CYP2R1和GC基因多态性对糖尿病前期补充维生素D3后血清25(OH)D反应的影响

IF 3.6 3区医学 Q2 NUTRITION & DIETETICS

European Journal of Clinical Nutrition Pub Date : 2025-03-20 DOI:10.1038/s41430-024-01564-z

Peng Ni, Ze Xu, Yujing Zhang, Dongdong Zhang, Hongwei Wen, Yaping Liu, Wenjie Li, Xing Li

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引用次数: 0

摘要

背景：糖尿病前期是预防和控制糖尿病的关键时期。本研究旨在探讨CYP2R1/GC基因多态性对糖尿病前期维生素D3补充反应性的影响。方法：总共240名糖尿病前期参与者每天口服1600 IU维生素D3或安慰剂，持续24周。结果：CYP2R1 rs12794714 AA携带者与GG携带者相比，添加后25(OH)D3水平升高幅度较小（3.42（0.05,6.79）比8.49 (6.14,10.83),P = 0.038）。此外，GC rs4588 GA携带者25(OH)D3水平较GG携带者低（4.71（2.64,6.79）比8.17 (6.37,9.98),P = 0.033）；其补充反应性也较低（0.35 (0.14,0.91),P = 0.032）。GC rs4752 AG携带者的补充应答性高于AA携带者（3.48 (1.05,11.59),P = 0.042）。结论：CYP2R1 rs12794714、GC rs4588和GC rs4752多态性与糖尿病前期维生素D3补充反应性相关。

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Effect of CYP2R1 and GC gene polymorphisms on serum 25(OH)D response to vitamin D₃ supplementation in prediabetes.

Background: Prediabetes is a crucial period for preventing and managing diabetes. This study aimed to explore the effects of CYP2R1/GC gene polymorphisms on vitamin D₃ supplementation responsiveness in prediabetes.

Methods: A total of 240 prediabetic participants received orally 1600 IU of vitamin D₃ or placebo daily for 24 weeks.

Results: CYP2R1 rs12794714 AA carriers had less increased 25(OH)D₃ levels compared with GG carriers after supplementation (3.42 (0.05, 6.79) vs. 8.49 (6.14, 10.83), P = 0.038). Moreover, GC rs4588 GA carriers had less increased 25(OH)D₃ levels compared with GG carriers (4.71 (2.64, 6.79) vs. 8.17 (6.37, 9.98), P = 0.033); it also had lower supplementation responsiveness (0.35 (0.14, 0.91), P = 0.032). GC rs4752 AG carriers had higher supplementation responsiveness compared with AA carriers (3.48 (1.05, 11.59), P = 0.042).

Conclusions: The results indicated that CYP2R1 rs12794714, GC rs4588, and GC rs4752 polymorphism were associated with vitamin D₃ supplementation responsiveness in prediabetes.

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来源期刊

European Journal of Clinical Nutrition 医学-营养学

CiteScore

10.60

自引率

2.10%

发文量

189

审稿时长

3-6 weeks

期刊介绍： The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)