European Journal of Oral Sciences最新文献_第2页

Fluoride toothpaste, sugar and the limits of the Nordic lesson. 含氟牙膏、糖和北欧人的极限教训。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-21 DOI: 10.1111/eos.70132

Habib Benzian, Eugenio Beltrán-Aguilar, Benoit Varenne

引用次数: 0

Letter to the Editor in response to Benzian et al.: Fluoride toothpaste, sugar, and the limits to the Nordic lesson. 给编辑的回复本先等人的信：含氟牙膏、糖和对北欧教训的限制。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-21 DOI: 10.1111/eos.70133

Bente Nyvad, Ole Fejerskov

引用次数: 0

Effects of triethylene glycol dimethacrylate and bisphenol A-glycidyl methacrylate on annexin A proteins in human mesangial cells 三甘醇二甲基丙烯酸酯和双酚A-甲基丙烯酸缩水甘油酯对人系膜细胞膜联蛋白A的影响。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-17 Epub Date: 2026-05-11 DOI: 10.1111/eos.70095

Ayşe Nur Doğan, Niharika Bala, Zenab Shahzad, Erika S. Galban, Abdel A. Alli

{"title":"Effects of triethylene glycol dimethacrylate and bisphenol A-glycidyl methacrylate on annexin A proteins in human mesangial cells","authors":"Ayşe Nur Doğan, Niharika Bala, Zenab Shahzad, Erika S. Galban, Abdel A. Alli","doi":"10.1111/eos.70095","DOIUrl":"10.1111/eos.70095","url":null,"abstract":"Dental resin monomers are widely used in restorative dentistry, yet their potential effects on kidney-related cell types remain poorly understood. This study investigated the effects of bisphenol A-glycidyl methacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) on protein expression and cytoskeletal regulatory pathways in human mesangial cells. A proteomic analysis demonstrated differential expression of multiple members of the annexin A protein family in treated human mesangial cells compared with vehicle-treated controls. These findings were validated by western blotting and densitometric analysis, which revealed reduced expression of annexin A proteins, including annexin A2 and annexin A5, following exposure to TEGDMA. To further explore the functional relevance of annexin A2, transient knockdown using small interfering RNA was performed. Reduction of annexin A2 expression using siRNA resulted in decreased levels of alpha-smooth muscle actin and non-muscle myosin proteins compared with cells transfected with non-targeting control RNA. Collectively, these results indicate that commonly used dental resin monomers may influence protein expression and cytoskeletal-associated pathways in human mesangial cells through alterations in annexin A protein expression. The findings highlight a previously underexplored cellular response to dental methacrylates and suggest potential implications for renal cell biology under controlled in vitro conditions.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between oral health clusters and oral health-related quality of life: A population‑based study of 5‑yr‑old children 口腔健康集群与口腔健康相关生活质量之间的关系：一项以5岁儿童为基础的人群研究

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-17 Epub Date: 2026-04-30 DOI: 10.1111/eos.70100

Pedro Henrique Duarte França de Castro, Maria Augusta Bessa Rebelo, Mario Vianna Vettore

{"title":"The association between oral health clusters and oral health-related quality of life: A population‑based study of 5‑yr‑old children","authors":"Pedro Henrique Duarte França de Castro, Maria Augusta Bessa Rebelo, Mario Vianna Vettore","doi":"10.1111/eos.70100","DOIUrl":"10.1111/eos.70100","url":null,"abstract":"This study aimed to describe oral health clusters that combine dental conditions and perceived oral health and to examine the association of oral health indicators and their clusters with oral health-related quality of life (OHRQoL) in 5-yr-old children. This cross-sectional study analysed data from 4354 5-yr-old children participating in the Brazilian National Oral Health Survey (SB Brasil 2023). Oral health assessment included decayed, missing and filled teeth; clinical consequences of untreated dental caries (pufa index); malocclusion; perceived oral health; and OHRQoL (SOHO-5). Latent profile analysis was performed to identify oral health clusters, and regression models examined associations between clusters, oral health indicators and OHRQoL. Four distinct clusters emerged: healthy teeth and very good/good perceived oral health (56.3%), restored teeth and good/fair perceived oral health (8.9%), high caries and good/fair perceived oral health (24.9%) and high caries/high pufa and fair/poor perceived oral health (9.9%). Oral health indicators (except malocclusion) and oral health clusters were associated with worse OHRQoL, but cluster-based associations were stronger. Children in clusters with high caries, pufa and poor perceived oral health showed markedly poorer OHRQoL across all domains. This approach may explain OHRQoL better than oral health indicators, providing a more nuanced understanding of oral health disparities.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of adjunctive methacryloyloxydecyl dihydrogen phosphate primers on dentin bond strength of universal adhesives under saliva and artificial aging 唾液和人工老化条件下，甲基丙烯氧癸基磷酸二氢引物对通用胶粘剂牙本质结合强度的影响。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-17 Epub Date: 2026-05-14 DOI: 10.1111/eos.70105

Marjorie Zanini, Amélie Mainjot, Stéphane Le Goff, Jean-François Nguyen

{"title":"Role of adjunctive methacryloyloxydecyl dihydrogen phosphate primers on dentin bond strength of universal adhesives under saliva and artificial aging","authors":"Marjorie Zanini, Amélie Mainjot, Stéphane Le Goff, Jean-François Nguyen","doi":"10.1111/eos.70105","DOIUrl":"10.1111/eos.70105","url":null,"abstract":"This study evaluated whether adjunctive 10-methacryloyloxydecyl dihydrogen phosphate (MDP) primers enhance the microtensile bond strength (µTBS) of two universal adhesives (UAs) to dentin under artificial aging and repeated salivary contamination applied at each bonding step. One hundred fifty-two human molars were assigned to 24 groups based on UA type, MDP primer application, contamination, and aging period (1, 30, and 180 d). Resin–dentin beams were sectioned and loaded to failure to determine µTBS. Failure modes were analyzed, and scanning electron microscopy (SEM) was used to assess hybrid layer quality and interfacial morphology. FTIR–ATR evaluated the effect of MDP primers on the degree of conversion (DC). Data were analyzed using one and three-way anova, Scheffé’s test, and Weibull statistics. Under uncontaminated conditions, MDP primers significantly increased µTBS for both UAs after 180 d. Repeated contamination significantly reduced µTBS; however, adjunctive MDP priming restored bond strength to levels comparable to uncontaminated controls. FTIR–ATR demonstrated higher DC in MDP primer groups, suggesting enhanced interfacial polymerization. Weibull analysis confirmed improved bonding reliability with primer use. SEM revealed continuous hybrid layers in MDP groups regardless of contamination, whereas failure modes shifted toward more cohesive patterns. Adjunctive MDP priming mitigates the adverse effects of salivary contamination and aging on UA-dentin bonding.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fracture load and three-dimensional internal void analysis of direct composites used to restore worn molars 直接复合材料修复磨牙的断裂载荷及三维内空洞分析。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-17 Epub Date: 2026-05-06 DOI: 10.1111/eos.70104

Topias Yli-Urpo, Jorma Määttä, Auli Suominen, Pekka K. Vallittu, Timo Närhi, Anna-Maria Le Bell-Rönnlöf, Jasmina Bijelic-Donova

{"title":"Fracture load and three-dimensional internal void analysis of direct composites used to restore worn molars","authors":"Topias Yli-Urpo, Jorma Määttä, Auli Suominen, Pekka K. Vallittu, Timo Närhi, Anna-Maria Le Bell-Rönnlöf, Jasmina Bijelic-Donova","doi":"10.1111/eos.70104","DOIUrl":"10.1111/eos.70104","url":null,"abstract":"This study evaluated (1) the load-bearing capacity of molars restored with direct occlusal veneers fabricated either from short-fiber-reinforced composite (SFRC) or particulate-filled composite (PFC) and the presence of internal voids within the materials, and (2) effect of water storage on the fracture load and correlation between internal voids and fracture load. Sixty human molars (n = 10/group) were prepared with flat occlusal surfaces and preserved enamel margins simulating worn teeth. Conventional molds were taken for each tooth to control the preparation depth and transparent molds to restore the teeth to their original shape. Following bonding procedure, teeth were restored with flowable SFRC, flowable PFC, or condensable PFC using either injectable or pressing technique. Restored teeth were stored in water for 1 d or 6 months before the static loading test. Fracture mode and three-dimensional internal void analyses were additionally conducted. SFRC occlusal veneers showed significantly higher fracture load (3661 ± 446 N) than both PFC materials, flowable PFC (2064 ± 372 N) and condensable PFC (2183 ± 563 N). SFRC redirected the fractures towards the periphery of the restoration. Prolonged water storage duration or single voids did not adversely affect the fracture load. The use of SFRC as occlusal veneers for restoring molars improves the fracture load and the fracture propagation.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmembrane MUC1 assists oral microbial colonization in oral mucosa of potentially malignant disorders and oral squamous carcinoma. 跨膜MUC1协助口腔微生物在潜在恶性疾病和口腔鳞状癌的口腔黏膜定植。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-17 DOI: 10.1111/eos.70144

Lauriina Soiniemi, Matias Kanniainen, Saga Ramsay, Arja Kullaa, Bina Kashyap

{"title":"Transmembrane MUC1 assists oral microbial colonization in oral mucosa of potentially malignant disorders and oral squamous carcinoma.","authors":"Lauriina Soiniemi, Matias Kanniainen, Saga Ramsay, Arja Kullaa, Bina Kashyap","doi":"10.1111/eos.70144","DOIUrl":"https://doi.org/10.1111/eos.70144","url":null,"abstract":"Transmembrane mucin 1 (tMUC1) provides oral mucosal barrier against pathogens. The invasion of oncopathogenic microbes can promote cancerous proliferation of cells via inflammatory responses, abnormal cellular signaling, angiogenesis, anti-adhesion, and tumorigenesis. Oral potentially malignant disorders (OPMDs), such as oral lichen planus (OLP) and oral leukoplakia (OLK), include lesions with often dysplastic features and a risk of malignant transformation to oral squamous cell carcinoma (OSCC). This study examined the expression of tMUC1 and oral microbial colonization in these conditions using scanning electron microscopy (SEM). Forty-one formalin-fixed, paraffin-embedded biopsies were distinguished into controls, OLP, OLK, and OSCC groups. They were immunohistochemically stained for tMUC1 and were evaluated on light microscopy and SEM. Immunohistochemical expression of tMUC1 was limited to superficial layers in controls. OSCC presented considerable staining in all epithelial layers, whereas OLP and OLK samples showed no to minimal staining in the intermediate and superficial layers of epithelium. SEM displayed increased oral microbial colonization on the superficial surface of OLP and OLK when compared to controls. The altered expression of tMUC1 in OLP, OLK, and OSCC may enhance oral microbial colonization. OPMDs' transformation to OSCC could be due to influence of inflammatory response to microbial colonization.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70144"},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single- or two-visits endodontic treatment: Impact of irrigants on surface roughness, microhardness, topography, and fracture resistance of root dentin 单次或两次根管治疗：冲洗剂对牙根表面粗糙度、显微硬度、形貌和抗折断性的影响。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-17 Epub Date: 2026-05-06 DOI: 10.1111/eos.70103

Yasmin Padoin, Sidnei Flores de Pellegrin, Duvan Cala Castillo, William Lemos Bevilaqua, Gabriel Kalil Rocha Pereira, Guilherme Pauletto

{"title":"Single- or two-visits endodontic treatment: Impact of irrigants on surface roughness, microhardness, topography, and fracture resistance of root dentin","authors":"Yasmin Padoin, Sidnei Flores de Pellegrin, Duvan Cala Castillo, William Lemos Bevilaqua, Gabriel Kalil Rocha Pereira, Guilherme Pauletto","doi":"10.1111/eos.70103","DOIUrl":"10.1111/eos.70103","url":null,"abstract":"This study evaluated the effect of the number of simulated endodontic treatment visits and the type of irrigant on the surface roughness, microhardness, topography, and fracture resistance of root dentin. Bovine roots were distributed into six groups (n = 14) according to the irrigant and number of treatment visits: 0.9% saline solution (single- or two-visits); 2.5% sodium hypochlorite (NaOCl) (single- or two-visits); 2% chlorhexidine (CHX) (single- or two-visits). Next, the roots were embedded in cylindrical acrylic molds for fracture resistance testing and fracture pattern analysis. In addition, dentin blocks were subjected to the same experimental protocols (n = 7) and analyzed for surface roughness, topography, and microhardness. Two-way anova, Tukey's post hoc and Fisher's exact tests were performed. There was no difference between the groups for fracture resistance or failure pattern. For surface roughness, highest values were observed when 2.5% NaOCl was used in combination with two simulated visits, findings that corroborate the dentin erosion observed in the microscopic analysis. For dentin microhardness, 2% CHX resulted in a reduction in this property, whereas the number of visits did not affect the outcome. In conclusion, different irrigants caused microstructural changes in dentin under simulated single- and two-visits treatments, but fracture resistance remained unaffected.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats 大鼠口腔癌发生中的神经免疫改变和伤害性行为。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-17 Epub Date: 2026-05-14 DOI: 10.1111/eos.70107

Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim

{"title":"Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats","authors":"Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim","doi":"10.1111/eos.70107","DOIUrl":"10.1111/eos.70107","url":null,"abstract":"Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood. In this study, male Wistar rats were exposed to 4-nitroquinoline-1-oxide for 8, 12, 16, or 20 wk. Mechanical allodynia was assessed using the von Frey test, and immunohistochemistry/immunofluorescence analyzed macrophage infiltration in the tongue and activation markers (nitrotyrosine, p-p38, glutamine synthetase, and Iba-1) in the trigeminal ganglion (TG) and spinal trigeminal subnucleus caudalis (Sp5C), focusing on animals with the highest nociceptive responses and macrophage infiltration. A reduction in mechanical thresholds was observed from Week 8, coinciding with histopathological alterations in the tongue. At 16 and 20 wk, Iba-1 immunoreactivity increased in the tongue and Sp5C, accompanied by morphological microglial changes, whereas nitrotyrosine and p-p38 expression were elevated in the TG. These findings indicate a temporal association between peripheral tissue changes, nociceptive behavior, and glial/immune activation in both central and peripheral trigeminal structures, suggesting that neuroimmune interactions may contribute to the development of oral cancer pain.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How does thermocycling affect the surface properties of ion-releasing bulk‑fill resin composites? 热循环如何影响离子释放体填充树脂复合材料的表面性能？

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-09-17 Epub Date: 2026-05-06 DOI: 10.1111/eos.70098

Ahmed Abdullah Al-Malwi, Abrar Nasser Bin Nooh, Rawan N. Al-Kahtani, Abdulaziz Abdullah Al-Khureif, Hanan Al-Sunbul, Aftab Ahmed Khan, Muhammad Sohail Zafar, Jukka P. Matinlinna

{"title":"How does thermocycling affect the surface properties of ion-releasing bulk‑fill resin composites?","authors":"Ahmed Abdullah Al-Malwi, Abrar Nasser Bin Nooh, Rawan N. Al-Kahtani, Abdulaziz Abdullah Al-Khureif, Hanan Al-Sunbul, Aftab Ahmed Khan, Muhammad Sohail Zafar, Jukka P. Matinlinna","doi":"10.1111/eos.70098","DOIUrl":"10.1111/eos.70098","url":null,"abstract":"This in vitro study evaluated the effect of thermocycling on the surface properties of ion-releasing and non-ion-releasing bulk-fill resin composites. Disc-shaped samples were fabricated from three commonly used ion-releasing resin composites and one non-ion-releasing control (Filtek Bulk). The baseline readings were recorded for one-third of randomly selected samples, whereas the rest underwent thermocycling (5000 and 10,000 cycles between 5 and 55°C, 30 s dwell time, 10 s transfer). Surface morphology, topography, nanoindentation, contact angle, pH, and color changes were evaluated. Data were analyzed using one-way analysis of variance, followed by post hoc tests (p < 0.05). Thermocycling led to increased roughness, reduced hardness, and elastic modulus in ion-releasing groups. Filtek Bulk exhibited minimal changes, with roughness increasing slightly (0.64 ± 0.08 to 0.79 ± 0.08 µm) and nanohardness decreasing (0.67 to 0.58 GPa). Beautifil Bulk Restorative and Fill-Up! showed moderate degradation, whereas Cention Forte experienced the sharpest decline in tested properties. Filtek Bulk maintained the highest color stability, whereas Cention Forte showed pronounced discoloration. Thermocycling was pronounced in ion-releasing bulk-fill restorative resin composites compared to non-ion-releasing ones. These findings suggest that, alongside therapeutic benefits, surface integrity, mechanical stability, and long-term esthetics must be considered when selecting ion-releasing bulk-fill restorative composites.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0