European Journal of Oral Sciences最新文献_第4页

Effect of interleukin-17A on inflammatory mediator production in interleukin-1β-stimulated human dental pulp fibroblasts 白细胞介素-17A 对白细胞介素-1β 刺激人牙髓成纤维细胞产生炎症介质的影响

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-09-20 DOI: 10.1111/eos.13019

Tadashi Nakanishi, Katsuhiro Mieda, Hitomi Kuramoto, Daisuke Takegawa

{"title":"Effect of interleukin-17A on inflammatory mediator production in interleukin-1β-stimulated human dental pulp fibroblasts","authors":"Tadashi Nakanishi, Katsuhiro Mieda, Hitomi Kuramoto, Daisuke Takegawa","doi":"10.1111/eos.13019","DOIUrl":"10.1111/eos.13019","url":null,"abstract":"In response to pro-inflammatory cytokines such as interleukin (IL)-1β, dental pulp fibroblasts produce various inflammatory mediators, including IL-6, IL-8, CC chemokine ligand 20 (CCL20), and CXC chemokine ligand 10 (CXCL10), leading to the progression of pulpitis. IL-17/IL-17A (IL-17A) is a pro-inflammatory cytokine secreted by T helper (Th) 17 cells following their recruitment to inflamed sites; however, the roles of IL-17A during pulpitis remain unclear. The purpose of this study was to investigate the effect of IL-17A on IL-6, IL-8, CCL20 and CXCL10 production by human dental pulp fibroblasts (HDPFs) in vitro. IL-17A at a concentration of 100 ng/ml induced the production of 10 times more IL-8 and 4 times more CXCL10, but not IL-6 and CCL20, compared to controls. Co-stimulation of HDPFs with IL-17A and IL-1β synergistically enhanced the production of IL-6, CCL20, IL-8 and CXCL10. IL-1β increased expression of IL-17 receptor/IL-17RA (IL-17R) on HDPFs. Moreover, the cell signal pathways of p38 mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) were more potently activated by simultaneous stimulation with IL-17A and IL-1β. These findings suggest that IL-17A participates in the progression of dental pulp inflammation through the enhanced production of inflammatory mediators in HDPFs.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of peroxide-free and peroxide-based in-office bleaching on the surface and mechanical properties of CAD/CAM esthetic restorative materials 不含过氧化物和含过氧化物的诊室漂白对 CAD/CAM 美学修复材料表面和机械性能的影响

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-09-13 DOI: 10.1111/eos.13016

Majed M. Alsarani, Aftab Ahmed Khan, Leonel S. J. Bautista, Hanan Alsunbul, Jukka P. Matinlinna

{"title":"Effect of peroxide-free and peroxide-based in-office bleaching on the surface and mechanical properties of CAD/CAM esthetic restorative materials","authors":"Majed M. Alsarani, Aftab Ahmed Khan, Leonel S. J. Bautista, Hanan Alsunbul, Jukka P. Matinlinna","doi":"10.1111/eos.13016","DOIUrl":"10.1111/eos.13016","url":null,"abstract":"The study aimed to investigate the influence of H2O2-based and H2O2-free in-office bleaching on the surface and mechanical attributes of CAD/CAM composite blocks. CAD/CAM composite blocks from five different composite materials (CC1, CC2, CC3, CC4, and CC5) were randomly divided into two groups according to bleaching application (H2O2-based and H2O2-free). The surface topography, morphology, nanohardness, elastic modulus, flexural strength, and fracture toughness were measured. A paired and unpaired sample t-tests gauged the effect of pre- and post-bleaching on the substrates. The estimated mean differences (before-after bleaching) suggested an increase in surface roughness for two materials CC2 and CC4, and a significant decrease in nanohardness for material CC4 and in elastic modulus for materials CC2 and CC4 with H2O2-based bleaching, whereas H2O2-free bleaching resulted in changes compatible with no change in these properties. Flexural strength and fracture toughness showed no evidence of changes, irrespective of the bleaching gel used. Scanning electron microscopic analysis revealed erosive effects and micropore formation due to H2O2-based bleaching. H2O2-based bleaching deteriorates the surface of CAD/CAM composite materials while H2O2-free bleaching gel had an insignificant effect on both surface and bulk properties. The clinician should carefully evaluate the potential effects of H2O2-based bleaching on the surface properties of CAD/CAM composites.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of blockage of Trem1 on the M1 polarization of macrophages in the regulation dental pulp inflammation 阻断 Trem1 对调控牙髓炎症中巨噬细胞 M1 极化的影响

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-09-12 DOI: 10.1111/eos.13018

Ting-Ting Wang, Wen-Rui Jiang, Li Xu, Mei-Yun Zhou, Yong-Song Huang

引用次数: 0

Effect of combining aminomethacrylate and fluoride against erosive and abrasive challenges on enamel and dentin 结合使用氨基甲基丙烯酸酯和氟化物对珐琅质和牙本质的腐蚀性和磨蚀性挑战的影响。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-08-29 DOI: 10.1111/eos.13015

Marina Gullo Augusto, Luis Felipe Oliveira da Silva, Giovanna Lotto, Tamires Maria de Andrade Santos, Idalina Vieira Aoki, Carlos Rocha Gomes Torres, Tais Scaramucci, Alessandra Bühler Borges

{"title":"Effect of combining aminomethacrylate and fluoride against erosive and abrasive challenges on enamel and dentin","authors":"Marina Gullo Augusto, Luis Felipe Oliveira da Silva, Giovanna Lotto, Tamires Maria de Andrade Santos, Idalina Vieira Aoki, Carlos Rocha Gomes Torres, Tais Scaramucci, Alessandra Bühler Borges","doi":"10.1111/eos.13015","DOIUrl":"10.1111/eos.13015","url":null,"abstract":"This study evaluated the effect of solutions containing aminomethacrylate copolymer (AA) and sodium fluoride (F; 225 ppm F−) or fluoride plus stannous chloride (FSn; 225 ppm F−, 800 ppm Sn2+) against enamel and dentin erosion/abrasion. Solutions F, FSn, AA, F+AA, FSn+AA, and deionized water as negative control were tested. Bovine enamel and dentin specimens (n = 13/solution/substrate) underwent a set of erosion-abrasion cycles (0.3% citric acid [5 min, 4×/day], human saliva [1 h, 4×/day], brushing [15 s, 2×/day], and treatments [2 min, 2×/day]) for each of five days. Initial enamel erosion was evaluated using Knoop microhardness after the first and second acid challenge on day 1, and surface loss with profilometry after day 5. KOH-soluble fluoride was assessed. Data were analyzed with ANOVA/Tukey tests. The combination of fluoride and AA resulted in higher protection against enamel erosion, whereas this was not the case for the combination of AA and FSn. All treatments protected against enamel and dentin loss. The lowest surface loss values were observed with F+AA and FSn+AA. The polymer did not significantly influence the KOH-soluble fluoride formation on enamel/dentin specimens. The aminomethacrylate copolymer effectively enhanced the efficacy of sodium fluoride against initial erosion and improved the control of enamel and dentin wear of F and FSn solutions.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of estrogen depression on alveolar bone microarchitecture and periodontal ligament cells during orthodontic movement 雌激素抑制对正畸过程中牙槽骨微结构和牙周韧带细胞的影响

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-08-19 DOI: 10.1111/eos.13014

Andréa Karina Ruivo, Bruno Calsa, Matheus Gomez Cancellara, João Paulo Nascimento Lima, Karla Rovaris da Silva, Marcelo Augusto Marretto Esquisatto, Milton Santamaria-Jr

{"title":"Effect of estrogen depression on alveolar bone microarchitecture and periodontal ligament cells during orthodontic movement","authors":"Andréa Karina Ruivo, Bruno Calsa, Matheus Gomez Cancellara, João Paulo Nascimento Lima, Karla Rovaris da Silva, Marcelo Augusto Marretto Esquisatto, Milton Santamaria-Jr","doi":"10.1111/eos.13014","DOIUrl":"10.1111/eos.13014","url":null,"abstract":"This study aimed to evaluate the effects of the estrogen depression during orthodontic tooth movement on alveolar bone microarchitecture and periodontal ligament. Female Wistar rats were divided into two groups, one consisting of non-ovariectomized animals subjected to orthodontic tooth movement, and one comprising ovariectomized animals subjected to orthodontic tooth movement. Micro-CT assessment of bone volume to total volume (BV/TV), total porosity, trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) in the alveolar bone of the orthodontically moved tooth was performed. Histomorphometric analyses were made in the periodontal ligament, and immunoexpression of RANK, RANKL, OPG, and TUNEL were quantified. Orthodontic tooth movement in the group of ovariectomized rats was faster than in non-ovariectomized animals. The alveolar bone area showed lower values of BV/TV and trabecular thickness, and higher bone porosity and trabeculae numbers in the ovariectomized rats. Histological analyses in the ovariectomized group revealed an increase in collagen fibers in the periodontal ligament. The apoptotic cell counts in the periodontal ligament were higher in the group of ovariectomized rats than in the sham-operated rats. Ovariectomy resulted in an increase in tooth movement and alteration of the alveolar bone microstructure in the first 7 day of orthodontic tooth movement, and in the presence of apoptotic cells in the periodontal ligament.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of laser irradiation during in-office tooth bleaching on surface properties of resin-based restorative materials 诊室牙齿漂白过程中激光照射对树脂基修复材料表面特性的影响。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-08-15 DOI: 10.1111/eos.13013

Christina Karanasiou, Dimitrios Dionysopoulos, Petros Mourouzis, Dimitrios Strakas, Olga Naka, Kosmas Tolidis

{"title":"Effect of laser irradiation during in-office tooth bleaching on surface properties of resin-based restorative materials","authors":"Christina Karanasiou, Dimitrios Dionysopoulos, Petros Mourouzis, Dimitrios Strakas, Olga Naka, Kosmas Tolidis","doi":"10.1111/eos.13013","DOIUrl":"10.1111/eos.13013","url":null,"abstract":"This study evaluated the changes in surface properties of three resin-based restorative materials after two laser-assisted, in-office tooth bleaching protocols using erbium, chromium: yttrium-scandium-gallium-garnet (Er,Cr:YSGG) or diode (980 nm) lasers. A nanohybrid composite (Enamel Plus HRi), a Bis-GMA-free composite (Enamel Plus HRi Bio Function), and a resin-matrix CAD-CAM ceramic (Shofu Block HC) were tested. Forty specimens for each material were prepared and divided into four groups (n = 10/group). The control specimens did not undergo any bleaching treatment, whereas group 2 received bleaching with 40% hydrogen peroxide (H2O2), while groups 3 and 4 underwent the same bleaching procedure with the use of diode (980 nm) or Er,Cr:YSGG lasers, respectively. Surface microhardness and roughness measurements were conducted using a Vickers tester and an optical profilometer. Microhardness was lower in bleached specimens, with the nanohybrid composite exhibiting the largest difference from the no bleaching group. For the Bis-GMA-free composite the microhardness difference between no bleaching and laser-assisted bleaching were smaller than seen for the conventional bleaching technique. Surface roughness was higher in bleached specimens, with nanohybrid composite showing the largest differences from the control specimens. The examined laser-assisted tooth bleaching protocols were found not to impact surface microhardness and roughness of the tested resin-based specimens and they are deemed suitable for clinical use.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to letter to the Editor 回复致编辑的信。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-08-07 DOI: 10.1111/eos.13012

Guido Artemio Marañón-Vásquez, Flares Baratto-Filho, Christian Kirschneck, Erika Calvano Küchler

引用次数: 0

Genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment: Correspondence 关键维生素-D通路基因的遗传变异和外根尖吸收与正畸治疗有关：通讯。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-08-07 DOI: 10.1111/eos.13011

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

The expression of immune checkpoint proteins PD-L1 and TIM3 in mouse and human head and neck squamous cell carcinoma 免疫检查点蛋白 PD-L1 和 TIM3 在小鼠和人类头颈部鳞状细胞癌中的表达。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-08-01 DOI: 10.1111/eos.13010

Areeg Elmusrati, Cun-Yu Wang

引用次数: 0

Epigenetic mechanisms and oral mucositis in children with acute lymphoblastic leukaemia 表观遗传机制与急性淋巴细胞白血病患儿的口腔黏膜炎。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2024-07-29 DOI: 10.1111/eos.13009

Juliana Ramalho Guimarães, Beatriz Fernandes de Souza, José Maria Chagas Viana Filho, Lecidamia Cristina Leite Damascena, Ana Maria Gondim Valença, Darlene Camati Persuhn, Naila Francis Paulo de Oliveira

{"title":"Epigenetic mechanisms and oral mucositis in children with acute lymphoblastic leukaemia","authors":"Juliana Ramalho Guimarães, Beatriz Fernandes de Souza, José Maria Chagas Viana Filho, Lecidamia Cristina Leite Damascena, Ana Maria Gondim Valença, Darlene Camati Persuhn, Naila Francis Paulo de Oliveira","doi":"10.1111/eos.13009","DOIUrl":"10.1111/eos.13009","url":null,"abstract":"This study aimed to investigate the relationship between epigenetic mechanisms and oral mucositis (OM) in paediatric patients with acute lymphoblastic leukaemia. Oral cells were collected from 76 participants, including 15 healthy individuals, 10 patients with acute lymphoblastic leukaemia but without a history of OM and 51 acute lymphoblastic leukaemia patients with a history of OM (35 with active OM and 16 who had recovered from OM). Global DNA methylation in the miR-9-1 and miR-9-3 genes was performed. Seven polymorphisms rs1801131, rs1801133 (MTHFR), rs2228611 (DNMT1), rs7590760, rs1550117 (DNMT3A), rs6087990, rs2424913 (DNMT3B) were genotyped and an analysis of association with global DNA methylation was performed. The global methylation levels were lower in cancer patients recovered from OM than in the other groups. A higher frequency of unmethylated profile for miR-9-1 and partially methylated profile for miR-9-3 was observed in cancer patients regardless of OM history compared to healthy patients. The GG genotype of the rs2228611 (DNMT1) polymorphism was associated with higher levels of global methylation in cancer patients irrespective of OM. It was concluded that global methylation is associated with mucosal recovery. The effect of DNMT1 genotype on the global DNA methylation profile, as well as the methylation profile of miR-9-1 and miR-9-3 in cancer patients is independent of OM.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0