肥胖症的心脏代谢医学

Il Diabete Pub Date : 2024-01-16 DOI:10.30682/ildia2304d
Direzione Scientifica, S. Squatrito, Catania Direttore, Responsabile Stefano Melloni, L. Frittitta, Dario Tuccinardi, Mikiko Watanabe, S. Manfrini
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引用次数: 0

摘要

全球肥胖症发病率的上升已成为一个重大的健康问题,尤其是作为心血管疾病(CVD)的一个关键风险因素。肥胖与各种心脏并发症有关,如冠状动脉疾病、心力衰竭和突发心脏事件的风险增加。肥胖还会导致其他心血管风险因素,如血脂异常、2 型糖尿病、高血压和睡眠障碍,从而增加患心血管疾病的风险。了解肥胖与心血管疾病之间的病理生理学联系对于肥胖患者的有效治疗至关重要。这包括考虑脂肪组织功能障碍、慢性炎症、免疫失调和肠道微生物组的变化。最近的欧洲心脏病学会(ESC)指南强调了诊断和治疗肥胖症以预防心血管疾病的迫切需要。肥胖与心血管疾病之间复杂的相互作用给临床实践带来了挑战:肥胖会阻碍心血管疾病的精确诊断,因此必须谨慎调整药物治疗和心脏手术。糖尿病专家必须考虑超重对改善肥胖患者心脏代谢结果的影响。本文旨在澄清在管理超重或肥胖患者心脏病方面存在的争议,并回顾当前体重管理干预措施对心脏代谢结果的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
La medicina cardiometabolica nell’obesità
The rising prevalence of obesity worldwide has become a significant health issue, particularly as a key risk factor for cardiovascular disease (CVD). Obesity is linked to various cardiac complications, such as coronary artery disease, heart failure, and an increased risk of sudden cardiac events. It also contributes to other cardiovascular risk factors like dyslipidemia, type 2 diabetes, hypertension, and sleep disorders, heightening the risk of CVD. Understanding the pathophysiology connecting obesity and CVD is essential for effective treatment in obese patients. This includes considering adipose tissue dysfunction, chronic inflammation, immune dysregulation, and changes in the gut microbiome. Recent European Society of Cardiology (ESC) guidelines highlight the critical need to diagnose and treat obesity to prevent CVD. The complex interplay between obesity and CVD presents challenges in clinical practice: obesity can hinder precise CVD diagnosis and necessitates careful tailoring of pharmacological treatments and cardiac procedures. It’s imperative for diabetologists to consider the impact of excess weight in improving cardiometabolic outcomes for those with obesity. This article aims to clarify controversial aspects of managing heart disease in patients with overweight or obesity and reviews evidence on cardiometabolic outcomes from current weight management interventions.
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