ERJ Open Research最新文献

{"title":"Priorities and barriers for research related to primary ciliary dyskinesia.","authors":"Myrofora Goutaki, Yin Ting Lam, Bruna Rubbo, James D Chalmers, Panayiotis Kouis, Gemma Marsh, Jean-François Papon, Johanna Raidt, Phil Robinson, Laura Behan, Jane S Lucas","doi":"10.1183/23120541.00026-2024","DOIUrl":"10.1183/23120541.00026-2024","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in primary ciliary dyskinesia (PCD) research, many questions remain; diagnosis is complex and no disease-specific therapies exist. Using a mixed-methods approach, we aimed to identify priorities for clinical and epidemiological research and explore barriers to research.</p><p><strong>Methods: </strong>To obtain rich, relevant, diverse data, we performed in-depth semi-structured interviews with PCD specialists selected using purposive sampling. We transcribed, coded and analysed interview data using thematic analysis. Based on interview themes that we identified, we developed an anonymous survey and circulated it widely through the BEAT-PCD network.</p><p><strong>Results: </strong>We interviewed 28 participants from 15 countries across different disciplines and expertise levels. The main themes identified as priorities for PCD research were improving diagnosis; understanding prevalence and disease course; phenotypic variability; disease monitoring; treatment strategies; clinical trial end-points; and poorly researched areas. In total, 136 participants (49% paediatric pulmonologists) from 36 countries completed the survey. Most commonly reported barriers for research were low awareness about PCD and difficulties securing funding - in more than one-third of cases, participants reported undertaking predominantly unfunded research. Research questions ranked highest included priorities related to further improving diagnosis, treating PCD, managing upper and lower airway problems, and studying clinical variability and disease prognosis.</p><p><strong>Conclusion: </strong>We need to overcome barriers of limited funding and low awareness and promote collaborations between centres, disciplines, experts and patients to address identified PCD priorities effectively. Our results contribute to the ongoing efforts of guiding the use of existing limited research resources and setting up a roadmap for future research activities.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms of COPD in the absence of airflow obstruction are more indicative of pre-COPD than overdiagnosis.","authors":"Daniella A Spittle, Maximillian Thomas, Caitlin Stevens, Abdulrhman Gazwani, Sally Fenton, Joshua De Soyza, Alice M Turner","doi":"10.1183/23120541.00264-2024","DOIUrl":"10.1183/23120541.00264-2024","url":null,"abstract":"<p><strong>Background: </strong>Dysfunction of the small airways is a precursor of COPD but is not detectable on standard spirometric testing until significant destruction has occurred. A proportion of COPD patients have a forced expiratory volume in 1 s (FEV₁)/forced vital capacity (FVC) <0.7 which is greater than the lower limit of normal (LLN), when adjusted for their age and sex. It is not understood whether this group of patients, known as \"discordant COPD\", are representative of \"early COPD\" or overdiagnosis.</p><p><strong>Methods: </strong>We sought to characterise discordant COPD (disCOPD) using radiology, lung function, serum biomarkers, activity monitoring and quality-of-life scores, comparing with COPD patients with an FEV₁/FVC <0.7 and <LLN and healthy, age-matched controls.</p><p><strong>Results: </strong>Six out of eight serum biomarkers were significantly different in the disCOPD group <i>versus</i> healthy controls, as were the scores of all four quality-of-life questionnaires. Activity monitoring revealed similar levels of sedentary time between the disCOPD group and concordant COPD (conCOPD). Computed tomography analysis showed less involvement of small airway dysfunction and emphysema in the disCOPD group <i>versus</i> conCOPD.</p><p><strong>Conclusions: </strong>Collectively, our findings support the hypothesis that disCOPD is a clinically relevant phenomenon that represents a pre-COPD state. Identification of such patients is important for early intervention and management before progression to fully established COPD.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of microRNA analysis in exhaled breath condensate of sarcoidosis and mediastinal tuberculosis patients: a pilot study.","authors":"Bijay Pattnaik, Sryma Pb, Naveen Bhatraju, Saurabh Mittal, Sudheer Arava, Deepali Jain, Baibaswata Nayak, Pavan Tiwari, Vijay Hadda, Anant Mohan, Anurag Agrawal, Randeep Guleria, Karan Madan","doi":"10.1183/23120541.00078-2024","DOIUrl":"10.1183/23120541.00078-2024","url":null,"abstract":"<p><strong>Background: </strong>Sarcoidosis and tuberculosis (TB) are the two most common causes of granulomatous mediastinal lymphadenopathy. These often exhibit overlapping clinical and radiological characteristics, rendering accurate diagnosis difficult. MicroRNA (miRNA) analysis is increasingly utilised as a potential biomarker for various diseases. Exhaled breath condensate (EBC) is a noninvasive technique for biomarker evaluation in different respiratory conditions. We attempted to identify differentially expressed miRNAs in the EBC of sarcoidosis and mediastinal TB patients.</p><p><strong>Methods: </strong>EBC was obtained from subjects with a definitive diagnosis of sarcoidosis and mediastinal TB. EBC was also obtained from age- and sex-matched control subjects. From EBC, miRNA isolation, cDNA preparation and qPCR array were performed. Differentially expressed miRNAs were shortlisted. Further validation was conducted in the EBC of a new subset.</p><p><strong>Results: </strong>Subjects with a definitive diagnosis of sarcoidosis (50) and TB (50), and control subjects (50) were included. qPCR array from EBC (20 subjects from each group) shortlisted eight differentially expressed miRNAs (miR-126, miR-132, miR-139-3p, miR-139-5p, miR-181c, miR-454, miR-512-3p and miR-362-5p). In the validation set (EBC of 30 subjects from each group), miR-126 and miR-132 were differentially expressed significantly. The miR-126 and miR-132 expression ratio could differentiate sarcoidosis from mediastinal TB with an AUC of 0.618 (82% specificity and 41% sensitivity).</p><p><strong>Conclusion: </strong>While EBC miRNA expression is significantly and differently altered in sarcoidosis and mediastinal TB, a simple ratiometric approach failed to provide clinically useful signatures for differentiating between the two in patients with mediastinal lymphadenopathy.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-pandemic seasonal dynamics of hospitalised COPD exacerbations and aetiologies in the COPD population.","authors":"Hnin Aung, Aye Aung, Hamish J C McAuley, Omer Elneima, Cara Flynn, Tracy Thornton, Helen Evans, Christopher E Brightling, Adam Wright, Neil J Greening","doi":"10.1183/23120541.00258-2024","DOIUrl":"10.1183/23120541.00258-2024","url":null,"abstract":"<p><p><b>This study uncovered a reversal of seasonal variation in hospitalised COPD exacerbation events after the COVID-19 pandemic. Investigation of updated seasonal exacerbation patterns and triggers can help initiate preventive strategies effectively.</b> https://bit.ly/3wN71h0.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective measurement of cough in pulmonary fibrosis: a cohort study - ImpaCT.","authors":"Jad Kebbe, Simon P Hart, Robert J Kaner, Tejaswini Kulkarni, Lutz Wollin, Carl Coeck, Richard Vinisko, Nina Patel, Marlies S Wijsenbeek","doi":"10.1183/23120541.00310-2024","DOIUrl":"10.1183/23120541.00310-2024","url":null,"abstract":"<p><p><b>Using both objective cough monitoring and patient-reported outcomes measures, this study describes the burden of cough for patients with non-IPF pulmonary fibrosis</b> https://bit.ly/3wFm0th.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin 33: a suitable target for biological therapies of COPD?","authors":"Corrado Pelaia","doi":"10.1183/23120541.00433-2024","DOIUrl":"https://doi.org/10.1183/23120541.00433-2024","url":null,"abstract":"<p><p><b>Because of the relevant importance of the IL-33/ST2 axis in COPD pathobiology, the future results of AERIFY-1 and AERIFY-2 trials could disclose new information about subgroups of responder patients to biologic therapies for this highly prevalent disease</b> https://bit.ly/3USJCUP.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the gap: fractional exhaled nitric oxide and clinical responsiveness to biological therapy in severe asthma - a retrospective study.","authors":"Mauro Maniscalco, Claudio Candia, Dina Visca, Maria D'Amato, Cecilia Calabrese, Pasquale Ambrosino, Antonio Molino, Salvatore Fuschillo","doi":"10.1183/23120541.00296-2024","DOIUrl":"https://doi.org/10.1183/23120541.00296-2024","url":null,"abstract":"<p><p><b>A proportion of patients with severe asthma treated with biological drugs undergoes a significant decline in <i>F</i> _ENO. However, variations in <i>F</i> _ENO are largely independent of the clinical efficacy of the biological drug therapy.</b> https://bit.ly/3xWszYJ.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipomatous hypertrophy of the interatrial septum: a distinct adipose tissue type in COPD?","authors":"Pietro G Lacaita, Benedikt Kindl, Fabian Plank, Christoph Beyer, Valentin Bilgeri, Fabian Barbieri, Thomas Senoner, Wolfgang Dichtl, Ivan Tancevski, Michael Swoboda, Anna Luger, Johannes Deeg, Gerlig Widmann, Gudrun M Feuchtner","doi":"10.1183/23120541.00295-2024","DOIUrl":"https://doi.org/10.1183/23120541.00295-2024","url":null,"abstract":"<p><strong>Objective: </strong>Lipomatous hypertrophy of the interatrial septum (LHIS) is a distinct section of epicardial adipose tissue. However, its association with COPD is poorly documented.</p><p><strong>Methods: </strong>Patients undergoing coronary computed tomography angiography (CTA) for clinical indications were recruited retrospectively and screened for LHIS and COPD. LHIS density and the coronary artery disease profile were quantified by CTA: stenosis severity (coronary artery disease radiological reporting system (CADRADS)), coronary artery calcium (CAC) and high-risk plaque (HRP). COPD patients with LHIS were matched for age and sex, the major cardiovascular risk factors (CVRFs), and compared to controls.</p><p><strong>Results: </strong>The prevalence of LHIS in all 5466 patients was 5.9%. 151 (72.6%) of 208 patients with COPD had LHIS. LHIS density in COPD patients was higher (-10.93 HU <i>versus</i> -21.1 HU; p<0.001), despite body mass index (BMI) (28.8 <i>versus</i> 27.01 kg·m^-2; p=0.002) being lower. LHIS density was lower in obese (BMI >30 kg·m^-2) patients (20.4 <i>versus</i> 13.6 HU; p=0.02). BMI was inversely correlated with LHIS density (BetaR -0.031; 95% CI: -0.054- -0.008; p=0.007). LHIS density was associated with COPD, but not with BMI on multivariate models. CAC and coronary stenosis severity (CADRADS and >50% stenosis) were not different (p=0.106, p=0.156 and p=0.350, respectively). HRPs were observed more frequently in COPD patients with severe Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages ≥2 (32.3% <i>versus</i> 20.1%; p=0.044), but not when adding mild GOLD stages.</p><p><strong>Conclusions: </strong>The prevalence of LHIS in COPD patients is high (72.6%), and the adipose tissue density is higher, indicating a higher brown fat component. In obese, patients LHIS density is lower and declines along with BMI. Coronary stenosis severity and calcium were not different; however HRPs were more frequent in severe COPD.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: \"Does COVID-19 vaccination increase the risk of interstitial lung disease at a population level?\" Taehee Kim, Hyun Lee, Cho Yun Jeong, Sang Woo Yeom, Bo-Guen Kim, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim and Jong Seung Kim. <i>ERJ Open Res</i> 2024; 10: 00690-2023.","authors":"","doi":"10.1183/23120541.50690-2023","DOIUrl":"https://doi.org/10.1183/23120541.50690-2023","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/23120541.00690-2023.].</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time is lung: Higher preservation of lung function in severe asthma patients after earlier mepolizumab treatment","authors":"Francisco-Javier González-Barcala, Irina Bobolea, Javier Domínguez-Ortega, David Bañas-Conejero, Esteban Antelo-Cea, Eva Martínez-Moragón, Teresa Carrillo, Marina Blanco-Aparicio, Christian Domingo","doi":"10.1183/23120541.00211-2024","DOIUrl":"https://doi.org/10.1183/23120541.00211-2024","url":null,"abstract":"Severe asthma involves a persistent inflammation of the airways that is associated with a greater risk of exacerbations. Exacerbations are associated with a higher lung function decline over time. The prevention of lung function decline could become a strategy for disease modification, and this could be more likely to happen in patients with an earlier therapeutic approach. Thus, this study means to analyze the effect of asthma duration in clinical outcomes such as lung function, in patients from the REDES study. REDES was an observational real-world study that assessed the effectiveness and safety of mepolizumab 100 mg SC every 4 weeks for 12 months in 318 patients with severe asthma in Spain. This post hoc analysis evaluated how disease duration affected the study results through a stratification according to quartiles on their disease progression. Continuous analyses were also performed to assess the impact of confounder variables on FEV1(%). At baseline, patients with shorter time of disease had a significantly higher lung function than patients with longer asthma duration. At 12 months, pre-BD FEV1values and the proportion of patients with ≥80% pre-BD FEV1were higher according to a shorter disease persistence (Q1>Q2>Q3>Q4). These results support that time of disease persistence contributes to the lung function decline of patients with severe asthma uncontrolled while on previous treatment, and that an earlier approach with mepolizumab may imply a higher preservation of their lung function.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141929245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}