European Journal of Clinical Microbiology & Infectious Diseases最新文献

{"title":"Treponema denticola as a potential pathogen of pneumonia in individuals with poor oral hygiene: a case report.","authors":"Yan Guo, Yan Zhu, Li Jiang","doi":"10.1007/s10096-025-05270-x","DOIUrl":"https://doi.org/10.1007/s10096-025-05270-x","url":null,"abstract":"<p><p>Treponema denticola is an oral spirochete closely related to periodontal disease. However, the association between Treponema denticola and pneumonia has seldom been reported. In this report, we present a case wherein pneumonia attributable to Treponema denticola was identified through the application of metagenomic next-generation sequencing analysis. The patient had a history of oral operation and poor oral hygiene, which were likely the risk factors of the infection. The results indicated the association between oral microbes and pneumonia and highlighted the importance of maintaining optimal oral health.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small bowel perforation by Anisakis infection due to raw fish consumption: a rare entity to consider.","authors":"V Fleury, G Liegeois, M Benkabouche, S Vora, M Pannatier, P Buono, M Genevay, L Buhler","doi":"10.1007/s10096-025-05245-y","DOIUrl":"https://doi.org/10.1007/s10096-025-05245-y","url":null,"abstract":"<p><p>Anisakidosis is a parasitic infection caused by ingesting the third-stage larvae of the Anisakidae family, a group of nematode parasites found in raw or undercooked aquatic animals including fish. The incidence of this zoonosis is increasing in Western countries, driven by the growing consumption of seafood, especially Japanese cuisine, and influenced by climate change, which is altering the distribution of parasites and the availability of their hosts. Intestinal manifestations are uncommon compared to gastric involvement, and the diagnosis remains difficult. Treatment is conservative in most cases, but some complications will require surgical intervention. We report here un uncommon case of anisakidosis in a young woman who consumed raw fish, complicated by intestinal perforation causing symptoms and radiological images of intestinal obstruction. Diagnostic laparoscopy converted to laparotomy was performed which revealed a covered perforation close to the ileocaecal valve. Small bowel resection and excision of a nodule located close to the perforation were performed. Granulomatous tissue, necrosis in the epiploic nodule with an eosinophilic infiltration and a remnant of an Anisakis larva in its center, were found by pathology. The clinical course was favorable, and no further medication was administrated. Despite this, anisakidosis remains a challenging diagnosis with neither specific laboratory nor radiological findings, and medical history remains a key to guide the diagnosis. The present case is a reminder that, in rare occasions, intestinal anisakidosis may cause serious life-threatening complications requiring surgical intervention for both early definite diagnosis and decision of therapeutic intervention.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the detection of Drug-Resistant bacteria: current trends and innovations.","authors":"Danni Ma, Fuman Cai, Ting Zhang","doi":"10.1007/s10096-025-05250-1","DOIUrl":"https://doi.org/10.1007/s10096-025-05250-1","url":null,"abstract":"<p><p>Facing challenges in the fields of microbial detection and antimicrobial resistance (AMR) monitoring, the scientific community is opening new research avenues with the help of cutting-edge technologies such as molecular biology, genomics, proteomics, nanotechnology, and bioinformatics. In this review, we comprehensively collate and elaborate on revolutionary detection methods and AMR surveillance strategies that go beyond traditional microbial culture techniques. These innovative methods have not only improved the sensitivity and speed of detection but also broadened our understanding of the microbial world, providing new weapons in the fight against drug-resistant microorganisms. Through the integration and innovation of interdisciplinary approaches, we are gradually constructing a more precise, efficient, and comprehensive new paradigm for microbial detection and AMR testing.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptococcal antigen cross-reactivity is associated with fatal trichosporonosis in patients with hematologic diseases.","authors":"Ting-An Lin, Yi-Tsung Lin, Chia-Jen Liu","doi":"10.1007/s10096-025-05273-8","DOIUrl":"https://doi.org/10.1007/s10096-025-05273-8","url":null,"abstract":"<p><strong>Purpose: </strong>Invasive trichosporonosis is an emerging, life-threatening fungal infection in immunocompromised patients with hematologic diseases. The lack of reliable diagnostic biomarkers makes early diagnosis challenging, hindering prompt and effective management.</p><p><strong>Methods: </strong>We conducted a retrospective single-center study of 88 patients with positive Trichosporon cultures, identified from a cohort of 6,169 inpatients with hematologic diseases at a tertiary medical center from 2004 to 2023. Trichosporon species were identified using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF). We investigated the risk factors, clinical characteristics, and outcomes of invasive trichosporonosis in the patient population.</p><p><strong>Results: </strong>Prolonged corticosteroid treatment and broad-spectrum antibiotic use were associated with an increased risk of developing invasive trichosporonosis. Invasive trichosporonosis presented as a breakthrough infection in 58.5% of cases, predominantly during echinocandin therapy. Second-generation triazole therapy, particularly voriconazole, was associated with improved outcomes. Cryptococcal antigen cross-reactivity was significantly associated with fatal outcomes in our cohort.</p><p><strong>Conclusion: </strong>Invasive trichosporonosis frequently manifests as a breakthrough infection during echinocandin therapy, often leading to fatal outcomes in hematologic patients. Early initiation of second-generation triazole therapy is crucial. Cryptococcal antigen cross-reactivity may be a useful diagnostic tool, as well as a prognostic marker, in invasive trichosporonosis. Although this cross-reactivity poses diagnostic challenges if misinterpreted, it offers an opportunity for early diagnosis and prompt initiation of appropriate antifungal therapy.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal peritonitis in peritoneal dialysis patients: a nationwide cohort study.","authors":"Margarita Kunin, Tatiana Tanasiychuk, Nabil Abu-Amer, Hila Soetendorp, Yael Einbinder, Sharon Mini, Alon Bnaya, Yael Kenig-Kozlovsky, Yael Golomb, Regina Gershkovitz, Roza Rosenberg, Netta Lev, Marwan Abu-Sneineh, Shira Goldman, Larissa Levadev, Irina Rubinchik, Pazit Beckerman","doi":"10.1007/s10096-025-05259-6","DOIUrl":"https://doi.org/10.1007/s10096-025-05259-6","url":null,"abstract":"<p><strong>Background: </strong>Fungal peritonitis is a rare but serious complication of peritoneal dialysis (PD), associated with high morbidity, mortality, and technique failure. This study aimed to evaluate the clinical course, risk factors, and outcomes of fungal peritonitis in adult PD patients.</p><p><strong>Methods: </strong>We conducted a nationwide retrospective study including all cases of PD-associated fungal peritonitis identified over the past decade in medical centers across Israel. Clinical, microbiological, and outcome data were analyzed.</p><p><strong>Results: </strong>Forty patients were identified, with a median age of 72.5 years. The most common symptoms were abdominal pain and cloudy effluent. In 82.5% of cases, cultures grew Candida, most frequently Candida parapsilosis. During the peritonitis episode, 95% of patients required hospitalization, 90% underwent Tenckhoff catheter removal, and 27.5% died. Fluconazole was the most commonly used antifungal (80%). In the preceding three months, 55% of patients had bacterial peritonitis and 62.5% received two or more antibiotic types. Polymicrobial infections and Enterococcus species were common in preceding bacterial episodes. Compared to bacterial peritonitis cases, fungal peritonitis was associated with significantly higher rates of hospitalization (95% vs. 39.1%, p < 0.001), catheter removal (90% vs. 9.4%, p < 0.001), and permanent transfer to hemodialysis (67.5% vs. 3.1%, p < 0.001). Use of multiple antibiotics in the prior 3 months was independently associated with fungal peritonitis (OR 1.940, 95% CI 1.291-2.917; p = 0.001).</p><p><strong>Conclusions: </strong>Fungal peritonitis in PD patients carries a poor prognosis. Recent bacterial peritonitis-particularly complicated cases such as polymicrobial or enteric-origin infections as well as recent exposure to multiple antibacterial agents, may serve as predisposing risk factors.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leuconostoc as an emerging pathogen in humans: an updated systematic review.","authors":"Xun Zhou, Yunxiu Huang, Wenyuan Zhang, Cuimei Zhao, Linmu Chen","doi":"10.1007/s10096-025-05258-7","DOIUrl":"https://doi.org/10.1007/s10096-025-05258-7","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schaalia cardiffensis: an infrequent etiology of empyema with community-acquired pneumonia.","authors":"Kai Wu, Qingyao Li, Wei Wang, Lei Wang, Shuxia Wang","doi":"10.1007/s10096-025-05261-y","DOIUrl":"https://doi.org/10.1007/s10096-025-05261-y","url":null,"abstract":"<p><p>Schaalia infections are uncommon, with Schaalia cardiffensis infections being exceptionally rare. A 66-year-old, penicillin-allergic female presented with fever, cough and purulent sputum. Chest computed tomography revealed bilateral pneumonia, right loculated empyema and right lower lobe atelectasis. Initial drainage cultures identified only Streptococcus oralis, but subsequent anaerobic enrichment and 16 S rRNA gene sequencing confirmed S. cardiffensis, an obligate anaerobe. Due to absent susceptibility data, we established initial antimicrobial susceptibility profile for S. cardiffensis. Successful management was achieved using alternative antibiotics combined with percutaneous drainagein. This first Chinese case of an empyema co-infected with S. cardiffensis and S. oralis highlights diagnostic challenges and provides crucial susceptibility guidance.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possibility of Escherichia coli transmission from pregnant women to the neonates.","authors":"Dongmiao Zhang, Xiaoling Ge, Yajuan Wang, Wei Gao, Yijun Ding, Jinjing Zhang","doi":"10.1007/s10096-025-05257-8","DOIUrl":"https://doi.org/10.1007/s10096-025-05257-8","url":null,"abstract":"<p><strong>Objective: </strong>To assess the homology of Escherichia coli between pregnant women and neonates and to identify the vertical transmission risk factors.</p><p><strong>Study design: </strong>Pregnant women in 35-37 gestational weeks who underwent prenatal checkups between May 1st, 2015, and April 30th, 2016 were screened for Escherichia coli. Paired swabs from pregnant women and neonates were collected to evaluate the vertical transmission rate. Drug resistance, Multi-locus Sequence Typing, and potential risk factors were acquired to evaluate the homology and risk factors. Multiple logistic regression was used to account for potential confounders and evaluate the predictive ability of variables.</p><p><strong>Results: </strong>There were 201 (42.5%) positive swabs from pregnant women and 27 (5.7%) from neonates. Escherichia coli vertical transmission rate was 22 (11.0%, 95% CI 6.7%-15.3%). The most common ST was ST1193. Age of pregnant women (OR 1.19, 95% CI 1.06-1.34), time of premature rupture of membranes (OR 1.09, 95% CI 1.01-1.18), time of prenatal antibiotics use (OR 0.87 95% CI 0.74-0.98), and drug-resistant categories (OR 1.42 95% CI 1.00-2.07) were identified as significant factors. The predictive model achieved an area under the curve of 0.795 (95% CI: 0.683-0.908) and 0.743 (95% CI: 0.628-0.859) for the model of 10 factors and 4 factors, respectively. Escherichia coli positivity increases the likelihood of neonate hospitalization.</p><p><strong>Conclusion: </strong>The strong homology of Escherichia coli between pregnant women and neonates indicates the potential transmission of pathogenic strains, which should be screened and managed.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding phage Receptor-binding protein interaction with host surface receptor: the key for phage-Mediated detection and elimination of Pseudomonas aeruginosa.","authors":"Shihui Peng, Ying Liu, Huiqing Liu, Lili Chen, Xiangheng Niu, Hao Liang, Paul G Higgins, Qinqin Bai","doi":"10.1007/s10096-025-05262-x","DOIUrl":"https://doi.org/10.1007/s10096-025-05262-x","url":null,"abstract":"<p><p>Pseudomonas aeruginosa poses a significant clinical challenge due to its intrinsic and acquired antimicrobial resistance and robust biofilm formation, which complicates treatment. Bacteriophages (phages), viruses targeting bacteria, are emerging as a promising alternative or adjunct to combat multidrug-resistant P. aeruginosa infections. This review systematically examines the taxonomic diversity of phages infecting P. aeruginosa, with emphasis on those that remain unclassified at the family taxonomic level, such as Pbunavirus and Pakpunavirus. It comprehensively synthesizes current knowledge on phage receptor-binding proteins (RBPs) - the molecular determinants of host specificity - and their corresponding receptors on the P. aeruginosa surface, such as lipopolysaccharide (LPS), pili, flagella, outer membrane proteins, and alginate. Critically, the review underscores the urgent need to decipher the precise molecular mechanisms governing RBP-receptor interactions. A deeper understanding of these specific recognition events is paramount. This knowledge is essential not only for rationally optimizing phage therapy efficacy, including through engineered phages or RBP-based antimicrobials, but also for developing highly sensitive and specific phage-derived diagnostic tools, utilizing whole phages or purified RBPs as recognition elements for rapid P. aeruginosa detection.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic and additive effects of rifampicin, moxifloxacin, ethambutol, and azithromycin against M. simiae clinical isolates.","authors":"Hershko Yizhak, Adler Amos","doi":"10.1007/s10096-025-05266-7","DOIUrl":"https://doi.org/10.1007/s10096-025-05266-7","url":null,"abstract":"<p><p>Pulmonary disease caused by Mycobacterium simiae is challenging to treat due to intrinsic resistance and limited guidelines. We assessed synergy among rifampicin, moxifloxacin, ethambutol, and azithromycin using the checkerboard method. Synergy (FICI = 0.5) was found only for the moxifloxacin-ethambutol combination in 63% of 27 clinical isolates, with the remainder showing additive effects. No synergy was observed for rifampicin or azithromycin. These findings suggest potential therapeutic benefit for the moxifloxacin-ethambutol combination, even in non-susceptible isolates, supporting reconsideration of ethambutol in treatment regimens. Clinical studies are needed to validate the observed in vitro synergy.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}