Alejandro Flores-Alanis, Griselda Rodríguez-Martínez, Zeus Saldaña-Ahuactzi, Israel Parra-Ortega, Ebzadrel Carbajal-Franco, Marcela Salazar-García, Fernando Ortega-Riosvelasco, Víctor Olivar-López, Yolanda P Alemán-García, Guillermina Campos-Valdez, Jorge González-Gutiérrez, Silvia Martínez-Valverde, Victor M Luna-Pineda
{"title":"人口统计学和临床因素与儿科患者呼吸道感染相关：墨西哥的一项横断面研究。","authors":"Alejandro Flores-Alanis, Griselda Rodríguez-Martínez, Zeus Saldaña-Ahuactzi, Israel Parra-Ortega, Ebzadrel Carbajal-Franco, Marcela Salazar-García, Fernando Ortega-Riosvelasco, Víctor Olivar-López, Yolanda P Alemán-García, Guillermina Campos-Valdez, Jorge González-Gutiérrez, Silvia Martínez-Valverde, Victor M Luna-Pineda","doi":"10.1007/s10096-025-05168-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The role of factors that could be associated with the diagnosis, hospitalisation, and severity risk of virus-caused acute respiratory infections (ARIs) is limited in Mexican children and adolescents.</p><p><strong>Methods: </strong>To determine whether demographic and clinical factors may be associated with viral infections, a cross-sectional study was conducted at the Hospital Infantil de México \"Federico Gómez\" from January 2021 to December 2022. Nasopharyngeal swabs from patients with respiratory symptoms were tested for a PCR-based multiplexed nucleic acid test to identify respiratory pathogens, including SARS-CoV-2.</p><p><strong>Results: </strong>Among the 2,133 positive viral tests, 71% were mono-infections, and 29% were co-infections, with Rhinovirus/Enterovirus being the most frequent virus in this population. Besides, a negative association was identified in co-infecting viruses. Several demographics (age and gender) and clinical factors (signs/symptoms, comorbidities [immunosuppression and cardiovascular disease], and immunisation status [Flu and COVID-19 vaccination]) were associated with virus aetiology, the nature of the infection and patient status.</p><p><strong>Conclusions: </strong>Our data highlights the relevance of the factors related to virus-caused ARIs in paediatric patients. These factors could help clinicians manage medical cases regarding diagnosis, hospitalisation, and severity risk.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Demographic and clinical factors are relevant in respiratory infections among paediatric patients: a cross-sectional study in Mexico.\",\"authors\":\"Alejandro Flores-Alanis, Griselda Rodríguez-Martínez, Zeus Saldaña-Ahuactzi, Israel Parra-Ortega, Ebzadrel Carbajal-Franco, Marcela Salazar-García, Fernando Ortega-Riosvelasco, Víctor Olivar-López, Yolanda P Alemán-García, Guillermina Campos-Valdez, Jorge González-Gutiérrez, Silvia Martínez-Valverde, Victor M Luna-Pineda\",\"doi\":\"10.1007/s10096-025-05168-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The role of factors that could be associated with the diagnosis, hospitalisation, and severity risk of virus-caused acute respiratory infections (ARIs) is limited in Mexican children and adolescents.</p><p><strong>Methods: </strong>To determine whether demographic and clinical factors may be associated with viral infections, a cross-sectional study was conducted at the Hospital Infantil de México \\\"Federico Gómez\\\" from January 2021 to December 2022. Nasopharyngeal swabs from patients with respiratory symptoms were tested for a PCR-based multiplexed nucleic acid test to identify respiratory pathogens, including SARS-CoV-2.</p><p><strong>Results: </strong>Among the 2,133 positive viral tests, 71% were mono-infections, and 29% were co-infections, with Rhinovirus/Enterovirus being the most frequent virus in this population. Besides, a negative association was identified in co-infecting viruses. Several demographics (age and gender) and clinical factors (signs/symptoms, comorbidities [immunosuppression and cardiovascular disease], and immunisation status [Flu and COVID-19 vaccination]) were associated with virus aetiology, the nature of the infection and patient status.</p><p><strong>Conclusions: </strong>Our data highlights the relevance of the factors related to virus-caused ARIs in paediatric patients. 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Demographic and clinical factors are relevant in respiratory infections among paediatric patients: a cross-sectional study in Mexico.
Purpose: The role of factors that could be associated with the diagnosis, hospitalisation, and severity risk of virus-caused acute respiratory infections (ARIs) is limited in Mexican children and adolescents.
Methods: To determine whether demographic and clinical factors may be associated with viral infections, a cross-sectional study was conducted at the Hospital Infantil de México "Federico Gómez" from January 2021 to December 2022. Nasopharyngeal swabs from patients with respiratory symptoms were tested for a PCR-based multiplexed nucleic acid test to identify respiratory pathogens, including SARS-CoV-2.
Results: Among the 2,133 positive viral tests, 71% were mono-infections, and 29% were co-infections, with Rhinovirus/Enterovirus being the most frequent virus in this population. Besides, a negative association was identified in co-infecting viruses. Several demographics (age and gender) and clinical factors (signs/symptoms, comorbidities [immunosuppression and cardiovascular disease], and immunisation status [Flu and COVID-19 vaccination]) were associated with virus aetiology, the nature of the infection and patient status.
Conclusions: Our data highlights the relevance of the factors related to virus-caused ARIs in paediatric patients. These factors could help clinicians manage medical cases regarding diagnosis, hospitalisation, and severity risk.
期刊介绍：
EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.
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