European Journal of Oral Sciences最新文献_第2页

Quantitative proteomic analysis of whole saliva and candidate predictive biomarkers for early childhood caries. 全唾液定量蛋白质组学分析及早期儿童龋齿候选预测生物标志物。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-06-09 DOI: 10.1111/eos.70026

Yuwen Fang, Yangyang Pan, Huidi Ren, Yuwen Ma, Liyan Shi, Dingwei Ye, Jing Zou, Yuan Zhou

{"title":"Quantitative proteomic analysis of whole saliva and candidate predictive biomarkers for early childhood caries.","authors":"Yuwen Fang, Yangyang Pan, Huidi Ren, Yuwen Ma, Liyan Shi, Dingwei Ye, Jing Zou, Yuan Zhou","doi":"10.1111/eos.70026","DOIUrl":"https://doi.org/10.1111/eos.70026","url":null,"abstract":"We aimed to characterize the salivary proteomic profile and the salivary protein expression in children with and without early childhood caries (ECC) in order to identify salivary protein biomarkers for ECC. We recruited 56 children into the ECC (n = 28) and caries-free (n = 28) groups. Stimulated whole saliva was collected on ice, followed by protein analysis using a label-free proteomic technique. Moreover, we performed a multidisciplinary bioinformatic analysis. Proteomic analysis revealed significant between-group differences in the salivary protein expression profiles. Based on the protein-protein interaction network analysis and protein function identification, we identified L-lactate dehydrogenase as a potential biomarker. Accordingly, in a validation study, we performed an enzyme-linked immunosorbent assay to detect the differential expression of salivary L-lactate dehydrogenase between 20 preschool children with ECC and 19 caries-free children. The ECC children had significantly higher levels of L-lactate dehydrogenase than the caries-free children, which suggests its predictive utility for ECC. Taken together, our findings suggest that L-lactate dehydrogenase, as well as peroxiredoxin-5, glucose-6-phosphate-1-dehydrogenase, glutathione reductase, malate dehydrogenase, and talin-1, may be potential biomarkers of ECC.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70026"},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal study of factors predicting toothbrushing less than twice daily at age 2 years in the FinnBrain Birth Cohort Study 芬兰大脑出生队列研究中预测2岁儿童每天刷牙少于两次的因素的纵向研究。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-06-09 DOI: 10.1111/eos.70024

Hanna Suokko, Mimmi Tolvanen, Jorma Virtanen, Auli Suominen, Linnea Karlsson, Hasse Karlsson, Satu Lahti

{"title":"Longitudinal study of factors predicting toothbrushing less than twice daily at age 2 years in the FinnBrain Birth Cohort Study","authors":"Hanna Suokko, Mimmi Tolvanen, Jorma Virtanen, Auli Suominen, Linnea Karlsson, Hasse Karlsson, Satu Lahti","doi":"10.1111/eos.70024","DOIUrl":"10.1111/eos.70024","url":null,"abstract":"We aimed to identify factors predicting toothbrushing less than twice daily at the age of 2 years. The data from the FinnBrain Birth Cohort Study of 506 mother–father pairs (with 506 children) were used. Logistic regression analyses were conducted of the outcome (brushing less than twice daily) at the age of 24 months. Independent variables were parental age, parental education, siblings in the household, use of childcare service, and information about whether the parents are divorced, as well as brushing of the child's teeth and the parents’ own teeth at 12 months with their first order interactions. More than one quarter of the parents reported brushing their child's teeth less than twice daily at the age of 2 years. The strongest predictor for brushing the child's teeth less than twice daily at the age of 24 months was brushing child's teeth less than twice daily at the age of 12 months; the effect was significantly stronger for those children whose fathers had low education than for those whose fathers had medium/high education. Other predictors were mother's and father's own brushing at 12 months, childcare at home, and mother's low education. To improve toothbrushing in young children, early intervention is needed in families where parents brush their own teeth less than twice daily and in families with low education.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating dental anxiety for patients with a trauma history or severe dental anxiety: A scoping review 治疗牙科焦虑症患者的创伤史或严重的牙科焦虑症：范围审查。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-06-06 DOI: 10.1111/eos.70018

Regina Skavhellen Aarvik, Karin Goplerud Berge, Maren Lillehaug Agdal, Emilie Bryne

{"title":"Treating dental anxiety for patients with a trauma history or severe dental anxiety: A scoping review","authors":"Regina Skavhellen Aarvik, Karin Goplerud Berge, Maren Lillehaug Agdal, Emilie Bryne","doi":"10.1111/eos.70018","DOIUrl":"10.1111/eos.70018","url":null,"abstract":"Dental anxiety can impact the ability of dental services to cater to specific patient groups. The aim of this review was to map existing psychological interventions used to treat dental anxiety for patients with a history of torture, abuse, or dental anxiety/phobia. The review was prospectively registered (Open Science Framework). Following the Joanna Briggs Institute (JBI) scoping review methodology, six databases (MEDLINE ALL [Ovid], Embase [Ovid], PsycInfo [Ovid], Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Cumulative Index to Nursing and Allied Health (CINAHL) [EBSCO]) were systematically searched. A total of 1743 studies from 1984 to 2024 were retrieved and screened, resulting in 39 articles meeting the predefined inclusion criteria. This review reveals a notable gap: Minimal research exists on psychological interventions treating dental anxiety for patients with a history of torture or abuse. In contrast, studies on patients with dental anxiety or phobia highlight a range of effective treatments demonstrating positive outcomes. However, many of these studies lacked detailed reporting on patient comorbidities and dropout rates, limiting a comprehensive understanding of their findings. Therefore, further research is needed to explore psychological interventions for survivors of torture and abuse.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of the success of Er,Cr:YSGG laser, ferric sulfate, or a herbal hemostatic agent for hemostasis in primary molar pulpotomy Er、Cr:YSGG激光、硫酸铁或草药止血剂在一磨牙髓切开术中止血成功的比较评价。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-06-05 DOI: 10.1111/eos.70022

Necibe Damla Şahin, Volkan Arikan, Firdevs Tulga Öz

{"title":"Comparative evaluation of the success of Er,Cr:YSGG laser, ferric sulfate, or a herbal hemostatic agent for hemostasis in primary molar pulpotomy","authors":"Necibe Damla Şahin, Volkan Arikan, Firdevs Tulga Öz","doi":"10.1111/eos.70022","DOIUrl":"10.1111/eos.70022","url":null,"abstract":"The objective of this study was to evaluate the clinical and radiographic success of the use of the Er,Cr:YSGG laser, ferric sulfate, or a herbal hemostatic agent for hemostasis in primary molar pulpotomy. Sixty-five children aged 5–9 years with a total of 81 primary mandibular second molars indicated for pulpotomy were included in the study. The teeth were randomly divided into the following three groups according to the pulpotomy agents used: ferric sulfate, herbal hemostatic agent, or Er,Cr:YSGG laser. Following pulpotomy treatments, the patients were followed up for 12 months. Pearson Chi-square and Fisher's exact tests were used for statistical analysis. At the end of the follow-up period, the clinical success rates for ferric sulfate, the herbal hemostatic agent, and the Er,Cr:YSGG laser were 96, 100, and 100%, respectively, while the radiographic success rates were 76, 73, and 96%, respectively. There was a statistically significant difference between treatments with respect to radiographic success rates, with the Er,Cr:YSGG laser showing a higher success rate compared with the other groups. Based on the results of the present study, it can be concluded that the Er,Cr:YSGG laser can be used as a hemostatic agent in the pulpotomy of primary teeth and is considered a suitable alternative to ferric sulfate and the herbal hemostatic agent.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of different kinematics and perforation diameter on integrated electronic apex locator accuracy in detecting root canal perforations 不同运动学和穿孔直径对集成电子根尖定位仪检测根管穿孔精度的影响。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-06-04 DOI: 10.1111/eos.70020

Ecenur Tuzcu, Safa Kurnaz

{"title":"Effect of different kinematics and perforation diameter on integrated electronic apex locator accuracy in detecting root canal perforations","authors":"Ecenur Tuzcu, Safa Kurnaz","doi":"10.1111/eos.70020","DOIUrl":"10.1111/eos.70020","url":null,"abstract":"This study aimed to evaluate the precision and reliability of the integrated electronic apex locator in determining various root perforation diameters and to examine the impact of instrumentation kinematics on perforation site detection. One hundred extracted single-root mandibular premolars were artificially perforated at five distinct diameters (0.25–1.25 mm), located 5 mm above the root apex. The teeth were then divided into 10 groups based on perforation size and kinematic subgroup (rotary, reciprocation; n = 10/subgroup). Actual distances to the perforation site (actual length) were measured under a dental operating microscope. Electronic distances (electronic length) were determined using an endodontic motor with an integrated electronic apex locator using rotary or reciprocating instrumentation kinematics during root canal treatment. To quantify the actual length to the electronic length discrepancies, individual tooth measurements were compared. The integrated electronic apex locator failed to identify perforations ≤ 0.50 mm in diameter. Electronic length measurements were similarly accurate for 1.00 and 1.25 mm perforations but more precise than for 0.75 mm perforations. Instrumentation kinematics did not affect the electronic length measurement accuracy. Integrated electronic apex locators failed to detect small perforations during root canal treatment. The perforation diameter influenced the detection accuracy of integrated electronic apex locators, whereas kinematics had no effect.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of compressive and adhesive strengths of a hybrid ceramic and 5Y-PSZ zirconia cemented with three different materials 三种不同材料复合陶瓷与5Y-PSZ氧化锆的抗压和粘接强度评价。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-05-27 DOI: 10.1111/eos.70017

Letícia Moreschi, João Paulo De Carli, Marciele Cristiane Spanemberg Fuhr, Renan Brandenburg dos Santos, Paulo Renato Pulga da Silva, Pedro Henrique Corazza

{"title":"Evaluation of compressive and adhesive strengths of a hybrid ceramic and 5Y-PSZ zirconia cemented with three different materials","authors":"Letícia Moreschi, João Paulo De Carli, Marciele Cristiane Spanemberg Fuhr, Renan Brandenburg dos Santos, Paulo Renato Pulga da Silva, Pedro Henrique Corazza","doi":"10.1111/eos.70017","DOIUrl":"10.1111/eos.70017","url":null,"abstract":"This study aimed to evaluate the compressive and adhesive strengths of ceramic restorations (PICN and 5Y-PSZ zirconia) cemented with one of three types of cements: conventional glass ionomer cement (GI), resin-modified glass ionomer cement (RM-GI), and self-adhesive resin cement (R). Ceramic specimens (5Y-PSZ, n = 72; PICN, n = 60) were prepared for testing after cementation onto glass fiber-reinforced resin-based composite tooth analogs. The 5Y-PSZ specimens underwent tribochemical silica coating before cementation. Specimens intended for compressive strength evaluation were mechanically cycled (500,000 cycles) before testing. A microtensile bond strength test was used to evaluate adhesive strength, with specimens sectioned into microbars (1 mm2 cross-section) and loaded until fracture. If pre-test failures occurred, bond strength was assessed using microshear tests. PICN restorations showed significantly higher compressive strength than 5Y-PSZ. For PICN, self-adhesive resin cement yielded the highest compressive strength. For adhesive strength, PICN restorations cemented with self-adhesive or RM-GI cements outperformed GI. The 5Y-PSZ+R combination showed the highest microshear bond strength, superior to 5Y-PSZ+RM-GI and 5Y-PSZ+GI. Resin cements showed higher compressive and adhesive strengths for PICN than glass ionomer-based cements. For 5Y-PSZ, the cement type did not significantly affect compressive strength. Overall, PICN restorations outperformed 5Y-PSZ in compressive and adhesive strengths.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of human survivin-2B-specific cytotoxic CD8+ T lymphocytes on CD44+/− HSC-2 and HSC-3 oral cancer cells 人survivin- 2b特异性细胞毒性CD8+ T淋巴细胞对CD44+/- HSC-2和HSC-3口腔癌细胞的影响

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-05-21 DOI: 10.1111/eos.70019

Sho Miyamoto, Azuna Osaki, Aiko Murai, Yoshihiko Hirohashi, Takanori Sasaki, Kazuhiro Ogi, Taka-aki Tokura, Takayuki Kanaseki, Tomohide Tsukahara, Shinichiro Kina, Toshihiko Torigoe, Akihiro Miyazaki

{"title":"Effect of human survivin-2B-specific cytotoxic CD8+ T lymphocytes on CD44+/− HSC-2 and HSC-3 oral cancer cells","authors":"Sho Miyamoto, Azuna Osaki, Aiko Murai, Yoshihiko Hirohashi, Takanori Sasaki, Kazuhiro Ogi, Taka-aki Tokura, Takayuki Kanaseki, Tomohide Tsukahara, Shinichiro Kina, Toshihiko Torigoe, Akihiro Miyazaki","doi":"10.1111/eos.70019","DOIUrl":"10.1111/eos.70019","url":null,"abstract":"Despite advancements in the treatment of oral cancer, cancer survival rates remain low, highlighting the need for new therapeutic strategies targeting cancer stem-like cells. Cancer stem-like cells are a small population of cancer cells within tumors that drive recurrence and metastasis. They are often resistant to conventional treatments. Immunotherapy has shown promise against cancer stem-like cells, particularly with the use of cytotoxic T lymphocytes targeting specific markers. Survivin, an apoptosis protein inhibitor, is overexpressed in several malignancies, including oral cancer, and is associated with tumor recurrence and reduced survival. Survivin-2B-specific cytotoxic T lymphocytes were produced and evaluated for their ability to target CD44+ (cancer stem-like cells) and CD44− cells (non-cancer stem-like cells), respectively, from oral cancer cell lines (HSC-2 and HSC-3, respectively). Quantitative polymerase chain reaction (qPCR) analysis confirmed similar survivin-2B expression in both cell types. Cytotoxic T lymphocyte assays revealed the effective lysis of both cancer stem-like cells and CD44− cell populations, supporting the potential of survivin-2B-specific cytotoxic T lymphocytes to overcome cancer stem-like cell-associated resistance. These findings suggest that survivin-2B peptide vaccines are effective in preventing cancer relapse by targeting cancer stem-like cells, with future directions aimed at developing multipeptide “cocktail” vaccines to reduce the risk of immune evasion.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical proprioception and dysphagia severity in multiple sclerosis: A cross-sectional clinical analysis 多发性硬化症颈椎本体感觉和吞咽困难严重程度：一项横断面临床分析。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-05-13 DOI: 10.1111/eos.70012

Hanife Abakay, M. Fatih Yetkin, Ayşe Güç, Gizem Şekercan

{"title":"Cervical proprioception and dysphagia severity in multiple sclerosis: A cross-sectional clinical analysis","authors":"Hanife Abakay, M. Fatih Yetkin, Ayşe Güç, Gizem Şekercan","doi":"10.1111/eos.70012","DOIUrl":"10.1111/eos.70012","url":null,"abstract":"This study aimed to investigate the relationship between dysphagia severity and neck proprioception, pain, and mood in individuals with multiple sclerosis (MS). The individuals were divided into two groups according to the severity of dysphagia: dysphagia group (n = 13) with a score of 3 and above on the Dysphagia Assessment Scale in Multiple Sclerosis (DYMUS) scale and mild dysphagia group (n = 13) with a score of 2 and below. Clinical swallowing function was evaluated with the Turkish version of the Eating Assessment Tool-10 (T-EAT-10) and DYMUS. Proprioception was assessed with a laser by noting the deviation from the center target in centimeters. Neck pain severity was assessed with the Visual Analogue Scale (VAS), and mood was assessed with the Beck Depression Inventory (BDI). Individuals with severe dysphagia demonstrated statistically significantly greater proprioceptive impairment in cervical extension and right rotation. A significant difference was also found between the two groups in terms of clinical swallowing evaluations, neck pain status, and mood measurements. The findings suggest that proprioceptive deficits, increased pain, and mood disturbances are closely associated with dysphagia severity in MS. A multidimensional approach addressing dysphagia, proprioception, and pain management may be beneficial in optimizing dysphagia rehabilitation in patients with MS.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 3","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of surface conditioning protocols on the repair bond strength of resin composite to CAD/CAM blocks: Bioactive-glass, silica-coated alumina, or aluminum oxide? 表面调理方案对树脂复合材料与CAD/CAM块的修复结合强度的影响：生物活性玻璃、二氧化硅涂层氧化铝或氧化铝？

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-05-13 DOI: 10.1111/eos.70016

Büşra Karabulut Gençer, Ayşe Aslı Şenol, Ezgi Acar, Pınar Yılmaz Atalı, Bilge Tarçın, Mutlu Özcan

{"title":"Effect of surface conditioning protocols on the repair bond strength of resin composite to CAD/CAM blocks: Bioactive-glass, silica-coated alumina, or aluminum oxide?","authors":"Büşra Karabulut Gençer, Ayşe Aslı Şenol, Ezgi Acar, Pınar Yılmaz Atalı, Bilge Tarçın, Mutlu Özcan","doi":"10.1111/eos.70016","DOIUrl":"10.1111/eos.70016","url":null,"abstract":"This study evaluated the repair bond strengths of ceramic and hybrid ceramic CAD/CAM restorations following bioactive-glass, silica-coated alumina, and aluminum oxide surface treatments. Shear bond strength (SBS) tests, surface roughness, and scanning electron microscopic (SEM) evaluations were performed on 180 specimens (7×12×2 mm3 and 5×5×3 mm3, respectively) of ceramic (IPS Empress) and hybrid ceramic (Cerasmart270) blocks. Samples were thermocycled (5°C–55°C, 5000 cycles) and silica-coated alumina, Al2O3, or bioactive-glass were used for surface conditioning. Resin composite was applied on substrate using two- (Tokuyama Universal) or one-bottle (G-Premio) universal adhesives, combined with the same brand universal shade composites (Omnichroma, Essentia Universal). SBS values were measured using a universal testing machine; failure types were analyzed using a stereomicroscope. Surface roughness was assessed with a profilometer, followed by SEM. Statistical analysis included ANOVA, Tukey HSD, and Fisher's Exact tests. The highest mean SBS values were observed for ceramics in conjunction with two-bottle universal adhesives. No statistically significant differences were found in the SBS values for different surface conditioning treatments except for hybrid ceramic conditioned with Al2O3. Bioactive-glass and silica-coated alumina caused similar surface roughness as indicated by the SEM images. A surface conditioning method and an adhesive system are both essential for hybrid ceramic repairs, while the adhesive system was more critical for ceramics.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of genetic variations in retinoid X receptor alpha on the risk and prognosis of HPV-negative oral carcinoma 类视黄醇X受体α基因变异对hpv阴性口腔癌风险和预后的影响。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-05-12 DOI: 10.1111/eos.70015

Dragan Pandzic, Gordana Supic, Debora Misic, Aleksandra Petkovic Curcin, Sasa Jovic, Marko Brkic, Zoran Kozomara, Katarina Djurdjevic, Srboljub Stosic, Ruzica Kozomara

{"title":"The impact of genetic variations in retinoid X receptor alpha on the risk and prognosis of HPV-negative oral carcinoma","authors":"Dragan Pandzic, Gordana Supic, Debora Misic, Aleksandra Petkovic Curcin, Sasa Jovic, Marko Brkic, Zoran Kozomara, Katarina Djurdjevic, Srboljub Stosic, Ruzica Kozomara","doi":"10.1111/eos.70015","DOIUrl":"10.1111/eos.70015","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) is characterized by a high recurrence rate and poor survival. The retinoid X receptor (RXR) is a nuclear receptor that modulates a variety of biological processes related to cancer, including apoptosis, cellular adhesion, and immune function. A number of cancers exhibit aberrant expression and altered function of the RXR isoform alpha (RXRA), but the polymorphisms in the RXRA gene have not been investigated previously in patients with oral cancer. The current study examined the RXRA rs7864987 and rs3118523 genetic variants, assessed by the real-time PCR Taq-Man method, in 95 HPV-negative OSCC patients and 101 age- and sex-matched healthy controls. Kaplan-Meier analysis revealed that RXRA rs7864987 was significantly associated with worse overall survival and showed a tendency toward lower recurrence-free survival when compared with the wild-type allele carriers (combined TC+TT genotypes) to the mutant genotype CC. RXRA rs7864987, however, did not independently predict overall survival. The C allele of the RXRA rs3118523 genetic variant was associated with a reduced risk of OSCC. Our study indicates that polymorphisms of the RXRA gene may be prognostic and disease-predisposing genetic factors for OSCC. Additionally, RXRA polymorphisms might influence a potential genetic profile-based approach for retinoid therapy in OSCC.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 3","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0