MEDICINA RIGENERATIVA E DIABETE DI TIPO 1: I PROGRESSI DELLA BIOINGEGNERIA APPLICATI ALLA SOSTITUZIONE DELLA FUNZIONE BETA-CELLULARE

Abstract

Intrahepatic islet transplantation holds promise for T1D treatment, yet faces challenges like inflammatory storms and graft revascularization delays. Endocrine pancreas bioengineering, especially with encapsulation technologies, aims to recreate vascular and endocrine compartments ex vivo to generate a functional device for successful in vivo application. This review explores the synergy of diverse encapsulation techniques and alternative cell sources in crafting a functional vascularized endocrine scaffold.