Borislav Dinov, Samuel Sossalla, Nikolaos Tsianakas, Kerstin Piayda
{"title":"Role of atrial fibrillation ablation in the management of atrial mitral and atrial tricuspid regurgitation: a case report.","authors":"Borislav Dinov, Samuel Sossalla, Nikolaos Tsianakas, Kerstin Piayda","doi":"10.1093/ehjcr/ytaf397","DOIUrl":"10.1093/ehjcr/ytaf397","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) and functional mitral regurgitation (FMR) frequently coexist. Surgical treatment or transcatheter edge-to-edge repair is the standard of care for severe FMR. In patients with atrial FMR (aFMR), atrial fibrillation is an important precipitating factor. Since catheter ablation (CA) is a safe and effective treatment of AF, it has been suggested that it may decrease the severity of aFMR. However, data are scarce and the mechanisms of aFMR improvement are not completely understood.</p><p><strong>Case summary: </strong>We describe a case of an 86-year-old female with a history of AF and previous pulmonary vein isolation presenting with symptoms of acutely decompensated heart failure and recurrence of atrial flutter. Her echocardiography demonstrated non-dilated left ventricle with a normal ejection fraction, left atrial (LA) dilatation, severe FMR, and tricuspid regurgitation (TR). Due to failed electrical cardioversion and amiodarone intolerance, a successful catheter ablation of a LA flutter was performed. Electro-anatomical mapping revealed extensive LA low-voltage areas. During the follow-up of 18 months, the patient remained in sinus rhythm, and the FMR improved to MR II (effective regurgitant orifice area of 9 mm<sup>2</sup> and regurgitant volume of 18 mL); no improvement of the TR occurred.</p><p><strong>Discussion: </strong>Catheter ablation can restore sinus rhythm, decrease LA volume, and improve the severity of atrial FMR. Reverse LA electrical remodelling plays a minor role in the amelioration of MR. Lack of improvement of the TR suggests a different mechanism of TR.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 8","pages":"ytaf397"},"PeriodicalIF":0.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Resistant hypertension treated with laparoscopic-assisted renal denervation in a patient with end-stage renal disease: a case report.","authors":"Jiapeng Chu, Xiaolong Liu, Chunlai Shao","doi":"10.1093/ehjcr/ytaf387","DOIUrl":"10.1093/ehjcr/ytaf387","url":null,"abstract":"<p><strong>Background: </strong>In patients with end-stage renal disease (ESRD) on dialysis, hypertension is commonly detected and inadequately controlled despite the use of multiple anti-hypertensive medications. Sympathetic hyperactivation is a key feature in chronic kidney disease and can be targeted by renal denervation (RDN).</p><p><strong>Case summary: </strong>A 47-year-old male patient with pharmacologically resistant hypertension and ESRD on peritoneal dialysis underwent radiofrequency renal nerve ablation using a laparoscopic-assisted system. During the 6-month follow-up after the operation, we observed a remarkable and sustained reduction in blood pressure, with a significant decrease in oral anti-hypertensive medications.</p><p><strong>Discussion: </strong>This case demonstrates the safety and effectiveness of laparoscopic-assisted RDN for lowering blood pressure. This technology, as an alternative to catheter-based RDN, bears the potential for wider application in high-risk patients with severe renal failure.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 8","pages":"ytaf387"},"PeriodicalIF":0.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erika Tempo, Edoardo Bertero, Gabriele Crimi, Matteo Vercellino, Italo Porto
{"title":"Treatment of impending paradoxical embolism with systemic thrombolysis and cerebral embolic protection: a case report.","authors":"Erika Tempo, Edoardo Bertero, Gabriele Crimi, Matteo Vercellino, Italo Porto","doi":"10.1093/ehjcr/ytaf391","DOIUrl":"10.1093/ehjcr/ytaf391","url":null,"abstract":"<p><strong>Background: </strong>Impending paradoxical embolism is a rare and life-threatening occurrence and evidence guiding its optimal management is lacking.</p><p><strong>Case presentation: </strong>A 73-year-old man presenting with ST-elevation myocardial infarction was diagnosed with impending paradoxical embolism, as a large thrombus was visualized entrapped in a patent foramen ovale. We performed systemic thrombolysis after deployment of a cerebral protection device, which resulted in complete dissolution of the thrombus without major thromboembolic events. Thrombolysis was complicated by development of intracranial haemorrhage that resolved without major neurological sequelae. The patient was discharged on a direct oral anticoagulant.</p><p><strong>Discussion: </strong>Treatment strategies for impending paradoxical embolism include surgical thrombectomy, percutaneous thrombus retrieval, and systemic thrombolysis. We report for the first time the effective use of a cerebral embolic protection device to reduce the risk of ischaemic injury to the brain during systemic thrombolysis.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 8","pages":"ytaf391"},"PeriodicalIF":0.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling diagnostic challenges and therapeutic triumphs: endovascular management of a paediatric internal carotid artery pseudoaneurysm-a case report.","authors":"Zubair Farooq, Sachin Gautam, Abhinav Aggarwal, Preeti Gupta","doi":"10.1093/ehjcr/ytaf372","DOIUrl":"10.1093/ehjcr/ytaf372","url":null,"abstract":"<p><strong>Background: </strong>Internal carotid artery (ICA) pseudoaneurysms (PSAs) are exceedingly rare in the paediatric population and may arise secondary to infections, trauma, or congenital vessel wall abnormalities. Their diagnosis can be challenging due to non-specific presentations and a lack of established guidelines in children. Early recognition and appropriate intervention are critical, as complications such as rupture can be life-threatening. This case adds to the limited literature on paediatric ICA PSAs and highlights the role of endovascular treatment.</p><p><strong>Case summary: </strong>A 5-year-old boy presented with a pulsatile neck swelling persisting for 3 months, intermittent fever, and an episode of oral bleeding. Physical examination revealed a globular, pulsatile neck mass below the angle of the mandible, and imaging confirmed a right ICA PSA with a surrounding haematoma. A possible infectious or traumatic aetiology was considered. Due to the risk of rupture during intubation, a tracheostomy was performed to secure the airway. The PSA was successfully treated with endovascular coiling while preserving collateral circulation. Post-procedure recovery required intensive care monitoring due to intraoperative complications. However, the child was discharged with no neurological deficits, and at 1-month follow-up, the neck swelling had markedly reduced.</p><p><strong>Discussion: </strong>This case emphasizes the importance of considering both infectious and traumatic aetiologies in paediatric vascular lesions. It highlights the need for a multidisciplinary approach, tailored airway management, and individualized therapeutic strategies to achieve successful outcomes.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 8","pages":"ytaf372"},"PeriodicalIF":0.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauritz Schoof, Marc D Lemoine, Gerold Söffker, Andreas Rillig, Shinwan Kany
{"title":"Pulsed field ablation for rhythm control in acute heart failure and extracorporeal membrane oxygenation: a case report.","authors":"Lauritz Schoof, Marc D Lemoine, Gerold Söffker, Andreas Rillig, Shinwan Kany","doi":"10.1093/ehjcr/ytaf373","DOIUrl":"10.1093/ehjcr/ytaf373","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) can be associated with acute heart failure (HF) and can complicate cardiogenic shock. The interaction between AF and HF is challenging, both diagnostically and therapeutically. While AF ablation has been shown to be beneficial in patients with HF, the role of interventional treatment of AF in acute HF remains largely unexplored.</p><p><strong>Case summary: </strong>A 59-year-old male patient was admitted from an outside hospital after a prolonged intensive care stay developing acute respiratory failure with concomitant acute HF. Previously, the patient experienced a cardiogenic shock after a non-synchronized cardioversion that induced ventricular fibrillation at the end of an AF ablation procedure. After initial improvement, he was transferred to a rehabilitation hospital where he showed signs of respiratory failure and HF. Upon transfer to our hospital, a veno-arterial-venous extracorporeal membrane oxygenation (VAV-ECMO) device was implanted in addition to diuretic and inotropic therapy. While the respiratory function steadily improved, allowing de-escalation to a VV-ECMO device, recurrent episodes of AF with rapid ventricular rate were observed. This resulted in a severely reduced biventricular function despite antiarrhythmic therapy with amiodarone. We opted for pulsed field ablation (PFA) of the pulmonary veins, which finally enabled us to explant the ECMO system under sustained sinus rhythm and improved haemodynamics. An echocardiographic assessment 3 weeks post-ablation demonstrated improved cardiac function and maintained sinus rhythm.</p><p><strong>Discussion: </strong>This case illustrates the complexities of treating patients with acute HF and AF. Our experience highlights the value of the fast, efficient, and safe PFA modality for ablation in critically ill patients.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 8","pages":"ytaf373"},"PeriodicalIF":0.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zheng Liu, Kun Zuo, Dongdong Deng, Ling Xia, Jianjun Zhang
{"title":"Case report of ventricular tachycardia simulation facilitated ablation for refractory ventricular arrhythmia post-myocardial infarction: aiming before firing.","authors":"Zheng Liu, Kun Zuo, Dongdong Deng, Ling Xia, Jianjun Zhang","doi":"10.1093/ehjcr/ytaf384","DOIUrl":"10.1093/ehjcr/ytaf384","url":null,"abstract":"<p><strong>Background: </strong>The management of ventricular arrhythmias (VA) following myocardial infarction presents substantial challenges due to the high morbidity and mortality rates, particularly in cases refractory to medical therapy. In certain cases, the arrhythmogenic anatomical substrate is located in the epicardium. Consequently, achieving a transmural injury by endocardial catheter ablation has always been infeasible.</p><p><strong>Case summary: </strong>The present describes a case of refractory VA after unsuccessful endocardial ablation associated with a previous myocardial infarction. Consequently, the successful attempts were implemented through transcoronary venous ethanol ablation targeted at the site of epicardial sustained re-entry in the simulation process, generated from cardiac late gadolinium-enhanced magnetic resonance imaging.</p><p><strong>Discussion: </strong>Ventricular tachycardia simulation guided by cardiac magnetic resonance optimizes ablation strategies for scar-related arrhythmias, while transvenous ethanol ablation serves as a safe alternative when epicardial access is restricted. Further validation is needed to enhance its precision in clinical practice.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 8","pages":"ytaf384"},"PeriodicalIF":0.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea D'Amuri, Pietro Di Gangi, Mauro Pagani, Corrado Lettieri
{"title":"The challenge of secondary cardiovascular prevention in very high Lipoprotein (a) level: a case report.","authors":"Andrea D'Amuri, Pietro Di Gangi, Mauro Pagani, Corrado Lettieri","doi":"10.1093/ehjcr/ytaf389","DOIUrl":"10.1093/ehjcr/ytaf389","url":null,"abstract":"<p><strong>Background: </strong>While advances in technology and procedural techniques have significantly improved outcomes post-PCI, two pharmacological strategies have gained particular attention for their effectiveness in reducing long-term cardiovascular (CV) risk: anti-platelet therapies and lipid-lowering therapies (LLT). The 10-year recurrence risk for major CV events remains as high as 10-30%, due to various pathophysiological pathways collectively known as residual risk (RR), even with optimal CV risk factor management after acute coronary syndrome (ACS). RR includes factors such as elevated lipoprotein(a) [Lp(a)], triglycerides, pro-thrombotic states, hyperglycemia, and persistent subclinical arterial inflammation.</p><p><strong>Aims: </strong>This case highlights the challenge of managing a patient with multiple recurrent cardiac ischaemic events and in-stent restenosis, despite good medical therapy and no other significant CV risk factors except for markedly elevated Lp(a) levels.</p><p><strong>Conclusion: </strong>Three critical aspects of daily practice emerge from our observation. First, Lp(a) is a valuable parameter for CV risk stratification in primary prevention. Second, measurement of Lp(a) post-CV event may provide valuable information on the risk of ischaemic recurrence, influencing decisions regarding long-term dual anti-platelet therapy (DAPT). Finally, this case illustrates the importance of a multidisciplinary approach in managing patients with very high cardiovascular risk. Close collaboration between cardiologists and lipidologists facilitated the identification of a rare lipid disorder and the decision to pursue lipoprotein apheresis, an intensive but effective treatment option for lipid metabolism disorders lacking conventional medical therapy.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 9","pages":"ytaf389"},"PeriodicalIF":0.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful resection of a large asymptomatic lipoma in the left ventricle with infiltration of the myocardial free wall: a case report.","authors":"Tobias Heer, Christian Hagl, Stefan Sack","doi":"10.1093/ehjcr/ytaf395","DOIUrl":"10.1093/ehjcr/ytaf395","url":null,"abstract":"","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 8","pages":"ytaf395"},"PeriodicalIF":0.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rajin Choudhury, Victor H Jimenez-Zepeda, Etienne Mahe, Nowell M Fine
{"title":"Case report of isolated aortic valve AL-amyloidosis following aortic valve replacement.","authors":"Rajin Choudhury, Victor H Jimenez-Zepeda, Etienne Mahe, Nowell M Fine","doi":"10.1093/ehjcr/ytaf393","DOIUrl":"10.1093/ehjcr/ytaf393","url":null,"abstract":"<p><strong>Background: </strong>Light chain (AL)-amyloidosis is a haematologic malignancy where cardiac involvement confers a worse prognosis. There is a recognized association between aortic stenosis (AS) and transthyretin amyloidosis (ATTR) cardiomyopathy. However, there is no such reported association with AL amyloidosis.</p><p><strong>Case summary: </strong>We present a case of degenerative AS where the pathology analysis post-surgical replacement demonstrated amyloid deposits subsequently identified as AL subtype by mass spectrometry. Subsequent investigations demonstrated no myocardial or systemic involvement. Following multidisciplinary discussion, cardiac biopsy and chemotherapy were deferred given the isolated nature of aortic valve involvement and clinical stability.</p><p><strong>Discussion: </strong>Incidental detection of aortic valve AL-amyloidosis in this case demonstrates that such deposits cannot be assumed to be ATTR, and further work-up and amyloid typing is necessary.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 9","pages":"ytaf393"},"PeriodicalIF":0.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lac Duy Le, Binh Duc Doan, Anh Thai Nguyen, Tri Cong Le, Thanh Tri Vu
{"title":"Concurrent inferior stemi with third-degree AV block and acute intracranial haemorrhage: how we overcame this clinical challenge-a case report.","authors":"Lac Duy Le, Binh Duc Doan, Anh Thai Nguyen, Tri Cong Le, Thanh Tri Vu","doi":"10.1093/ehjcr/ytaf385","DOIUrl":"10.1093/ehjcr/ytaf385","url":null,"abstract":"<p><strong>Background: </strong>The concurrent management of ST-elevation myocardial infarction (STEMI) and acute intracerebral haemorrhage (ICH) poses a significant clinical challenge due to conflicting treatment goals. While the management of STEMI requires coronary reperfusion with antithrombotic agents (anticoagulants and antiplatelets), such treatments are contraindicated in cases of ICH. The coexistence of STEMI and ICH is exceedingly rare in the literature and is associated with high mortality rates. Furthermore, no specific guidelines currently exist for managing such cases.</p><p><strong>Case summary: </strong>We report a case of a 67-year-old male presenting with acute ICH who subsequently developed inferior STEMI complicated by third-degree atrioventricular block. The patient underwent a deferred percutaneous coronary intervention (PCI) strategy, involving only balloon angioplasty and thrombectomy without stent placement, to restore coronary flow while minimizing the risk of exacerbating the intracranial haemorrhage. Three days later, ischaemia progressed to recurrent myocardial infarction, at which point reassessment revealed stabilization of the ICH, allowing for stent placement in the right coronary artery (RCA) and the administration of antithrombotic therapy.</p><p><strong>Discussion: </strong>The deferred PCI strategy, involving initial thrombectomy and balloon angioplasty without stent placement, facilitated temporary restoration of coronary flow and provided a critical time window for the stabilization of the ICH. This approach enabled subsequent stent implantation and the reintroduction of antithrombotic therapy (anticoagulants and antiplatelets). This strategy demonstrates its effectiveness in managing patients with concurrent STEMI and ICH by balancing the risks of ischaemia and haemorrhage, thereby improving clinical outcomes.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 8","pages":"ytaf385"},"PeriodicalIF":0.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}