European Journal of Oral Sciences最新文献_第6页

Finishing technique effect on strength of zirconia-reinforced lithium silicate ceramic 抛光技术对氧化锆增强硅酸锂陶瓷强度的影响

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-12-07 DOI: 10.1111/eos.12964

Ernesto Byron Benalcazar-Jalkh, Verena Souza Cunha, Edmara Tatiely Pedroso Bergamo, Larissa Marcia Martins Alves, Raphaelle Santos de Monteiro-Sousa, Tiago Moreira Bastos Campos, Ricardo Tanaka, Giovana de Assis Marcolino, Felipe Machado de Souza, Estevam Augusto Bonfante

{"title":"Finishing technique effect on strength of zirconia-reinforced lithium silicate ceramic","authors":"Ernesto Byron Benalcazar-Jalkh, Verena Souza Cunha, Edmara Tatiely Pedroso Bergamo, Larissa Marcia Martins Alves, Raphaelle Santos de Monteiro-Sousa, Tiago Moreira Bastos Campos, Ricardo Tanaka, Giovana de Assis Marcolino, Felipe Machado de Souza, Estevam Augusto Bonfante","doi":"10.1111/eos.12964","DOIUrl":"10.1111/eos.12964","url":null,"abstract":"The aim of this study was to evaluate the effect of two finishing techniques, glazing or polishing, in comparison with the as-cut condition, on the biaxial-flexural-strength (BFS) of a zirconia-reinforced lithium silicate ceramic (ZLS). Cylinders were milled from CAD/CAM blocks and sliced to obtain disc-shaped specimens (ISO6872:2015). Polished and glazed specimens were processed following the manufacturer's instructions. Thirty-three specimens were obtained for each condition and microstructural and BFS/fractographic characterizations were performed. BFS and roughness data were analyzed using Weibull statistics and ANOVA one-way with Tukey post-hoc test, respectively. While a rougher surface was observed for as-cut specimens, smoother surfaces were observed for polished and glazed ZLS at microscopical evaluation and confirmed through surface-roughness evaluation. X-ray spectra depicted a glass phase for all groups and characteristic metasilicate, lithium disilicate, and lithium phosphate peaks for the as-cut and polished specimens. Glazed specimens showed higher characteristic strength than polished and as-cut specimens, which did not differ significantly. While higher Weibull-modulus was observed for the polished than for the as-cut specimens, no statistically significant differences were noted between glazed and polished, and between glazed and as-cut specimens. ZLS presents higher strength when glazed, and polishing increases the structural reliability of the material relative to the as-cut condition. Both finishing techniques reduced surface roughness similarly.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138560579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degree of cure of orthodontic composite attachments underneath aligners 正畸矫正器下复合附着体的治愈程度。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-12-01 DOI: 10.1111/eos.12963

Sandrine Janine Lasance, Despina Koletsi, George Eliades, Theodore Eliades

{"title":"Degree of cure of orthodontic composite attachments underneath aligners","authors":"Sandrine Janine Lasance, Despina Koletsi, George Eliades, Theodore Eliades","doi":"10.1111/eos.12963","DOIUrl":"10.1111/eos.12963","url":null,"abstract":"The aim of this study was to assess the percentage degree of cure (DC%) of 2-mm-thick resin composite attachments used for aligner treatment. Three types of aligner – two thermoformed aligners (Clear Aligner [CLA], polyethylene terephthalate glycol modified; and Invisalign [INV], polyester urethane) and a three-dimensional-printed aligner (Graphy TC-85DAC [GRP], an acrylate-methacrylate copolymer) – were selected, along with two universal resin composites (3M Filtek Universal [FTU] and Charisma Topaz ONE [CTO]). Samples of each composite were placed under each aligner, and the degree of cure of each composite was evaluated on the top (facing the aligner) and the bottom (facing the substrate) attachment surfaces after curing. Five specimens were used per combination of aligner and composite, and an additional group of composites irradiated without aligners served as the control. The DC% measurements were performed using attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. The DC% across the aligners were (median values) 33.8%–44.8% for CLA, 33.6%–40.8% for INV, 32.8%–40.6% for GRP, and 40.0%–51.7% for the control group. The DC% values of the attachments cured under any aligner were significantly lower than that of the corresponding control, with the values recorded on the top surfaces being 6% higher than those on the bottom surfaces after adjusting for aligner group and composite type.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case study evaluating the effect of clustering, publication bias, and heterogeneity on the meta-analysis estimates in implant dentistry 一个评估聚类、发表偏倚和异质性对种植牙科meta分析估计影响的案例研究。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-11-29 DOI: 10.1111/eos.12962

Clovis Mariano Faggion Jr, Momen A. Atieh, Michail Tsagris, Jadbinder Seehra, Nikolaos Pandis

{"title":"A case study evaluating the effect of clustering, publication bias, and heterogeneity on the meta-analysis estimates in implant dentistry","authors":"Clovis Mariano Faggion Jr, Momen A. Atieh, Michail Tsagris, Jadbinder Seehra, Nikolaos Pandis","doi":"10.1111/eos.12962","DOIUrl":"10.1111/eos.12962","url":null,"abstract":"Meta-analyses may provide imprecise estimates when important meta-analysis parameters are not considered during the synthesis. The aim of this case study was to highlight the influence of meta-analysis parameters that can affect reported estimates using as an example pre-existing meta-analyses on the association between implant survival and sinus membrane perforation. PubMed was searched on 7 July 2021 for meta-analyses comparing implant failure in perforated and non-perforated sinus membranes. Primary studies identified in these meta-analyses were combined in a new random-effects model with odds ratios (ORs), confidence intervals (CIs), and prediction intervals reported. Using this new meta-analysis, further meta-analyses were then undertaken considering the clinical, methodological, and statistical heterogeneity of the primary studies, publication bias, and clustering effects. The meta-analyses with the greatest number and more homogeneous studies provided lower odds of implant failure in non-perforated sites (OR 0.49, 95 % CI = [0.26, 0.92]). However, when considering heterogeneity, publication bias, and clustering (number of implants), the confidence in these results was reduced. Interpretation of estimates reported in systematic reviews can vary depending on the assumptions made in the meta-analysis. Users of these analyses need to carefully consider the impact of heterogeneity, publication bias, and clustering, which can affect the size, direction, and interpretation of the reported estimates.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12962","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of theanine on the hyperexcitability of trigeminal secondary nociceptive neurons following orofacial inflammation in rats 茶氨酸对大鼠口面部炎症后三叉神经次级痛觉神经元高兴奋性的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-11-20 DOI: 10.1111/eos.12961

Yui Watanuki, Sora Yajima, Yukito Sashide, Mamoru Takeda

{"title":"Effect of theanine on the hyperexcitability of trigeminal secondary nociceptive neurons following orofacial inflammation in rats","authors":"Yui Watanuki, Sora Yajima, Yukito Sashide, Mamoru Takeda","doi":"10.1111/eos.12961","DOIUrl":"10.1111/eos.12961","url":null,"abstract":"The present in vivo study investigated whether systemic administration of theanine attenuates the inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons associated with hyperalgesia. Complete Freund's adjuvant (CFA) was injected into the whisker pads of 24 rats to induce inflammation, and then mechanical stimulation was applied to the orofacial area to assess the threshold of escape. The mechanical threshold was statistically significantly lower in CFA-inflamed rats compared to uninjected naïve rats, and this lowered threshold returned to control levels after 2 days of theanine administration. The mean discharge frequency of SpVc wide-dynamic range (WDR) neurons to mechanical stimuli in anesthetized CFA-inflamed rats was statistically significantly lower after two days of theanine administration. In addition, the increased mean spontaneous discharge of SpVc WDR neurons in CFA-inflamed rats statistically significantly decreased after theanine administration. Similarly, theanine restored the expanded mean receptive field size in CFA-inflamed rats to control levels. Taken together, these results suggest that administration of theanine attenuates inflammatory hyperalgesia associated with hyperexcitability of nociceptive SpVc WDR neurons. These findings support the potential of theanine as a therapeutic agent in complementary alternative medicine strategies to prevent inflammatory hyperalgesia.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138175971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between malocclusion and health-related quality of life in adolescents: A mediation analysis 青少年错牙合与健康相关生活质量之间的关系：一项中介分析。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-11-09 DOI: 10.1111/eos.12960

Sarah Debora Camardella Leite, Fernando José Herkrath, Mario Vianna Vettore, Maria Augusta Bessa Rebelo, Adriana Corrêa de Queiroz, Juliana Vianna Pereira, Ana Paula Corrêa de Queiroz de Herkrath

{"title":"The association between malocclusion and health-related quality of life in adolescents: A mediation analysis","authors":"Sarah Debora Camardella Leite, Fernando José Herkrath, Mario Vianna Vettore, Maria Augusta Bessa Rebelo, Adriana Corrêa de Queiroz, Juliana Vianna Pereira, Ana Paula Corrêa de Queiroz de Herkrath","doi":"10.1111/eos.12960","DOIUrl":"10.1111/eos.12960","url":null,"abstract":"This study investigated the role of oral health-related functional limitations and social well-being, self-perceived health, psychosocial factors, and social support in mediating the impact of malocclusion on health-related quality of life (HRQoL). A school-based 6-month cohort study was conducted with 376 12-year-old deprived adolescents. Measures at baseline included malocclusion (DAI score), dental caries, sociodemographic characteristics, psychosocial traits (self-esteem, sense of coherence, oral health beliefs), and social support. The oral health-related functional limitations and symptoms (social well-being) domains of the CPQ11-14, self-perceived health, and HRQoL (Kiddo-KINDL) were evaluated at the 6-month follow-up. Associations between observed and latent variables (social support, psychosocial factors, and HRQoL) were evaluated using structural equation modelling, according to the Wilson and Cleary theoretical model. Malocclusion was indirectly associated with worse HRQoL, mediated by functional limitations, social well-being, and self-perceived health. Better psychosocial status was directly associated with better HRQoL, and higher social support was indirectly associated with better HRQoL via psychosocial factors. Dental caries experience, female sex, and lower family income were indirectly associated with worse HRQoL. The impact of malocclusion on HRQoL was mediated by oral health-related functional limitations, social well-being, and self-perceived health. Sociodemographic and psychosocial factors, and social support also impacted HRQoL.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of propranolol on temporomandibular joint pain in repeatedly stressed rats 普萘洛尔对反复应激大鼠颞下颌关节疼痛的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-10-31 DOI: 10.1111/eos.12957

Fernanda Barchesi Zanelatto, Willians Fernando Vieira, Catarine Massucato Nishijima, Tamires Marques Zanotto, Silviane Fernandes de Magalhães, César Renato Sartori, Carlos Amilcar Parada, Claudia Herrera Tambeli

{"title":"Effect of propranolol on temporomandibular joint pain in repeatedly stressed rats","authors":"Fernanda Barchesi Zanelatto, Willians Fernando Vieira, Catarine Massucato Nishijima, Tamires Marques Zanotto, Silviane Fernandes de Magalhães, César Renato Sartori, Carlos Amilcar Parada, Claudia Herrera Tambeli","doi":"10.1111/eos.12957","DOIUrl":"10.1111/eos.12957","url":null,"abstract":"Stress substantially increases the risk of developing painful temporomandibular disorders (TMDs) by influencing the release of endogenous catecholamines. Propranolol, an antagonist of β-adrenergic receptors, has shown potential in alleviating TMD-associated pain, particularly when the level of catecholamines is elevated. The aim of this study was to explore whether intra-articular propranolol administration is effective in diminishing temporomandibular joint (TMJ) pain during repeated stress situations. Additionally, we investigated the effect of repeated stress on the expression of genes encoding β-adrenoceptors in the trigeminal ganglion. In the present study, rats were exposed to a stress protocol induced by sound, then to the administration of formalin in the TMJ (to elicit a nociceptive response), followed immediately afterward by different doses of propranolol, after which the analgesic response to propranolol was evaluated. We also assessed the levels of beta-1 and beta-2 adrenergic receptor mRNAs (Adrb1 and Adrb2, respectively) using reverse transcription–quantitative PCR (RT-qPCR). Our findings revealed that propranolol administration reduces formalin-induced TMJ nociception more effectively in stressed rats than in non-stressed rats. Furthermore, repeated stress decreases the expression of the Adrb2 gene within the trigeminal ganglion. The findings of this study are noteworthy as they suggest that individuals with a chronic stress history might find potential benefits from β-blockers in TMD treatment.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructure, physical and mechanical properties of dental polychromic multilayer zirconia of uniform composition 组成均匀的牙科多色多层氧化锆的微观结构、物理力学性能。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-10-20 DOI: 10.1111/eos.12959

Konstantinos Dimitriadis, Dimitrios Moschovas, Dilshat U. Tulyaganov, Simeon Agathopoulos

{"title":"Microstructure, physical and mechanical properties of dental polychromic multilayer zirconia of uniform composition","authors":"Konstantinos Dimitriadis, Dimitrios Moschovas, Dilshat U. Tulyaganov, Simeon Agathopoulos","doi":"10.1111/eos.12959","DOIUrl":"10.1111/eos.12959","url":null,"abstract":"The present study aimed to compare the microstructure, physical, and mechanical properties of three commercially available dental polychromatic multilayer zirconia materials of uniform composition: Dima Mill Zirconia ML, VITA YZ/ST Multicolor, and VITA YZ/XT Multicolor (with 3, 4, and 5 mol% Y2O3, respectively); thus, the influence of Y2O3 content on the above properties of the produced materials was experimentally studied. Homogeneous zirconia ceramics with a dense micro- and nanostructure, without pores or defects, were produced after milling the blocks and sintering, which resulted in yttrium-stabilized tetragonal and cubic zirconia. Statistical analysis of the results of measurable magnitudes was performed by the one-way ANOVA test. The increase of Y2O3 content (from 3 to 5 mol%) favored larger grain and crystallite sizes and a decrease of the values of the mechanical properties; yet, the differences were statistically insignificant. Clinically, these differences are expected to have no impact on their function in the oral cavity, both in terms of their fracture propensity and the damage that can be caused to the opposing teeth. Accordingly, the experimental results qualify the polychromic multilayer zirconia ceramics of uniform composition fabricated by milling technology for use in dental restorations.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eos.12959","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49675752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of enamel moistening and repositioning guide color on tooth whitening outcomes: A clinical trial 牙釉质润湿和重新定位引导色对牙齿美白效果的影响：一项临床试验。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-10-18 DOI: 10.1111/eos.12958

Tauan Rosa Santana, Paula Fernanda Damasceno Silva, Márcia Luciana Carregosa Santana, Clara Lemos Leal Barata de Mattos, André Luis Faria-e-Silva

{"title":"Effects of enamel moistening and repositioning guide color on tooth whitening outcomes: A clinical trial","authors":"Tauan Rosa Santana, Paula Fernanda Damasceno Silva, Márcia Luciana Carregosa Santana, Clara Lemos Leal Barata de Mattos, André Luis Faria-e-Silva","doi":"10.1111/eos.12958","DOIUrl":"10.1111/eos.12958","url":null,"abstract":"This clinical trial investigated the effects of pre-application enamel moistening on the impact of a 37% carbamide peroxide whitener on tooth color changes and the influence of repositioning guide colors. Forty participants were randomly assigned to in-office tooth bleaching with either moistened enamel (experimental) or dry enamel (control). The whitener was applied for 45 min over two sessions. Tooth color was visually measured or assessed using a spectrophotometer with purple or green silicone guides. Tooth bleaching was assessed using CIE76 (ΔEab) and CIEDE2000 (ΔE00) formulas and by whitening and bleaching index score changes. Moistening the enamel did not significantly affect tooth color. However, the guide color choice only impacted tooth color when measured instrumentally. At baseline, the green guide resulted in statistically significantly whiter teeth than the purple guide. Less pronounced differences in the b* coordinate between baseline and final measurements were found using the green guide. The green guide also produced lower ΔEab values and less change in indexes. In conclusion, moistening the enamel did not significantly impact tooth color changes. However, the repositioning guide color influenced the tooth bleaching measured instrumentally, except for ΔE00.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49675751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of alpha smooth muscle actin in odontogenic differentiation of dental pulp stem cells α-平滑肌肌动蛋白在牙髓干细胞牙源性分化中的作用。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-10-17 DOI: 10.1111/eos.12956

Zeyi Ma, Peiqi Shen, Xiaoqing Xu, Weiyu Li, Yaoyin Li

{"title":"Role of alpha smooth muscle actin in odontogenic differentiation of dental pulp stem cells","authors":"Zeyi Ma, Peiqi Shen, Xiaoqing Xu, Weiyu Li, Yaoyin Li","doi":"10.1111/eos.12956","DOIUrl":"10.1111/eos.12956","url":null,"abstract":"Pulpotomy is an effective treatment for retaining vital pulp after pulp exposure caused by caries removal and/or trauma. The expression of alpha smooth muscle actin (α-SMA) is increased during the wound-healing process, and α-SMA-positive fibroblasts accelerate tissue repair. However, it remains largely unknown whether α-SMA-positive fibroblasts influence pulpal repair. In this study, we established an experimental rat pulpotomy model and found that the expression of α-SMA was increased in dental pulp after pulpotomy relative to that in normal dental pulp. In vitro results showed that the expression of α-SMA was increased during the induction of odontogenic differentiation in dental pulp stem cells (DPSCs) compared with untreated DPSCs. Moreover, α-SMA overexpression promoted the odontogenic differentiation of DPSCs via increasing mitochondrial function. Mechanistically, α-SMA overexpression activated the mammalian target of rapamycin (mTOR) signaling pathway. Inhibition of the mTOR signaling pathway by rapamycin decreased the mitochondrial function in α-SMA-overexpressing DPSCs and suppressed the odontogenic differentiation of DPSCs. Furthermore, we found that α-SMA overexpression increased the secretion of transforming growth factor beta-1 (TGF-β1). In sum, our present study demonstrates a novel mechanism by which α-SMA promotes odontogenic differentiation of DPSCs by increasing mitochondrial respiratory activity via the mTOR signaling pathway.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41233489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The onset of adenosine monophosphate-activated protein kinase activity on orthodontic tooth movement in rats with type 2 diabetes 腺苷激活蛋白激酶活性对2型糖尿病大鼠正畸牙齿运动的影响。

IF 1.9 4区医学

European Journal of Oral Sciences Pub Date : 2023-10-07 DOI: 10.1111/eos.12955

Danyuan Huang, Yuyu Li, Shuo Chen, Han Wang, Yukun Jiang, Yuanyuan Wei, Hengyi Lin, Shujuan Zou

{"title":"The onset of adenosine monophosphate-activated protein kinase activity on orthodontic tooth movement in rats with type 2 diabetes","authors":"Danyuan Huang, Yuyu Li, Shuo Chen, Han Wang, Yukun Jiang, Yuanyuan Wei, Hengyi Lin, Shujuan Zou","doi":"10.1111/eos.12955","DOIUrl":"10.1111/eos.12955","url":null,"abstract":"Adenosine monophosphate-activated protein kinase (AMPK) plays pivotal roles in metabolic diseases including type 2 diabetes. However, the specific role of AMPK for orthodontic tooth movement in type 2 diabetes is unclear. In this study, a diabetic rat model was established through dietary manipulation and streptozocin injection. Examinations were conducted to select qualified type 2 diabetic rats. Then, an orthodontic device was applied to these rats for 0, 3, 7, or 14 days. The distance of orthodontic tooth movement and parameters of alveolar bone were analyzed by micro-computed tomography. Periodontal osteoclastic activity, inflammatory status, and AMPK activity were measured via histological analyses. Next, we repeated the establishment of diabetic rats to investigate whether change of AMPK activity was associated with orthodontic tooth movement under type 2 diabetes. The results showed that diabetic rats exhibited an exacerbated alveolar bone resorption, overactive inflammation, and decreased periodontal AMPK activity during orthodontic tooth movement. Injection of the AMPK agonist alleviated type 2 diabetes-induced periodontal inflammation and alveolar bone resorption, thus normalizing distance of orthodontic tooth movement. Our study indicates that type 2 diabetes decreases periodontal AMPK activity, leading to excessive inflammation elevating osteoclast formation and alveolar bone resorption, which could be reversed by AMPK activation.","PeriodicalId":11983,"journal":{"name":"European Journal of Oral Sciences","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0