European Journal of Oral Sciences最新文献_第7页

Effect of open windows on airborne contamination and its topographical distribution in the dental operatory 牙科手术中开窗对空气污染及其地形分布的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-09-24 DOI: 10.1111/eos.12954

James R. Collins, Nathaly Rodríguez, Silvia Soto, Andrei C. Ionescu, Eugenio Brambilla, Franklin Garcia-Godoy

{"title":"Effect of open windows on airborne contamination and its topographical distribution in the dental operatory","authors":"James R. Collins, Nathaly Rodríguez, Silvia Soto, Andrei C. Ionescu, Eugenio Brambilla, Franklin Garcia-Godoy","doi":"10.1111/eos.12954","DOIUrl":"10.1111/eos.12954","url":null,"abstract":"Aerosols produced by dental handpieces represent a permanent risk of disease transmission in the dental environment. The current study evaluated the effects of natural ventilation (open windows) on Streptococcus mutans airborne contamination by dental handpieces in simulated clinical conditions. A dental phantom was placed on a dental chair at a standard university dental clinic operatory. An S. mutans suspension was infused into the phantom's mouth while an operator performed standardized dental procedures using low (contra-angle) and high speed (turbine) dental handpieces or an ultrasonic scaler, with windows open or closed. Selective medium Petri dishes were placed in 18 sites of the operatory environment to evaluate contamination topographically. Sites were clustered as: wall, floor, ceiling, dental chair, and cabinet. Contamination was expressed as log10CFU/cm2. A linear mixed model analysis was used, nesting the sites within each ventilation and handpiece combination. Open windows significantly reduced contamination. The high-speed handpiece provided the highest contamination, followed by the ultrasonic scaler and the low-speed handpiece. Contamination values were much smaller at the ceiling, and much larger at the chair. Opening windows produced more homogeneous contamination of the operatory compared to closed windows. Natural ventilation during dental procedures decreases contamination and affects its topographical distribution.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-wide association study identifies novel caries-associated loci showing sex-specificity—A study on the Northern Finland Birth Cohort 1966 全基因组关联研究确定了新的显示性别特异性的龋齿相关基因座——1966年芬兰北部出生队列的研究。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-09-14 DOI: 10.1111/eos.12953

Anne Laajala, Paula Pesonen, Viivi Alaraudanjoki, Vuokko Anttonen, Marja-Liisa Laitala

{"title":"Genome-wide association study identifies novel caries-associated loci showing sex-specificity—A study on the Northern Finland Birth Cohort 1966","authors":"Anne Laajala, Paula Pesonen, Viivi Alaraudanjoki, Vuokko Anttonen, Marja-Liisa Laitala","doi":"10.1111/eos.12953","DOIUrl":"10.1111/eos.12953","url":null,"abstract":"A genome-wide association study was performed in sex-stratified groups representing three different caries phenotypes among adults. The study sample consisted of 46-year-old participants of the Northern Finland Birth Cohort 1966 study (n = 1481). The phenotypes for analyses were the dentin caries phenotype (persons having at least one tooth with dentin caries lesion), and the enamel caries phenotype (those having teeth with more than 10 enamel caries lesions), while the control group had <10 enamel caries lesions and no teeth with dentin caries, respectively. A third phenotype dubbed the caries severity phenotype had a below-average number of teeth with initial lesions and at least one extensive dentin caries lesion; their controls had an above-average number of teeth with initial caries lesions and no teeth with extensive dentin caries lesions. All analyses were performed for the whole group and for sex-stratified subgroups. In females, loci in chromosomes 2, 5, and 15 showed a statistically significant association with caries severity. In males, there was a novel association between chromosome 5 and dentin caries. The results of this study may suggest a genetic background of caries among adults. In the future, the detection of genetic predisposing variants may allow the identification of patients at risk for caries, even in the absence of behavioral and environmental risk factors.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the phosphoproteome in human dental follicle cells during osteogenic differentiation 成骨分化过程中人牙毛囊细胞磷酸化蛋白质组的分析。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-09-04 DOI: 10.1111/eos.12952

Christian Morsczeck, Oliver Pieles, Hans-Christian Beck

{"title":"Analysis of the phosphoproteome in human dental follicle cells during osteogenic differentiation","authors":"Christian Morsczeck, Oliver Pieles, Hans-Christian Beck","doi":"10.1111/eos.12952","DOIUrl":"10.1111/eos.12952","url":null,"abstract":"Dental follicle cells (DFCs) are osteogenic progenitor cells and are well suited for molecular studies of differentiation of alveolar osteoblasts. A recent study examined the metabolism in DFCs during osteogenic differentiation and showed that energy metabolism is increased after 14 days of differentiation (mid phase). However, previous studies have examined proteomes at early (2 h, 24 h) or very late (28 days) stages of differentiation, but not during the phase of increased metabolic activity. In this study, we examined the phosphoproteome at the mid phase (14 days) of osteogenic differentiation. Analysis of DFC phosphoproteomes showed that during this phase of osteogenic differentiation, proteins that are part of signal transduction are significantly regulated. Proteins involved in the regulation of the cytoskeleton and apoptosis were also increased in expression. As osteogenic differentiation induced oxidative stress and apoptosis in DFCs, the oxidative stress defense protein, catalase, was also upregulated during osteogenic differentiation, which supports the biomineralization of DFCs. In summary, this study revealed that during the middle phase (14 days) of osteogenic differentiation, processes in DFCs related to the control of cell organization, apoptosis, and oxidative stress are regulated.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10146559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontitis in patients with primary Sjögren's syndrome: A nation-wide register study 原发性干燥综合征患者的牙周炎：一项全国范围的注册研究。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-08-31 DOI: 10.1111/eos.12950

Odd-Olav Aga, Anne Isine Bolstad, Stein Atle Lie, Bjørg-Tilde Svanes Fevang

{"title":"Periodontitis in patients with primary Sjögren's syndrome: A nation-wide register study","authors":"Odd-Olav Aga, Anne Isine Bolstad, Stein Atle Lie, Bjørg-Tilde Svanes Fevang","doi":"10.1111/eos.12950","DOIUrl":"10.1111/eos.12950","url":null,"abstract":"The aim of this study was to compare the occurrence of periodontitis in patients with primary Sjögren's syndrome (pSS) and a non-Sjögren's patient group during a 7-year period from 2011 through 2017. In this population-based study, the patients were identified based on the International Classification of Diseases-10 (ICD-10) codes registered in the Norwegian Patient Registry (NPR), which contains information on diagnosis and time of admission for all hospitalized patients in Norway. The pSS group comprised patients with ≥4 registrations with ICD-10 code M35.0 (Sjögren's syndrome) as the main diagnosis. The dependent variable was periodontitis, defined by procedure codes registered in the Norwegian Control and Payment of Health Reimbursement (KUHR). Logistic regression analyses estimated the odds ratio for periodontitis in pSS patients relative to non-pSS patients, adjusted for relevant covariates. Lastly, regression analyses were performed separately for each of the 6 age categories. In total, 760 (7.5%) patients in the pSS group and 22,178 (7.1%) in the non-pSS group had periodontitis. When adjusting for covariates, the presence of pSS had no association with periodontitis (OR = 1.06, 95% CI: 0.98–1.14).","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10122633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Load-bearing capacity and wear characteristics of short fiber-reinforced composite and glass ceramic fixed partial dentures 短纤维增强复合材料和玻璃陶瓷固定局部义齿的承载能力和磨损特性。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-08-28 DOI: 10.1111/eos.12951

Enas Mangoush, Sufyan Garoushi, Pekka Vallittu, Lippo Lassila

{"title":"Load-bearing capacity and wear characteristics of short fiber-reinforced composite and glass ceramic fixed partial dentures","authors":"Enas Mangoush, Sufyan Garoushi, Pekka Vallittu, Lippo Lassila","doi":"10.1111/eos.12951","DOIUrl":"10.1111/eos.12951","url":null,"abstract":"The aim of this study was to evaluate load-bearing capacity and wear performance of experimental short fiber-reinforced composite (SFRC) and conventional lithium-disilicate CAD/CAM fabricated fixed partial dentures (FPDs). Two groups (n = 12/group) of three-unit CAD/CAM fabricated posterior FPDs were made. The first group used experimental SFRC blocks, and the second group fabricated from lithium-disilicate (IPS e.max CAD). All FPDs were luted on a zirconia testing jig with dual-curing resin cement. Half of FPDs per group were quasi-statically loaded until fracture. The other half experienced cyclic fatigue aging (100.000 cycles, Fmax = 500 N) before loading quasi-statically until fracture. Fracture mode was examined using SEM. Wear test was performed using 15,000 loading cycles. Both material type and aging had a significant effect on the load-bearing capacity of FPDs. Experimental SFRC CAD without fatigue aging had significantly the highest load-bearing capacity (2096 ± 149N). Cyclic fatigue aging decreased the load-bearing capacity of the SFRC group (1709 ± 188N) but increased it for the lithium-disilicate group (1546 ± 155N). Wear depth values of SFRC CAD (29.3μm) were significantly lower compared to lithium-disilicate (54.2μm). Experimental SFRC CAD demonstrated the highest load-bearing capacity before and after cyclic fatigue aging, and superior wear behavior compared to the control material.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10110901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five-year radiological findings from a randomized controlled trial of four periodontitis treatment strategies 四种牙周炎治疗策略的随机对照试验的五年放射学结果。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-08-18 DOI: 10.1111/eos.12949

Jon Olav Kubberød, Gerald Ruiner Torgersen, Per Gjermo, Vibeke Baelum, Hans R. Preus

{"title":"Five-year radiological findings from a randomized controlled trial of four periodontitis treatment strategies","authors":"Jon Olav Kubberød, Gerald Ruiner Torgersen, Per Gjermo, Vibeke Baelum, Hans R. Preus","doi":"10.1111/eos.12949","DOIUrl":"10.1111/eos.12949","url":null,"abstract":"Radiographic findings from long-term studies of periodontitis treatment have rarely been reported. Although bone destruction is a prominent feature of periodontitis, the long-term effect on alveolar bone levels of different treatment strategies, with or without adjunctive metronidazole (MTZ), has not been reported. We investigated the 5-year radiographic outcome of therapy in patient groups treated with conventional scaling and root planing (SRP) or same-day full-mouth disinfection (FDIS), with or without adjunctive MTZ. Following a 3-month oral hygiene phase, 184 periodontitis patients were randomly allocated to one of four treatment regimens: (i) FDIS+MTZ; (ii) FDIS+placebo; (iii) SRP+MTZ; or (iv) SRP+placebo. Following active treatment, patients received biannual maintenance. In total, 161 patients (87.5%) completed the 5-year follow-up examination, at which the radiographic bone level (RBL), clinical attachment level, probing pocket depth, presence of plaque, and bleeding were recorded again. At the 5-year follow up examination, minor radiological bone loss was observed in the intervention groups FDIS+placebo, SRP+MTZ, and SRP+placebo; by contrast, the FDIS+MTZ group did not show any change in RBL. Full-mouth disinfection did not generally perform better than conventional SRP performed over a period of 2 to 4 weeks.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10019201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of bioactive materials in preventing Streptococcus mutans-induced caries on enamel and dentine 生物活性材料预防变形链球菌引起的牙釉质和牙本质龋齿的疗效。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-08-15 DOI: 10.1111/eos.12948

Sheila Mondragón Contreras, Juliana Benace Fernandes, Manuela da Silva Spinola, Maíra Terra Garcia, Juliana Campos Junqueira, Eduardo Bresciani, Taciana Marco Ferraz Caneppele

{"title":"Efficacy of bioactive materials in preventing Streptococcus mutans-induced caries on enamel and dentine","authors":"Sheila Mondragón Contreras, Juliana Benace Fernandes, Manuela da Silva Spinola, Maíra Terra Garcia, Juliana Campos Junqueira, Eduardo Bresciani, Taciana Marco Ferraz Caneppele","doi":"10.1111/eos.12948","DOIUrl":"10.1111/eos.12948","url":null,"abstract":"The study investigated the ability of bioactive materials used to restore enamel and dentine specimens to prevent caries. Enamel (n = 50) and dentine (n = 50) specimens were obtained from bovine incisors, prepared, and randomly allocated to one of five groups according to the restorative treatment: alkasite without adhesive system; alkasite with adhesive system; high viscosity glass ionomer cement; resin composite; no restoration; negative control group. Specimens were restored, exposed to a thermal cycling aging protocol, sterilized, and exposed to a cariogenic challenge induced by Streptococcus mutans and then submitted to surface and subsurface microhardness tests and polarized light microscopy to verify the caries lesion development in enamel or dentine surrounding the restorative materials. Data were analyzed using one-way ANOVA. In enamel and dentine, glass ionomer cement, alkasite without and with adhesive system presented a lower percentage surface microhardness loss than resin composite and negative control. Enamel subsurface microhardness presented no statistically significant differences between glass ionomer cement, alkasite without and with adhesive system. Glass ionomer cement also did not present statistically significant differences from resin composite and the negative control. In dentine, glass ionomer cement showed the highest subsurface microhardness values. In conclusion, bioactive restorative materials provide greater protection to enamel and dentine against surface caries development than resin composite.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10061563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyether ether ketone coated with nanohydroxyapatite/graphene oxide composite promotes bioactivity and antibacterial activity at the surface of the material 用纳米羟基磷灰石/氧化石墨烯复合材料涂覆聚醚醚酮可以提高材料表面的生物活性和抗菌活性。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-08-02 DOI: 10.1111/eos.12946

Ahmed Al-Noaman, Simon C. F. Rawlinson

{"title":"Polyether ether ketone coated with nanohydroxyapatite/graphene oxide composite promotes bioactivity and antibacterial activity at the surface of the material","authors":"Ahmed Al-Noaman, Simon C. F. Rawlinson","doi":"10.1111/eos.12946","DOIUrl":"10.1111/eos.12946","url":null,"abstract":"Polyether ether ketone (PEEK) is considered an alternative material for manufacturing dental implants. However, PEEK lacks bioactivity and antibacterial action. In a series of experiments designed to enhance the surface properties of PEEK, we present a nanohydroxyapatite (nHA) and graphene oxide (GO) composite as a coating for PEEK-based dental implants to improve biological properties and antibacterial action. PEEK discs were polished, cleaned, and coated with the composite consisting of nHA particles doped with 0.75 wt% graphene oxide by a micro-emulsion technique according to patent US8,206,813. X-ray diffraction, field emission scanning electron microscopy-energy dispersive spectroscopy, and atomic force microscopy were utilized to characterize the composite coating. The wettability of the coated and non-coated samples was assessed by optical contact angle measurement. Antibacterial action of the composite coating was explored against S. aureus and E. coli and cytotoxicity determined utilizing osteoblast-like cells and gingival fibroblasts. The findings showed that the nHA/GO composite coating, approximately 1.3 μm thick, was homogenous with few micro-cracks and adhered to the PEEK surface. The surface roughness was reduced to 21.26 nm and the wettability was improved to 54.6⁰ after coating with the composite coating. Antibacterial activity was moderate, killing 99% of S. aureus and E. coli, with acceptable levels of cytotoxicity to mammalian osteoblast-like cells and gingival fibroblasts.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9917200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of limonene associated with bioactive glass-ceramic on dentin/adhesive interface 柠檬烯与生物活性微晶玻璃结合对牙本质/粘合剂界面的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-07-27 DOI: 10.1111/eos.12947

Arthur Henrique Garcia Pinto, Rocio Geng-Vivanco, Fernanda de Carvalho Panzeri Pires-de-Souza

{"title":"Effect of limonene associated with bioactive glass-ceramic on dentin/adhesive interface","authors":"Arthur Henrique Garcia Pinto, Rocio Geng-Vivanco, Fernanda de Carvalho Panzeri Pires-de-Souza","doi":"10.1111/eos.12947","DOIUrl":"10.1111/eos.12947","url":null,"abstract":"This study evaluated the effect of pretreatment with limonene and/or biosilicate on the bond strength of a universal adhesive system in self-etch mode to dentin. Occlusal cavities were prepared in 80 human molars and the teeth were randomly allocated to one of four groups (n = 20), according to the pretreatment regimens applied before the adhesive. The pretreatments were (i) Control, no pretreatment, (ii) LIM, 0.5% limonene; (iii) Bio, 10% biosilicate; and (iv) LIMBio, LIM + Bio. After adhesive application and restoration, the specimens were sectioned into sticks, separated, and stored in distilled water at 37°C for 24 h or 6 months. Microtensile bond strength test was carried out and measurements were compared across pretreatment groups and storage times. Fracture patterns and adhesive interfaces were observed. Loss of dry mass was calculated (n = 10). There was no statistically significant difference in the bond strength between the groups and the most prevalent fracture pattern was the non-adhesive. LIM and LIMBio resulted in more open dentinal tubules. LIM and Bio, whether separate or combined, showed particles of those substances, which decreased in size and number after 6 months. All groups lost mass weight after treatment, with no statistically significant differences between them. Limonene and biosilicate pretreatment did not affect the bond strength to dentin of the universal adhesive system, but resulted in more non-adhesive fractures, even after 6 months.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9937679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of mesencephalic astrocyte-derived neurotrophic factor on the inflammatory response in human gingival fibroblasts cells 中脑星形胶质细胞源性神经营养因子对人牙龈成纤维细胞炎症反应的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-07-17 DOI: 10.1111/eos.12945

Lei Gong, Jie Dong, Kai Huang, Keqing Pan, Shengzhi Wang, Hao Liu

{"title":"Effect of mesencephalic astrocyte-derived neurotrophic factor on the inflammatory response in human gingival fibroblasts cells","authors":"Lei Gong, Jie Dong, Kai Huang, Keqing Pan, Shengzhi Wang, Hao Liu","doi":"10.1111/eos.12945","DOIUrl":"10.1111/eos.12945","url":null,"abstract":"Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a unique member of the neurotrophic factor family residing in the endoplasmic reticulum, where it functions as a stress response protein maintaining endoplasmic reticulum homeostasis, in addition to being secreted extracellularly as a neurotrophic factor to bind with receptors to initiate intracellular signal transduction pathways. Interestingly, MANF has shown an important protective role in the inflammatory response of many diseases. In neural stem cells, pancreatic β cells, and retinal cells, MANF can inhibit the inflammatory response, modulate the immune response, and promote tissue repair. However, the role of MANF in the periodontal inflammatory response remains unclear. In the present study, we used lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg) to establish a Pg-LPS-stimulated periodontal inflammatory model in human gingival fibroblasts cells (HGF-1) to investigate the role of MANF in vitro. We found that MANF could inhibit pro-inflammatory cytokine secretion, alleviate the endoplasmic reticulum stress response, promote cell survival, and inhibit cell apoptosis. Therefore, MANF might be a novel promising target for the treatment of periodontitis.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0