{"title":"Drug challenge test for early symptom control in patients with coronary artery spasm: a case report.","authors":"Yoshiaki Kawase, Kento Kikuchi, Takuya Mizukami, Hitoshi Matsuo","doi":"10.1093/ehjcr/ytaf134","DOIUrl":"10.1093/ehjcr/ytaf134","url":null,"abstract":"<p><strong>Background: </strong>Calcium channel blockers are the first-line treatment option, followed by long-acting nitrates or nicorandil as second-line medications for patient with coronary artery spasm (CAS). However, there are cases where symptoms cannot be controlled by a combination of these drugs. The drug choice after first- and second-line treatment options is varied and challenging.</p><p><strong>Case summary: </strong>A 70-year-old woman presented to our hospital with complaints of angina at rest. The patient was diagnosed with CAS based on a positive acetylcholine provocation test result. Nitrates were intolerable due to headaches. The combination of calcium channel blocker and nicorandil was not effective in mitigating her symptoms. Four potential symptom relief drugs-trimetazidine, shigyakusan, keishibukuryogan, and denopamine-were prescribed. Each drug was administered for one week, and symptom improvement was assessed one month later. Two drugs (shigyakusan and keishibukuryogan) were effective in relieving her symptoms, but neither was satisfactory on its own. Therefore, these two drugs were combined and added on top of the calcium channel blocker and nicorandil. Her symptoms were well controlled thereafter.</p><p><strong>Discussion: </strong>The drug challenge test, which involves prescribing various types of drugs for short durations to evaluate their effects, may be an effective option for quickly controlling symptoms in patients with refractory CAS who exhibit frequent symptoms.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf134"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ludovic Maxo, Mohammed Nejjari, Franck Digne, Arthur Darmon
{"title":"How to deal with an entrapped nose cone during transcatheter aortic valve replacement with the Evolut® platform: images in cardiology.","authors":"Ludovic Maxo, Mohammed Nejjari, Franck Digne, Arthur Darmon","doi":"10.1093/ehjcr/ytaf176","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf176","url":null,"abstract":"","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf176"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of arrhythmia and heart failure in a 60-year-old with unrepaired D-transposition of the great arteries, atrial septal defect, and partial anomalous pulmonary venous return: a case report.","authors":"Tomoko Machino-Ohtsuka, Miyako Igarashi, Naoto Kawamatsu, Tomoko Ishizu","doi":"10.1093/ehjcr/ytaf170","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf170","url":null,"abstract":"<p><strong>Background: </strong>Dextro-transposition of the great arteries (d-TGA) typically results in death within the first year of life without surgery. Shunts can allow sufficient blood mixing and survival into adulthood; however, survival of patients with unrepaired d-TGA beyond 60 years has not been reported.</p><p><strong>Case summary: </strong>A 60-year-old woman with unrepaired d-TGA, an unrestricted atrial septal defect, and partial anomalous pulmonary venous return presented with recurrent syncope due to atrial tachycardia (AT) following two sessions of radiofrequency catheter ablation (RFCA) and sinus node dysfunction. She had a history of recurrent heart failure (HF) because of severe systemic right ventricle (sRV) dysfunction and tricuspid regurgitation. Multiple inducible ATs persisted even after repeated RFCA, making pacemaker implantation (PMI) and anti-arrhythmic therapy the preferred options. Although transvenous lead implantation was relatively contraindicated due to the presence of an intracardiac shunt, transvenous DDD PMI was deemed the most viable option considering the patient's fragile haemodynamic state. Pacing studies indicated that sRV pacing was superior to left ventricular septal pacing, as it reduced the QRS duration and improved RV synchrony. Following successful sRV septal lead implantation and atrioventricular delay (AVD) optimization, HF symptoms improved, ATs were suppressed with amiodarone, and syncope resolved. The patient remained stable for 2 years with no thromboembolic events under apixaban therapy and no HF or arrhythmia recurrence.</p><p><strong>Discussion: </strong>Although continuous close monitoring is warranted, endocardial pacing, AVD optimization, and medication enabled effective stabilization over 2 years in this rare case of unrepaired d-TGA with bradytachyarrhythmia and sRV dysfunction.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf170"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Donovon Allen, Ahmed Saleh, Kais Tounsi, Alexander Yang, Min Xie
{"title":"Supra-aortic valve tendon mimicking an acute aortic dissection: a case report.","authors":"Donovon Allen, Ahmed Saleh, Kais Tounsi, Alexander Yang, Min Xie","doi":"10.1093/ehjcr/ytaf160","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf160","url":null,"abstract":"","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf160"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A heart full of nails: complex management of multiple nail gun cardiac injuries.","authors":"Shaun Abid, Anton Stolear, Stuart Zarich","doi":"10.1093/ehjcr/ytaf168","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf168","url":null,"abstract":"","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf168"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Del Mestre, Teresa Maria Capovilla, Alessia Paldino, Marco Cittar, Martina Setti, Matteo Dal Ferro, Marco Merlo, Gianfranco Sinagra
{"title":"The contribution of cardiopulmonary exercise testing in the familial screening for dilated and non-dilated left ventricular cardiomyopathies: case series.","authors":"Eva Del Mestre, Teresa Maria Capovilla, Alessia Paldino, Marco Cittar, Martina Setti, Matteo Dal Ferro, Marco Merlo, Gianfranco Sinagra","doi":"10.1093/ehjcr/ytaf162","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf162","url":null,"abstract":"<p><strong>Background: </strong>The importance of family screening in relatives of patients affected by cardiomyopathies is highlighted in the international guidelines. Although electrocardiogram (ECG) and echocardiogram represent cornerstones of family screening, they may not always be sufficient to detect subtle abnormalities, especially in genotype-positive/phenotype-negative relatives. The role of cardiopulmonary exercise testing (CPET) in providing additional clinical information during family screening, remains to be fully elucidated.</p><p><strong>Case summary: </strong>Ten asymptomatic genotype-positive/phenotype-negative first-degree relatives of probands affected by dilated cardiomyopathy (DCM) and non-dilated left ventricular cardiomyopathy (NDLVC) were evaluated in the context of family screening. Cardiopulmonary exercise testing was integrated into the initial diagnostic evaluation. Two out of 10 relatives showed an abnormal CPET, with alteration in O<sub>2</sub> kinetic.</p><p><strong>Discussion: </strong>Family screening in relatives of DCM and NDLVC patients, particularly in genotype-positive/phenotype-negative subjects, remains challenging due to difficulties in assessing the subtle abnormalities that may represent an initial clinical manifestation of the disease and support early treatment initiation. A more accurate and comprehensive familial screening may be achieved by integrating ECG and echocardiogram-the current first-line assessments-with data from additional tools, such as global longitudinal strain on echocardiogram, cardiac magnetic resonance, Holter ECG, and CPET.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf162"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case report of MYH7 mutation-induced restrictive cardiomyopathy.","authors":"Shaozhen Zhang, Wang Zhao","doi":"10.1093/ehjcr/ytaf166","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf166","url":null,"abstract":"<p><strong>Background: </strong>Restrictive cardiomyopathy (RCM) is characterized by impaired diastolic function and ventricular filling, often due to genetic and environmental factors. The <i>MYH7</i> gene, encoding myosin heavy chain in muscle fibres critical for muscle contraction, has been implicated in RCM.</p><p><strong>Case summary: </strong>We describe the case of a female patient who was presented with recurrent chest tightness and shortness of breath. Based on imagining findings and genetic testing, she was diagnosed with <i>MYH7</i>-induced RCM. Her daughter inherited the same variant but presented with a hypertrophic phenotype.</p><p><strong>Conclusion: </strong><i>MYH7</i>-induced cardiomyopathy is a complex condition, associated with variable clinical presentation and phenotype. While imagining and endomyocardial biopsy play important roles in diagnosing RCM, their application might be limited for economic and safety reasons. Further research is needed to elucidate the pathogenesis and develop safer and cheaper approaches to diagnose <i>MYH7</i>-induced restrictive cardiomyopathy.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf166"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martin Benedikt, Martin Manninger, Anna-Sophie Eberl, Dirk von Lewinski, Daniel Scherr
{"title":"Post-traumatic ventricular septal defect manifesting as intermittent third-degree atrioventricular block: a case report.","authors":"Martin Benedikt, Martin Manninger, Anna-Sophie Eberl, Dirk von Lewinski, Daniel Scherr","doi":"10.1093/ehjcr/ytaf172","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf172","url":null,"abstract":"<p><strong>Background: </strong>Traumatic cardiac injuries are rare, but patients may present with symptoms like arrhythmias, heart failure, or cardiogenic shock.</p><p><strong>Case summary: </strong>A 50-year-old Caucasian construction worker was admitted to our emergency department with a new-onset third-degree atrioventricular (AV) block following a traumatic blunt chest injury at work. The arrhythmia was controlled by a continuous application of isoprenaline. After stabilization, the electrocardiogram showed sinus rhythm with a new-onset left bundle branch block. Transthoracic echocardiography revealed a ventricular septal defect, which could be confirmed by transoesophageal echocardiography, including a contrast study; however, the patient was initially rejected for acute cardiac surgery due to haemodynamic stable conditions. After several hours, the patient developed acute dyspnoea with pulmonary oedema and cardiogenic shock. Echocardiography revealed severe tricuspid regurgitation caused by rupture of the anterior papillary muscle, and the patient was immediately transferred to the department for cardiac surgery for acute ventricular septal patch plastic and tricuspid valve replacement. Post-surgery, the patient developed haemodynamically compromising third-degree AV block, required catecholamines and temporary transvenous pacing. A permanent pacemaker implantation was performed on the following day.</p><p><strong>Discussion: </strong>Mechanical complications after blunt chest injury are rare and surgical repair in unstable conditions are still the treatment of choice. In concomitant conduction disorders, close monitoring for arrythmias is obligatory in the early phase; however, implantation of a permanent pacemaker is often necessary.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf172"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Luisa Benesch Vidal, Han Ki Park, Kouichi Toda, Geetha Kandavello, Lucy Youngmin Eun, Dominica Zentner, Motoki Komori, Christoph Sinning
{"title":"Congenitally corrected transposition of the great arteries: one disease, diverse manifestations-a case series.","authors":"Maria Luisa Benesch Vidal, Han Ki Park, Kouichi Toda, Geetha Kandavello, Lucy Youngmin Eun, Dominica Zentner, Motoki Komori, Christoph Sinning","doi":"10.1093/ehjcr/ytaf174","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf174","url":null,"abstract":"<p><strong>Background: </strong>Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart defect with heterogenous clinical manifestations that can pose both diagnostic and management challenges throughout life.</p><p><strong>Case summary: </strong>We describe four patients with ccTGA and different presentations including sudden cardiac arrest, progressive heart failure, post-partum heart failure, and NSTEMI.</p><p><strong>Aims and discussion: </strong>This case series aims to illustrate the importance of multimodality imaging to assist the diagnosis and support treatment strategies in patients with ccTGA. Direct long-term sequalae, such as arrythmias and heart failure, and the associated management challenges are highlighted. Additionally, the challenges of managing pregnancy with a sRV and the development of acquired heart disease demonstrate the clinical care challenges in caring for this population across the life span.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf174"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling the invisible culprit: a multimodality approach for myocardial infarction with non-obstructive coronary arteries diagnosis-a case report.","authors":"Riccardo Terzi, Pasquale Paolisso, Francesca Di Lenarda, Edoardo Conte, Emanuele Gallinoro","doi":"10.1093/ehjcr/ytaf173","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf173","url":null,"abstract":"<p><strong>Background: </strong>Myocardial infarction with non-obstructive coronary arteries (MINOCA) affects up to 10% of patients undergoing coronary angiography for acute myocardial infarction. Despite the lack of obstructive lesions, these patients face significant risks, requiring thorough diagnostic evaluations, often using both invasive and non-invasive methods. Recent guidelines emphasize the importance of performing intravascular imaging, coronary functional testing (CFT), and cardiac magnetic resonance (CMR) in the working diagnosis of MINOCA.</p><p><strong>Case summary: </strong>A 48-year-old woman presented with chest pain, elevated cardiac troponins, and signs of non-ST-elevation myocardial infarction. Echocardiography showed normal left ventricular ejection fraction with focal inferior-lateral mid-apical hypokinesia and no significant valvular heart disease. Coronary angiography revealed normal arteries with hypoplasia of the right coronary artery. Further testing, including CMR and CFT with acetylcholine provocation, confirmed severe coronary spasm, diagnosing epicardial vasospastic angina causing MINOCA.</p><p><strong>Discussion: </strong>Diagnosing MINOCA is challenging and requires a multimodal approach. Invasive testing can reveal vasospasm or microvascular dysfunction. This case emphasizes the need for repeated imaging and functional tests to reach a diagnosis. Calcium channel blockers like diltiazem are commonly used in treatment.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf173"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}