阻断 Trem1 对调控牙髓炎症中巨噬细胞 M1 极化的影响

IF 1.8 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Ting-Ting Wang, Wen-Rui Jiang, Li Xu, Mei-Yun Zhou, Yong-Song Huang
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引用次数: 0

摘要

牙髓炎症是导致牙科预后不良的常见重要因素。目前的治疗策略主要集中于控制炎症反应,具体的干预目标仍在研究之中。髓系细胞上表达的触发受体(TREMs)是一组广泛存在于髓系细胞表面的受体分子,对炎症过程的调控至关重要。我们对数据集 GSE77459 中的临床牙髓样本和动物模型的转录组测序数据进行了分析,发现牙髓炎期间 Trem1 上调。服用Trem1阻断肽LP17后,体内和体外几种促炎因子的水平都降低了(超过1倍),M1巨噬细胞的极化也受到了抑制。这项关于Trem1在牙髓炎症发展过程中的表达模式和功能的研究为临床牙髓炎的治疗策略提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of blockage of Trem1 on the M1 polarization of macrophages in the regulation dental pulp inflammation

Dental pulp inflammation is a common and significant factor related to poor dental prognosis. Current treatment strategies primarily concentrate on managing the inflammatory response, with specific targets for intervention still under investigation. Triggering receptors expressed on myeloid cells (TREMs) are a group of receptor molecules extensively present on myeloid cell surfaces, crucial in the regulation of inflammatory process. Our analysis of transcriptomic sequencing data from clinical pulp samples of dataset GSE77459 and animal models revealed up-regulation of Trem1 during pulpitis. Administration of the Trem1-blocking peptide LP17 led to lower (more than 1-fold) levels of several pro-inflammatory factors and inhibition of M1 macrophage polarization both in vivo and in vitro. This study of the expression patterns and functions of Trem1 in the development of dental pulp inflammation provides novel insights into the therapeutic strategies for clinical pulpitis.

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来源期刊
European Journal of Oral Sciences
European Journal of Oral Sciences 医学-牙科与口腔外科
CiteScore
3.50
自引率
5.30%
发文量
61
审稿时长
2 months
期刊介绍: The European Journal of Oral Sciences is an international journal which publishes original research papers within clinical dentistry, on all basic science aspects of structure, chemistry, developmental biology, physiology and pathology of relevant tissues, as well as on microbiology, biomaterials and the behavioural sciences as they relate to dentistry. In general, analytical studies are preferred to descriptive ones. Reviews, Short Communications and Letters to the Editor will also be considered for publication. The journal is published bimonthly.
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