脂肪变性:当瘦并不等同于代谢健康时

Il Diabete Pub Date : 2024-07-11 DOI:10.30682/ildia2402d
Lavinia Palladino, G. Ceccarini, D. Gilio, Silvia Magno, Caterina Pelosini, Melania Paoli, M. Sessa, Ferruccio Santini
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引用次数: 0

摘要

脂肪营养不良综合征是一种罕见的异质性疾病,对健康有重大影响,损害生活质量。其特征是先天性或后天性完全或部分脂肪组织缺乏,通常伴有血清瘦素水平低和严重的代谢异常,如糖尿病和血脂异常。由于表型多变且发病率低,诊断具有挑战性。治疗需要采用多学科方法,包括改变生活方式,并可能需要瘦素替代疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LIPODISTROFIE: QUANDO MAGRO NON È SINONIMO DI METABOLICAMENTE SANO
Lipodystrophy syndromes are rare, heterogeneous disorders with significant health impacts, compromising quality of life. Characterized by complete or partial adipose tissue deficiency, either congenital or acquired, they are often associated with low serum leptin levels and severe metabolic abnormalities like diabetes mellitus and dyslipidemia. Diagnosis is challenging due to phenotypic variability and low prevalence. Management requires a multidisciplinary approach, including lifestyle changes and may necessitate leptin replacement therapy.
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