ERJ Open Research最新文献_第3页

Validation of new predictors of mortality and BODE index variants in patients with COPD at moderate altitude 中等海拔地区慢性阻塞性肺病患者死亡率新预测指标和 BODE 指数变体的验证

IF 4.3 3区医学

ERJ Open Research Pub Date : 2024-08-08 DOI: 10.1183/23120541.00333-2024

R. Robles-Hernández, Gustavo I. Centeno-Saenz, Alejandra Ramírez-Venegas, Ireri Thirión-Romero, R. Hernández-Zenteno, Sandra P. Guinto-Ramírez, María C. Maya-García, Diana Villegas-Trejo, F. Montiel-Lopez, Lila M. Cordero-Silis, Rogelio Pérez-Padilla

引用次数: 0

Dry Powder Inhaler Use in Primary School Aged Children with Asthma: A Systematic Review 干粉吸入器在学龄儿童哮喘患者中的使用：系统回顾

IF 4.3 3区医学

ERJ Open Research Pub Date : 2024-08-08 DOI: 10.1183/23120541.00455-2024

Stephanie L Kuek, Nicole X Wong, Stuart Dalziel, L. Hatter, Louise J. Fleming, Andrew Bush, R. Beasley, S. Shanthikumar

{"title":"Dry Powder Inhaler Use in Primary School Aged Children with Asthma: A Systematic Review","authors":"Stephanie L Kuek, Nicole X Wong, Stuart Dalziel, L. Hatter, Louise J. Fleming, Andrew Bush, R. Beasley, S. Shanthikumar","doi":"10.1183/23120541.00455-2024","DOIUrl":"https://doi.org/10.1183/23120541.00455-2024","url":null,"abstract":"Asthma is the most common chronic disease in children. Dry powder inhalers (DPI) are effective for medication delivery in adults and adolescents, and provide a lower environmental footprint and more portability when compared to metered dose inhaler (MDI) with spacer. They require specific technique, and it is necessary to ascertain whether they can be used in younger age groups. We aimed to assess evidence regarding whether primary school aged (5–11 years) children can use DPI with adequate technique both during stable and acute asthma.Ovid MEDLINE, Embase and PubMed were searched for studies assessing DPI use in children aged 5–11 years with asthma or wheeze. Results of studies were synthesised by study design and outcome measure.Thirty-eight studies were identified for analysis. These were analysed in three groups: (1) 25 studies assessing children's ability to use DPI by peak inspiratory flow measurement, (2) 10 studies assessing children's ability to use DPI by physician assessment, and (3) three studies measuring efficacy of DPI compared to gold standard (MDI with spacer). Five studies included children during acute exacerbations.The majority of primary school aged children have the ability to use a DPI with adequate training, support and practice. Some younger children may have difficulties, and clinician assessment and ongoing review is crucial in determining which children are likely to benefit from a DPI. Consistent correct use and adherence remains a challenge, but this is also an issue with MDI plus spacer and does not appear to be significantly worse with DPI. Evidence of the use of DPI during acute illness is limited, and more studies are required in this setting.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141928375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oscillometry Reference Values for Children and Adolescents 儿童和青少年振荡测量参考值

IF 4.3 3区医学

ERJ Open Research Pub Date : 2024-08-08 DOI: 10.1183/23120541.00278-2024

C. Valach, Emiel F. M. Wouters, A. Ofenheimer, P. Pompilio, Alessandro Gobbi, M. Breyer, Sylvia Hartl, C. Veneroni, T. Mraz, C. Schiffers, O. C. Burghuber, Ahmad Karimi, Christoph Gross, Charles G. Irvin, R. Breyer-Kohansal

{"title":"Oscillometry Reference Values for Children and Adolescents","authors":"C. Valach, Emiel F. M. Wouters, A. Ofenheimer, P. Pompilio, Alessandro Gobbi, M. Breyer, Sylvia Hartl, C. Veneroni, T. Mraz, C. Schiffers, O. C. Burghuber, Ahmad Karimi, Christoph Gross, Charles G. Irvin, R. Breyer-Kohansal","doi":"10.1183/23120541.00278-2024","DOIUrl":"https://doi.org/10.1183/23120541.00278-2024","url":null,"abstract":"Oscillometry devices allow quantification of respiratory function at tidal breathing but device-specific reference equations are scarce: the present study aims to create sex-specific oscillometric reference values for children and adolescents using the Resmon PRO FULL device.Healthy participants (N=981) aged 6 to 17 years of the Austrian LEAD general population cohort were included. Subjects had normal weight (BMI≤99th percentile) and normal lung volumes (total lung capacity (TLC)≥lower limit of normal). Oscillometry data were collected using a single frequency mode of 8 Hz. Sex-specific prediction equations were developed for total (tot), inspiratory (insp) and expiratory (exp) resistance (R) and reactance (X) as well as for the modulus of impedance (Z) value using the LMS (lambda, mu, sigma) method. Height was used as a single covariate.Reference equations for all oscillometry parameters were created for Caucasian children aged 6 to 17 years with a height span from 101 to 183 cm and a lung volume span from 1.7 L to 8.8 L TLC. R and Z values progressively decrease and X values increase with increasing height. Oscillometry parametersversuslung volume curves differ from thoseversusheight curves. Stratified for lung size, no sex differences are found for oscillometry parameters.Our study provides reference values for oscillometry parameters in children and adolescents using strictly defined criteria for weight and lung volumes. No sex related differences in oscillometry parameters corrected for height or lung size are found.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141929452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of e-Lung automated quantitative CT biomarkers in idiopathic pulmonary fibrosis 评估特发性肺纤维化中的 e-Lung 自动定量 CT 生物标记物

IF 4.3 3区医学

ERJ Open Research Pub Date : 2024-08-08 DOI: 10.1183/23120541.00570-2024

Peter M. George, C. Rennison-Jones, Giacomo Benvenuti, Aliki Sifostratoudaki, F. Ottink, W. Bou-Zeid, Roberta Eufrasia Ledda, Roqia Fatmawati, Abul Kadir, Bushra Johari, C. Fernandez, G. Harston, O. Joly, S. Gerry, A. Devaraj

{"title":"Evaluation of e-Lung automated quantitative CT biomarkers in idiopathic pulmonary fibrosis","authors":"Peter M. George, C. Rennison-Jones, Giacomo Benvenuti, Aliki Sifostratoudaki, F. Ottink, W. Bou-Zeid, Roberta Eufrasia Ledda, Roqia Fatmawati, Abul Kadir, Bushra Johari, C. Fernandez, G. Harston, O. Joly, S. Gerry, A. Devaraj","doi":"10.1183/23120541.00570-2024","DOIUrl":"https://doi.org/10.1183/23120541.00570-2024","url":null,"abstract":"In patients with idiopathic pulmonary fibrosis (IPF), there is a need to identify biomarkers that i) are associated with increased risk of adverse outcome and ii) can be used to monitor treatment response or identify disease progression over time.Two consecutive cohorts of patients with IPF were accessed from the Open Source Imaging Consortium database. Automated CT biomarkers of disease severity incorporating fibrotic and pulmonary vascular features (the reticulovascular score and weighted reticulovascular score (WRVS)), were studied. Relationships between imaging biomarkers, lung function and survival were analysed.In separate test and validation cohorts, 168 and 176 patients with IPF respectively (median survival 2.6 years) were studied. A threshold of WRVS ≥15% at baseline CT was most strongly associated with transplant free survival (HR 3.00, 95% CI 1.47, 6.10, p=0.002) when adjusted for baseline FVC and age. In patients with 12 month follow up CT and lung function tests (n=89) an increase in 3% of WRVS (the minimal clinically important difference) was also significantly associated with reduced survival independent of FVC, and outperformed visual evaluation of progressive fibrosis.WRVS is an automated CT biomarker which can identify patients with IPF at increased risk of progression and is able to reliably capture disease progression over time.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141926443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplementary Oxygen Efficacy for Chronic Pulmonary Disorders and Exertion Desaturation 补充氧气对慢性肺部疾病和劳累性饱和度降低的疗效

IF 4.3 3区医学

ERJ Open Research Pub Date : 2024-08-08 DOI: 10.1183/23120541.00411-2024

Paraschos Archontakis Barakakis, Adam Wolfe, Andrei Schwartz, Gabriel J. Hernandez Romero, V. Gidwani, Shaylika Chauhan, Shinichi Arizono, Ralph J. Panos, Spyridon Fortis

{"title":"Supplementary Oxygen Efficacy for Chronic Pulmonary Disorders and Exertion Desaturation","authors":"Paraschos Archontakis Barakakis, Adam Wolfe, Andrei Schwartz, Gabriel J. Hernandez Romero, V. Gidwani, Shaylika Chauhan, Shinichi Arizono, Ralph J. Panos, Spyridon Fortis","doi":"10.1183/23120541.00411-2024","DOIUrl":"https://doi.org/10.1183/23120541.00411-2024","url":null,"abstract":"Exertion-Induced Desaturation (EID) is a common complication of numerous pulmonary disorders and often treated with supplementary oxygen during exertion. We performed a systematic review and meta-analysis of Randomized Clinical Trials (RCTs) to evaluate the efficacy of supplementary oxygen for EID in pulmonary disorders.Medline and Embase were systematically searched from July 2022 to June 2023 following PRISMA guidelines. RCTs that met predefined inclusion criteria were included. Means and Standard Deviations were extracted and Standardized Mean Differences (SMD), the difference in means between groups divided by the Standard Deviation, and 95% Confidence Intervals (CI) calculated. Exercise capacity was the primary outcome; exercise dyspnea, baseline dyspnea, quality of life were the secondary objectives. The immediate, post-rehabilitation, short-term, and ambulatory effects of oxygen supplementation were evaluated.We included 15 studies in our analysis. Oxygen supplementation to treat EID had been investigated for Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Pulmonary Fibrosis (IPF) only. Oxygen supplementation was superior to placebo for its immediate effect on exercise capacity for COPD (SMD: 0.42, 95% CI: 0.15 to 0.69, I2=3%) and IPF (SMD: 0.41, 95% CI: 0.08 to 0.75, I2=57%) and exercise dyspnea for COPD (SMD: −0.40, 95% CI: −0.76 to −0.04, I2=31%). Sensitivity analysis revealed similar results.Our study revealed efficacy of supplemental oxygen for EID and only a positive immediate effect on exercise capacity and dyspnea but no improvement in short-term or long-term measures.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141929439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of ultrasound settings on lung vertical artifacts: an observational study in mechanically ventilated patients 超声波设置对肺垂直伪影的影响：对机械通气患者的观察研究

IF 4.3 3区医学

ERJ Open Research Pub Date : 2024-08-08 DOI: 10.1183/23120541.00483-2024

J. Leote, Andreia Gonçalves, Júlia Fonseca, Ricardo Loução, Hermínia Dias, Maria Inês Ribeiro, Ricardo Meireles, Rita Varudo, Jacobo Bacariza, Filipe Gonzalez

{"title":"Impact of ultrasound settings on lung vertical artifacts: an observational study in mechanically ventilated patients","authors":"J. Leote, Andreia Gonçalves, Júlia Fonseca, Ricardo Loução, Hermínia Dias, Maria Inês Ribeiro, Ricardo Meireles, Rita Varudo, Jacobo Bacariza, Filipe Gonzalez","doi":"10.1183/23120541.00483-2024","DOIUrl":"https://doi.org/10.1183/23120541.00483-2024","url":null,"abstract":"The number of vertical artifacts (VA) in lung ultrasound (LUS) impacts patients’ clinical management. This study aimed to demonstrate the influence of ultrasound settings on the number of VA in patients under invasive mechanical ventilation (IMV).Patients under IMV were recruited for LUS including three breathing cycles with a motionless curvilinear probe on the thoracic region with the most VA. Three experts in LUS were randomly inquired about the number of VA [RL1] and blindly after altering settings for a total of 20 test recordings per patient. The correlation between expert classifications was tested after grading the classifications. The number of VA across clinicians was compared between baseline recordings and test conditions recordings to determine statistical differences.Twenty-nine patients were enrolled with a median SOFA score of 6 (and an interquartile range (median±IQR) of 3. IMV was mainly due to stroke (n=10) and pneumonia (n=6). LUS was made between days 1 and 6 (IQR). Baseline recordings showed a median VA number of 2±2 in inspiration and a median of 1±2 in expiration from a total of 3636 expert classifications with a strong agreement within patients. The probe frequency of 8MHz, artifact filtering, speckle reduction and frame average reduced the median VA number by one. The power of −20dB and dynamic range of 32dB abolished the VA. Gain above 90% increased the median number of VA by one.In thisin vivostudy, the LUS settings influenced the VA number in IMV patients, after controlling for physiological and operator confounders.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension 用血管扩张剂逆转肺动脉高压的炎症重编程

IF 4.3 3区医学

ERJ Open Research Pub Date : 2024-08-08 DOI: 10.1183/23120541.00486-2024

Anna Kirillova, M. Sethuraman, Xishuang Dong, A. Kirdar, G. Speyer, Yassmin Al Aaraj, Annie M. Watson, Lily K. Schneider, M. Creager, Robert Lafyatis, S. Okawa, Seungchan Kim, Stephen Y. Chan

{"title":"Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension","authors":"Anna Kirillova, M. Sethuraman, Xishuang Dong, A. Kirdar, G. Speyer, Yassmin Al Aaraj, Annie M. Watson, Lily K. Schneider, M. Creager, Robert Lafyatis, S. Okawa, Seungchan Kim, Stephen Y. Chan","doi":"10.1183/23120541.00486-2024","DOIUrl":"https://doi.org/10.1183/23120541.00486-2024","url":null,"abstract":"Pulmonary arterial hypertension (PAH) is a deadly disease without effective non-invasive diagnostic and prognostic testing. It remains unclear whether vasodilators reverse inflammatory activation, a part of PAH pathogenesis. Single-cell profiling of inflammatory cells in blood could clarify these PAH mechanisms.We evaluated a University of Pittsburgh Medical Center (UPMC) cohort consisting of idiopathic PAH and scleroderma associated PAH (iPAH and sscPAH) patients and non-PAH controls. We performed single cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) from controls (N=3) and PAH patients (iPAH and sscPAH), naïve to treatment (N=4), 3 months after phosphodiesterase 5 inhibitor (PDE5i) treatment (N=7), and 3 months after PDE5i+macitentan (N=6). We compared the transcriptomes of 5 PBMC subtypes from iPAH and sscPAH to observe their serial responses to treatments. Furthermore, we utilized network analysis to illuminate the altered connectivity of biological networks in this complex disease.We defined differential gene expression and perturbed network connectivity in PBMCs of PAH patients following PDE5i or PDE5i+macitentan. Importantly, we identified significant reversal of inflammatory transcripts and pathways in the combined PAH patient cohort after vasodilator therapy in every PBMC type assessed. The “Glucagon Signaling in Metabolic Regulation” pathway in monocytes was reversed after vasodilator therapyviatwo independent analysis modalities.Viaa systems biology approach, we define inflammatory reprogramming in blood of PAH patients and the anti-inflammatory activity of vasodilators. Such findings establish diagnostic and prognostic blood-based tools for tracking inflammatory progression of PAH and response to therapy.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141927257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peeping at COPD through the keyhole: time to broaden the view to the complexity of the disease by the heterogeneity of symptoms. 通过 "钥匙孔 "窥视慢性阻塞性肺病：是时候通过症状的异质性来拓宽视野，了解疾病的复杂性了。

IF 4.3 3区医学

ERJ Open Research Pub Date : 2024-08-05 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00422-2024

Panaiotis Finamore, Ernesto Crisafulli