honey in managing minor aphthous ulcers for the first time and revealed clinical efficiency with satisfactory patient outcomes.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e13032"},"PeriodicalIF":1.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tip efficiency of a customized lingual appliance: Performance of wires with two different ligatures.

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-12-16 DOI: 10.1111/eos.13031

Sara Drago, Alberto Lagazzo, Anna De Mari, Luigi Rizzi, Roberto Stradi, Maria Menini, Marco Migliorati

{"title":"Tip efficiency of a customized lingual appliance: Performance of wires with two different ligatures.","authors":"Sara Drago, Alberto Lagazzo, Anna De Mari, Luigi Rizzi, Roberto Stradi, Maria Menini, Marco Migliorati","doi":"10.1111/eos.13031","DOIUrl":"https://doi.org/10.1111/eos.13031","url":null,"abstract":"Tip control in lingual orthodontics may be challenging because of the presence of a vertical slot and the particular configuration of the customized appliances. The aim of this in vitro experimental study was to investigate the role of the ligature-wire-slot system in achieving better tip control. A set of customized lingual brackets was obtained for a dedicated typodont made of extracted human teeth. A compression/traction machine tested two types of ligatures in combination with seven different wires, and the tipping angle of each configuration was derived. A statistically significant difference was found between ligatures when the complete set of data was tested. In addition, differences between ligatures were found when testing each wire separately. A statistically significant difference was found among all wires. Full-size wires showed the smallest angles, which correspond to the greatest efficiency of the slot-archwire-ligation system in terms of tip control, and this efficiency appeared to be ligature-related. The role played by the type of ligature was more relevant for undersized wires.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e13031"},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of autophagy blockage on trigeminal neuropathic pain in rats: Role of microglia.

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-12-03 DOI: 10.1111/eos.13029

Xuechun Yuan, Yanzhu Lu, Xiaoqi Zhang, Yufei Tang, Shangyou Wen, Wenli Lai, Hu Long

{"title":"Effect of autophagy blockage on trigeminal neuropathic pain in rats: Role of microglia.","authors":"Xuechun Yuan, Yanzhu Lu, Xiaoqi Zhang, Yufei Tang, Shangyou Wen, Wenli Lai, Hu Long","doi":"10.1111/eos.13029","DOIUrl":"https://doi.org/10.1111/eos.13029","url":null,"abstract":"Microglia activation and autophagy changes are associated with the regulation of pain, but no study to date has been designed to address whether these features apply to trigeminal neuropathic pain. This study aimed to investigate how alterations in autophagy affect nociceptive behaviors may be associated with microglia activation in the caudal part of the spinal trigeminal nucleus (SpVC) in a rat model of trigeminal neuropathic pain. This model was established by chronic constriction injury of the infraorbital nerve. Autophagy inhibitors and agonists were injected into the lateral ventricle to regulate autophagy. The autophagy markers microtubule-associated protein light chain 3 I (LC3-I), LC3-II, sequestosome1 (p62), and LC-3 were examined by western blotting and/or immunofluorescence. The microglia marker ionized calcium binding adapter molecule 1 (Iba-1) was examined by immunohistochemistry. Nociceptive behavior changes were detected by measuring the mechanical thresholds and face-grooming duration. The results showed that microglia in SpVC were activated, and autophagy flux was blocked in the trigeminal neuropathic pain model. Autophagy agonists inhibited microglia activation and alleviated nociceptive behaviors. In contrast, autophagy inhibitors further activated microglia and exacerbated nociceptive behaviors. In a rat model of trigeminal neuropathic pain, autophagy blockage leads to microglia activation, which significantly influences nociceptive processes.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e13029"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta-analysis of in vitro studies 交联剂对羟脯氨酸释放和龋齿根损大小的影响：体外研究的系统回顾和网络荟萃分析。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-11-23 DOI: 10.1111/eos.13028

Isabela Monici Silva, Cecília de Brito Barbosa, Jéssica Alves de Cena, Erick Ribeiro, Fernanda Cristina Pimentel Garcia, Cristine Miron Stefani, Naile Dame-Teixeira

{"title":"Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta-analysis of in vitro studies","authors":"Isabela Monici Silva, Cecília de Brito Barbosa, Jéssica Alves de Cena, Erick Ribeiro, Fernanda Cristina Pimentel Garcia, Cristine Miron Stefani, Naile Dame-Teixeira","doi":"10.1111/eos.13028","DOIUrl":"10.1111/eos.13028","url":null,"abstract":"A promising approach for managing root caries is the use of cross-linking agents to stabilize collagen. However, despite testing various natural and synthetic agents in vitro, their efficacy remains uncertain. The aim of this review was to examine which cross-linking agent performs better in reducing root caries lesion depth and the release of hydroxyproline, which is a marker of collagen degradation. Studies evaluating the impact of cross-linking agents on dentin were included, while studies performed on enamel surface/cell cultures and studies evaluating collagenase inhibitors were excluded, among others. A comprehensive search covered eight databases, and study quality was assessed using the QUINN Tool for in vitro dental studies. Synthesis of the results was done using a Bayesian network meta-analysis to compare agents. Fifty studies involving 31 cross-linking agents were included for qualitative synthesis. The network meta-analysis for lesion depth involved 284 samples across 36 comparisons and ranked cross-linking agents in terms of their caries lesion depth-reducing effect (from best to worst): naringin > quercetin > riboflavin > proanthocyanidins > hesperidin > glutaraldehyde > cranberry > grape seed extract > untreated controls. Only naringin, quercetin, proanthocyanidins, and glutaraldehyde showed statistically significant efficacy over untreated controls. Cranberry extract excelled in reducing hydroxyproline release, followed by proanthocyanidins. In conclusion, proanthocyanidins positively affected both outcomes, suggesting they are prime candidates for translational research. Clinical studies are now essential to evaluate their real-world effectiveness against root caries. PROSPERO-CRD42023404911.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of masticatory muscle function on the craniofacial sutures of the anterior viscerocranium in growing rats 咀嚼肌功能对生长期大鼠前粘膜颅面缝的影响

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-11-17 DOI: 10.1111/eos.13027

Hande Gorucu-Coskuner, Mustafa Al-Yassary, Kelly Billiaert, Stavros Kiliaridis, Gregory S. Antonarakis

{"title":"Effect of masticatory muscle function on the craniofacial sutures of the anterior viscerocranium in growing rats","authors":"Hande Gorucu-Coskuner, Mustafa Al-Yassary, Kelly Billiaert, Stavros Kiliaridis, Gregory S. Antonarakis","doi":"10.1111/eos.13027","DOIUrl":"10.1111/eos.13027","url":null,"abstract":"The transverse dimensions of internasal and nasopremaxillary sutures in rats were assessed at different ages and following different dietary functional demands.Eighty-four male Wistar rats were divided into two groups fed either a hard or a soft diet from 4 weeks of age, and sacrificed at 4 weeks (baseline: n = 12),16 weeks (n = 24), 26 weeks (n = 24), or 38 weeks (n = 24) of age. High-resolution micro-computed tomograms of the internasal and left nasopremaxillary sutures were obtained with 10 µm voxel size and 5 × 5 mm field of view. The endocranial and ectocranial suture widths, the mean suture width, and the suture height were measured. Linear regression analysis was used to estimate the effects of age and type of diet on suture dimensions. Internasal and nasopremaxillary suture dimensions were influenced by age, with a generally lower width and a larger height in the older animal. Regarding diet consistency, internasal suture widths were on average larger in the hard-diet group (e.g., mean suture width 43 µm in the hard- versus 30 µm in the soft-diet group at 26 weeks). In conclusion, the internasal and nasopremaxillary sutures tend to become narrower with age, while being influenced by masticatory functional demands.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender variability in palpation performance for temporomandibular disorders with three different methods: An experimental study 使用三种不同方法对颞下颌关节紊乱进行触诊时的性别差异：实验研究。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-11-14 DOI: 10.1111/eos.13026

Hessamoddin Faghihian, Alicia Böthun, Birgitta Häggman-Henrikson, Maria Lalouni, Peter Svensson, Fredrik Hellström, Linus Andersson, Anna Lövgren

{"title":"Gender variability in palpation performance for temporomandibular disorders with three different methods: An experimental study","authors":"Hessamoddin Faghihian, Alicia Böthun, Birgitta Häggman-Henrikson, Maria Lalouni, Peter Svensson, Fredrik Hellström, Linus Andersson, Anna Lövgren","doi":"10.1111/eos.13026","DOIUrl":"10.1111/eos.13026","url":null,"abstract":"Gender differences in pain reporting and prevalence have been demonstrated. As gender of examiner also affects reporting of pain on palpation, the aim of this study was to evaluate the effects of examiner gender on palpation performance using three different palpation methods. Examiners of both genders were instructed on the correct technique for each palpation method by either a female or male instructor. The target was to achieve a pressure of 100 kPa, corresponding to the 1 kg of force for muscle palpation described in the diagnostic criteria for temporomandibular disorders (DC/TMD). All examiners performed traditional palpation with the index finger, palpation with a palpometer, and a novel bimanual palpation with visual feedback, in a randomized order. The examiner's gender, and its interaction with the gender of the instructor did not significantly affect magnitude, accuracy, or precision of the pressure applied. The method of palpation was the only factor that significantly impacted all metrics. The palpometer achieved the lowest palpation magnitude (mean pressure applied = 113.7 kPa, 95% CI: 109.8–117.6), the highest accuracy (absolute difference = 15.7 kPa, 95% CI: 12.3–19.1), and the highest precision (mean coefficient of variation = 6.8, 95% CI: 6.0–7.6), followed by bimanual palpation and traditional palpation. The results suggest that gender differences in pain reporting in patients are not likely to be a result of the technical aspects associated with the gender of the examiner. Instead, these differences may be attributed to other factors, such as sociocultural influences.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bond strength of resin-based restorative materials to fast-setting calcium silicate cement using different resin adhesive systems 使用不同树脂粘合剂系统的树脂基修复材料与速凝硅酸钙水泥的粘合强度。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-10-27 DOI: 10.1111/eos.13025

Bahram Ranjkesh, Hilde M. Kopperud, Henrik Løvschall

{"title":"Bond strength of resin-based restorative materials to fast-setting calcium silicate cement using different resin adhesive systems","authors":"Bahram Ranjkesh, Hilde M. Kopperud, Henrik Løvschall","doi":"10.1111/eos.13025","DOIUrl":"10.1111/eos.13025","url":null,"abstract":"This study assessed the bond strength of resin-based restorative materials to fast-setting calcium silicate cement (Aarhus Uinversity, Denmark) when treated with each of two one-bottle universal adhesive systems. The cement surface (N = 256) was treated with a self-priming adhesive and a self-etch phosphate monomer-containing adhesive with and without etching of the cement surface. Specimens then received either resin composite or compomer restorative materials (n = 32). The bond strength was measured after 1 day and 1500 thermocycles (n = 16). The failure type was visually inspected. The cement-adhesive-restorative material interface was visualized using scanning electron microscopy (SEM). The data were analyzed using multiple linear regression. Restorative material type, resin adhesive system, and thermocycling had a statistically significant effect on the bond strength. Compomer restorative material and self-etch universal adhesive system demonstrated statistically significantly higher bond strength values to fast-setting calcium silicate cement, predominantly exhibiting cement cohesive failure. Etching the cement surface enhanced the bond strength of the self-priming universal adhesive. Thermocycling significantly reduced the bond strength. SEM showed self-etch universal adhesive seemingly diffused over the etched cement surface compared to other groups. Self-etch phosphate monomer-containing universal adhesive and compomer resulted in the highest bond strength to fast-setting calcium silicate cement.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0