Alessandro Parlato, Moneeb Khalaph, Philipp Sommer, Christian Sohns
{"title":"Left atrial substrate modification in addition to pulmonary vein isolation using a novel circular variable loop pulsed field ablation catheter.","authors":"Alessandro Parlato, Moneeb Khalaph, Philipp Sommer, Christian Sohns","doi":"10.1093/ehjcr/ytaf209","DOIUrl":"10.1093/ehjcr/ytaf209","url":null,"abstract":"<p><strong>Background: </strong>Pulsed field ablation (PFA) is a recently developed technology that causes tissue necrosis through electroporation and has been employed and validated for pulmonary vein isolation (PVI) in atrial fibrillation (AF) ablation. Only few devices have received a CE mark for this use and the Varipulse<sup>TM</sup> catheter (Varipulse<sup>TM</sup>, Biosense Webster, Irvine, USA), a variable loop PFA catheter, has been recently approved. Despite the growing experience with PVI, evidence is lacking about the use of PFA catheters and linear ablation lesions, which could potentially be performed with PFA catheters, reducing procedure related costs and time.</p><p><strong>Case summary: </strong>A 73-year-old Caucasian woman with multiple cardiovascular risk factors presented with highly symptomatic paroxysmal AF and was scheduled to undergo PFA AF ablation using the new Varipulse catheter. The procedure was performed under deep sedation and the catheters were advanced through trans-septal puncture. 3D electroanatomic mapping of the left atrium showed significant anterior wall fibrosis. After PVI, substrate modification through an anterior mitral line (AML) approach was pursued. The AML was performed with additional PFA applications and successful bidirectional block was confirmed by pacing maneuvers without any procedural complications. The patient was discharged the following day, asymptomatic and in a state of well-being.</p><p><strong>Conclusion: </strong>Individual LA substrate modification, including linear lesion sets, can be delivered in addition to PVI using the novel Varipulse PFA catheter in patients with AF.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf209"},"PeriodicalIF":0.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extended support of HeartMate 3 with transseptal left atrial cannulation using a modified wire-reinforced graft: a case report.","authors":"Hsun-Yi Fu, Weng-Kin Lou, Heng-Wen Chou, Yih-Sharng Chen","doi":"10.1093/ehjcr/ytaf225","DOIUrl":"10.1093/ehjcr/ytaf225","url":null,"abstract":"<p><strong>Background: </strong>A small left ventricular cavity is one of the major limitations of HeartMate 3 implantation. Therefore, innovations in implantation techniques are required to expand the use of HeartMate 3, the only durable ventricular assist device approved by the US Food and Drug Administration for use in adults.</p><p><strong>Case summary: </strong>A 65-year-old male was diagnosed with multiple myeloma (MM) and cardiac amyloidosis. Guideline-directed medical therapy was used to treat heart failure secondary to restrictive cardiomyopathy with a small left ventricle (LV). However, after three chemotherapy courses for MM, the patient developed refractory acute decompensated heart failure. He underwent urgent HeartMate 3 implantation as a bridge to chemotherapy. We adopted the left atrium-to-aorta configuration for HeartMate 3 implantation and performed trans-septal left atrial cannulation using a modified Intergard Woven vascular graft. After discharge, the patient resumed chemotherapy on post-operative day 172 and achieved complete response on post-operative day 259. At the time of writing this report, he has been supported with HeartMate 3 for 36 months, and no major adverse events have been recorded.</p><p><strong>Discussion: </strong>In most reports of trans-septal left atrial cannulation for durable ventricular assist device implantation, a 20-mm ringed Gore-Tex graft was used as the interposition conduit. Some technical difficulties with this graft have been described. Thus, we decided to modify the Intergard Woven graft as the interposition conduit. The favourable outcome in our patient could suggest the potential of extended support with the left atrium-to-aorta configuration of HeartMate 3 for patients with a small LV.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf225"},"PeriodicalIF":0.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rare cause of MINOCA: embolism of a thrombus arising from accessory mitral valve tissue.","authors":"En Ze Chan, Giap Swee Kang, Amelia Xin Chun Goh","doi":"10.1093/ehjcr/ytaf222","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf222","url":null,"abstract":"","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf222"},"PeriodicalIF":0.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Theodore J Sklavos, Sean Lawrence, Vladimir Andelkovic, Chris Cole, Yohan Chacko
{"title":"Heart team rescues a bleeding heart: a case report of cardiac angiosarcoma causing life-threatening tamponade.","authors":"Theodore J Sklavos, Sean Lawrence, Vladimir Andelkovic, Chris Cole, Yohan Chacko","doi":"10.1093/ehjcr/ytaf220","DOIUrl":"10.1093/ehjcr/ytaf220","url":null,"abstract":"<p><strong>Background: </strong>There are many causes of pericardial effusion and if the accumulating fluid results in cardiac tamponade, it may lead to life-threatening haemodynamic collapse. Therefore, rapid diagnosis and treatment of cardiac tamponade is critical.</p><p><strong>Case summary: </strong>A 53-year-old woman presented to the emergency department with chest pain and undifferentiated shock. A computer tomography (CT) aortogram showed a pericardial effusion, active contrast extravasation (possibly arising from the right coronary artery), but no aortic dissection. Echocardiography confirmed a large pericardial effusion with tamponade physiology. The consensus between cardiology and cardiothoracic surgery was for urgent coronary angiography to identify the source of bleeding. This showed a network of vessels from the right coronary artery that appeared to supply a mass. Re-review of the CT scan and repeat targeted echocardiography showed the silhouette of a mass adjacent to the right atrium. The patient was taken immediately for cardiac surgery. A cardiac tumour extending through the right atrial wall was identified, resected, and subsequently was diagnosed histologically as a cardiac angiosarcoma.</p><p><strong>Discussion: </strong>Malignancy is responsible for only a small proportion of pericardial effusions and metastatic disease is overwhelmingly more common than primary cardiac neoplasms. This case highlights the use of multi-modality cardiac imaging to guide diagnosis and treatment, and the need to consider the rarer causes of haemopericardium in cases where the more common causes have been excluded.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf220"},"PeriodicalIF":0.8,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Loeffler endocarditis revealing chronic eosinophilic leukaemia with FIP1L1-PDGFRA rearrangement: a case report.","authors":"Raid Faraj, Zineb El Bougrini, Aatif Benyass, Youssef Sekkach, Ilyasse Asfalou","doi":"10.1093/ehjcr/ytaf218","DOIUrl":"10.1093/ehjcr/ytaf218","url":null,"abstract":"<p><strong>Background: </strong>Hypereosinophilic syndrome (HES) is an infrequent multisystemic disorder with a serious prognosis, defined by persistent marked eosinophilia (>1500 eosinophils/mm3) associated with organ damage from eosinophil-mediated cytotoxicity. Cardiac involvement is a significant and unpredictable complication of hypereosinophilic syndrome, particularly prevalent in patients carrying the FIP1L1-PDGFRA fusion.</p><p><strong>Case summary: </strong>Reported is a case of chronic eosinophilic leukaemia (CEL) with a FIP1L1-PDGFRA rearrangement, diagnosed in a 31-year-old patient presenting with Loeffler endocarditis. Intracardiac thrombi and embolic cerebral infarctions complicated the case. The patient demonstrated haematological remission following chemotherapy, and anticoagulation treatment led to thrombi resolution.</p><p><strong>Discussion: </strong>This case highlights that Loeffler endocarditis can present as the primary and sole manifestation of chronic eosinophilic leukaemia. Effective collaboration between cardiologists and internists is crucial for timely diagnosis and comprehensive management, ultimately resulting in enhanced outcomes.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf218"},"PeriodicalIF":0.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A young man experiencing dyspnoea after pulmonary embolism: a rare but classical electrocardiogram.","authors":"Lukas Ley, Hossein Ardeschir Ghofrani, Dirk Bandorski","doi":"10.1093/ehjcr/ytaf219","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf219","url":null,"abstract":"","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf219"},"PeriodicalIF":0.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan Karlsson, Niall O'Rourke, Chithra Varghese, Caroline Daly, Rajesh Kumar
{"title":"Complete heart block as the first manifestation of systemic sarcoidosis: a case report highlighting the diagnostic utility of multimodality imaging.","authors":"Ryan Karlsson, Niall O'Rourke, Chithra Varghese, Caroline Daly, Rajesh Kumar","doi":"10.1093/ehjcr/ytaf210","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf210","url":null,"abstract":"<p><strong>Background: </strong>Sarcoidosis is a systemic inflammatory disease of unknown aetiology characterized by the formation of non-caseating granulomas. Cardiac involvement occurs in up to 30% of cases but only manifests clinically in 5%. In young patients presenting with high-grade atrioventricular block, infiltrative processes such as sarcoidosis should be considered in the differential diagnosis.</p><p><strong>Case summary: </strong>We present the case of a 35-year-old male who presented to hospital with symptomatic complete heart block as the first manifestation of multi-system sarcoidosis with cardiac involvement. Initial blood testing, chest x-ray and transthoracic echocardiography were unremarkable, leaving a broad differential to be considered. Cardiac magnetic resonance imaging revealed late gadolinium enhancement in a highly variable and non-coronary distribution, with simultaneous involvement of subepicardial, subendocardial, and midwall tissue. High-resolution computed tomography of the thorax revealed significant intrathoracic lymphadenopathy. Endobronchial ultrasound-guided lymph node sampling and analysis revealed the presence of non-caseating granulomas, providing histological confirmation of the disease. The patient's clinical course was complicated by the development of ventricular standstill, thus insertion of an implantable cardioverter-defibrillator was carried out. Immunosuppressive therapy with oral prednisolone was commenced prior to discharge.</p><p><strong>Discussion: </strong>Cardiac sarcoidosis can produce life-threatening complications if left untreated. Our case serves to highlight the need for consideration of sarcoidosis as a cause for cardiac conduction disease in young patients, and the utility of multimodality imaging in its diagnosis. Cardiac magnetic resonance imaging serves as a useful tool when faced with this clinical picture.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf210"},"PeriodicalIF":0.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rabea Shehadi, Robert Zukerman, Gil Gross, Sergey Yalonetsky
{"title":"A case report of ruptured abdominal aortic aneurysm presenting as an inferior ST elevation myocardial ischaemia.","authors":"Rabea Shehadi, Robert Zukerman, Gil Gross, Sergey Yalonetsky","doi":"10.1093/ehjcr/ytaf214","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf214","url":null,"abstract":"<p><strong>Background: </strong>Ruptured abdominal aortic aneurysm (RAAA) is a life-threatening condition requiring prompt diagnosis and urgent surgical management. Misdiagnosis is common due to atypical presentations, complicating timely treatment.</p><p><strong>Case summary: </strong>This case report presents a rare instance of RAAA initially diagnosed as an ST elevation inferior myocardial infarction (STEMI). An otherwise healthy 66-year-old male presented to the emergency room with syncope while the ECG revealed ST segment elevation in the inferior leads. Urgent coronary angiography demonstrated three-vessel disease with no clear culprit lesion, leading to no intervention. An abdominal CT performed shortly afterward confirmed a ruptured infrarenal abdominal aortic aneurysm.</p><p><strong>Discussion: </strong>This case highlights the importance of considering RAAA in the differential diagnosis of patients presenting with ST segment elevation and no identifiable culprit coronary lesion.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf214"},"PeriodicalIF":0.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transcatheter edge-to-edge repair for post-surgical recurrent mitral regurgitation in hereditary spherocytosis: a case report.","authors":"Hiroto Yagasaki, Yukio Umeda, Takeki Suzuki, Ryota Watanabe, Toshiyuki Noda","doi":"10.1093/ehjcr/ytaf211","DOIUrl":"https://doi.org/10.1093/ehjcr/ytaf211","url":null,"abstract":"<p><strong>Background: </strong>Management of mitral regurgitation (MR) in patients with hereditary spherocytosis (HS) poses unique challenges due to increased haemolysis risk. While surgical mitral valve repair is the standard treatment, the optimal strategy for recurrent MR after initial repair remains unclear, particularly regarding the safety and durability of transcatheter interventions in this high-risk population.</p><p><strong>Case summary: </strong>A 57-year-old woman with HS developed severe recurrent MR 4 years after initial surgical repair that intentionally omitted annuloplasty to minimize haemolysis risk. Given the risks of redo surgery and mechanical valve replacement, mitral valve transcatheter edge-to-edge repair (M-TEER) was performed. The procedure achieved successful MR reduction without causing haemolysis. At the 5-year follow-up, the patient maintained improved functional status with stable moderate MR and no evidence of haemolysis, despite her underlying condition.</p><p><strong>Discussion: </strong>This case demonstrates successful long-term outcomes of M-TEER for post-surgical recurrent MR in a patient with HS. The strategic approach-initial ring-less surgical repair followed by M-TEER-suggests a viable treatment pathway for patients with inherited haemolytic disorders, particularly when minimizing prosthetic material exposure is crucial.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 5","pages":"ytaf211"},"PeriodicalIF":0.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}