European Journal of Oral Sciences最新文献_第2页

Reviewers 2024

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-31 DOI: 10.1111/eos.13039

引用次数: 0

Effect of c-Myb overexpression on osteoblastic-, odontoblastic-, and cementoblastic differentiation of primary human periodontal ligament cells

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-25 DOI: 10.1111/eos.13040

Young-Hee Lee, Ho-Keun Yi, Paras Man Pradhan, Tae-Kun Kim, Sungil Jang

{"title":"Effect of c-Myb overexpression on osteoblastic-, odontoblastic-, and cementoblastic differentiation of primary human periodontal ligament cells","authors":"Young-Hee Lee, Ho-Keun Yi, Paras Man Pradhan, Tae-Kun Kim, Sungil Jang","doi":"10.1111/eos.13040","DOIUrl":"10.1111/eos.13040","url":null,"abstract":"The periodontal ligament (PDL) is a connective tissue, and PDL cells have a potential to differentiate into cementoblasts, osteoblasts, and gingival fibroblasts. This study investigated whether transcription factor c-Myb could induce differentiation of PDL cells for periodontal regeneration. PDL cells were isolated from extracted teeth and cultured. c-Myb was transfected to PDL cells using replication-deficient adenoviral vector. Differentiation of the PDL cells was analyzed by immunoblot, alkaline phosphatase activity, Alizarin red stain, and immunofluorescence analysis. Cell viability on titanium surfaces was analyzed by crystal violet stain and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. PDL cells cultured in osteogenic medium showed increased production of osteogenic and cementogenic molecules. Moreover, c-Myb-transfected cells showed increased production of dentinogenic molecules, in addition to the osteogenic and cementogenic molecules, even in normal culture condition. c-Myb-transfected cells also exhibited increased autophagy and type I collagen production under nutrient deprivation. When grown on a titanium surface, c-Myb-transfected cells showed increased production of osteogenesis-, dentinogenesis-, and cementogenesis-related molecules and cell viability. Thus, these results suggest that c-Myb might play an essential role during periodontal regeneration by improving the differentiation of PDL cells, and c-Myb can be utilized for enhancing the attachment of PDL cells to dental implant surfaces.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of surface roughness and microbiological retention on custom abutments produced by different techniques and materials

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-22 DOI: 10.1111/eos.13038

Serter Mert Selamet, Ovul Kumbuloglu, Asli Sahiner, Guven Ozdemir

{"title":"Assessment of surface roughness and microbiological retention on custom abutments produced by different techniques and materials","authors":"Serter Mert Selamet, Ovul Kumbuloglu, Asli Sahiner, Guven Ozdemir","doi":"10.1111/eos.13038","DOIUrl":"10.1111/eos.13038","url":null,"abstract":"The aims of this study were twofold: first, to investigate the surface roughness of different abutment materials prepared using various manufacturing methods; and, second, to evaluate colonization by Streptococcus mutans and Candida albicans according to abutment material and manufacturing method. Six material/manufacturing method combinations were investigated in this study, namely chromium–cobalt (Cr–Co) (prepared using casting, milling, and laser sintering) and titanium, zirconia, and anodized titanium (all prepared using milling); titanium (stock) abutments were used as the control group. Surface roughness of seven specimens from each group was evaluated using atomic force microscopy and scanning electron microscopy. Laser-sintered Cr–Co had the lowest values of Ra (mean ± SD = 4.8 ± 0.8 nm), Rq (mean ± SD = 7.0 ± 1.2 nm), and Rmax (mean ± SD = 133.5 ± 31.7 nm), whereas milled zirconia had the highest values of Ra (mean ± SD = 112.9 ± 44.2 nm), Rq (mean ± SD = 142.8 ± 54.0 nm), and Rmax (mean ± SD = 1,035.7 ± 350.4 nm). Three specimens from each group were infected with S. mutans and three with C. albicans, and microbial counts were evaluated after culture. Colonization of Streptococcus mutans was highest on milled zirconia (mean log10 count ± SD = 5.87 ± 0.08) and lowest on milled Cr–Co (mean log10 count ± SD = 4.04 ± 0.11). For C. albicans, colonization was highest on milled titanium stock (mean log10 count ± SD = 6.62 ± 0.03) and lowest on milled anodized titanium (mean log10 count ± SD = 6.13 ± 0.03). Differences in surface roughness and microbial colonization among groups can aid clinicians in selecting materials based on clinical relevance, considering their potential impact on outcomes.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of an intervention on immigrant parents' knowledge and attitudes toward their children's oral health: A cluster randomized trial in Norway 干预对移民父母对子女口腔健康的知识和态度的影响：挪威的一项集群随机试验。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-17 DOI: 10.1111/eos.13037

Mariam Reda, Abhijit Sen, Anne N. Åstrøm, Manal Mustafa

{"title":"Effects of an intervention on immigrant parents' knowledge and attitudes toward their children's oral health: A cluster randomized trial in Norway","authors":"Mariam Reda, Abhijit Sen, Anne N. Åstrøm, Manal Mustafa","doi":"10.1111/eos.13037","DOIUrl":"10.1111/eos.13037","url":null,"abstract":"There are no interventional studies on the oral health of immigrant children in Norway. This study aimed to assess the effectiveness of a culturally adapted oral health intervention for parental knowledge, attitude to oral hygiene, attitude to diet, and indulgence (permissiveness toward oral hygiene and sugar intake) concerning their children's oral health. A cluster randomized control trial, including immigrant parents of newborns, was conducted at seven health centers in Bergen (Norway) involving a 2-session one-to-one motivational interviews, toothbrushing demonstrations and pamphlets in the participants’ native languages at baseline and after 6 months. Mean differences in outcome scores were assessed and compared between intervention and control groups using generalized linear mixed model. In an intention-to-treat (ITT) analysis (n = 345), the estimated mean difference in parental attitude to diet and indulgence between the groups indicated more improvement in the control than in the intervention group in the adjusted models. For all outcomes within both groups, a slight positive change was observed in marginal mean scores from baseline to follow-up. The two culturally adapted intervention sessions had no impact on oral health-related knowledge, attitudes, and indulgence of immigrant parents. These findings suggest that more comprehensive interventions may be needed to improve parental knowledge and attitudes toward children's oral health.Trial Registration number: ClinicalTrials.gov Identifier: NCT05758454","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to letter to the editor 回复给编辑的信。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-09 DOI: 10.1111/eos.13035

Bahram Ranjkesh

引用次数: 0

Effect of changing the internal structure on the mechanical properties of three-dimensional-printed custom tray material: An in vitro study 改变内部结构对三维打印定制托盘材料力学性能的影响：体外研究。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-08 DOI: 10.1111/eos.13033

Cafer Anıl Erdem, Selin Çelik Öge, Orhun Ekren

{"title":"Effect of changing the internal structure on the mechanical properties of three-dimensional-printed custom tray material: An in vitro study","authors":"Cafer Anıl Erdem, Selin Çelik Öge, Orhun Ekren","doi":"10.1111/eos.13033","DOIUrl":"10.1111/eos.13033","url":null,"abstract":"The main challenges to the widespread clinical application of three-dimensional (3D)-printed customized trays include cost and time limitations. This study examined how changing the internal structure of 3D-printed materials used for customized trays affects flexural strength (FS), flexural modulus (FM), manufacturing time, and material weight. Specimens (64 × 10 × 3.3 mm) were printed using a light-sensitive liquid resin. The internal structures of control specimens were completely filled, whereas the internal structures of test groups comprised vertical bars spaced 1 mm (Test 1) or 2 mm (Test 2) apart. Specimens were weighed and then subjected to a three-point bending test to evaluate their FS and FM. Data were analyzed using one-way ANOVA and Tukey's test, with Weibull analysis applied to FS values. Control specimens had the highest FS (106 ± 4 MPa), while Test 2 specimens demonstrated the highest FM (6101 ± 1407 MPa). No significant differences were found between Test 1 and Test 2 specimens in FS or FM. Test 2 specimens had the lowest mean weight (1440 ± 42 mg). Manufacturing times were 80 min for control and Test 1 specimens and 60 min for Test 2 specimens. Including spaces in the internal structure of 3D-printed custom tray material saves material and manufacturing time while maintaining mechanical properties.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of metformin and verteporfin treatment alone or in combination in a murine head and neck cancer xenograft model 二甲双胍和维替波芬单独或联合治疗小鼠头颈癌异种移植模型的疗效。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-08 DOI: 10.1111/eos.13034

Aung Phyo Shan, Khin Swe Hlaing, Asada Leelahavanichkul, Panomwat Amornphimoltham

{"title":"Efficacy of metformin and verteporfin treatment alone or in combination in a murine head and neck cancer xenograft model","authors":"Aung Phyo Shan, Khin Swe Hlaing, Asada Leelahavanichkul, Panomwat Amornphimoltham","doi":"10.1111/eos.13034","DOIUrl":"10.1111/eos.13034","url":null,"abstract":"Despite treatment advances, head and neck squamous cell carcinoma (HNSCC) still poses a significant global health challenge. Combination therapies have emerged as more effective strategies than traditional chemotherapy in clinical practice by improving tumor response rates and patient survival while minimizing treatment-related toxicity. This study investigates the anticancer effects of metformin and verteporfin (Yes-associated protein 1 [YAP1] inhibitor) alone or in combination in HNSCC using vitro and in vivo approaches. Quantitative RT-PCR analysis of HNSCC cell lines reveals upregulation of YAP1 and related genes in the Hippo signaling pathway. Cell viability assays demonstrate a beneficial synergistic effect between metformin and verteporfin in inhibiting HNSCC tumor growth. In male BALB/cAJcl-nu/nu mice harboring HNSCC tumor xenografts, intraperitoneal administration of metformin and verteporfin enhances the inhibitory effect on tumor growth and suppresses YAP1 nuclear translocation when compared to vehicle or monotherapies. Furthermore, combination of these drugs reduces tumor cell proliferation (marked by Ki-67) and inhibits phosphoS6 ribosomal protein, as observed through immunofluorescent and immunohistochemical (IHC) analyses. The in vivo study underscores the therapeutic potential of the dual targeting approach with metformin and verteporfin in treating HNSCC, with minimal toxicity.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing bond strength: Insights into resin-based restorative materials and calcium silicate cement interactions

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2025-01-06 DOI: 10.1111/eos.13036

Carlos M. Ardila

引用次数: 0

Efficacy of thyme honey in the management of oral aphthous ulcers: A randomized controlled clinical trial 百里香蜂蜜治疗口腔溃疡的疗效：一项随机对照临床试验。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-12-26 DOI: 10.1111/eos.13032

Dalia Ghalwash, Ayman El-Gawish, Ahmed Ammar, Asmaa Abou-Bakr

{"title":"Efficacy of thyme honey in the management of oral aphthous ulcers: A randomized controlled clinical trial","authors":"Dalia Ghalwash, Ayman El-Gawish, Ahmed Ammar, Asmaa Abou-Bakr","doi":"10.1111/eos.13032","DOIUrl":"10.1111/eos.13032","url":null,"abstract":"The current study aimed to assess the effect of thyme honey on pain relief in patients with minor aphthous ulcers as a primary objective, its healing effect on ulcer size reduction, and the Oral Health Impact Profile (OHIP-14). In this randomized clinical trial, 30 patients (15 in each group) having minor aphthous ulcers at the oral diagnostic clinic at the British University in Egypt were treated with either thyme honey or triamcinolone acetonide in orabase. Different clinical parameters were recorded for both groups at various intervals, such as pain intensity using the Visual Analog Scale (VAS), size of ulcers in mm, and OHIP-14. Thyme honey intervention showed more significant ulcer size reduction than the triamcinolone acetonide group on days 5, and 7, and a more substantial decrease in pain intensity on days 3, 5, and 7. Additionally, the thyme honey group showed significantly lower OHIP values than the triamcinolone acetonide group after 7 days. The current clinical trial furnished evidence of the effectiveness of thyme honey in managing minor aphthous ulcers for the first time and revealed clinical efficiency with satisfactory patient outcomes.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tip efficiency of a customized lingual appliance: Performance of wires with two different ligatures 定制语言器具的尖端效率：两种不同结扎线的性能。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-12-16 DOI: 10.1111/eos.13031

Sara Drago, Alberto Lagazzo, Anna De Mari, Luigi Rizzi, Roberto Stradi, Maria Menini, Marco Migliorati

{"title":"Tip efficiency of a customized lingual appliance: Performance of wires with two different ligatures","authors":"Sara Drago, Alberto Lagazzo, Anna De Mari, Luigi Rizzi, Roberto Stradi, Maria Menini, Marco Migliorati","doi":"10.1111/eos.13031","DOIUrl":"10.1111/eos.13031","url":null,"abstract":"Tip control in lingual orthodontics may be challenging because of the presence of a vertical slot and the particular configuration of the customized appliances. The aim of this in vitro experimental study was to investigate the role of the ligature–wire–slot system in achieving better tip control. A set of customized lingual brackets was obtained for a dedicated typodont made of extracted human teeth. A compression/traction machine tested two types of ligatures in combination with seven different wires, and the tipping angle of each configuration was derived. A statistically significant difference was found between ligatures when the complete set of data was tested. In addition, differences between ligatures were found when testing each wire separately. A statistically significant difference was found among all wires. Full-size wires showed the smallest angles, which correspond to the greatest efficiency of the slot–archwire–ligation system in terms of tip control, and this efficiency appeared to be ligature-related. The role played by the type of ligature was more relevant for undersized wires.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"133 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0