ERJ Open Research最新文献

{"title":"Estimation of tuberculosis mortality burden in Spain: a review of the major data sources.","authors":"Miriam Roncal Redin, Diana Gómez Barroso, Laura Herrera, Javier Gómez-Castellá, Zaida Herrador","doi":"10.1183/23120541.00636-2024","DOIUrl":"10.1183/23120541.00636-2024","url":null,"abstract":"<p><strong>Introduction: </strong>In Spain, notifications of cases of tuberculosis (TB) are registered through the National Epidemiological Surveillance Network (RENAVE). The Minimum Basic Data Set (CMBD) provides information on hospital discharge and the National Statistics Institute (INE) draws on medical death certificates. This study aimed to describe TB mortality in Spain and to compare estimates across data sources, as well as with EU/EEA countries.</p><p><strong>Material and methods: </strong>A retrospective study of TB data between 2008 and 2021 was performed. Mortality rates (MRs) were calculated for the three databases as well as case fatality rates (CFRs) for TB location and HIV status using RENAVE data. Time trends were calculated and the mean MR and annual mean percentage change for Spain were compared with EU/EEA countries.</p><p><strong>Results: </strong>Between 2008 and 2021, 4127 TB deaths were reported to RENAVE, 3877 to INE and 4775 to CMBD. The MR was 0.62 per 100 000 inhabitants for RENAVE, 0.59 for INE and 0.72 for CMBD. A statistically significant downward annual trend was observed. Highest MRs across all databases were found in men and in those over 80 years old. CFR was higher for meningeal TB and for HIV patients with a risk ratio of 2.02 (95% CI 1.82-2.2; p<0.05).</p><p><strong>Conclusion: </strong>Although the TB MR in Spain has followed a downward annual trend, it is necessary to continue improving prevention, diagnosis and treatment. This will require comprehensive measurement, better knowledge and better use of all information to complement surveillance systems.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles in sarcoidosis: unlocking molecular signatures for precision therapy.","authors":"Sahil Pandya, Scott M Matson","doi":"10.1183/23120541.01028-2024","DOIUrl":"10.1183/23120541.01028-2024","url":null,"abstract":"<p><p><b>Extracellular vesicles and proteomics make a powerful combination for treatment prediction in sarcoidosis</b> https://bit.ly/3Uw5lB7.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of telemonitoring algorithms for the management of home noninvasive ventilation.","authors":"Clara Bianquis, Kinan El Husseini, Léa Razakamanantsoa, Adrien Kerfourn, Emeline Fresnel, Jean-Christian Borel, Antoine Cuvelier, Johan Dupuis, Frédéric Gagnadoux, Capucine Morélot-Panzini, Jesus Gonzalez-Bermejo, Jean-François Muir, Arnaud Prigent, Claudio Rabec, Wojciech Trzepizur, Joao Winck, Patrick Brian Murphy, Maxime Patout","doi":"10.1183/23120541.00509-2024","DOIUrl":"10.1183/23120541.00509-2024","url":null,"abstract":"<p><strong>Background and objective: </strong>The increasing number of patients requiring home noninvasive ventilation (HNIV) is a challenge for our healthcare system. Telemonitoring may be used to facilitate the management of HNIV patients. We aimed to assess the ability of telemonitoring algorithms to identify patients not adequately ventilated. Our secondary aim was to assess the consequences related to these algorithms, including costs.</p><p><strong>Methods: </strong>11 HNIV experts each provided an algorithm to identify patients with suboptimal ventilation. Each algorithm was tested using real-life data from a cohort of patients over a 90-day period. Inadequate HNIV was defined as the presence of at least one criterion amongst the following: uncontrolled hypoventilation, daily adherence <4 h·day^-1, HNIV-related severe side-effect, or a residual event index >10·h^-1.</p><p><strong>Results: </strong>100 patients were included in the cohort. According to our criteria, HNIV was considered as inadequate in 66 (66%) patients, without difference between underlying respiratory disease. Telemonitoring algorithms correctly classified patients in 65% (52-66) of cases. They had a global sensitivity of 78% (95% CI 37-95%), a specificity of 40% (95% CI 19-78%), a positive predictive value of 72% (95% CI 65-77%) and a negative predictive value of 45% (95% CI 37-51%). Applying telemonitoring algorithms resulted in median (interquartile range) 127 (84-238) alerts across the study population with a median cost increase of EUR 2064 (952-6262).</p><p><strong>Conclusion: </strong>Telemonitoring algorithms have poor diagnostic performances in identifying inadequately ventilated patients. They increase workload for healthcare workers and costs.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in self-efficacy mediates the effect of a physical activity intervention in COPD.","authors":"Stephanie A Robinson, Patricia M Bamonti, Emily S Wan, Marilyn L Moy","doi":"10.1183/23120541.00713-2024","DOIUrl":"10.1183/23120541.00713-2024","url":null,"abstract":"<p><p><b>Exercise self-efficacy may play an important role in mediating clinical improvements in daily step count when using technology-based interventions to promote physical activity in COPD</b> https://bit.ly/4dJL8iX.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between age, sex, geography and incidence of nontuberculous mycobacteria in Denmark from 1991 to 2022.","authors":"Victor N Dahl, Andreas A Pedersen, Jakko van Ingen, Aase B Andersen, Troels Lillebaek, Christian M Wejse","doi":"10.1183/23120541.00437-2024","DOIUrl":"10.1183/23120541.00437-2024","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated age, sex and geographical differences in nontuberculous mycobacteria (NTM) incidence in Denmark.</p><p><strong>Methods: </strong>A nationwide register-based study of all patients with NTM isolates in Denmark from 1991 to 2022 based on centralised microbiological data from the International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark. A Poisson regression model was used to calculate incidence rates (IRs) and rate ratios (IRRs).</p><p><strong>Results: </strong>4123 patients had NTM isolated for the first time. Their median age was 59 years (interquartile range 33-72), which increased over time. Males were younger than females. The proportion of females increased significantly over time. The type of NTM and patient age were closely associated. Pulmonary NTM isolation was increasingly common with higher age, while extrapulmonary NTM isolation was mainly seen in small children. Pulmonary NTM IRs were almost twice as high for females in 2008-2022 compared to 1991-2007 (IRR 1.9, 95% CI 1.7-2.1, p<0.001), with increases mainly seen in older age groups. The increase was less pronounced for males (IRR 1.3, 95% CI 1.1-1.4, p<0.001). There were considerable geographical differences, with age- and sex-adjusted NTM IRs being 10-40% higher in countryside, provincial and catchment municipalities than in the capital.</p><p><strong>Conclusion: </strong>Age, sex and geography are essential determinants in NTM epidemiology. We found that rates of pulmonary NTM have been increasing, particularly in older females, while changes for males were less pronounced. Finally, we observed considerable geographical differences in NTM IRs in Denmark, with higher rates in less populated municipalities.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate recovery after the 6-min walk test in people with bronchiectasis.","authors":"Juan Antonio Sáez-Pérez, Ane Arbillaga-Etxarri, Victoria Alcaraz-Serrano, Elena Gimeno-Santos, Antoni Torres, Beatriz Herrero-Cortina","doi":"10.1183/23120541.00694-2024","DOIUrl":"10.1183/23120541.00694-2024","url":null,"abstract":"<p><strong>Background: </strong>The cardiac autonomic response to exercise and during recovery has been poorly explored in bronchiectasis.</p><p><strong>Methods: </strong>A longitudinal study was conducted in adults with bronchiectasis. Sociodemographic and clinical data were collected at baseline and after 12 months of follow-up. The heart rate recovery after the first (HRR₁) and second minute (HRR₂) of recovery in the six-min walk test (6MWT) was estimated in both assessments. Adjusted regression models were used to identify predictors of a delayed HRR₁ (HRR₁≤14).</p><p><strong>Results: </strong>104 participants with a mean±sd age of 64±13 years and mostly women (67%) were included. A delayed HRR₁ after the baseline 6MWT was identified in 36% of participants. These participants presented a higher proportion of males, increased body mass index, higher disease severity, more likely to require hospitalisation, more impact on quality of life, lower exercise capacity, lower heart rate at the end of the 6MWT and lower HRR₂. Disease severity (β, 95% CI) (moderate and severe <i>versus</i> mild, -0.47 (-0.94 to -0.01)) and distance walked (0.34 (0.11 to 0.56)) were the independent variables associated with HRR₁. Of the 45 participants who completed the entire follow-up period, 24% exhibited delayed HRR₁. The presence of at least two exacerbations during the follow-up period (OR 16.89, 95% CI 1.44 to 197.48) was the only predictor of a delayed HRR₁ in the assessment completed at the end of the study.</p><p><strong>Conclusion: </strong>HRR₁ is related to disease severity and is mainly affected by having severe exacerbations in people with bronchiectasis.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and survival of interstitial lung diseases in the UK in 2010-2019.","authors":"Francesca Gonnelli, Neva Eleangovan, Ursie Smith, Heath Heatley, Vidya Navarantam, Tamera J Corte, David B Price, Victoria Carter, Martina Bonifazi, Caitlin C Fermoyle, Richard Hubbard","doi":"10.1183/23120541.00823-2024","DOIUrl":"10.1183/23120541.00823-2024","url":null,"abstract":"<p><strong>Background: </strong>With the introduction of the antifibrotic drugs targeting progressive pulmonary fibroses, it becomes imperative to provide reliable contemporary estimates of the most common interstitial lung diseases. We aimed to provide contemporary estimates of the incidence and survival of idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and connective tissue disease-associated interstitial lung disease (CTD-ILDs), and to compare their survival to that of the general population. To do this we have used data extracted from the Optimum Patient Care Research Database (OPCRD).</p><p><strong>Methods: </strong>In this matched cohort study, we extracted incident cases of HP, CTD-ILD and IPF, and age and sex matched controls for each case, for the years 2010-2019. We calculated annual incidence rates and analysed incidence trends over time using segmented regression modelling. We estimated survival for cases and controls using the Kaplan-Meier model.</p><p><strong>Results: </strong>We extracted data for 18 914 incident cases of interstitial lung diseases between 2010 and 2019 from the OPRCD. Incidence rates varied across the different diseases, with rates of 18.12, 7.96 and 2.63 per 100 000 person-years for IPF, CTD-ILD and HP, respectively. 5-year survival for IPF, CTD-ILD and HP was 40%, 54% and 66%, respectively, and this was generally ∼50% lower than that of the general population.</p><p><strong>Conclusion: </strong>Our population-based study emphasises the considerable burden of interstitial lung diseases, with >20 000 new cases diagnosed each year in the UK, many of whom will be eligible for antifibrotic drugs.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic therapy <i>versus</i> video-assisted thoracoscopic surgery for pleural infections: a systematic review and meta-analysis.","authors":"Weija R de Jonge, Bo Smits, Johannes C F Ket, Josje Altenburg, Jouke Annema, Johannes M A Daniels, Chris Dickhoff, Martijn van Dorp, Jerry Braun, Daniel A Korevaar, David J Heineman","doi":"10.1183/23120541.00619-2024","DOIUrl":"10.1183/23120541.00619-2024","url":null,"abstract":"<p><strong>Aims: </strong>Parapneumonic pleural infections are frequently encountered, but the optimal treatment regimen remains controversial. The aim of this systematic review was to investigate whether immediate video-assisted thoracoscopic surgery (VATS) has advantages over intrapleural enzymatic therapy (IET).</p><p><strong>Methods: </strong>We searched MEDLINE, Embase and Web of Science Core Collection till November 2023 and included studies comparing IET and VATS in adult patients with parapneumonic pleural infections. Primary outcome was length of hospital stay (LOS); secondary outcomes included mortality and morbidity. Study quality was assessed using ROBINS-I and RoB 2. Inverse variance random-effects meta-analysis was performed.</p><p><strong>Results: </strong>We screened 2263 articles; eight were included in the final analysis, covering 1023 patients (n=465 IET (mostly single agent IET); n=558 VATS). Six were non-randomised studies (n=5 with serious risk of bias) comprising 964 patients, and two were small, randomised feasibility studies (n=1 with high risk of bias), comprising 59 patients. In the meta-analysis, LOS in non-randomised studies was shorter for patients treated by VATS (mean difference 4.2 days; 95% CI 1.5-7.0). However, no significant difference was reported in the randomised feasibility studies. Mortality and morbidity rates showed no significant difference.</p><p><strong>Interpretation: </strong>In this meta-analysis of non-randomised studies with a high risk of selection bias, VATS appears superior to IET regarding LOS in the treatment of parapneumonic pleural infections, without increased mortality and morbidity rate. Two recently published randomised feasibility studies failed to confirm this finding, but were not designed to detect a difference in LOS. This meta-analysis highlights the need for high-quality studies.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal spirometry thresholds for the prediction of chronic airflow obstruction: a multinational longitudinal study.","authors":"Abby H S Lam, Sheikhah A Alhajri, James Potts, Imed Harrabi, Mahesh Padukudru Anand, Christer Janson, Rune Nielsen, Dhiraj Agarwal, Andrei Malinovschi, Sanjay Juvekar, Meriam Denguezli, Thorarinn Gislason, Rain Jõgi, Vanessa Garcia-Larsen, Rana Ahmed, Asaad Ahmed Nafees, Parvaiz A Koul, Althea Aquat-Stewart, Peter Burney, Ben Knox-Brown, Andre F S Amaral","doi":"10.1183/23120541.00624-2024","DOIUrl":"10.1183/23120541.00624-2024","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic airflow obstruction is key for COPD diagnosis, but strategies for its early detection are limited. We aimed to define the optimal z-score thresholds for spirometry parameters to discriminate chronic airflow obstruction incidence.</p><p><strong>Methods: </strong>The Burden of Obstructive Lung Disease study is a multinational cohort study. Information on respiratory symptoms was collected and pre- and post-bronchodilator spirometry was performed at baseline. 18 study sites were followed-up with repeat measurements after a median of 8.4 years. We converted lung function measurements into z-scores using the Third National Health and Nutrition Survey reference equations. We used the Youden index to calculate the optimal z-score thresholds for discriminating chronic airflow obstruction incidence. We further examined differences by smoking status.</p><p><strong>Results: </strong>We analysed data from 3057 adults (57% female, mean age: 51 years at baseline). Spirometry parameters were good at discriminating chronic airflow obstruction incidence (area under the curve 0.80-0.84), while respiratory symptoms performed poorly. The optimal z-score threshold was identified for pre-bronchodilator forced expiratory volume in 1 s to forced vital capacity ratio (FEV₁/FVC) <-1.336, equivalent to the 9th percentile (sensitivity: 78%, specificity: 72%). All z-score thresholds associated with a lower post-bronchodilator FEV₁/FVC and greater odds of chronic airflow obstruction at follow-up. The risk of chronic airflow obstruction was slightly greater for current smokers and, to some extent, never-smokers with a pre-bronchodilator FEV₁/FVC <9th/10th percentiles at baseline, particularly among males.</p><p><strong>Conclusions: </strong>Spirometry is better than respiratory symptoms at predicting chronic airflow obstruction incidence. A pre-bronchodilator FEV₁/FVC <9th/10th percentiles, particularly among current smokers, could suggest early airflow obstruction or pre-COPD.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemonitoring for the follow-up of home noninvasive ventilation: a promising future with ongoing challenges.","authors":"Judith Elshof, Marieke L Duiverman","doi":"10.1183/23120541.01002-2024","DOIUrl":"10.1183/23120541.01002-2024","url":null,"abstract":"<p><p><b>There is no agreement or clear evidence on the usefulness of algorithms using ventilator data predicting deterioration. Future research is needed focusing on algorithms that predict outcomes relevant to patients and the healthcare system.</b> https://bit.ly/4083nL2.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}