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MEDICINA RIGENERATIVA E DIABETE DI TIPO 1: I PROGRESSI DELLA BIOINGEGNERIA APPLICATI ALLA SOSTITUZIONE DELLA FUNZIONE BETA-CELLULARE 再生医学与 1 型糖尿病：应用于替代 β 细胞功能的生物工程进展
Il Diabete Pub Date : 2024-07-11 DOI: 10.30682/ildia2402f
Cataldo Pignatelli, Alessia Neroni, F. Campo, Matteo Monieri, Francesca Servidio, Alessia Nolli, Camilla Teruzzi, Sofia Cochi, Antonio Citro
{"title":"MEDICINA RIGENERATIVA E DIABETE DI TIPO 1: I PROGRESSI DELLA BIOINGEGNERIA APPLICATI ALLA SOSTITUZIONE DELLA FUNZIONE BETA-CELLULARE","authors":"Cataldo Pignatelli, Alessia Neroni, F. Campo, Matteo Monieri, Francesca Servidio, Alessia Nolli, Camilla Teruzzi, Sofia Cochi, Antonio Citro","doi":"10.30682/ildia2402f","DOIUrl":"https://doi.org/10.30682/ildia2402f","url":null,"abstract":"Intrahepatic islet transplantation holds promise for T1D treatment, yet faces challenges like inflammatory storms and graft revascularization delays. Endocrine pancreas bioengineering, especially with encapsulation technologies, aims to recreate vascular and endocrine compartments ex vivo to generate a functional device for successful in vivo application. This review explores the synergy of diverse encapsulation techniques and alternative cell sources in crafting a functional vascularized endocrine scaffold.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"104 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SMARTWATCH, ACTIVITY TRACKER E SALUTE NELLA PERSONA CON DIABETE 智能手表、活动追踪器和对糖尿病患者的关爱
Il Diabete Pub Date : 2024-07-11 DOI: 10.30682/ildia2402g
A. Di Blasio, Leandro Ditali, Maria Pompea Antonia Baldassarre, Gloria Formoso
{"title":"SMARTWATCH, ACTIVITY TRACKER E SALUTE NELLA PERSONA CON DIABETE","authors":"A. Di Blasio, Leandro Ditali, Maria Pompea Antonia Baldassarre, Gloria Formoso","doi":"10.30682/ildia2402g","DOIUrl":"https://doi.org/10.30682/ildia2402g","url":null,"abstract":"For people with diabetes, technological development represents an important opportunity to optimize therapeutic outcomes through an approach aimed at improving the quality of physical activity, exercise, and sleep, while combating sedentary behavior. However, this approach requires adequate training of members of the health care team and includes, in addition to knowledge of the dimensions of the aforementioned behavioral variables, an understanding of the dynamics of change associated with them. It is also crucial not to overlook the importance of active patient participation and the selection of appropriate tools and equipment.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"94 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFETTI BENEFICI DI UN NUOVO COMPOSTO OMEGA-3 一种新型欧米伽-3化合物的益处
Il Diabete Pub Date : 2024-07-11 DOI: 10.30682/ildia2402e
Marta Letizia Hribal
{"title":"EFFETTI BENEFICI DI UN NUOVO COMPOSTO OMEGA-3","authors":"Marta Letizia Hribal","doi":"10.30682/ildia2402e","DOIUrl":"https://doi.org/10.30682/ildia2402e","url":null,"abstract":"","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"95 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALIMENTI E PREVENZIONE DELLE MALATTIE CARDIOVASCOLARI 食物与心血管疾病的预防
Il Diabete Pub Date : 2024-07-11 DOI: 10.30682/ildia2402b
Olga Vaccaro, Annalisa Giosuè, Marilena Vitale
{"title":"ALIMENTI E PREVENZIONE DELLE MALATTIE CARDIOVASCOLARI","authors":"Olga Vaccaro, Annalisa Giosuè, Marilena Vitale","doi":"10.30682/ildia2402b","DOIUrl":"https://doi.org/10.30682/ildia2402b","url":null,"abstract":"We review the evidence for food choices aimed at reducing cardiovascular disease (CVD). Low consumption of red meat, processed meat, and salt and increased intake of plant-based foods – whole grains, fruits, vegetables, legumes, and nuts – are linked with reduced CV risk. The same applies for the replacement of animal and tropical fats with olive oil and polyunsaturated fat rich oils. Moderate consumption of wine, coffee and tea is associated with a reduced CV risk, whereas soft drinks substantially increase CV risk. New data support the replacement of high glycemic index (GI) foods with whole grains and low GI foods, and a moderate consumption of fermented dairy as appropriate choices for the reduction of CVD.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"63 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I TRIGLICERIDI COME FATTORE DI RISCHIO CARDIOVASCOLARE 作为心血管风险因素的甘油三酯
Il Diabete Pub Date : 2024-07-11 DOI: 10.30682/ildia2402c
Mario Luca Morieri
{"title":"I TRIGLICERIDI COME FATTORE DI RISCHIO CARDIOVASCOLARE","authors":"Mario Luca Morieri","doi":"10.30682/ildia2402c","DOIUrl":"https://doi.org/10.30682/ildia2402c","url":null,"abstract":"Triglycerides and cardiovascular prevention have become increasingly important, especially in diabetic patients who continue to have a higher cardiovascular risk compared to the general population. Elevated triglycerides, part of the typical “diabetic dyslipidemia”, are often under-recognized but play a crucial role in cardiovascular risk. Treatments focusing on triglycerides as fenofibrate and omega-3 fatty acids, particularly Icosapent Ethyl (IPE), have shown to reduce cardiovascular events in well-selected patients. This review addressed how and why it is important to consider hypertriglyceridemia in cardiovascular prevention among patients with diabetes.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"61 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LO SCREENING DEL DIABETE DI TIPO 1 IN ITALIA, IL PROGETTO PROPEDEUTICO E LE IMPLICAZIONI PRATICHE 意大利的 1 型糖尿病筛查、筹备项目和实际影响
Il Diabete Pub Date : 2024-07-11 DOI: 10.30682/ildia2402a
Valentina Tiberi, Umberto Agrimi, R. Bonfanti, E. Bosi, D. Iafusco, Enza Mozzillo, C. Ripoli, Antonio D’Avino, Flavia Pricci, Olimpia Vincentini, Marco Silano, Valentino Cherubini
{"title":"LO SCREENING DEL DIABETE DI TIPO 1 IN ITALIA, IL PROGETTO PROPEDEUTICO E LE IMPLICAZIONI PRATICHE","authors":"Valentina Tiberi, Umberto Agrimi, R. Bonfanti, E. Bosi, D. Iafusco, Enza Mozzillo, C. Ripoli, Antonio D’Avino, Flavia Pricci, Olimpia Vincentini, Marco Silano, Valentino Cherubini","doi":"10.30682/ildia2402a","DOIUrl":"https://doi.org/10.30682/ildia2402a","url":null,"abstract":"Type 1 diabetes (T1D) is a common and serious disease that affects children, adolescents, and young adults. Diagnosis is often with diabetic ketoacidosis (DKA), which poses serious health risks. Autoantibody studies have shown that presymptomatic stages can be identified before clinical diagnosis. Screening for autoantibodies in the general population could help reduce and prevent DKA. This review focuses on Italian law 130/2023 on population screening of T1D.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"23 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LIPODISTROFIE: QUANDO MAGRO NON È SINONIMO DI METABOLICAMENTE SANO 脂肪变性：当瘦并不等同于代谢健康时
Il Diabete Pub Date : 2024-07-11 DOI: 10.30682/ildia2402d
Lavinia Palladino, G. Ceccarini, D. Gilio, Silvia Magno, Caterina Pelosini, Melania Paoli, M. Sessa, Ferruccio Santini
{"title":"LIPODISTROFIE: QUANDO MAGRO NON È SINONIMO DI METABOLICAMENTE SANO","authors":"Lavinia Palladino, G. Ceccarini, D. Gilio, Silvia Magno, Caterina Pelosini, Melania Paoli, M. Sessa, Ferruccio Santini","doi":"10.30682/ildia2402d","DOIUrl":"https://doi.org/10.30682/ildia2402d","url":null,"abstract":"Lipodystrophy syndromes are rare, heterogeneous disorders with significant health impacts, compromising quality of life. Characterized by complete or partial adipose tissue deficiency, either congenital or acquired, they are often associated with low serum leptin levels and severe metabolic abnormalities like diabetes mellitus and dyslipidemia. Diagnosis is challenging due to phenotypic variability and low prevalence. Management requires a multidisciplinary approach, including lifestyle changes and may necessitate leptin replacement therapy.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"130 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Il ruolo dello svuotamento gastrico nell’omeostasi e nella controregolazione glucidica 胃排空在平衡和葡萄糖反调节中的作用
Il Diabete Pub Date : 2024-01-16 DOI: 10.30682/ildia2304b
Direzione Scientifica, S. Squatrito, Catania Direttore, Responsabile Stefano Melloni
{"title":"Il ruolo dello svuotamento gastrico nell’omeostasi e nella controregolazione glucidica","authors":"Direzione Scientifica, S. Squatrito, Catania Direttore, Responsabile Stefano Melloni","doi":"10.30682/ildia2304b","DOIUrl":"https://doi.org/10.30682/ildia2304b","url":null,"abstract":"Maintenance of plasma glucose (PG) homeostasis is accomplished thanks to a complex network system. Even a minor fall in PG may activate multiple neuroendocrine actions promoting hierarchical responses, to prevent and ultimately recover hypoglycemia, primarily neuroglycopenia. Among these responses, gastric emptying (GE) plays an important role by coordinated mechanisms which regulate transit and absorption of nutrients through the small intestine. A bidirectional relationship between GE and glycemia has been established: GE may explain the up to 30-40% variance in glycemic response following a carbohydrate-rich meal. In addition, acute and chronic hyperglycemia induce deceleration of GE after meals. Hypoglycemia accelerates GE, in order to speed up carbohydrate absorption, but its role in counterregulation has been poorly investigated, although it was recognized shortly after the initial use of insulin in human.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139618789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
La rigenerazione del miocardio nello scompenso cardiaco: ieri, oggi e domani 心力衰竭的心肌再生：昨天、今天和明天
Il Diabete Pub Date : 2024-01-16 DOI: 10.30682/ildia2304f
{"title":"La rigenerazione del miocardio nello scompenso cardiaco: ieri, oggi e domani","authors":"","doi":"10.30682/ildia2304f","DOIUrl":"https://doi.org/10.30682/ildia2304f","url":null,"abstract":"Heart failure is the leading cause of death worldwide, due to the limited capacity of the adult heart to regenerate. Today, the treatment of heart failure is based on the use of devices, pharmacological therapy of symptoms, and heart transplantation. However, these approaches do not represent a long-term solution and the availability of heart donors is inadequate. For this reason, there is great interest in regenerative medicine to treat heart failure. This review summarizes primary strategies of cardiac regenerative medicine, their present status, and future perspectives and challenges.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"34 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La medicina cardiometabolica nell’obesità 肥胖症的心脏代谢医学
Il Diabete Pub Date : 2024-01-16 DOI: 10.30682/ildia2304d
Direzione Scientifica, S. Squatrito, Catania Direttore, Responsabile Stefano Melloni, L. Frittitta, Dario Tuccinardi, Mikiko Watanabe, S. Manfrini
{"title":"La medicina cardiometabolica nell’obesità","authors":"Direzione Scientifica, S. Squatrito, Catania Direttore, Responsabile Stefano Melloni, L. Frittitta, Dario Tuccinardi, Mikiko Watanabe, S. Manfrini","doi":"10.30682/ildia2304d","DOIUrl":"https://doi.org/10.30682/ildia2304d","url":null,"abstract":"The rising prevalence of obesity worldwide has become a significant health issue, particularly as a key risk factor for cardiovascular disease (CVD). Obesity is linked to various cardiac complications, such as coronary artery disease, heart failure, and an increased risk of sudden cardiac events. It also contributes to other cardiovascular risk factors like dyslipidemia, type 2 diabetes, hypertension, and sleep disorders, heightening the risk of CVD. Understanding the pathophysiology connecting obesity and CVD is essential for effective treatment in obese patients. This includes considering adipose tissue dysfunction, chronic inflammation, immune dysregulation, and changes in the gut microbiome. Recent European Society of Cardiology (ESC) guidelines highlight the critical need to diagnose and treat obesity to prevent CVD. The complex interplay between obesity and CVD presents challenges in clinical practice: obesity can hinder precise CVD diagnosis and necessitates careful tailoring of pharmacological treatments and cardiac procedures. It’s imperative for diabetologists to consider the impact of excess weight in improving cardiometabolic outcomes for those with obesity. This article aims to clarify controversial aspects of managing heart disease in patients with overweight or obesity and reviews evidence on cardiometabolic outcomes from current weight management interventions.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139619627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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