Felipe Machado Souza, Larissa M. M. Alves, Edisa O. Sousa, Tiago Moreira Bastos Campos, Giovana Assis Marcolino, Mariana Miranda de Toledo Piza, Rainã S. Dias, Satoshi Yamaguchi, Petra C. Gierthmuehlen, Lukasz Witek, Paulo G. Coelho, Estevam A. Bonfante, Ernesto B. Benalcazar-Jalkh
{"title":"Improving fatigue resistance of translucent 4Y-PSZ zirconia through glass gradation","authors":"Felipe Machado Souza, Larissa M. M. Alves, Edisa O. Sousa, Tiago Moreira Bastos Campos, Giovana Assis Marcolino, Mariana Miranda de Toledo Piza, Rainã S. Dias, Satoshi Yamaguchi, Petra C. Gierthmuehlen, Lukasz Witek, Paulo G. Coelho, Estevam A. Bonfante, Ernesto B. Benalcazar-Jalkh","doi":"10.1111/eos.70101","DOIUrl":"10.1111/eos.70101","url":null,"abstract":"<p>To evaluate the effect of graded glass infiltration on the fatigue behavior and mechanical reliability of translucent 4Y-PSZ zirconia before and after hydrothermal aging, disc-shaped specimens were fabricated by uniaxial pressing and divided into control and glass-graded groups (<i>n</i> = 36/group). Glass infiltration was performed on pre-sintered specimens followed by final sintering, and half of the specimens from each group underwent hydrothermal aging (134°C, 2.2 bar, 20 h). Microstructure and phase composition were assessed by scanning electron microscopy and x-ray diffraction. Mechanical performance was evaluated using step-stress accelerated life testing, with Weibull statistics, reliability analysis, and inverse power-law modeling. Glass-graded specimens demonstrated higher reliability and characteristic strength (≈330 MPa increase) with similar Weibull modulus compared to controls. The inverse power-law parameter <i>α</i><sub>0</sub> was higher for the glass-graded group, indicating extended fatigue life, whereas comparable <i>α</i><sub>1</sub> values suggested similar life–stress relationships. Hydrothermal aging did not significantly affect mechanical performance, although phase transformation occurred in the control group. Fractography revealed surface-initiated failures in controls and interface-related crack initiation in glass-graded specimens. Graded glass infiltration improved the fatigue reliability and characteristic strength without compromising hydrothermal stability of 4Y-PSZ. These results suggest that glass-graded 4Y-PSZ may expand the clinical applicability of translucent zirconia for long-span (≥4-unit) prosthetic reconstructions.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Animal models of chronic graft-versus-host disease with oral involvement: A review","authors":"Shuqian Wang, Qiaozhi Jiang, Renchuan Tao","doi":"10.1111/eos.70110","DOIUrl":"10.1111/eos.70110","url":null,"abstract":"<p>Chronic graft-versus-host disease (cGVHD) remains a significant complication following allogeneic hematopoietic stem cell transplantation, with the oral cavity being one of the most frequently affected sites. Oral cGVHD manifests mucosal inflammation, salivary gland dysfunction, and fibrosis, all of which substantially impair patients’ quality of life. To date, research efforts have predominantly focused on clinical investigations, with relatively limited exploration of animal models for in vivo studies, despite animal models playing a pivotal role in deciphering the pathobiology of cGVHD and developing therapeutic strategies. This review synthesizes the classification, modeling methodologies, and pathological characteristics of systemic GVHD animal models, with particular emphasis on the phenotypic manifestations of oral involvement. By critically assessing the strengths and limitations of murine, rat, canine, and nonhuman primate models, this article aims to provide a comprehensive narrative framework for selecting appropriate animal models in future in vivo studies of oral cGVHD.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ândrea Pires Daneris, Letícia Regina Morello Sartori, Marina da Costa Rocha, Flávio Fernando Demarco, Marcos Britto Correa, Sarah Arangurem Karam
{"title":"Self-reported sexual assault and dental service use among adolescents: The moderating role of dental pain","authors":"Ândrea Pires Daneris, Letícia Regina Morello Sartori, Marina da Costa Rocha, Flávio Fernando Demarco, Marcos Britto Correa, Sarah Arangurem Karam","doi":"10.1111/eos.70111","DOIUrl":"10.1111/eos.70111","url":null,"abstract":"<p>This study investigated the association between self-reported sexual assault and dental service utilization among Brazilian adolescents (13–17-yr), considering sex differences and the moderating role of dental pain. Cross-sectional analyses using data from the 2019 Brazilian National School Health Survey were performed with <span>stata 18.5</span>, applying survey weights. The outcome was dental service use in the previous year, and the exposure was lifetime self-reported sexual assault. A total of 124,106 adolescents were included; 50.4% were female and 66.3% aged 13–15-yr. Overall, 66.7% reported dental visits in the previous year, 18.6% reported dental pain, and 6.2% reported sexual abuse. Adolescents with a history of sexual assault showed lower prevalence of dental service use compared with their non-abused peers (prevalence ratio [PR] = 0.96; 95% confidence interval [CI]: 0.92–1.00), particularly among girls (PR = 0.94; 95% CI: 0.89–0.98). Dental pain was associated with a modest increase in dental service utilization across all groups, with no evidence of effect modification. These findings suggest that sexual abuse is linked to reduced engagement with dental services during adolescence, especially among females, although the magnitude of this association is modest. The results emphasize the importance of trauma-informed and intersectoral strategies to improve access to oral healthcare for vulnerable populations.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ido Luiz de Azevedo Feiten, Bruno Borges de Oliveira, Karin de Mello Weig, Luise Gomes da Motta, Luis Felipe J. Schneider, Larissa Maria Assad Cavalcante
{"title":"The influence of post-curing protocols on the optical properties of provisional and long-term 3D-printable resin composites","authors":"Ido Luiz de Azevedo Feiten, Bruno Borges de Oliveira, Karin de Mello Weig, Luise Gomes da Motta, Luis Felipe J. Schneider, Larissa Maria Assad Cavalcante","doi":"10.1111/eos.70106","DOIUrl":"10.1111/eos.70106","url":null,"abstract":"<p>This study determined the influence of post-curing protocols on the color stability of provisional and long-term 3D-printable resin composites. Disc-shaped specimens were fabricated from a provisional (Prov) and long-term (Crown) 3D-printable resin composites using a digital light processing printer. Post-curing protocols included exposure to 405 nm-based light sources (Anycubic for 30 or 60 min in the standard mode or Procure 1) and one 385 nm-based light source (Procure 2 with distinct protocols). Color parameters (<i>L</i>*, <i>a</i>*, <i>b</i>*) were measured at baseline, after 14 and 21 d of dry storage, and after 7 d of water immersion. Post-curing protocol, material, and storage condition significantly influenced color stability. High-irradiance protocols resulted in the highest color change values, exceeding the clinical acceptability threshold (Δ<i>E</i><sub>00</sub> > 1.8). Water immersion induced a significant whitening effect and increased total color change in all groups. The long-term resin demonstrated superior color stability compared to the provisional one across all post-curing protocols. The choice of post-curing protocol is critical for aesthetic performance, as high-irradiance parameters, while potentially beneficial for mechanical properties, can compromise chromatic stability, particularly in materials with low filler content.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min-Ji Choi, Eun-Sook Kang, Min-Kyeong Kim, Kenta Tsuchiya, Jukka P. Matinlinna, Kwang-Won Lee, Kyung-San Min
{"title":"Biological effects of a premixed calcium silicate pulp-capping material containing dimethyl sulphoxide as a vehicle: In vitro and in vivo study","authors":"Min-Ji Choi, Eun-Sook Kang, Min-Kyeong Kim, Kenta Tsuchiya, Jukka P. Matinlinna, Kwang-Won Lee, Kyung-San Min","doi":"10.1111/eos.70096","DOIUrl":"10.1111/eos.70096","url":null,"abstract":"<p>This study aimed to compare the biological performance of a hydraulic calcium silicate cement (EndocemMTA Premixed) containing dimethyl sulphoxide (DMSO), developed to improve handling properties, in comparison with ProRoot mineral trioxide aggregate and Biodentine. Human dental pulp cells were used for in vitro evaluation of cytocompatibility, cell migration and cell–material interactions. Odontogenic differentiation was assessed using a 3D culture model designed to simulate the clinical environment. Pulp capping was performed in vivo on rat maxillary molars, and reparative dentin formation and pulpal inflammatory responses were evaluated using micro-computed tomography (<i>µ</i>CT) and histological analyses. In vitro, all investigated materials exhibited comparable cytocompatibility, cell migratory behaviour and odontogenic marker expression, with no significant differences among study groups. The <i>µ</i>CT analysis demonstrated significantly greater reparative dentin formation in all experimental groups compared with the control, with Biodentine producing a higher dentin volume than EndocemMTA Premixed. Histological evaluation revealed no significant differences among the experimental groups with respect to pulpal inflammation or dentin bridge continuity. These findings suggest that the incorporation of DMSO into premixed formulations would not adversely affect cytocompatibility or pulp healing. Moreover, the 3D model used in this study might serve as a clinically relevant platform for evaluating pulp–material interactions.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"134 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of carbonate apatite nanoparticles incorporated into commercial dental adhesives on immediate and long-term microtensile bond strength.","authors":"Heba E AbdelRazik, Jon E Dahl, Mina Aker Sagen","doi":"10.1111/eos.70138","DOIUrl":"https://doi.org/10.1111/eos.70138","url":null,"abstract":"<p><p>This study assessed whether integrating carbonate apatite nanoparticles with a CO<sub>3</sub>/PO<sub>4</sub> molar ratio of 5 (CA5n) into commercial adhesives affected the immediate or the long-term microtensile bond strength (µTBS) between composite resin and dentin. Scotchbond Multipurpose and Scotchbond Universal were tested with 0, 0.5, and 1 wt.% CA5n added. For Multipurpose, CA5n were incorporated into either the primer or the adhesive. Solutions were sonicated to minimize agglomeration. Sound human molars (n = 6/group) were prepared, and modified adhesives were applied as instructed. Composite was incrementally built up to 4 mm thick. Specimens were sectioned into beams and stored in water for 24 h or for 6 months before testing. Failure modes were observed. Data were analyzed using aligned rank transform anova (α < 0.05). CA5n had no impact on the bond strength of Multipurpose at either time point, irrespective of placement. Universal with 1% CA5n exhibited significantly higher 24 h µTBS than all other groups, but this advantage declined after 6 months. Mixed and adhesive failures increased over time, with the highest adhesive failure in Universal 1% at 6 months. Incorporation of CA5n into the tested adhesive systems did not significantly affect µTBS at 24 h or after 6 months of aging.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70138"},"PeriodicalIF":2.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interpretation of oral glutamate and cognitive change after periodontal treatment.","authors":"Fen-Lan Lin, Lien-Chung Wei","doi":"10.1111/eos.70142","DOIUrl":"https://doi.org/10.1111/eos.70142","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70142"},"PeriodicalIF":2.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Munishwar Rama, Nichani Ashish S, Pai B S Jagadish
{"title":"Response to \"Interpretation of oral glutamate and cognitive change after periodontal treatment\".","authors":"Munishwar Rama, Nichani Ashish S, Pai B S Jagadish","doi":"10.1111/eos.70143","DOIUrl":"https://doi.org/10.1111/eos.70143","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70143"},"PeriodicalIF":2.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carolina Ruis Ferrari, Hannah Zomignan Barros, Julia Pereira Bicalho, João Victor Frazão Câmara, Monique Malta Francese, Lethycia Almeida Santos, Juliano Pelim Pessan, Naiara Maia Pereira, Reinaldo Marchetto, Marília Afonso Rabelo Buzalaf
{"title":"Phosphomimetic statherin-derived peptide protects against intrinsic enamel erosion independently of sodium trimetaphosphate.","authors":"Carolina Ruis Ferrari, Hannah Zomignan Barros, Julia Pereira Bicalho, João Victor Frazão Câmara, Monique Malta Francese, Lethycia Almeida Santos, Juliano Pelim Pessan, Naiara Maia Pereira, Reinaldo Marchetto, Marília Afonso Rabelo Buzalaf","doi":"10.1111/eos.70141","DOIUrl":"https://doi.org/10.1111/eos.70141","url":null,"abstract":"<p><p>This in vitro study evaluated the effect of a phosphomimetic statherin-derived peptide (DDSt15), alone or combined with sodium trimetaphosphate (TMP), on the protection against initial enamel erosion. A total of 102 bovine enamel samples (4 × 4 mm<sup>2</sup>) were prepared and randomly allocated into six groups (n = 17): deionized water (negative control), Elmex Erosion Protection (reference material), 0.94 × 10<sup>-5</sup> M DDSt15, and DDSt15 associated with 0.5%, 1.0%, or 3.0% TMP. Samples were treated with the respective solutions for 2 h, followed by acquired enamel pellicle formation for 2 h using pooled stimulated human saliva. Subsequently, specimens were subjected to an erosive challenge with 0.01 M HCl (pH 2.3, 10 s). This protocol was performed daily for 3-d. Demineralization was assessed by percentage surface microhardness change (%SMC) and relative surface reflection intensity (%SRI). %SMC data were analyzed by anova with Tukey's post hoc test, whereas %SRI data were analyzed by Kruskal-Wallis with Dunn's post hoc test (p < 0.05). The negative control showed significantly lower protection compared to all other groups. Although DDSt15 combined with TMP improved protection relative to the negative control, no synergistic effect was observed for %SMC or %SRI. DDSt15 demonstrated protective potential against initial enamel erosion, particularly under intrinsic acidic conditions, independently of TMP.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70141"},"PeriodicalIF":2.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos M Ardila, Eliana Pineda-Vélez, Alejandro I Díaz-Laclaustra
{"title":"Considerations on TNF-α inhibition in ligature-induced periodontitis mice with the Alzheimer's disease risk factor APOE4.","authors":"Carlos M Ardila, Eliana Pineda-Vélez, Alejandro I Díaz-Laclaustra","doi":"10.1111/eos.70134","DOIUrl":"https://doi.org/10.1111/eos.70134","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70134"},"PeriodicalIF":2.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}