胃排空在平衡和葡萄糖反调节中的作用

Il Diabete Pub Date : 2024-01-16 DOI:10.30682/ildia2304b
Direzione Scientifica, S. Squatrito, Catania Direttore, Responsabile Stefano Melloni
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引用次数: 3

摘要

血浆葡萄糖(PG)平衡的维持是通过一个复杂的网络系统实现的。即使血浆葡萄糖(PG)略有下降,也会激活多种神经内分泌作用,促进分级反应,以预防并最终恢复低血糖症,主要是神经性糖耐量减低症。在这些反应中,胃排空(GE)通过协调机制调节营养物质通过小肠的转运和吸收,发挥着重要作用。胃排空与血糖之间的双向关系已经确立:在进食富含碳水化合物的食物后,GE 可解释高达 30-40% 的血糖反应差异。此外,急性和慢性高血糖会导致餐后血糖生成素减速。低血糖会加速血糖生成,以加快碳水化合物的吸收,但低血糖在反调节中的作用却鲜有研究,尽管在人类首次使用胰岛素后不久,人们就认识到了这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Il ruolo dello svuotamento gastrico nell’omeostasi e nella controregolazione glucidica
Maintenance of plasma glucose (PG) homeostasis is accomplished thanks to a complex network system. Even a minor fall in PG may activate multiple neuroendocrine actions promoting hierarchical responses, to prevent and ultimately recover hypoglycemia, primarily neuroglycopenia. Among these responses, gastric emptying (GE) plays an important role by coordinated mechanisms which regulate transit and absorption of nutrients through the small intestine. A bidirectional relationship between GE and glycemia has been established: GE may explain the up to 30-40% variance in glycemic response following a carbohydrate-rich meal. In addition, acute and chronic hyperglycemia induce deceleration of GE after meals. Hypoglycemia accelerates GE, in order to speed up carbohydrate absorption, but its role in counterregulation has been poorly investigated, although it was recognized shortly after the initial use of insulin in human.
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