European Journal of Clinical Nutrition最新文献

{"title":"Quantifying vitamin D intake among Aboriginal and Torres Strait Islander peoples in Australia.","authors":"Belinda Neo, Dale Tilbrook, Noel Nannup, Alison Daly, Eleanor Dunlop, John Jacky, Carol Michie, Cindy Prior, Brad Farrant, Carrington C J Shepherd, Anita S Lawrence, Edoardo Tescari, Lucinda J Black","doi":"10.1038/s41430-025-01580-7","DOIUrl":"https://doi.org/10.1038/s41430-025-01580-7","url":null,"abstract":"<p><strong>Background/objective: </strong>Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] concentration < 50 nmol/L) is prevalent among Aboriginal and Torres Strait Islander peoples in Australia. Alternative to sun exposure (the primary source of vitamin D), vitamin D can also be obtained from food (e.g. fish, eggs, and meat) and supplements. However, the vitamin D intake of this population group is unknown. We aimed to provide the first quantification of vitamin D intake using nationally representative data from Aboriginal and Torres Strait Islander peoples.</p><p><strong>Methods: </strong>We used food consumption data collected in the 2012-2013 National Aboriginal and Torres Strait Islander Nutrition and Physical Activity Survey (n = 4109) and vitamin D food composition data to quantify vitamin D intake by sex, age group, and remoteness of location. Wilcoxon rank-sum test was used to assess the difference in vitamin D intake between sexes and remoteness of location.</p><p><strong>Results: </strong>The median (25th, 75th percentile) vitamin D intake among Aboriginal and Torres Strait Islander peoples aged ≥ 2 years was 80 (45, 145) IU/day. Vitamin D intake was statistically significantly different between males and females (p = < 0.001). There was no statistically significant difference between vitamin D intake in non-remote and remote areas (p = 0.292).</p><p><strong>Conclusions: </strong>Vitamin D intake among Aboriginal and Torres Strait Islander peoples is low. Food-based public health strategies guided by Aboriginal and Torres Strait Islander Elders and communities could be developed to promote higher vitamin D intake among this population.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of physical activity recall questionnaire and log using doubly-labelled water in Sri Lankan children.","authors":"Prasangi Dabare, Pujitha Wickramasinghe, Indu Waidyatilaka, Sarita Devi, Maduka de Lanerolle Dias, Rajitha Wickremasinghe, Dulani Samaranayake, Ranil Jayawardena, Andrew P Hills, Pulani Lanerolle","doi":"10.1038/s41430-025-01579-0","DOIUrl":"https://doi.org/10.1038/s41430-025-01579-0","url":null,"abstract":"<p><strong>Background and objective: </strong>Valid and cost-effective approaches are essential to assess physical activity and sedentary behaviours in individuals of all ages. This study aimed to validate a physical activity recall questionnaire (PAR-Q) and a physical activity log against the doubly labelled water (DLW) technique in 11-13-year-old Sri Lankan children.</p><p><strong>Method: </strong>Total energy expenditure (TEE) was determined using the criterion DLW technique (TEE_DLW) and physical activity energy expenditure (PAEE_DLW) was estimated. Subsequently, physical activity assessment methods were validated in a group of children (n = 79). PAR-Q was adapted from the adolescent physical activity questionnaire and the physical activity log from the Bouchard activity diary. The youth physical activity compendium was used to calculate PAEE from both PAR-Q (PAEE_PAR-Q) and activity log (PAEE_PALog). Statistical analysis included Pearson's correlation coefficient and Bland-Altman analyses.</p><p><strong>Results: </strong>Mean age of the study sample was 12.0 ± 0.8 years where the greater proportion were males (51.9%, n = 41). PAEE_PAR-Q and PAEE_PALog were significantly correlated with the PAEE_DLW (r = 0.69 and r = 0.49, p < 0.05). PAR-Q underestimated PAEE by 230.1 ± 1071.1 kJ/day. Physical activity log overestimated PAEE by 14.6 ± 1283.2 kJ/day; for unit increase in the mean of the two measurements, the difference between the measurements increased by 0.48 (R² = 0.16, p < 0.001).</p><p><strong>Conclusion: </strong>PAR-Q is a valid tool for predicting PAEE in Sri Lankan children whereas the physical activity log was not. Researchers and practitioners can confidently use the PAR-Q to assess physical activity in this population, with potential applications in various research and intervention settings.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal assessment of maternal micronutrients (folate and vitamin B₁₂) and homocysteine levels in women who develop gestational diabetes mellitus.","authors":"Shweta Madiwale, Nikita Joshi, Karuna Randhir, Hemlata Pisal, Vrushali Kadam, Ghattu Krishnaveni, Girija Wagh, Sanjay Gupte, Caroline Fall, Sadhana Joshi","doi":"10.1038/s41430-025-01581-6","DOIUrl":"https://doi.org/10.1038/s41430-025-01581-6","url":null,"abstract":"<p><strong>Background: </strong>Micronutrients (folate and vitamin B₁₂) and homocysteine are key components of the one-carbon metabolism and literature on the associations of these micronutrients with the pathophysiology of gestational diabetes mellitus (GDM) is unclear. The current study aims to examine the levels of these micronutrients across pregnancy in women who develop GDM and compare them with non-GDM women.</p><p><strong>Methods: </strong>A total of 200 pregnant women (100 Non-GDM and 100 GDM) were included in the study and blood samples were collected at 4 different time intervals throughout pregnancy (Visit-1 = 11-14 weeks, Visit-2 = 18-22 weeks, Visit-3 = 26-28 weeks, and Visit-4 = at delivery).</p><p><strong>Results: </strong>Vitamin B₁₂ levels at V3 and V4 (p = 0.031 and p = 0.001) and folate levels from V2, till delivery (p < 0.01 for V2, V3 and p = 0.025 for V4) were higher in GDM as compared to non-GDM. However, homocysteine levels were lower at all time points across gestation (p < 0.01 for all) in women with GDM. Intake of vitamin B₁₂ & folate rich foods was comparable in GDM and Non-GDM women. Also, the percentage of GDM women who took vitamin B₁₂ supplements was comparable between groups, while folate supplements were higher V1 (p < 0.01) in GDM women.</p><p><strong>Conclusions: </strong>Elevated micronutrients and lower homocysteine levels in GDM women necessitate more research for better understanding the role of these one carbon nutrients in the etiology of GDM and emphasizes the need to establish the optimum maternal vitamin B₁₂ and folate levels for fetal development.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Meta-analysis of the association between the dietary inflammatory index and risk of chronic kidney disease\" by Chen et al. 2024.","authors":"Amirhossein Ataei Kachouei, Frazam Kamrani, Fahimeh Haghighatdoost","doi":"10.1038/s41430-025-01582-5","DOIUrl":"https://doi.org/10.1038/s41430-025-01582-5","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting energy expenditure of females mid- to long-term after bariatric surgery: agreement between indirect calorimetry and predictive methods.","authors":"Fernando Lamarca, Flávio T Vieira, Mariana S Melendez-Araújo, Ricardo M Lima, Eliane Said Dutra, Kênia Mara Baiocchi de Carvalho","doi":"10.1038/s41430-025-01577-2","DOIUrl":"https://doi.org/10.1038/s41430-025-01577-2","url":null,"abstract":"<p><strong>Background/objectives: </strong>Predictive equations estimate post-bariatric surgery resting energy expenditure (REE), but lack accuracy assessment, especially for the remaining body mass. This study aimed to evaluate the agreement between indirect calorimetry and REE predictive methods.</p><p><strong>Subjects/methods: </strong>It enrolled 226 females [median age 43.0 (36.2; 50.4) years] who underwent mid- to long-term post-Roux-en-Y gastric bypass [median postoperative time 6.1 (4.0; 9.0) years]. The measured REE (mREE) was obtained using indirect calorimetry, while the estimated REE (eREE) was derived from 18 predictive equations and an artificial neural network model. Analyses were performed for the total sample and body mass index (BMI) subgroups (<30 kg/m² and ≥30 kg/m²). eREE within ±10% of mREE was considered accurate; Bland-Altman plots were performed to evaluate agreement.</p><p><strong>Results: </strong>In the BMI < 30 kg/m² subgroup [n = 115; 1372 ± 153 kcal (5744.3 ± 640.6 kJ)], mREE did not differ from four predictive equations; Henry [1371 ± 95 kcal (5740.1 ± 397.8 kJ), p = 0.922, bias -1.0 kcal (-4.2 kJ)] and Dietary Reference Intakes-Institute of Medicine [1382 ± 102 kcal (5786.2 ± 427.1 kJ), p = 0.315, bias 10.2 kcal (42.7 kJ)] equations showed better agreement and accurate prediction performance among BMI categories (79.1 and 82.6%, respectively). The BMI ≥ 30 kg/m² subgroup mREE [n = 111; 1516 ± 186 kcal (6347.2 ± 778.7 kJ)] was significantly lower than all predictive methods and had higher bias and over-prediction, except for Mifflin-St Jeor equation [1523 ± 186 kcal (6376.5 ± 778.7 kJ), p = 0.469, bias 7.7 kcal (32.2 kJ)].</p><p><strong>Conclusion: </strong>Equations for estimating REE show wide performance variation, with limited accurate options in this population, especially among those with BMI > 30 kg/m².</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoration of gut microbiota with a specific synbiotic-containing infant formula in healthy Chinese infants born by cesarean section.","authors":"Ying Wang, Harm Wopereis, Alexia Kakourou, Min Liu, Jieling Wu, Zailing Li, Lili Zhang, Meizhen Tan, June Su Yin Low, Mengjin Liu, Guus Roeselers, Jan Knol, Wei Cai","doi":"10.1038/s41430-025-01571-8","DOIUrl":"https://doi.org/10.1038/s41430-025-01571-8","url":null,"abstract":"<p><strong>Background: </strong>Birth by cesarean section (C-section) is associated with a delayed colonization of bifidobacteria and Bacteroidota species with potential negative health consequences. Previously, an infant formula with a synbiotic mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS [9:1]) and Bifidobacterium breve M-16V was found to restore the timely colonization of bifidobacteria in C-section born infants. In this study, we investigated the effect of this synbiotic mixture on gut microbiota development in C-section and vaginally-born infants participating in a growth equivalence trial (NCT03520764).</p><p><strong>Methods: </strong>Healthy, fully formula-fed Chinese infants were randomized to receive a partially hydrolyzed whey-based protein formula with the synbiotic mixture (n = 112), or an intact protein formula with scGOS/lcFOS (prebiotic, n = 112). Breastfed infants served as reference group (n = 60). Gut microbiota profiling by 16S rRNA gene sequencing of stools collected at baseline, 17 weeks (end of intervention) and 12 months of age was complemented with analysis of stool pH, short-chain fatty acids, lactic acids, and secretory IgA concentrations.</p><p><strong>Results: </strong>Both the prebiotic and the synbiotic formula supported a dominant and diverse infant-type bifidobacterial community, but with increased abundance of Bifidobacterium breve in the synbiotic group. In C-section born infants (54.8% of randomized) the synbiotic but not the prebiotic, enhanced the bifidobacterial species diversity and showed restoration of Parabacteroides at 17 weeks, and Bacteroides spp. at 12 months closer to that of the vaginally-born infants.</p><p><strong>Conclusion: </strong>The synbiotic was confirmed to support the restoration of important gut colonizers in infants born by C-section with effects observed even beyond the intervention period.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Answer to Dr. Pedrolli's: comment on recent narrative review for ageing population focused on dysphagia and geriatric nutritional needs.","authors":"Edda Cava, Mauro Lombardo","doi":"10.1038/s41430-025-01572-7","DOIUrl":"https://doi.org/10.1038/s41430-025-01572-7","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of low muscle mass and myosteatosis on treatment toxicity and survival outcomes in non-resectable pancreatic cancer patients treated with chemoradiotherapy.","authors":"Marine Perrier, Marine Fontaine, Eric Bertin, Claire Carlier, Damien Botsen, Manel Djelouah, Eric François, Philippe Guilbert, Angélique Saint, Florian Slimano, Paolo Torielli, Mathias Brugel, Olivier Bouché","doi":"10.1038/s41430-025-01566-5","DOIUrl":"https://doi.org/10.1038/s41430-025-01566-5","url":null,"abstract":"<p><strong>Background: </strong>Low skeletal muscle mass and impaired muscle quality (myosteatosis) have been associated with poor outcomes in cancer patients. This study aimed to evaluate the impact of pre-therapeutic low muscle mass and myosteatosis on chemoradiotherapy (CRT)-induced toxicity and survival outcomes in patients with non-resectable pancreatic cancer (PC).</p><p><strong>Methods: </strong>In this retrospective study, pre-therapeutic CT scans were used to measure muscle mass/density. Low muscle mass was defined as a skeletal muscle index <38.5 cm²/m² (women) and <52.4 cm²/m² (men), and myosteatosis as a mean psoas density <41 HU if BMI < 25 kg/m² or <33 HU if BMI > 25 kg/m². Adverse effects were collected per week (W) of treatment. Dose-limiting toxicity (DLT) was defined as any toxicity leading to dose reduction, treatment delays or permanent discontinuation.</p><p><strong>Results: </strong>Among the 85 included patients, 75 (88.2%) and 18 (22.2%) had pre-therapeutic low muscle mass and myosteatosis, respectively. Only 12 patients (14.1%) experienced DLT. Patients with low muscle mass developed significantly more toxicities at W2 (p = 0.013) and W5 (p = 0.026), notably more nausea (p = 0.037) and anemia (p = 0.004). Low muscle mass was associated with poorer overall survival (HR 4.41 [1.50-12.94], p = 0.007) in multivariate Cox analysis, while myosteatosis was not associated with CRT toxicities, DLT and overall survival (p = 0.408).</p><p><strong>Conclusion: </strong>Patients with low muscle mass experienced more toxicities and poorer outcomes during CRT for non-resectable PC.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the social worker in the assessment and management of adults receiving Home Parenteral Nutrition.","authors":"Sharon Carey, Shannyn Brown, Suzie Ferrie","doi":"10.1038/s41430-024-01555-0","DOIUrl":"https://doi.org/10.1038/s41430-024-01555-0","url":null,"abstract":"<p><p>People diagnosed with Intestinal Failure (IF) requiring Home Parenteral Nutrition (HPN) have complex medical and nutritional requirements. To date, assessment for, and ongoing management of, HPN has relied on medical, nursing and dietetic input. However, success in assessing suitability for HPN and ongoing management is often reliant on non-medical factors. This paper aims to outline the critical clinical role the social worker can play and their scope of practice in assessing and managing people requiring HPN. This includes assessment across medical, psychosocial, financial, legal, quality-of-life and healthcare-related domains. This perspective paper highlights the vast scope in which the social worker can support people diagnosed with IF requiring HPN. More research is required to quantify the value of the social worker as a key member of the multidisciplinary IF team.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of β-glucans on fatigue: a systematic review and meta-analysis.","authors":"Masahiro Muroya, Kumiko Nakada, Kazushi Maruo, Koichi Hashimoto","doi":"10.1038/s41430-025-01567-4","DOIUrl":"https://doi.org/10.1038/s41430-025-01567-4","url":null,"abstract":"<p><p>Several clinical trials suggest that β-glucans may reduce feelings of fatigue, however the results of clinical trials are inconsistent. Additionally, no systematic reviews or meta-analyses have assessed the effects of β-glucans on fatigue. Therefore, this study investigates the effects of β-glucans on fatigue in healthy subjects through a systematic review and meta-analysis. PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from database inception to March 15, 2024. The inclusion criterion was a randomized controlled trial (RCT) investigating the effects of β-glucans on healthy subjects' fatigue, vigor, and mood state. To assess risk of bias, we employed the Cochrane risk of bias tool. A random-effects meta-analysis was conducted for the standardized mean difference (SMD). Sixteen RCTs with a total of 1,449 participants were included, and 12 studies provided data suitable for meta-analysis. Meta-analysis revealed that β-glucans significantly reduced feelings of fatigue (SMD = -0.32, 95% CI = -0.53 to -0.12; p = 0.0021), increased vigor (SMD = 0.46, 95% CI = 0.26-0.66; p < 0.0001), and improved mood state (SMD = 0.32, 95% CI = 0.11-0.53; p = 0.0026) compared to the placebo group. The results of the systematic review and meta-analysis indicate that β-glucans may be effective in reducing feelings of fatigue in healthy individuals. However, the number of studies included is insufficient, suggesting that further clinical trials are needed to validate this effect.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}