European Journal of Oral Sciences最新文献

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Effect of blockage of Trem1 on the M1 polarization of macrophages in the regulation dental pulp inflammation 阻断 Trem1 对调控牙髓炎症中巨噬细胞 M1 极化的影响
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-09-12 DOI: 10.1111/eos.13018
Ting-Ting Wang, Wen-Rui Jiang, Li Xu, Mei-Yun Zhou, Yong-Song Huang
{"title":"Effect of blockage of Trem1 on the M1 polarization of macrophages in the regulation dental pulp inflammation","authors":"Ting-Ting Wang,&nbsp;Wen-Rui Jiang,&nbsp;Li Xu,&nbsp;Mei-Yun Zhou,&nbsp;Yong-Song Huang","doi":"10.1111/eos.13018","DOIUrl":"10.1111/eos.13018","url":null,"abstract":"<p>Dental pulp inflammation is a common and significant factor related to poor dental prognosis. Current treatment strategies primarily concentrate on managing the inflammatory response, with specific targets for intervention still under investigation. Triggering receptors expressed on myeloid cells (TREMs) are a group of receptor molecules extensively present on myeloid cell surfaces, crucial in the regulation of inflammatory process. Our analysis of transcriptomic sequencing data from clinical pulp samples of dataset GSE77459 and animal models revealed up-regulation of Trem1 during pulpitis. Administration of the Trem1-blocking peptide LP17 led to lower (more than 1-fold) levels of several pro-inflammatory factors and inhibition of M1 macrophage polarization both in vivo and in vitro. This study of the expression patterns and functions of Trem1 in the development of dental pulp inflammation provides novel insights into the therapeutic strategies for clinical pulpitis.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of combining aminomethacrylate and fluoride against erosive and abrasive challenges on enamel and dentin 结合使用氨基甲基丙烯酸酯和氟化物对珐琅质和牙本质的腐蚀性和磨蚀性挑战的影响。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-29 DOI: 10.1111/eos.13015
Marina Gullo Augusto, Luis Felipe Oliveira da Silva, Giovanna Lotto, Tamires Maria de Andrade Santos, Idalina Vieira Aoki, Carlos Rocha Gomes Torres, Tais Scaramucci, Alessandra Bühler Borges
{"title":"Effect of combining aminomethacrylate and fluoride against erosive and abrasive challenges on enamel and dentin","authors":"Marina Gullo Augusto,&nbsp;Luis Felipe Oliveira da Silva,&nbsp;Giovanna Lotto,&nbsp;Tamires Maria de Andrade Santos,&nbsp;Idalina Vieira Aoki,&nbsp;Carlos Rocha Gomes Torres,&nbsp;Tais Scaramucci,&nbsp;Alessandra Bühler Borges","doi":"10.1111/eos.13015","DOIUrl":"10.1111/eos.13015","url":null,"abstract":"<p>This study evaluated the effect of solutions containing aminomethacrylate copolymer (AA) and sodium fluoride (F; 225 ppm F<sup>−</sup>) or fluoride plus stannous chloride (FSn; 225 ppm F<sup>−</sup>, 800 ppm Sn<sup>2+</sup>) against enamel and dentin erosion/abrasion. Solutions F, FSn, AA, F+AA, FSn+AA, and deionized water as negative control were tested. Bovine enamel and dentin specimens (<i>n</i> = 13/solution/substrate) underwent a set of erosion-abrasion cycles (0.3% citric acid [5 min, 4×/day], human saliva [1 h, 4×/day], brushing [15 s, 2×/day], and treatments [2 min, 2×/day]) for each of five days. Initial enamel erosion was evaluated using Knoop microhardness after the first and second acid challenge on day 1, and surface loss with profilometry after day 5. KOH-soluble fluoride was assessed. Data were analyzed with ANOVA/Tukey tests. The combination of fluoride and AA resulted in higher protection against enamel erosion, whereas this was not the case for the combination of AA and FSn. All treatments protected against enamel and dentin loss. The lowest surface loss values were observed with F+AA and FSn+AA. The polymer did not significantly influence the KOH-soluble fluoride formation on enamel/dentin specimens. The aminomethacrylate copolymer effectively enhanced the efficacy of sodium fluoride against initial erosion and improved the control of enamel and dentin wear of F and FSn solutions.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of estrogen depression on alveolar bone microarchitecture and periodontal ligament cells during orthodontic movement 雌激素抑制对正畸过程中牙槽骨微结构和牙周韧带细胞的影响
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-19 DOI: 10.1111/eos.13014
Andréa Karina Ruivo, Bruno Calsa, Matheus Gomez Cancellara, João Paulo Nascimento Lima, Karla Rovaris da Silva, Marcelo Augusto Marretto Esquisatto, Milton Santamaria-Jr
{"title":"Effect of estrogen depression on alveolar bone microarchitecture and periodontal ligament cells during orthodontic movement","authors":"Andréa Karina Ruivo,&nbsp;Bruno Calsa,&nbsp;Matheus Gomez Cancellara,&nbsp;João Paulo Nascimento Lima,&nbsp;Karla Rovaris da Silva,&nbsp;Marcelo Augusto Marretto Esquisatto,&nbsp;Milton Santamaria-Jr","doi":"10.1111/eos.13014","DOIUrl":"10.1111/eos.13014","url":null,"abstract":"<p>This study aimed to evaluate the effects of the estrogen depression during orthodontic tooth movement on alveolar bone microarchitecture and periodontal ligament. Female Wistar rats were divided into two groups, one consisting of non-ovariectomized animals subjected to orthodontic tooth movement, and one comprising ovariectomized animals subjected to orthodontic tooth movement. Micro-CT assessment of bone volume to total volume (BV/TV), total porosity, trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) in the alveolar bone of the orthodontically moved tooth was performed. Histomorphometric analyses were made in the periodontal ligament, and immunoexpression of RANK, RANKL, OPG, and TUNEL were quantified. Orthodontic tooth movement in the group of ovariectomized rats was faster than in non-ovariectomized animals. The alveolar bone area showed lower values of BV/TV and trabecular thickness, and higher bone porosity and trabeculae numbers in the ovariectomized rats. Histological analyses in the ovariectomized group revealed an increase in collagen fibers in the periodontal ligament. The apoptotic cell counts in the periodontal ligament were higher in the group of ovariectomized rats than in the sham-operated rats. Ovariectomy resulted in an increase in tooth movement and alteration of the alveolar bone microstructure in the first 7 day of orthodontic tooth movement, and in the presence of apoptotic cells in the periodontal ligament.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of laser irradiation during in-office tooth bleaching on surface properties of resin-based restorative materials 诊室牙齿漂白过程中激光照射对树脂基修复材料表面特性的影响。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-15 DOI: 10.1111/eos.13013
Christina Karanasiou, Dimitrios Dionysopoulos, Petros Mourouzis, Dimitrios Strakas, Olga Naka, Kosmas Tolidis
{"title":"Effect of laser irradiation during in-office tooth bleaching on surface properties of resin-based restorative materials","authors":"Christina Karanasiou,&nbsp;Dimitrios Dionysopoulos,&nbsp;Petros Mourouzis,&nbsp;Dimitrios Strakas,&nbsp;Olga Naka,&nbsp;Kosmas Tolidis","doi":"10.1111/eos.13013","DOIUrl":"10.1111/eos.13013","url":null,"abstract":"<p>This study evaluated the changes in surface properties of three resin-based restorative materials after two laser-assisted, in-office tooth bleaching protocols using erbium, chromium: yttrium-scandium-gallium-garnet (Er,Cr:YSGG) or diode (980 nm) lasers. A nanohybrid composite (Enamel Plus HRi), a Bis-GMA-free composite (Enamel Plus HRi Bio Function), and a resin-matrix CAD-CAM ceramic (Shofu Block HC) were tested. Forty specimens for each material were prepared and divided into four groups (<i>n</i> = 10/group). The control specimens did not undergo any bleaching treatment, whereas group 2 received bleaching with 40% hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), while groups 3 and 4 underwent the same bleaching procedure with the use of diode (980 nm) or Er,Cr:YSGG lasers, respectively. Surface microhardness and roughness measurements were conducted using a Vickers tester and an optical profilometer. Microhardness was lower in bleached specimens, with the nanohybrid composite exhibiting the largest difference from the no bleaching group. For the Bis-GMA-free composite the microhardness difference between no bleaching and laser-assisted bleaching were smaller than seen for the conventional bleaching technique. Surface roughness was higher in bleached specimens, with nanohybrid composite showing the largest differences from the control specimens. The examined laser-assisted tooth bleaching protocols were found not to impact surface microhardness and roughness of the tested resin-based specimens and they are deemed suitable for clinical use.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to letter to the Editor 回复致编辑的信。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-07 DOI: 10.1111/eos.13012
Guido Artemio Marañón-Vásquez, Flares Baratto-Filho, Christian Kirschneck, Erika Calvano Küchler
{"title":"Response to letter to the Editor","authors":"Guido Artemio Marañón-Vásquez,&nbsp;Flares Baratto-Filho,&nbsp;Christian Kirschneck,&nbsp;Erika Calvano Küchler","doi":"10.1111/eos.13012","DOIUrl":"10.1111/eos.13012","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment: Correspondence 关键维生素-D通路基因的遗传变异和外根尖吸收与正畸治疗有关:通讯。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-07 DOI: 10.1111/eos.13011
Hinpetch Daungsupawong, Viroj Wiwanitkit
{"title":"Genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment: Correspondence","authors":"Hinpetch Daungsupawong,&nbsp;Viroj Wiwanitkit","doi":"10.1111/eos.13011","DOIUrl":"10.1111/eos.13011","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The expression of immune checkpoint proteins PD-L1 and TIM3 in mouse and human head and neck squamous cell carcinoma 免疫检查点蛋白 PD-L1 和 TIM3 在小鼠和人类头颈部鳞状细胞癌中的表达。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-01 DOI: 10.1111/eos.13010
Areeg Elmusrati, Cun-Yu Wang
{"title":"The expression of immune checkpoint proteins PD-L1 and TIM3 in mouse and human head and neck squamous cell carcinoma","authors":"Areeg Elmusrati,&nbsp;Cun-Yu Wang","doi":"10.1111/eos.13010","DOIUrl":"10.1111/eos.13010","url":null,"abstract":"<p>The aim of this study was to examine the expression of programmed death-ligand 1 (PD-L1) and of T cell immunoglobulin and mucin domain-containing protein (TIM3) in oral epithelial dysplasia and head and neck squamous cell carcinoma (HNSCC). Mouse HNSCC was induced with 4-nitroquinoline-1 oxide (4NQO). Oral epithelial dysplastic lesions, carcinoma in situ and HNSCC lesions were stained with anti-PD-L1 and TIM3 antibodies. The expression of PD-L1 and TIM3 in tumor cells and immune cells was semiquantitatively measured and compared. In parallel, human dysplasia and HNSCC were stained with anti-PD-L1 and anti-TIM3. The expression pattern of PD-L1<sup>+</sup> and TIM3<sup>+</sup> cells was further compared. In human and mouse samples both PD-L1 and TIM3 were found to be expressed in neoplastic and immune cells in HNSCC, but not in dysplasia. There was no significant difference in PD-L1 and TIM3 expression between metastatic and nonmetastatic HNSCC. We conclude that the 4NQO-induced mouse HNSCC model may be an excellent preclinical model for immune checkpoint therapy.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic mechanisms and oral mucositis in children with acute lymphoblastic leukaemia 表观遗传机制与急性淋巴细胞白血病患儿的口腔黏膜炎。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-07-29 DOI: 10.1111/eos.13009
Juliana Ramalho Guimarães, Beatriz Fernandes de Souza, José Maria Chagas Viana Filho, Lecidamia Cristina Leite Damascena, Ana Maria Gondim Valença, Darlene Camati Persuhn, Naila Francis Paulo de Oliveira
{"title":"Epigenetic mechanisms and oral mucositis in children with acute lymphoblastic leukaemia","authors":"Juliana Ramalho Guimarães,&nbsp;Beatriz Fernandes de Souza,&nbsp;José Maria Chagas Viana Filho,&nbsp;Lecidamia Cristina Leite Damascena,&nbsp;Ana Maria Gondim Valença,&nbsp;Darlene Camati Persuhn,&nbsp;Naila Francis Paulo de Oliveira","doi":"10.1111/eos.13009","DOIUrl":"10.1111/eos.13009","url":null,"abstract":"<p>This study aimed to investigate the relationship between epigenetic mechanisms and oral mucositis (OM) in paediatric patients with acute lymphoblastic leukaemia. Oral cells were collected from 76 participants, including 15 healthy individuals, 10 patients with acute lymphoblastic leukaemia but without a history of OM and 51 acute lymphoblastic leukaemia patients with a history of OM (35 with active OM and 16 who had recovered from OM). Global DNA methylation in the <i>miR-9-1</i> and <i>miR-9-3</i> genes was performed. Seven polymorphisms rs1801131, rs1801133 (<i>MTHFR</i>), rs2228611 (<i>DNMT1</i>), rs7590760, rs1550117 (<i>DNMT3A</i>), rs6087990, rs2424913 (<i>DNMT3B</i>) were genotyped and an analysis of association with global DNA methylation was performed. The global methylation levels were lower in cancer patients recovered from OM than in the other groups. A higher frequency of unmethylated profile for <i>miR-9-1</i> and partially methylated profile for <i>miR-9-3</i> was observed in cancer patients regardless of OM history compared to healthy patients. The GG genotype of the rs2228611 (<i>DNMT1</i>) polymorphism was associated with higher levels of global methylation in cancer patients irrespective of OM. It was concluded that global methylation is associated with mucosal recovery. The effect of <i>DNMT1</i> genotype on the global DNA methylation profile, as well as the methylation profile of <i>miR-9-1</i> and <i>miR-9-3</i> in cancer patients is independent of OM.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Torture victims’ perspective on dental treatment: “Every sign you make, every move you take” – A qualitative study 酷刑受害者对牙科治疗的看法:"你的一举一动"--一项定性研究。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-07-17 DOI: 10.1111/eos.13007
Ann Catrin Høyvik, Tiril Willumsen, Birgit Lie, Per Kristian Hilden
{"title":"Torture victims’ perspective on dental treatment: “Every sign you make, every move you take” – A qualitative study","authors":"Ann Catrin Høyvik,&nbsp;Tiril Willumsen,&nbsp;Birgit Lie,&nbsp;Per Kristian Hilden","doi":"10.1111/eos.13007","DOIUrl":"10.1111/eos.13007","url":null,"abstract":"<p>Torture victims struggling with post-traumatic stress often experience elements in the dental treatment situation that may trigger trauma-related reactions. The aim of the study was to explore intervention strategies that will enable dental health workers to adapt dental treatment to the needs of torture survivors. Exploratory interviews were conducted with 10 torture-exposed resettled refugees with dental treatment experience in Norway. The data was analyzed using qualitative content analysis, which suggested that to minimize trauma-reactions, dental personnel should focus on creating a safe therapeutic space and strengthening the patient's sense of control. Four main categories of clinical advice were proposed: (i) Acquire knowledge about psychology, consequences of torture, cultural differences, trauma-informed care, and the patients’ individual needs; (ii) Recognize the trigger-potential of busyness or delays; (iii) Avoid surprises, such as sudden moves or actions and explore triggers individually, but make sure not to evoke images of interrogation, and; (iv) Provide overview both with respect to visibility in the clinical room, and to predictability regarding the dental treatment. Although undergoing dental treatment may be challenging for torture-exposed individuals, it is possible to reduce the predicaments considerably by making feasible adaptions to the treatment and adopting a trauma-informed approach.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic markers of tooth eruption – DNA methylation and histone acetylation 牙齿萌出的表观遗传标记--DNA 甲基化和组蛋白乙酰化。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-07-16 DOI: 10.1111/eos.13005
Anna Westerlund, Asal Shikhan, Nina Sabel, Farah Asa'ad, Lena Larsson
{"title":"Epigenetic markers of tooth eruption – DNA methylation and histone acetylation","authors":"Anna Westerlund,&nbsp;Asal Shikhan,&nbsp;Nina Sabel,&nbsp;Farah Asa'ad,&nbsp;Lena Larsson","doi":"10.1111/eos.13005","DOIUrl":"10.1111/eos.13005","url":null,"abstract":"<p>The present study aimed to evaluate whether epigenetic markers are expressed in the dental follicles surrounding ectopically erupting teeth. Twenty-one dental follicles were collected in 20 adolescent children through surgical exposure of ectopic teeth. The epigenetic modifications of DNA methylation and histone acetylation were evaluated by immunohistochemistry. The results showed cells positive for DNA-methyltransferase 1 (DNMT1), DNA methyltransferase 3 beta (DNMT3B), ten-eleven translocation-2 (TET2), acetyl-histone H3 (AcH3), acetyl-histone H4 (AcH4), 5-methylcytosine (5mC), and 5-hydroxymethylcytosine (5hmC) were present in all the samples. The levels of epigenetic markers representing active chromatin (5hmC, AcH3, AcH4, and TET2) were statistically significantly higher than those of markers representing inactive chromatin (5mC, DNMT3B, DNMT1). In conclusion, follicles in ectopic teeth display major epigenetic modifications. In the follicles, epigenetic markers associated with the activation of bone-related genes are more abundant than markers associated with the inactivation of bone-related genes.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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