European Journal of Oral Sciences最新文献_第7页

Artificial intelligence for detection and segmentation of accessory root canals in endodontic imaging: A systematic review. 人工智能在牙髓成像中辅助根管的检测和分割：系统综述。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-23 DOI: 10.1111/eos.70116

Hugo Henrique Dos Santos Dantas Guimarães, Karla Nogueira Matos

{"title":"Artificial intelligence for detection and segmentation of accessory root canals in endodontic imaging: A systematic review.","authors":"Hugo Henrique Dos Santos Dantas Guimarães, Karla Nogueira Matos","doi":"10.1111/eos.70116","DOIUrl":"https://doi.org/10.1111/eos.70116","url":null,"abstract":"Accessory root canal anatomy, including second mesiobuccal (MB2) and middle mesial canals (MMC), is difficult to identify and may compromise endodontic outcomes when missed, supporting artificial intelligence (AI)-based diagnostic tools. This systematic review (CRD420261415943) included studies evaluating AI models for accessory canal or root canal orifice identification, emphasizing MB2, MMC, and canal orifice detection. Study characteristics, imaging modalities, AI architectures, reference standards, outcomes, and validation strategies were extracted. Risk of bias was assessed using QUADAS-2 and certainty of evidence using GRADE. Seven studies were included. Most evaluated MB2 detection or segmentation on cone-beam computed tomography (CBCT); one assessed root canal orifice detection using dental operating microscope images, and one evaluated MMC detection. AI approaches included U-Net, YOLO, CNN-based pipelines, Inception V3-based machine learning, ChatGPT-4o, and nnU-Net. For MB2 detection/classification, sensitivity or recall ranged from 80.0% to 100%, specificity from 99.4% to 100% when reported, accuracy from 84.9% to 97.8%, and area under the curve from 0.57 to approximately 0.90. Segmentation/localization outcomes were heterogeneous. AI shows promise as an adjunct for accessory canal detection, particularly MB2 on CBCT, but evidence remains limited.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70116"},"PeriodicalIF":2.0,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of a novel piperazine-chalcone hybrid and calcium hydroxide formulations against root canal pathogens. 一种新型哌嗪-查尔酮杂合物与氢氧化钙制剂对根管病原菌的比较评价。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-18 DOI: 10.1111/eos.70115

Cenk Serhan Ozverel, Emine Erdag, Halil Doruk Kaynarca, Ege Namsoy, Hasan Guney Yilmaz

{"title":"Comparative evaluation of a novel piperazine-chalcone hybrid and calcium hydroxide formulations against root canal pathogens.","authors":"Cenk Serhan Ozverel, Emine Erdag, Halil Doruk Kaynarca, Ege Namsoy, Hasan Guney Yilmaz","doi":"10.1111/eos.70115","DOIUrl":"https://doi.org/10.1111/eos.70115","url":null,"abstract":"Root canal infections, particularly those involving Enterococcus faecalis and Candida albicans, continue to pose significant challenges in endodontic therapy due to both their inherent resistance to conventional agents. This study aimed to evaluate the antimicrobial efficacy of a newly synthesized piperazine-chalcone hybrid compound, both individually and in various formulations with calcium hydroxide, against these clinically relevant pathogens. The antimicrobial activities were assessed using the disk diffusion method over 24 and 48 h, whereas in silico analyses were conducted to further investigate the compound's molecular interactions, pharmacokinetics, and toxicity potential. Results demonstrated that the piperazine-chalcone hybrid exhibited strong antimicrobial activity against both pathogens, with inhibition zone diameters ranging from approximately 26-32 mm against E. faecalis and 18-28 mm against C. albicans, exceeding those observed for calcium hydroxide and standard antimicrobial controls. Molecular docking analysis revealed favorable binding interactions of the hybrid compound with d-alanine:d-alanine ligase, with a docking score of -8.6 kcal/mol. In silico toxicological assessment predicted a favorable safety profile, with an LD50 value >5000 mg/kg and no major toxicity alerts. These findings suggest that the piperazine-chalcone hybrid holds promise as a safe and effective candidate for enhanced endodontic disinfection.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70115"},"PeriodicalIF":2.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dentifrices for preventing erosive tooth wear: An in vitro comparative study. 防止牙齿侵蚀磨损的牙釉质：体外比较研究。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-01 Epub Date: 2026-02-24 DOI: 10.1111/eos.70076

Juliellen Luiz da Cunha, Anderson Gomes Forte, Elizabeth Barreto Galvão de Souza, Marcel Alves Avelino de Paiva, Débora Soares Bacelar, Fábio Correia Sampaio, Andressa Feitosa Bezerra de Oliveira

{"title":"Dentifrices for preventing erosive tooth wear: An in vitro comparative study.","authors":"Juliellen Luiz da Cunha, Anderson Gomes Forte, Elizabeth Barreto Galvão de Souza, Marcel Alves Avelino de Paiva, Débora Soares Bacelar, Fábio Correia Sampaio, Andressa Feitosa Bezerra de Oliveira","doi":"10.1111/eos.70076","DOIUrl":"10.1111/eos.70076","url":null,"abstract":"Erosive tooth wear is a progressive condition that compromises enamel structure and requires preventive strategies. This in vitro study aimed to compare the protective effects of fluoride-based dentifrices containing various bioactive agents on sound enamel subjected to simulated erosive-abrasive challenges. Sixty bovine enamel blocks were randomly assigned to five dentifrices containing: bioactive silica + 1100 ppm F- from sodium fluoride (BAS/NaF), 0.454% stannous fluoride (SnF), sodium-calcium phosphosilicate + 1426 ppm F- from sodium fluoride (SCP/NaF), 1100 ppm F- from sodium fluoride (NaF), and a fluoride-free (FF) control. Specimens underwent 7 days of pH cycling, including three daily acid challenges and 2-min immersion in dentifrice slurries including 15 s brushing. Measurements included surface microhardness, surface roughness, fluorescence loss, and surface loss. Between-group differences were assessed using one-way anova with Tukey post hoc tests. The BAS/NaF and SnF dentifrices outperformed the other formulations, maintaining higher surface hardness and lower surface loss and fluorescence loss (p < 0.05). The NaF and the SCP/NaF dentifrices showed intermediate results. The fluoride-free dentifrice exhibited the highest mineral loss. Dentifrices combining fluoride with bioactive ingredients enhanced enamel resistance to erosive-abrasive challenges, with bioactive silica and stannous fluoride showing the strongest effects.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70076"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of stress distribution and initial stability of different shield thicknesses in the socket shield technique: A finite element analysis. 套筒盾构技术中不同盾构厚度的应力分布及初始稳定性评价：有限元分析。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-01 DOI: 10.1111/eos.70112

Yiming Li, Jiayu Qiu, Xiechao Nie, Fufa Hou, TienChien Chang

{"title":"Evaluation of stress distribution and initial stability of different shield thicknesses in the socket shield technique: A finite element analysis.","authors":"Yiming Li, Jiayu Qiu, Xiechao Nie, Fufa Hou, TienChien Chang","doi":"10.1111/eos.70112","DOIUrl":"https://doi.org/10.1111/eos.70112","url":null,"abstract":"This study investigated the biomechanical effects of shield thickness in the socket shield technique under immediate implant loading using high-fidelity three-dimensional finite element analysis. A maxillary model was developed incorporating cortical bone, cancellous bone, labial root fragment (shield), implant, abutment, and crown, with high anatomical fidelity to clinical conditions. Four shield thicknesses (0.5, 1.0, 1.5, and 2.0 mm) were evaluated. Axial (0°) and oblique (30°) loads of 158.6 N were applied, and an abutment preload of 450 N was introduced to simulate prosthetic prestress. Equivalent stress, maximum principal stress, and total deformation of the shield, implant, and peri-implant bone were quantified. The biomechanical response exhibited nonlinear characteristics. Shield stress increased from 0.5 to 1.0 mm, peaked at 1.5 mm, and decreased at 2.0 mm, whereas total deformation increased progressively with increasing thickness. Peri-implant bone stress was concentrated at the shield-labial cortical bone interface and decreased as shield thickness increased. Implant stress reached its maximum at 1.5 mm and decreased toward both thinner and thicker configurations. A shield thickness of 1.0-1.5 mm demonstrated a favorable biomechanical balance between stress distribution and deformation control, potentially contributing to peri-implant bone preservation and enhanced early implant stability under clinically relevant loading conditions.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70112"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle-integrated biomaterial scaffolds for dental tissue engineering: Advances, clinical translation, and industrial manufacturing perspectives. 纳米颗粒集成生物材料支架用于牙科组织工程：进展、临床转化和工业制造前景。

IF 1.8 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-01 DOI: 10.1111/eos.70113

Viswanathan Kaliyaperumal, P S Manoharan

{"title":"Nanoparticle-integrated biomaterial scaffolds for dental tissue engineering: Advances, clinical translation, and industrial manufacturing perspectives.","authors":"Viswanathan Kaliyaperumal, P S Manoharan","doi":"10.1111/eos.70113","DOIUrl":"https://doi.org/10.1111/eos.70113","url":null,"abstract":"This review critically examines the rising significance of nanoparticle (NP)-loaded biomaterial scaffolds in dental tissue engineering, focusing on their translational potential, limitations, and clinical relevance. These dual-functional scaffolds imitate the extracellular matrix and promote cell adhesion and proliferation, allowing for tissue regeneration with improved antibacterial, osteoinductive, bioactive, and drug delivery capabilities via NP integration. This report covers natural and synthetic polymers, such as collagen, chitosan, alginate, PCL, polylactic acid, and poly(lactic-co-glycolic acid), as well as NPs, such as AgNPs, ZnO, and nano-hydroxyapatite, for bone, periodontal, and pulp-dentin regeneration. A comprehensive and comparative study is offered that links scaffold type, NP function, biocompatibility, and regenerative outcomes, revealing important translational obstacles. The manuscript also covers clinical translation, with an emphasis on commercialization and regulatory issues, such as nanotoxicity, biosafety, scalability, reproducibility, cost-effectiveness, and approval frameworks (Central Drugs Standard Control Organization, Food and Drug Administration, and CE). Despite considerable preclinical potential, the analysis identifies inadequate clinical evidence, standardization concerns, and regulatory constraints as significant challenges to clinical implementation. Overall, this review gives a more detailed and critical translational viewpoint on NP-based scaffolds in dental regeneration.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70113"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does attachment removal damage enamel? Influence of adhesive, resin, and bur on surface integrity. 去除附着物会损坏牙釉质吗？胶粘剂、树脂和橡胶对表面完整性的影响。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-01 Epub Date: 2026-03-18 DOI: 10.1111/eos.70088

Marilia Daniela Busnardo Canadas, Ana Beatriz Silva Sousa, Fernanda de Carvalho Panzeri

{"title":"Does attachment removal damage enamel? Influence of adhesive, resin, and bur on surface integrity.","authors":"Marilia Daniela Busnardo Canadas, Ana Beatriz Silva Sousa, Fernanda de Carvalho Panzeri","doi":"10.1111/eos.70088","DOIUrl":"10.1111/eos.70088","url":null,"abstract":"To evaluate the combination of composites, adhesive systems, and burs considering artificial accelerated aging (AAA), influence enamel roughness and morphology after attachment removal. One hundred ninety-two bovine enamel specimens were divided according to composite type (Transbond XT, flowable, bulk-fill flowable), adhesive system (Single Bond Universal or Transbond XT primer), and bur for attachment removal (multilaminated carbide or zirconia). Half of the samples were stored for 24 h at 37°C and the other half underwent 300 h of AAA. Surface roughness was measured using confocal laser scanning microscopy before and after attachment removal. Data were analyzed using three-way anova with Bonferroni post hoc tests. Significant differences in enamel roughness were observed according to composite type, adhesive system, and bur used. Multilaminated bur produced higher surface roughness compared to zirconia bur. Transbond composite, particularly when combined with orthodontic adhesive, exhibited greater enamel alteration after AAA. None of the protocols fully restored enamel surface to its original smoothness. Attachment removal inevitably alters enamel morphology, regardless of the materials used. Composite, adhesive, and bur's choice, as well as proper finishing and polishing, is essential to minimize enamel damage after clear aligner treatment.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70088"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diurnal and nocturnal salivary fluoride bioavailability following brushing with high- or regular-fluoride dentifrices. 用高氟化物或普通氟化物牙膏刷牙后，每日和夜间唾液氟化物的生物利用度。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-01 Epub Date: 2026-03-04 DOI: 10.1111/eos.70079

Guereth Carvalho, Guilherme Santana, Niciane Macena, Gláuber Vale

{"title":"Diurnal and nocturnal salivary fluoride bioavailability following brushing with high- or regular-fluoride dentifrices.","authors":"Guereth Carvalho, Guilherme Santana, Niciane Macena, Gláuber Vale","doi":"10.1111/eos.70079","DOIUrl":"10.1111/eos.70079","url":null,"abstract":"This study evaluated salivary fluoride (F) bioavailability during diurnal and nocturnal periods after using a high-fluoride or regular dentifrice. Fifteen healthy adults participated in a double-blind crossover study, brushing with either a 1450 ppm F or 5000 ppm F dentifrice. Saliva was collected at pre-brushing, immediately after brushing, and at 5 min, 2, 4, and 8 h post-brushing in both periods. Fluoride concentrations were measured using an ion-selective electrode and analyzed with the Wilcoxon matched-pairs and Kruskal-Wallis tests (5% significance). At pre-brushing, no statistically significant differences were detected between groups. Both dentifrices increased salivary fluoride concentrations, reaching peak levels immediately after brushing. However, the high-fluoride dentifrice consistently maintained significantly higher concentrations compared with the regular formulation. During the nocturnal period, elevated fluoride levels persisted for up to 8 h with the high-fluoride dentifrice, whereas concentrations returned to pre-brushing levels within 2 h with the regular formulation. In conclusion, fluoride bioavailability was greater and more sustained during the nocturnal period than during the diurnal period, emphasizing the influence of brushing time on salivary fluoride retention. High-fluoride dentifrice further enhanced this effect across both periods.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70079"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing universal dental adhesives: Biomimetic strategies for enhanced hybrid layer remineralisation and bond durability. 推进通用牙科粘合剂：增强混合层再矿化和粘合耐久性的仿生策略。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-01 Epub Date: 2026-02-27 DOI: 10.1111/eos.70078

Yasir Alnakib, Manhal A Majeed, Salvatore Sauro

{"title":"Advancing universal dental adhesives: Biomimetic strategies for enhanced hybrid layer remineralisation and bond durability.","authors":"Yasir Alnakib, Manhal A Majeed, Salvatore Sauro","doi":"10.1111/eos.70078","DOIUrl":"10.1111/eos.70078","url":null,"abstract":"Resin-dentine bonds degrade when water-rich, resin-sparse collagen persists within the hybrid layer. This study evaluated biomimetic remineralisation strategies that aimed to enhance adhesive durability: polyacrylic acid-stabilised amorphous calcium phosphate-loaded mesoporous silica nanoparticles (PA-ACP/MSN) incorporated at 15 vol% into the primer phases of two commercially available two-step universal adhesives (G2 Bond Universal and OptiBond eXTRa Universal) applied in etch-and-rinse mode, with or without phosphorylation pretreatment (5% PA + 5% sodium trimetaphosphate). Adhesive-dentine specimens were characterised using microtensile bond strength (µTBS), confocal Raman microscopy (Phosphate peaks; Resin CH2 peaks; Mineral-Matrix ratio MMR), nanoindentation across the hybrid layer and dye-assisted micropermeability assays. The incorporation of PA-ACP/MSN did not adversely affect the immediate µTBS of either adhesive. After ageing, the biomimetic treatment group demonstrated enhanced phosphate content, improved micro-mechanical properties, preservation of resin characteristics, a higher elastic modulus across the hybrid layer and a marked reduction in permeability relative to the control group. Adding the phosphorylation pretreatment step conferred no additional benefit over PA-ACP/MSN alone. These findings indicated that embedding PA-ACP/MSN in universal-adhesive primers promoted remineralisation, stiffened and sealed the hybrid layer, and preserved bonding effectiveness without adding clinical complexity, supporting a practical path to durable, bioactive/biomimetic resin-dentine interfaces.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70078"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical characterization of etch-and-rinse adhesive system doped with catechin-loaded polymeric microparticles. 掺杂儿茶素聚合物微粒的蚀刻漂洗胶粘剂体系的物理化学性质。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-01 Epub Date: 2026-03-12 DOI: 10.1111/eos.70087

Jiovanne Rabelo Neri, Nadine Luisa Guimarães Albuquerque, Marcelo Victor Sidou Lemos, Monica Yamauti, Francisco Fábio Oliveira de Sousa, Vanara Florêncio Passos, Sérgio Lima Santiago

{"title":"Physicochemical characterization of etch-and-rinse adhesive system doped with catechin-loaded polymeric microparticles.","authors":"Jiovanne Rabelo Neri, Nadine Luisa Guimarães Albuquerque, Marcelo Victor Sidou Lemos, Monica Yamauti, Francisco Fábio Oliveira de Sousa, Vanara Florêncio Passos, Sérgio Lima Santiago","doi":"10.1111/eos.70087","DOIUrl":"10.1111/eos.70087","url":null,"abstract":"This study evaluated the incorporation of epigallocatechin-3-gallate (EGCG)-loaded poly(lactide-co-glycolide) (PLGA) microparticles into a two-step etch-and-rinse adhesive and their effects on physicochemical properties and EGCG release. EGCG was added to Single Bond 2 either directly (0.01% and 0.1% w/w) or encapsulated in PLGA 50:50 or 75:25 microparticles (0.5%-2% w/w). Cumulative release was measured by UV-Vis spectrophotometry. Degree of conversion (DC) was analyzed by Fourier transform infrared spectroscopy; flexural strength and elastic modulus (E) were tested in three-point bending; and water sorption (WS) and solubility (SL) were evaluated following ISO standards (n = 10). Microtensile bond strength (TBS) was tested after 24 h, 6, and 12 months. Data were analyzed by anova with significance set at p < 0.05. PLGA 50:50/EGCG at 1% showed the highest release, reaching 77.30 µg. No significant differences were found in DC, E, WS, and SL among the groups. Bond strengths remained stable in all experimental groups after 6 and 12 months, except for the control. Incorporating 1% EGCG-loaded PLGA 50:50 microparticles into Single Bond 2 may represent a promising strategy for controlled release without compromising physicochemical or mechanical properties.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70087"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of vitamin C supplementation on periodontal inflammation and oxidative stress in cigarette-smoke-exposed rats with periodontitis. 补充维生素C对牙周炎暴露大鼠牙周炎症和氧化应激的影响。

IF 2 4区医学

European Journal of Oral Sciences Pub Date : 2026-06-01 Epub Date: 2026-03-12 DOI: 10.1111/eos.70080

Ilayda Ilday, N Vakur Olgac, Ilknur Bingul, Ulku Baser, Gokce Aykol-Sahin, Gulden Isik

{"title":"Effect of vitamin C supplementation on periodontal inflammation and oxidative stress in cigarette-smoke-exposed rats with periodontitis.","authors":"Ilayda Ilday, N Vakur Olgac, Ilknur Bingul, Ulku Baser, Gokce Aykol-Sahin, Gulden Isik","doi":"10.1111/eos.70080","DOIUrl":"10.1111/eos.70080","url":null,"abstract":"This study examined the effects of vitamin C on oxidative stress, antioxidant levels, and periodontal inflammation in a rat model of periodontitis exposed to cigarette smoke. Periodontitis was induced in 30 male Wistar albino rats using ligatures on maxillary second molars. All groups underwent 15 days of smoke exposure, which was then continued for another 15 days in the smoking-only (SO) and smoking + vitamin C. The vitamin C group received 200 mg/kg/day of intraperitoneal vitamin C; the saline group received 0.9% NaCl. On Day 28, rats were euthanized for biochemical and immunohistochemical analyses. The SO group showed significantly elevated cotinine and tumor necrotizing factor-α levels. Reactive oxygen species, thiobarbituric acid reacting substances, and catalase activity were also significantly higher in this group. Vitamin C groups showed lower levels, with no significant differences between them. Ferric-reducing antioxidant power levels in the saline group were significantly higher than in the SO group. Immunohistochemical analysis revealed significant differences in Ki-67 and matrix metalloproteinase-8-positive-stained cells between SO and vitamin C groups. Within the limitations of this model, vitamin C supplementation was associated with reduced oxidative stress and inflammatory responses in smoke-exposed rats with periodontitis. These results suggest vitamin C may modulate host antioxidant defense, though further clinical confirmation is needed.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":" ","pages":"e70080"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0