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Response to letter to the Editor 回复致编辑的信。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-07 DOI: 10.1111/eos.13012
Guido Artemio Marañón-Vásquez, Flares Baratto-Filho, Christian Kirschneck, Erika Calvano Küchler
{"title":"Response to letter to the Editor","authors":"Guido Artemio Marañón-Vásquez, Flares Baratto-Filho, Christian Kirschneck, Erika Calvano Küchler","doi":"10.1111/eos.13012","DOIUrl":"10.1111/eos.13012","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment: Correspondence 关键维生素-D通路基因的遗传变异和外根尖吸收与正畸治疗有关：通讯。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-07 DOI: 10.1111/eos.13011
Hinpetch Daungsupawong, Viroj Wiwanitkit
{"title":"Genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment: Correspondence","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1111/eos.13011","DOIUrl":"10.1111/eos.13011","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The expression of immune checkpoint proteins PD-L1 and TIM3 in mouse and human head and neck squamous cell carcinoma 免疫检查点蛋白 PD-L1 和 TIM3 在小鼠和人类头颈部鳞状细胞癌中的表达。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-08-01 DOI: 10.1111/eos.13010
Areeg Elmusrati, Cun-Yu Wang
{"title":"The expression of immune checkpoint proteins PD-L1 and TIM3 in mouse and human head and neck squamous cell carcinoma","authors":"Areeg Elmusrati,&nbsp;Cun-Yu Wang","doi":"10.1111/eos.13010","DOIUrl":"10.1111/eos.13010","url":null,"abstract":"<p>The aim of this study was to examine the expression of programmed death-ligand 1 (PD-L1) and of T cell immunoglobulin and mucin domain-containing protein (TIM3) in oral epithelial dysplasia and head and neck squamous cell carcinoma (HNSCC). Mouse HNSCC was induced with 4-nitroquinoline-1 oxide (4NQO). Oral epithelial dysplastic lesions, carcinoma in situ and HNSCC lesions were stained with anti-PD-L1 and TIM3 antibodies. The expression of PD-L1 and TIM3 in tumor cells and immune cells was semiquantitatively measured and compared. In parallel, human dysplasia and HNSCC were stained with anti-PD-L1 and anti-TIM3. The expression pattern of PD-L1<sup>+</sup> and TIM3<sup>+</sup> cells was further compared. In human and mouse samples both PD-L1 and TIM3 were found to be expressed in neoplastic and immune cells in HNSCC, but not in dysplasia. There was no significant difference in PD-L1 and TIM3 expression between metastatic and nonmetastatic HNSCC. We conclude that the 4NQO-induced mouse HNSCC model may be an excellent preclinical model for immune checkpoint therapy.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic mechanisms and oral mucositis in children with acute lymphoblastic leukaemia 表观遗传机制与急性淋巴细胞白血病患儿的口腔黏膜炎。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-07-29 DOI: 10.1111/eos.13009
Juliana Ramalho Guimarães, Beatriz Fernandes de Souza, José Maria Chagas Viana Filho, Lecidamia Cristina Leite Damascena, Ana Maria Gondim Valença, Darlene Camati Persuhn, Naila Francis Paulo de Oliveira
{"title":"Epigenetic mechanisms and oral mucositis in children with acute lymphoblastic leukaemia","authors":"Juliana Ramalho Guimarães,&nbsp;Beatriz Fernandes de Souza,&nbsp;José Maria Chagas Viana Filho,&nbsp;Lecidamia Cristina Leite Damascena,&nbsp;Ana Maria Gondim Valença,&nbsp;Darlene Camati Persuhn,&nbsp;Naila Francis Paulo de Oliveira","doi":"10.1111/eos.13009","DOIUrl":"10.1111/eos.13009","url":null,"abstract":"<p>This study aimed to investigate the relationship between epigenetic mechanisms and oral mucositis (OM) in paediatric patients with acute lymphoblastic leukaemia. Oral cells were collected from 76 participants, including 15 healthy individuals, 10 patients with acute lymphoblastic leukaemia but without a history of OM and 51 acute lymphoblastic leukaemia patients with a history of OM (35 with active OM and 16 who had recovered from OM). Global DNA methylation in the <i>miR-9-1</i> and <i>miR-9-3</i> genes was performed. Seven polymorphisms rs1801131, rs1801133 (<i>MTHFR</i>), rs2228611 (<i>DNMT1</i>), rs7590760, rs1550117 (<i>DNMT3A</i>), rs6087990, rs2424913 (<i>DNMT3B</i>) were genotyped and an analysis of association with global DNA methylation was performed. The global methylation levels were lower in cancer patients recovered from OM than in the other groups. A higher frequency of unmethylated profile for <i>miR-9-1</i> and partially methylated profile for <i>miR-9-3</i> was observed in cancer patients regardless of OM history compared to healthy patients. The GG genotype of the rs2228611 (<i>DNMT1</i>) polymorphism was associated with higher levels of global methylation in cancer patients irrespective of OM. It was concluded that global methylation is associated with mucosal recovery. The effect of <i>DNMT1</i> genotype on the global DNA methylation profile, as well as the methylation profile of <i>miR-9-1</i> and <i>miR-9-3</i> in cancer patients is independent of OM.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Torture victims’ perspective on dental treatment: “Every sign you make, every move you take” – A qualitative study 酷刑受害者对牙科治疗的看法："你的一举一动"--一项定性研究。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-07-17 DOI: 10.1111/eos.13007
Ann Catrin Høyvik, Tiril Willumsen, Birgit Lie, Per Kristian Hilden
{"title":"Torture victims’ perspective on dental treatment: “Every sign you make, every move you take” – A qualitative study","authors":"Ann Catrin Høyvik,&nbsp;Tiril Willumsen,&nbsp;Birgit Lie,&nbsp;Per Kristian Hilden","doi":"10.1111/eos.13007","DOIUrl":"10.1111/eos.13007","url":null,"abstract":"<p>Torture victims struggling with post-traumatic stress often experience elements in the dental treatment situation that may trigger trauma-related reactions. The aim of the study was to explore intervention strategies that will enable dental health workers to adapt dental treatment to the needs of torture survivors. Exploratory interviews were conducted with 10 torture-exposed resettled refugees with dental treatment experience in Norway. The data was analyzed using qualitative content analysis, which suggested that to minimize trauma-reactions, dental personnel should focus on creating a safe therapeutic space and strengthening the patient's sense of control. Four main categories of clinical advice were proposed: (i) Acquire knowledge about psychology, consequences of torture, cultural differences, trauma-informed care, and the patients’ individual needs; (ii) Recognize the trigger-potential of busyness or delays; (iii) Avoid surprises, such as sudden moves or actions and explore triggers individually, but make sure not to evoke images of interrogation, and; (iv) Provide overview both with respect to visibility in the clinical room, and to predictability regarding the dental treatment. Although undergoing dental treatment may be challenging for torture-exposed individuals, it is possible to reduce the predicaments considerably by making feasible adaptions to the treatment and adopting a trauma-informed approach.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic markers of tooth eruption – DNA methylation and histone acetylation 牙齿萌出的表观遗传标记--DNA 甲基化和组蛋白乙酰化。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-07-16 DOI: 10.1111/eos.13005
Anna Westerlund, Asal Shikhan, Nina Sabel, Farah Asa'ad, Lena Larsson
{"title":"Epigenetic markers of tooth eruption – DNA methylation and histone acetylation","authors":"Anna Westerlund,&nbsp;Asal Shikhan,&nbsp;Nina Sabel,&nbsp;Farah Asa'ad,&nbsp;Lena Larsson","doi":"10.1111/eos.13005","DOIUrl":"10.1111/eos.13005","url":null,"abstract":"<p>The present study aimed to evaluate whether epigenetic markers are expressed in the dental follicles surrounding ectopically erupting teeth. Twenty-one dental follicles were collected in 20 adolescent children through surgical exposure of ectopic teeth. The epigenetic modifications of DNA methylation and histone acetylation were evaluated by immunohistochemistry. The results showed cells positive for DNA-methyltransferase 1 (DNMT1), DNA methyltransferase 3 beta (DNMT3B), ten-eleven translocation-2 (TET2), acetyl-histone H3 (AcH3), acetyl-histone H4 (AcH4), 5-methylcytosine (5mC), and 5-hydroxymethylcytosine (5hmC) were present in all the samples. The levels of epigenetic markers representing active chromatin (5hmC, AcH3, AcH4, and TET2) were statistically significantly higher than those of markers representing inactive chromatin (5mC, DNMT3B, DNMT1). In conclusion, follicles in ectopic teeth display major epigenetic modifications. In the follicles, epigenetic markers associated with the activation of bone-related genes are more abundant than markers associated with the inactivation of bone-related genes.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contribution of initial lymphatics to oral wound healing after tooth extraction 拔牙后初始淋巴管对口腔伤口愈合的贡献。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-07-11 DOI: 10.1111/eos.13006
Anca Virtej, Larissa Marti, Marek Wagner, Helge Wiig, Ying Xue, Athanasia Bletsa, Ellen Berggreen
{"title":"Contribution of initial lymphatics to oral wound healing after tooth extraction","authors":"Anca Virtej,&nbsp;Larissa Marti,&nbsp;Marek Wagner,&nbsp;Helge Wiig,&nbsp;Ying Xue,&nbsp;Athanasia Bletsa,&nbsp;Ellen Berggreen","doi":"10.1111/eos.13006","DOIUrl":"10.1111/eos.13006","url":null,"abstract":"<p>Lymphatics are involved in the resolution of inflammation and wound healing, but their role in the oral wound healing process after tooth extraction has never been investigated. We therefore sought to evaluate the healing process following the extraction of maxillary molars in two transgenic mouse models: K14-VEGFR3-Ig mice, which lack initial mucosal lymphatic vessels, and K14-VEGFC mice, which have hyperplastic mucosal lymphatics. Maxillary molars were extracted from both transgenic mouse types and their corresponding wild-type (WT) controls. Mucosal and alveolar bone healing were evaluated. A delayed epithelialization and bone regeneration were observed in K14-VEGFR3-Ig mice compared with their WT littermates. The hampered wound closure was accompanied by decreased levels of epidermal growth factor (EGF) and persistent inflammation, characterized by infiltrates of immune cells and elevated levels of pro-inflammatory markers in the wounds. Hyperplastic mucosal lymphatics did not enhance the healing process after tooth extraction in K14-VEGFC mice. The findings indicate that initial mucosal lymphatics play a major role in the initial phase of the oral wound healing process.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.13006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Search for a new Editor-in-Chief 寻找新主编
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-07-10 DOI: 10.1111/eos.13004
{"title":"Search for a new Editor-in-Chief","authors":"","doi":"10.1111/eos.13004","DOIUrl":"10.1111/eos.13004","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141586732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salutogenic factors and oral health: A potential pathway for addressing health inequalities 致富因素与口腔健康：解决健康不平等问题的潜在途径。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-06-27 DOI: 10.1111/eos.13003
Waseem Jerjes
{"title":"Salutogenic factors and oral health: A potential pathway for addressing health inequalities","authors":"Waseem Jerjes","doi":"10.1111/eos.13003","DOIUrl":"10.1111/eos.13003","url":null,"abstract":"","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspects of glass and hybridization protocols for bonding of fiber posts to root dentine 纤维桩与根部牙本质粘接的玻璃和杂化规程的各个方面。
IF 1.8 4区 医学
European Journal of Oral Sciences Pub Date : 2024-06-27 DOI: 10.1111/eos.13002
Bárbara Facco Rauber, João Paulo De Carli, Felipe Gomes Dallepiane, Letícia Copatti Dogenski, Fábio Goedel, Doglas Cecchin, Huriel Scartazzini Palhano, Pedro Henrique Corazza, Kauê Farias Collares, Matheus Albino Souza, Ana Paula Farina
{"title":"Aspects of glass and hybridization protocols for bonding of fiber posts to root dentine","authors":"Bárbara Facco Rauber,&nbsp;João Paulo De Carli,&nbsp;Felipe Gomes Dallepiane,&nbsp;Letícia Copatti Dogenski,&nbsp;Fábio Goedel,&nbsp;Doglas Cecchin,&nbsp;Huriel Scartazzini Palhano,&nbsp;Pedro Henrique Corazza,&nbsp;Kauê Farias Collares,&nbsp;Matheus Albino Souza,&nbsp;Ana Paula Farina","doi":"10.1111/eos.13002","DOIUrl":"10.1111/eos.13002","url":null,"abstract":"<p>This study evaluated bond strength of glass fiber posts to root dentin using push-out (PO) and diametral compression (DC), testing glycolic acid as a conditioner and varying dentin moisture. An additional aim was to test whether DC can be an alternative test to PO for bond strength assessment. Eighty bovine teeth were divided into eight groups (<i>n</i> = 10) defined by the use of either 37% glycolic acid or 37% phosphoric acid (PA) on moist or wet dentin before bonding with either Adapter SingleBond/RelyX ARC or One Step Plus/Duo-Link Bisco. Each tooth provided discs with an internal diameter of 2 mm, external diameter of 5 mm, and height of 2 mm, which underwent PO and DC. Finite element analysis (FEA) was carried out on 3D models. When analyzing PO results through linear regression, the highest values of bond strength were observed using glycolic acid on wet dentin in the cervical and middle thirds of the teeth. Analyzing DC results, the only statistical influence on values was the dental thirds. The scatterplot of the DC results and the PO bond strength values indicated no relationship between the results of the two tests (<i>r</i> = 0.03; <i>p</i> = 0.64). PO test detected more sensitive changes in bond strength values than DC.</p>","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":"132 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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