ERJ Open Research最新文献

{"title":"Fine-scale regional frequency of the <i>MUC5B</i> promoter variant correlates with healthcare burden of idiopathic pulmonary fibrosis.","authors":"Edmund Gilbert, Aoife Carolan, Mari Ozaki, Niamh Logan, Khaled Musameh, Helen O'Brien, Wan Lin Ng, Jisha Jasmin, Cormac McCarthy, Michael P Keane, David A Schwartz, Michael T Henry, Killian Hurley","doi":"10.1183/23120541.00305-2025","DOIUrl":"10.1183/23120541.00305-2025","url":null,"abstract":"<p><p><b>Mapping the fine-scale geographic distribution of the <i>MUC5B</i> promoter variant across the island of Ireland demonstrated a strong correlation with IPF hospital discharge. This type of risk variant mapping could support more precise healthcare planning.</b> https://bit.ly/43tZYI7.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of diffuse parenchymal lung disease in patients meeting the Berlin definition of acute respiratory distress syndrome on mechanical ventilation.","authors":"Yasuhiro Norisue, Ryohei Yamamoto, Hideki Yamakawa, Makoto Hibino, Tatsuya Nagai, Yutaro Fujimoto, Jun Kataoka, Kenji Ishii, Takashi Hongo, Daisuke Kasugai, Yudai Iwasaki, Masaaki Sakuraya, Goji Shimizu, Tomoyuki Masuyama, Shigeki Fujitani, Yasuharu Tokuda, Takashi Ogura","doi":"10.1183/23120541.01296-2024","DOIUrl":"10.1183/23120541.01296-2024","url":null,"abstract":"<p><strong>Background: </strong>The simplicity of the diagnostic definition of acute respiratory distress syndrome (ARDS) has led to its diagnosis in patients with new-onset or exacerbation of diffuse parenchymal lung diseases (DPLDs). This study investigated the incidence of DPLDs in patients with acute hypoxic respiratory failure who met the Berlin definition.</p><p><strong>Methods: </strong>This Japan-based multicentre retrospective cohort study included patients on mechanical ventilation who met the Berlin definition. For all participants, diagnosis was made by pulmonology specialists in DPLD and thoracic radiology (blinded to clinical diagnoses) by reviewing an extensive database designed for DPLD diagnosis across 10 participating hospitals.</p><p><strong>Results: </strong>Of 13 612 patients admitted to the intensive care unit during the study period, 272 met the Berlin definition of ARDS and were included for analysis. All underwent at least one chest computed tomography scan; none underwent lung biopsy. Briefly, 182 were designated classic ARDS (67%), 69 non-IPF (idiopathic pulmonary fibrosis) DPLDs (25%) and 21 IPF (8%) by DPLD specialists. Of the 90 patients diagnosed with DPLD (IPF or non-IPF) by specialists, 35% were diagnosed with classic ARDS by intensivists at the end of the clinical course. Diagnostic classifications of classic ARDS and IPF by DPLD specialists were associated with time-to-death (adjusted hazard ratio (HR) 1.58 (95% CI 1.03-2.45), p=0.038, and adjusted HR 1.73 (95% CI 1.01-2.97), p=0.045, respectively) and in-hospital mortality (adjusted HR 1.54 (95% CI 1.06-2.23), p=0.022 for classic ARDS) <i>versus</i> non-IPF DPLDs; intensivist diagnostic classifications were not.</p><p><strong>Conclusion: </strong>Approximately one-third of patients within the Berlin definition were retrospectively diagnosed with new-onset or acutely exacerbated DPLD by specialists.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oropharyngeal enlargement in obstructive lung disease: quantification and machine learning.","authors":"Asma Abdolijomoor, Jiwoong Choi, David H Lee, So Ri Kim, Seoung Ju Park, Gong Yong Jin, Eric A Hoffman, Mario Castro, Chang Hyun Lee, Kum Ju Chae","doi":"10.1183/23120541.00961-2024","DOIUrl":"10.1183/23120541.00961-2024","url":null,"abstract":"<p><strong>Background: </strong>While lower airway remodelling of obstructive lung diseases (OLDs), such as asthma and COPD, is comprehensively studied, the understanding of upper airway remodelling in OLD remains limited. This study aimed to investigate upper airway dimensions in patients with OLD using quantitative computed tomography (QCT) imaging and to identify relevant parameters for predicting OLD using machine learning techniques.</p><p><strong>Methods: </strong>A prospective cohort of 26 healthy controls, 73 COPD patients and 86 asthma patients underwent upper airway computed tomography (CT) scans from the oral cavity to the subglottal region. Multiscale lung structure and function were assessed using ITK-SNAP and in-house QCT software. Feature-importance estimation methods from STREAMLINE were utilised to select potentially relevant upper airway metrics. The Wilcoxon rank-sum test and Pearson's correlation were employed for pairwise comparisons and correlation analysis, respectively. The Youden index was used to determine optimal cut-off values of relevant upper airway features.</p><p><strong>Results: </strong>After standardising QCT results, patients with OLD exhibited greater mouth-to-supraglottal metrics, notably greater oral space air fraction and pharyngeal length. Both metrics showed a negative correlation with forced expiratory volume in 1 s/forced vital capacity (R=-0.24; p=0.001). Feature-importance analysis identified oral space air fraction and normalised pharyngeal length as key features discriminating patients with OLD from healthy controls. An oral space air fraction value of ≥0.8 predicted OLD with approximately 100% sensitivity and 69% specificity.</p><p><strong>Conclusions: </strong>Quantitative upper airway CT measurement combined with machine learning analysis revealed oropharyngeal enlargement in patients with OLD.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung involvement in rheumatoid arthritis, a prospective study.","authors":"Antoine Froidure, Marie Perrot, Aleksandra Avramovska, Louis Vanderschueren, Stéphanie Dierckx, Marie Doyen, Maria Stoenoiu, Bertrand Bearzatto, Maxime Bonjean, Jérôme Ambroise, Jean-François Durant, Jean-Luc Gala, Benoît Ghaye, Patrick Durez","doi":"10.1183/23120541.01312-2024","DOIUrl":"10.1183/23120541.01312-2024","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of lung involvement in rheumatoid arthritis (RA) remains elusive. Therefore, we set up a multicentric prospective study to investigate the presence of interstitial lung disease (ILD), emphysema, bronchiolitis and nodules in early RA.</p><p><strong>Methods: </strong>We recruited patients with RA and a disease duration from 1 to 10 years to screening. Patients underwent comprehensive respiratory evaluation consisting of an environmental questionnaire, high-resolution computed tomography (HRCT), pulmonary function tests (PFTs) and sampling for genetic analysis of common variants associated with RA-ILD. HRCT scans were centrally reviewed.</p><p><strong>Results: </strong>We included 258 RA patients, median age 56 years old, 71% female and 49% ex- or current smokers. We detected ILD, emphysema and >20% air trapping in 38 (15%), 51 (20%) and 89 (34%) patients, respectively. Older age, male sex, disease activity and lower diffusing capacity of the lung for carbon monoxide (<i>D</i> _LCO) were significantly associated with ILD; and older age, male sex, smoking status and lower <i>D</i> _LCO were associated with emphysema. No variables were associated with air trapping. Finally, we built stepwise logistic regression models for ILD and emphysema. Older age, higher Disease Activity Score-28, seropositivity for rheumatoid factor, lower <i>D</i> _LCO and <i>MUC5B</i> variant were predictors of ILD, whereas the number of pack-years smoking was predictive of emphysema.</p><p><strong>Conclusions: </strong>Lung involvement affects a high proportion of early-stage RA patients, constrictive bronchiolitis being the most prevalent, followed by emphysema and ILD. Older age, uncontrolled disease, male sex and lower <i>D</i> _LCO were associated with both ILD and emphysema, suggesting that we should prioritise screening in these subpopulations.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term in-hospital mortality and chronic thromboembolic pulmonary hypertension after COVID-19-associated pulmonary embolism in France: a nationwide study.","authors":"Pierre Tankéré, Emilie Lajeune, Anne-Sophie Mariet, Jonathan Cottenet, Guillaume Beltramo, Marjolaine Georges, Philippe Bonniaud, Nicolas Favrolt, Catherine Quantin","doi":"10.1183/23120541.01387-2024","DOIUrl":"10.1183/23120541.01387-2024","url":null,"abstract":"<p><strong>Background: </strong>Although long-term effects of coronavirus disease-2019 (COVID-19) such as dyspnoea are frequent, the mechanisms are often poorly understood. The endothelial effects of COVID-19, such as venous or arterial thrombosis, are also well documented. Thus, the incidence of chronic thromboembolic pulmonary hypertension (CTEPH) following COVID-19 is an issue with many implications, particularly for screening in patients with long COVID.</p><p><strong>Methods: </strong>From the French National Hospital Discharge database (March 2020 to December 2021), we included all adults hospitalised for pulmonary embolism (PE). To study the hospital incidence of CTEPH, we excluded patients with previous pulmonary hypertension diagnoses. Then, in the 2 years following the admission for PE, we compared the hospital incidence of CTEPH between PE patients with COVID-19 (COVID-PE) and without (non-COVID-PE). We also studied in-hospital mortality.</p><p><strong>Results: </strong>Among the 136 505 patients included, 1.68% were diagnosed with CTEPH in the following 2 years with a significant difference between COVID-PE and non-COVID-PE (0.77% <i>versus</i> 1.82%; p<0.0001). The 2-year in-hospital mortality was significantly lower in COVID-PE than in non-COVID-PE (4.82% <i>versus</i> 13.34%; p<0.0001). These results were confirmed by multivariate analyses. Among COVID-PE, we found no difference in the hospital incidence of CTEPH between 2020 and 2021, while after the initial discharge, in-hospital mortality was significantly higher in 2020 compared with 2021.</p><p><strong>Conclusion: </strong>When investigating chronic dyspnoea in patients hospitalised for COVID-19 associated with PE, the risk of CTEPH should not be considered higher than for other PE. COVID-19 associated with hospitalised PE should not be considered an additional harmful factor if not associated with initial in-hospital mortality.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised controlled trial comparing epinephrine and dexamethasone to placebo in the treatment of infants with bronchiolitis: the Bronchiolitis in Infants Placebo <i>versus</i> Epinephrine and Dexamethasone (BIPED) study protocol.","authors":"Amy C Plint, Anna Heath, Tremaine Rowe, Kristina I Vogel, Natasha Wills-Ibarra, Sharon O'Brien, Meredith L Borland, David W Johnson, Joseph J Zorc, Petros Pechlivanoglou, Suzanne Schuh, Medhawani Rao, Megan Bonisch, Simon S Craig, Serge Gouin, Amit Kochar, Graham C Thompson, Chris Lash, Alexandra Wallace, Andrew Dixon, Scott Sawyer, Gary Joubert, Ed Oakley, Martin Offringa, Terry P Klassen, Stuart R Dalziel","doi":"10.1183/23120541.01298-2024","DOIUrl":"10.1183/23120541.01298-2024","url":null,"abstract":"<p><strong>Introduction: </strong>Bronchiolitis exerts a significant burden of illness on infants worldwide. National guidelines advise only supportive care. There is evidence that treating infants with bronchiolitis with a combination of inhaled epinephrine and dexamethasone may reduce hospital admissions.</p><p><strong>Objective: </strong>The aim of this study is to determine if infants with bronchiolitis treated with inhaled epinephrine (delivered by metered dose inhaler with spacer or nebuliser) in the emergency department and a 2-day course of oral dexamethasone have fewer hospitalisations compared to infants treated with placebo.</p><p><strong>Methods: </strong>The BIPED study (Bronchiolitis in Infants Placebo <i>versus</i> Epinephrine and Dexamethasone) is a randomised, placebo-controlled, observer, investigator, clinician and patient blinded superiority clinical trial being conducted in 12 emergency departments across three countries (Canada, New Zealand and Australia). We will recruit 864 infants between 60 days and 12 months of age with bronchiolitis to receive either: 1) two inhaled epinephrine treatments (3 mg <i>via</i> nebuliser or 625 µg <i>via</i> metered dose inhaler with spacer) 30 min apart and a simultaneous dose of oral dexamethasone (0.6 mg·kg^-1, maximum 10 mg) in the emergency department with the dexamethasone repeated at 24 h; or 2) inhaled placebo and oral placebo. The primary outcome is hospital admission for bronchiolitis within 7 days (168 h) of enrolment. Secondary outcomes include hospital admission during enrolment and all-cause hospital admissions within 21 days of enrolment.</p><p><strong>Conclusion: </strong>Given the burden of bronchiolitis, there is urgent need for a trial to confirm if combination therapy with epinephrine and dexamethasone is effective.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal clinically important difference for the S³ Noninvasive Ventilation questionnaire in individuals with COPD using home mechanical ventilation.","authors":"Pedro Viegas, Leonor Roseta, Cristina Jácome, Cátia Paixão, Luísa Castro, Carla Ribeiro","doi":"10.1183/23120541.01405-2024","DOIUrl":"10.1183/23120541.01405-2024","url":null,"abstract":"<p><strong>Introduction: </strong>The S³-Noninvasive Ventilation (S³-NIV) questionnaire is a simple tool that allows monitoring of symptoms and side-effects in individuals using home mechanical ventilation (HMV). Its longitudinal use in monitorisation is complicated by the current absence of a minimal clinically important difference (MCID), which could facilitate the application of a more tailored follow-up and therapy optimisation. We aimed to establish the MCID for the S³-NIV in people with COPD under HMV.</p><p><strong>Methods: </strong>We conducted an observational study with adult individuals with COPD treated with HMV, followed in an HMV outpatient clinic. The S³-NIV, the Severe Respiratory Insufficiency (SRI) questionnaire and the St George's Respiratory Questionnaire (SGRQ) were applied at baseline and after a 6-month period. Demographic and clinical data were collected from hospital records. The MCID was computed using both distribution- and anchor-based methods. The pooled MCID was computed using the weighted mean (two-thirds anchor- and one-third distribution-based methods).</p><p><strong>Results: </strong>A total of 99 participants (71% male) were included, with a mean±sd age of 72±9 years and a median (interquartile range (IQR)) forced expiratory volume in 1 s of 37 (29-49)% predicted. Median time under HMV was 40 (IQR 24-84) months. The SRI (r=0.311, p=0.002) and the SGRQ (r= -0.334, p=0.001) questionnaires were correlated with S³-NIV, and therefore were used as anchors. Our pooled analysis resulted in a MCID of 0.8 points.</p><p><strong>Conclusion: </strong>A MCID of 0.8 points in the S³-NIV questionnaire is proposed in stable individuals with COPD using HMV, supporting the identification of clinically significant changes and management improvement.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: \"Increased delay to lung transplantation for women candidates: gender-based disparity matters in the lung transplant trajectory\" Adrien Tissot, Anne-Sophie Coatanea, Olivia Rousseau, Antoine Roux, Benjamin Coiffard, Xavier Demant, Benjamin Renaud-Picard, Jérôme Le Pavec, Antoine Magnan, Jean-François Mornex, Thomas Villeneuve, Loïc Falque, Mathilde Salpin, Véronique Boussaud, Christiane Knoop, Martine Reynaud-Gaubert, Romain Kessler, Gaëlle Dauriat, David Lair, Aurore Foureau, François-Xavier Blanc, Mathilde Karakachoff, Patricia Lemarchand and the COLT consortium. <i>ERJ Open Res</i> 2025; 11: 00623-2024.","authors":"","doi":"10.1183/23120541.50623-2024","DOIUrl":"https://doi.org/10.1183/23120541.50623-2024","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/23120541.00623-2024.].</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring lung cavity access to endobronchial valve in chronic pulmonary aspergillosis and nontuberculosis mycobacterial diseases, a radiological feasibility study.","authors":"Thomas Maitre, Matthias Barral, Juliette Camuset, Thomas Egenod, Antoine Parrot, Harry Etienne, Cendrine Godet, Jacques Cadranel","doi":"10.1183/23120541.01366-2024","DOIUrl":"10.1183/23120541.01366-2024","url":null,"abstract":"<p><p><b>This study demonstrates the radiological feasibility of targeting cavities with endobronchial valves in patients with mycobacterial or aspergillosis chronic lung infection and provides essential data for protocol development.</b> https://bit.ly/43STpPH.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breath <i>versus</i> saliva for lung cancer detection with dogs.","authors":"Margaret A Crawford, Catherina L Chang, Clare M Browne, Sandra Hopping, Michael B Jameson, Timothy L Edwards","doi":"10.1183/23120541.00914-2024","DOIUrl":"10.1183/23120541.00914-2024","url":null,"abstract":"<p><strong>Background: </strong>While some research shows that dogs are able to detect lung cancer at above-chance levels using breath samples, the relative utility of other sample types has not been established. We evaluated the comparative utility of human breath and saliva samples for lung cancer detection using dogs.</p><p><strong>Methods: </strong>Seven dogs assessed breath and saliva samples from 154 patients attending a general respiratory clinic. Dogs were trained using an automated apparatus to identify samples from patients who were later diagnosed with lung cancer. Sensitivity and specificity measures were used to compare the dogs' performance with each sample type.</p><p><strong>Results: </strong>A mixed-methods logistic analysis of accurate responses to breath and saliva samples showed significantly higher detection of lung cancer-positive breath samples (mean 0.78, 95% CI 0.71-0.83) than of lung cancer-positive saliva samples (mean 0.42, 95% CI 0.34-0.50; p<0.001). There were no significant differences in accuracy of classification between non-target breath samples (mean 0.68, 95% CI 0.57-0.77) and non-target saliva samples (mean 0.68, 95% CI 0.56-0.77; p=0.854).</p><p><strong>Interpretation: </strong>The higher sensitivity of dogs to breath samples than to saliva samples suggests that breath samples have greater utility for canine scent detection of lung cancer. Although these findings support the continued use of breath samples for volatile-based lung cancer detection, with methodological improvements, saliva samples may also have utility for this purpose.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}