European Journal of Clinical Microbiology & Infectious Diseases最新文献

{"title":"Comparison of Meltpro Myco Assay with MALDI-TOF Mass Spectrometry for rapid and accurate detection of clinical Mycobacterium Species.","authors":"Kehao Peng, Liuyue Xu, Xuezhi Wang, Jianming Hong, Gengchen Zhang, Yuchuan Zhao, Yinong Ye, Zengqi Huang, Jinmei Zhang, Yuchun Huang, Zhiqiao Wu, Xiaolin Yu, Yanqin Song, Shihao Chen, Yongping Wang, Yuhui Chen, Huizhong Wu, Xiaoyu Lai, Meiling Yu, Jingjing Liang, Wenjing Wei","doi":"10.1007/s10096-025-05171-z","DOIUrl":"https://doi.org/10.1007/s10096-025-05171-z","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to compare the performance of the MeltPro Myco assay with that of MALDI-TOF mass spectrometry for detecting nontuberculous mycobacteria (NTMs) from clinical isolates and samples.</p><p><strong>Method: </strong>A total of 308 suspected NTM isolates from sputum or BALF samples of patients with pulmonary diseases were retrospectively analyzed. DNA sequencing was used as the gold standard method. An additional 164 clinical samples from patients with pulmonary diseases were used to assess the suitability of the MeltPro Myco assay for clinical use.</p><p><strong>Result: </strong>The results indicated that for NTM identification, the MeltPro Myco assay and MALDI-TOF had sensitivities of 99.3% and 97.2% and specificities of 90.9% and 100%.The MeltPro Myco assay achievies a sensitivity and specificity of 79.4% and 95.2% for the detection of NTM in clinical samples.</p><p><strong>Conclusion: </strong>Given its rapidity, straightforward operation, high accuracy, cost-effectiveness, and good reproducibility, the MeltPro Myco assay can be a valuable tool for timely screening of lung disease caused by NTM and has the potential to improve the diagnosis and prevention of NTM pulmonary disease in highly endemic areas.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fosfomycin for the treatment of patients with bacterial prostatitis: a systematic review.","authors":"Dimitrios S Kontogiannis, Maria Eleni Agoranou, Fotios Dimitriadis, Vassilios M Skouteris, Matthew E Falagas","doi":"10.1007/s10096-025-05173-x","DOIUrl":"https://doi.org/10.1007/s10096-025-05173-x","url":null,"abstract":"<p><strong>Background: </strong>Bacterial prostatitis is a common infection affecting the patient's quality of life. It is caused by various bacteria, including multidrug-resistant Enterobacterales. Fosfomycin is active against most implicated pathogens, has good penetration in the prostate, and thus, has been used in patients with bacterial prostatitis.</p><p><strong>Methods: </strong>A systematic review of studies assessing the effectiveness of fosfomycin in adult patients with bacterial prostatitis. The primary outcome was clinical cure and secondary outcomes were microbiological cure, re-occurrence, and adverse events.</p><p><strong>Results: </strong>Four cohort studies and 1 phase I-II trial were identified, including 117 patients with chronic and acute bacterial prostatitis. In 4 studies with chronic bacterial prostatitis, 72/99 (73%), 77/99 (78%), and 15/99 (15%) of patients had clinical cure, microbiological cure, and adverse events, respectively. In 1 study with acute bacterial prostatitis, 18/18 (100%), 11/12 (92%), and 2/18 (11%) of patients had clinical cure, microbiological cure, and adverse events, respectively. Also, 12 case reports were identified. In 5 cases with chronic bacterial prostatitis, 2/5 had both clinical and microbiological cures, and 1/5 had mild adverse events. In 8 patients with acute bacterial prostatitis, 8/8, 6/8, and 2/8 had clinical cure, microbiological cure, and adverse events, respectively.</p><p><strong>Conclusion: </strong>Fosfomycin could be valuable in the treatment of patients with bacterial prostatitis when there are no other antibiotic options. Due to the limited available published clinical data, a more rigorous evaluation of its effectiveness and safety in this population is needed.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and clinical factors are relevant in respiratory infections among paediatric patients: a cross-sectional study in Mexico.","authors":"Alejandro Flores-Alanis, Griselda Rodríguez-Martínez, Zeus Saldaña-Ahuactzi, Israel Parra-Ortega, Ebzadrel Carbajal-Franco, Marcela Salazar-García, Fernando Ortega-Riosvelasco, Víctor Olivar-López, Yolanda P Alemán-García, Guillermina Campos-Valdez, Jorge González-Gutiérrez, Silvia Martínez-Valverde, Victor M Luna-Pineda","doi":"10.1007/s10096-025-05168-8","DOIUrl":"https://doi.org/10.1007/s10096-025-05168-8","url":null,"abstract":"<p><strong>Purpose: </strong>The role of factors that could be associated with the diagnosis, hospitalisation, and severity risk of virus-caused acute respiratory infections (ARIs) is limited in Mexican children and adolescents.</p><p><strong>Methods: </strong>To determine whether demographic and clinical factors may be associated with viral infections, a cross-sectional study was conducted at the Hospital Infantil de México \"Federico Gómez\" from January 2021 to December 2022. Nasopharyngeal swabs from patients with respiratory symptoms were tested for a PCR-based multiplexed nucleic acid test to identify respiratory pathogens, including SARS-CoV-2.</p><p><strong>Results: </strong>Among the 2,133 positive viral tests, 71% were mono-infections, and 29% were co-infections, with Rhinovirus/Enterovirus being the most frequent virus in this population. Besides, a negative association was identified in co-infecting viruses. Several demographics (age and gender) and clinical factors (signs/symptoms, comorbidities [immunosuppression and cardiovascular disease], and immunisation status [Flu and COVID-19 vaccination]) were associated with virus aetiology, the nature of the infection and patient status.</p><p><strong>Conclusions: </strong>Our data highlights the relevance of the factors related to virus-caused ARIs in paediatric patients. These factors could help clinicians manage medical cases regarding diagnosis, hospitalisation, and severity risk.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast and visual RT-LAMP assay for detection of oropouche virus.","authors":"Livia do Carmo Silva, Diego Michel Fernandes Da Silva, Igor Marques Cesario Calassa, Juliana Santana De Curcio, Luiz Henrique Alves Costa, Flávia Barreto de Sousa, Carlos Eduardo Anunciação, Elisângela De Paula Silveira-Lacerda","doi":"10.1007/s10096-025-05174-w","DOIUrl":"https://doi.org/10.1007/s10096-025-05174-w","url":null,"abstract":"<p><strong>Background: </strong>The epidemic potential of Oropouche virus (OROV) highlights the urgent need for rapid and accessible diagnostic methods to improve testing capacity and reduce result turnaround times, especially in tropical regions where OROV prevalence is rising.</p><p><strong>Objective: </strong>To develop and validate a rapid, cost-effective diagnostic assay for OROV detection suitable for use in resource-limited and field settings.</p><p><strong>Methods: </strong>A reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was designed and optimized for OROV detection. The assay's performance was evaluated in terms of sensitivity, specificity, time to result, and ease of visual interpretation based on colorimetric changes.</p><p><strong>Results: </strong>The RT-LAMP assay produced results within 30 to 35 minutes and enabled straightforward visual detection through a clear color change. Its detection limit was comparable to that of real-time PCR, the current gold standard for molecular diagnosis. The assay's simplicity and minimal equipment requirements make it well-suited for decentralized testing environments.</p><p><strong>Conclusions: </strong>This RT-LAMP assay represents a rapid, sensitive, and accessible tool for OROV diagnosis, with significant potential to enhance outbreak response and surveillance efforts in endemic regions.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of invasive candidiasis in French ICUs: insights from a 2024 nationwide survey.","authors":"Mathieu Esposito, Florent Lemery, Nelly Agrinier, Marc Soudant, Alexandre Charmillon, Nicolas Degand, Joséphine Dorin, Jean Dellamonica, Lucas Morand, Claire Roger, Julien Scala-Bertola, Marc Leone, Emmanuel Novy","doi":"10.1007/s10096-025-05169-7","DOIUrl":"https://doi.org/10.1007/s10096-025-05169-7","url":null,"abstract":"<p><strong>Purpose: </strong>Invasive candidiasis (IC) is a major challenge in intensive care units (ICUs) given its high prevalence, mortality rate, and diagnostic complexity. This national survey aimed to evaluate the knowledge of French intensive care specialists, assess the available resources for IC management, and analyze current bedside practices in ICUs.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among senior ICU physicians from 221 French ICUs. A structured questionnaire addressing organizational, diagnostic, and therapeutic approaches to IC management, including clinical cases, was distributed, achieving a participation rate of 54.7%.</p><p><strong>Results: </strong>Of the 121 respondents, 75 provided complete data. Most respondents were experienced intensivists working in public centers and managing hematological oncology patients. Although 65 (74%) respondents reported organizing multidisciplinary staff meeting, mycologists were rarely involved. Despite the availability of rapid diagnostic tools such as serum (1,3)-β-D-glucan (BDG), which was accessible to 63 (75%) respondents, integrating them into patient management at the bedside remains challenging. Additionally, 55 (67%) respondents had access to antifungal therapeutic drug monitoring (TDM), with voriconazole being the most frequently monitored antifungal drug. However, only 5 (9.1%) respondents had access to TDM every day of the week.</p><p><strong>Conclusion: </strong>This survey highlights the strengths of multidisciplinary teams, TDM and rapid diagnostic tools for managing IC. However, significant gaps remain in their practical application, particularly the integration of diagnostic tools into clinical algorithms to guide bedside decision-making. Optimizing antifungal stewardship through coordinated interventions is essential for accelerating the diagnosis of IC, improving clinical outcomes, reducing resistance and adverse events.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RPA-CRISPR Cas13a-Based Point-of-Care Testing established for rapid detection of Methicillin-Resistant Staphylococcus aureus (MRSA) resistance genes.","authors":"Panpan Gu, Yuan Yuan, Longfei Qi, Fei Lan","doi":"10.1007/s10096-025-05167-9","DOIUrl":"https://doi.org/10.1007/s10096-025-05167-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop a streamlined and efficient method for detecting single nucleotide polymorphism (SNP), specifically the S643N mutation in the mecA gene of Staphylococcus aureus (S. aureus). Detecting this mutation is crucial for guiding appropriate antibiotic therapy, avoiding antibiotic misuse, and enhancing infection control measures, especially in the cases of methicillin-resistant S. aureus (MRSA) infections.</p><p><strong>Methods: </strong>We employed the RPA-CRISPR Cas13a method to detect the S643N mutation. This approach integrated recombinase polymerase amplification (RPA) with CRISPR Cas13a-mediated detection into a single-step procedure, significantly reducing detection time compared to the conventional two-step process.</p><p><strong>Results: </strong>The established RPA-CRISPR Cas13a-Based Point-of-Care Testing method achieved high sensitivity, detecting as few as 10 copies per reaction and successfully differentiating between wild-type and mutant mecA genes. The one-step procedure streamlined the workflow and reduced detection time to less than 30 min, while delivering results that were consistent with the conventional two-step method.</p><p><strong>Conclusion: </strong>The one-step RPA-CRISPR Cas13a method significantly facilitates the rapid and accurate detection of single nucleotide mutations, such as the S643N mutation in the mecA gene. This advancement holds substantial clinical value by guiding precise antibiotic therapy and improving the management of S. aureus infections.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Fourier-Transform Infrared Spectroscopy with IR Biotyper^® system for Streptococcus pneumoniae serotyping.","authors":"Camila Tondolo Romero, Natália Kehl Moreira, Gabriela Rosa da Cunha, Mariana Preussler Mott, Cícero Dias, Afonso Luis Barth, Juliana Caierão","doi":"10.1007/s10096-025-05162-0","DOIUrl":"https://doi.org/10.1007/s10096-025-05162-0","url":null,"abstract":"<p><strong>Purpose: </strong>Streptococcus pneumoniae is an important human pathogen and its virulence is centered on the expression of a polysaccharide capsule. Serotyping pneumococci has clinical and epidemiological relevance. As the gold standard (Quellung reaction) is expensive and somehow laborious, alternative methodologies for timely serotyping are desirable. We aimed to evaluate IR Biotyper^® (Bruker), which is based on FT-IRS, as a tool for serotyping S. pneumoniae by customizing a classifier focusing on PCV15 serotypes.</p><p><strong>Methods: </strong>Initially, we evaluated the Pneumococci serogrouper (Bruker) included in the IR Biotyper^® software (v.4.0) using 188 retrospective isolates of S. pneumoniae previously serotyped by the gold standard. Lately, these isolates were used to construct (n = 83) and validate (n = 105) the PCV15-Classifier. Overall, 1246 spectra were obtained to create a classification model using artificial neural network (ANN) machine learning in 400 cycles. Finally, prospective S. pneumoniae (n = 61), recovered from patients attended at hospitals in South Brazil, were used for a \"real-life\" evaluation of both classifiers.</p><p><strong>Results: </strong>Agreement was higher when using PCV15-Classifier instead of Pneumococci serogrouper (Bruker) among both, retrospective (86.7% versus 68.1%; p = 0.0004) and prospective isolates (75.4% versus 70.5%; p = 0.54), highlighting (i) its better performance for epidemiologically relevant serotypes, such as 3, and (ii) its capacity to discriminate between serotypes of serogroup 19 (19F and 19A).</p><p><strong>Conclusion: </strong>Altogether, our results reiterate the usefulness of IR Biotyper^® for serotyping S. pneumoniae applying a customized classifier, which can be re-trained whenever needed, following the evolution of serotype distribution.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and potential implications of the hook effect in a Borrelia burgdorferi IgG antibody chemiluminescence immunoassay.","authors":"Marc Westerholt, Torbjörn Kjerstadius, Lukas Frans Ocias","doi":"10.1007/s10096-025-05172-y","DOIUrl":"https://doi.org/10.1007/s10096-025-05172-y","url":null,"abstract":"<p><strong>Purpose: </strong>Lyme borreliosis is diagnosed based on clinical symptoms and serological analysis, with high IgG antibody levels associated with late manifestations. Immunoassays with a broad detection range can exhibit a hook effect, leading to false-low results and potential misdiagnosis. This study aimed to investigate the occurrence of the high-dose hook effect and determine a dilution threshold to detect the hook effect and avoid overdilutions for the Liaison Borrelia IgG immunoassay.</p><p><strong>Methods: </strong>In a two-year period, 5639 patient samples analysed for Borrelia antibodies were screened at Karlstad Hospital, Sweden. Samples with IgG ≥ 75 AU/mL and < 75 AU/mL with detectable IgM underwent 1:10 dilution, with a further 1:50 dilution for samples with IgG > 240 AU/mL. A Gaussian Mixture Model was used to group samples with and without hook effect.</p><p><strong>Results: </strong>Of 389 samples eligible for dilution, 262 with IgG < 240 AU/mL were analysed. Of these, 70 (26.7%) showed hook effect, corresponding to 18% of included and 1.2% of all screened samples. Overdilution occurred in 58 (22.1%) diluted samples. Dilution thresholds of 98.7 and 96 AU/mL detected 95% of hook effect and overdilution samples, respectively.</p><p><strong>Conclusion: </strong>A substantial number of samples showed hook effect, which could lead to missed late Lyme borreliosis manifestations and inaccurate intrathecal index calculations. A dilution threshold of 98.7 AU/mL in the Liaison Borrelia IgG immunoassay effectively identified 95% of hook effect and avoided more than 95% of overdilutions.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The status of malaria, challenges and opportunities to end malaria: an editorial.","authors":"Antonio Vitiello, Andrea Zovi","doi":"10.1007/s10096-025-05160-2","DOIUrl":"https://doi.org/10.1007/s10096-025-05160-2","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the clinical impact of targeting lower versus higher serum vancomycin trough: a retrospective study using a desirability of outcome ranking (DOOR) analysis.","authors":"Zong Heng Shi, Sean W X Ong, Lesley Palmay, Nathan H Ma, Marie-Félixe Granger, Philip W Lam, Marion Elligsen","doi":"10.1007/s10096-025-05161-1","DOIUrl":"https://doi.org/10.1007/s10096-025-05161-1","url":null,"abstract":"<p><strong>Purpose: </strong>Guidelines recommend a target AUC₂₄/MIC of 400-600 for vancomycin dosing in serious MRSA infections. However, various challenges hinder the implementation of AUC-based monitoring. Previously recommended target trough of 15-20 mg/L may be associated with increased nephrotoxicity.</p><p><strong>Methods: </strong>In this single-center, retrospective study, we compared outcomes of targeting troughs of 10-15 mg/L vs 15-20 mg/L for intermittent infusion of vancomycin (IIV) in adult hospitalized patients who received ≥ 48 h of IIV and had ≥ 1 trough measurement within recommended ranges. Local guidelines recommended target troughs of 15-20 mg/L between January 2019 and December 2020 and 10-15 mg/L between January 2022 and October 2023. Treatment failure, acute kidney injury (AKI) and inpatient mortality were compared using a desirability of outcome ranking (DOOR) analysis between the two time periods. The most desirable outcome was treatment success and no AKI, and the least desirable outcome was death.</p><p><strong>Results: </strong>A total of 173 IIV courses were included. The probability of obtaining a better DOOR was 57.9% (95%CI 50.5-64.9, p = 0.03) when targeting a lower trough. Secondary analyses demonstrated a similar trend. When analyzed separately, the lower target trough group experienced significantly less AKI (OR 0.40, 95%CI 0.16-0.96) with no significant effect on mortality and treatment failure.</p><p><strong>Conclusion: </strong>Our study showed that targeting a trough of 10-15 mg/L for IIV may be associated with a superior overall outcome compared to targeting 15-20 mg/L. In centers not using AUC-based monitoring for vancomycin dosing, a lower target trough may be preferable.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}