ERJ Open Research最新文献

{"title":"Unravelling the role of heart rate recovery in bronchiectasis: do we need to establish a cutoff value?","authors":"Arietta Spinou, Ioannis D Laoutaris","doi":"10.1183/23120541.01119-2024","DOIUrl":"10.1183/23120541.01119-2024","url":null,"abstract":"<p><p><b>Heart rate recovery after a field walking test could be a key indicator in bronchiectasis management. Establishing a clear cutoff value in future research will enhance its clinical utility. #HeartRateRecovery #Bronchiectasis #PulmonaryRehabilitation</b> https://bit.ly/4fNAWXe.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted proteomics in extracellular vesicles identifies biomarkers predictive for therapeutic response in sarcoidosis.","authors":"Raisa Kraaijvanger, Montse Janssen Bonás, Ioanna Paspali, Jan C Grutters, Marcel Veltkamp, Dominique P V de Kleijn, Coline H M van Moorsel","doi":"10.1183/23120541.00672-2024","DOIUrl":"10.1183/23120541.00672-2024","url":null,"abstract":"<p><strong>Background: </strong>∼30% of patients with sarcoidosis, a systemic granulomatous disease of unknown cause, need treatment to alleviate symptoms or prevent organ damage. Prednisone and methotrexate (MTX) are the most commonly used drugs; however, success of treatment varies from patient to patient. In this study, we search for biomarkers and pathways that predict response to treatment with prednisone or MTX in extracellular vesicles (EVs).</p><p><strong>Methods: </strong>A targeted proteomics approach (OLINK Bioscience) was used in which 92 proteins were measured in two baseline EV fractions in 32 patients treated for pulmonary sarcoidosis (eight responders and eight non-responders each for prednisone and MTX). The top three proteins were replicated in 62 prednisone- and 76 MTX-treated patients.</p><p><strong>Results: </strong>We identified 11 differentially expressed proteins (DEPs) between responders and non-responders to prednisone treatment, and 16 DEPs for patients treated with MTX. Reactome pathway analysis showed DEPs in prednisone to be involved in nuclear factor kappa B and interleukin signalling pathways. The DEPs in MTX were involved in transduction of GPI-anchored proteins and MAPK signalling pathway. CHI3L1 for prednisone and CPA1 for MTX were replicated as significant predictors of response.</p><p><strong>Conclusion: </strong>This study is the first to show that in pulmonary sarcoidosis the response to treatment with prednisone or MTX can be predicted at baseline by different EV proteins active in different pathways. Using these markers and associated pathways to identify patients with a high probability of response to therapy will aid personalised treatment choice and improve treatment outcome.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences of ventilatory muscle recruitment and work of breathing in COPD and interstitial lung disease: clarifications.","authors":"Jeferson George Ferreira, André L P de Albuquerque","doi":"10.1183/23120541.00946-2024","DOIUrl":"10.1183/23120541.00946-2024","url":null,"abstract":"<p><p><b>These clarifications are important for understanding the respiratory mechanics in COPD and ILD. This response provides the necessary clarification and reinforces the validity of the study's conclusions.</b> https://bit.ly/48k1Cws.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in self-efficacy mediates the effect of a physical activity intervention in COPD.","authors":"Stephanie A Robinson, Patricia M Bamonti, Emily S Wan, Marilyn L Moy","doi":"10.1183/23120541.00713-2024","DOIUrl":"10.1183/23120541.00713-2024","url":null,"abstract":"<p><p><b>Exercise self-efficacy may play an important role in mediating clinical improvements in daily step count when using technology-based interventions to promote physical activity in COPD</b> https://bit.ly/4dJL8iX.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of tuberculosis mortality burden in Spain: a review of the major data sources.","authors":"Miriam Roncal Redin, Diana Gómez Barroso, Laura Herrera, Javier Gómez-Castellá, Zaida Herrador","doi":"10.1183/23120541.00636-2024","DOIUrl":"10.1183/23120541.00636-2024","url":null,"abstract":"<p><strong>Introduction: </strong>In Spain, notifications of cases of tuberculosis (TB) are registered through the National Epidemiological Surveillance Network (RENAVE). The Minimum Basic Data Set (CMBD) provides information on hospital discharge and the National Statistics Institute (INE) draws on medical death certificates. This study aimed to describe TB mortality in Spain and to compare estimates across data sources, as well as with EU/EEA countries.</p><p><strong>Material and methods: </strong>A retrospective study of TB data between 2008 and 2021 was performed. Mortality rates (MRs) were calculated for the three databases as well as case fatality rates (CFRs) for TB location and HIV status using RENAVE data. Time trends were calculated and the mean MR and annual mean percentage change for Spain were compared with EU/EEA countries.</p><p><strong>Results: </strong>Between 2008 and 2021, 4127 TB deaths were reported to RENAVE, 3877 to INE and 4775 to CMBD. The MR was 0.62 per 100 000 inhabitants for RENAVE, 0.59 for INE and 0.72 for CMBD. A statistically significant downward annual trend was observed. Highest MRs across all databases were found in men and in those over 80 years old. CFR was higher for meningeal TB and for HIV patients with a risk ratio of 2.02 (95% CI 1.82-2.2; p<0.05).</p><p><strong>Conclusion: </strong>Although the TB MR in Spain has followed a downward annual trend, it is necessary to continue improving prevention, diagnosis and treatment. This will require comprehensive measurement, better knowledge and better use of all information to complement surveillance systems.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles in sarcoidosis: unlocking molecular signatures for precision therapy.","authors":"Sahil Pandya, Scott M Matson","doi":"10.1183/23120541.01028-2024","DOIUrl":"10.1183/23120541.01028-2024","url":null,"abstract":"<p><p><b>Extracellular vesicles and proteomics make a powerful combination for treatment prediction in sarcoidosis</b> https://bit.ly/3Uw5lB7.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of telemonitoring algorithms for the management of home noninvasive ventilation.","authors":"Clara Bianquis, Kinan El Husseini, Léa Razakamanantsoa, Adrien Kerfourn, Emeline Fresnel, Jean-Christian Borel, Antoine Cuvelier, Johan Dupuis, Frédéric Gagnadoux, Capucine Morélot-Panzini, Jesus Gonzalez-Bermejo, Jean-François Muir, Arnaud Prigent, Claudio Rabec, Wojciech Trzepizur, Joao Winck, Patrick Brian Murphy, Maxime Patout","doi":"10.1183/23120541.00509-2024","DOIUrl":"10.1183/23120541.00509-2024","url":null,"abstract":"<p><strong>Background and objective: </strong>The increasing number of patients requiring home noninvasive ventilation (HNIV) is a challenge for our healthcare system. Telemonitoring may be used to facilitate the management of HNIV patients. We aimed to assess the ability of telemonitoring algorithms to identify patients not adequately ventilated. Our secondary aim was to assess the consequences related to these algorithms, including costs.</p><p><strong>Methods: </strong>11 HNIV experts each provided an algorithm to identify patients with suboptimal ventilation. Each algorithm was tested using real-life data from a cohort of patients over a 90-day period. Inadequate HNIV was defined as the presence of at least one criterion amongst the following: uncontrolled hypoventilation, daily adherence <4 h·day^-1, HNIV-related severe side-effect, or a residual event index >10·h^-1.</p><p><strong>Results: </strong>100 patients were included in the cohort. According to our criteria, HNIV was considered as inadequate in 66 (66%) patients, without difference between underlying respiratory disease. Telemonitoring algorithms correctly classified patients in 65% (52-66) of cases. They had a global sensitivity of 78% (95% CI 37-95%), a specificity of 40% (95% CI 19-78%), a positive predictive value of 72% (95% CI 65-77%) and a negative predictive value of 45% (95% CI 37-51%). Applying telemonitoring algorithms resulted in median (interquartile range) 127 (84-238) alerts across the study population with a median cost increase of EUR 2064 (952-6262).</p><p><strong>Conclusion: </strong>Telemonitoring algorithms have poor diagnostic performances in identifying inadequately ventilated patients. They increase workload for healthcare workers and costs.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between age, sex, geography and incidence of nontuberculous mycobacteria in Denmark from 1991 to 2022.","authors":"Victor N Dahl, Andreas A Pedersen, Jakko van Ingen, Aase B Andersen, Troels Lillebaek, Christian M Wejse","doi":"10.1183/23120541.00437-2024","DOIUrl":"10.1183/23120541.00437-2024","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated age, sex and geographical differences in nontuberculous mycobacteria (NTM) incidence in Denmark.</p><p><strong>Methods: </strong>A nationwide register-based study of all patients with NTM isolates in Denmark from 1991 to 2022 based on centralised microbiological data from the International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark. A Poisson regression model was used to calculate incidence rates (IRs) and rate ratios (IRRs).</p><p><strong>Results: </strong>4123 patients had NTM isolated for the first time. Their median age was 59 years (interquartile range 33-72), which increased over time. Males were younger than females. The proportion of females increased significantly over time. The type of NTM and patient age were closely associated. Pulmonary NTM isolation was increasingly common with higher age, while extrapulmonary NTM isolation was mainly seen in small children. Pulmonary NTM IRs were almost twice as high for females in 2008-2022 compared to 1991-2007 (IRR 1.9, 95% CI 1.7-2.1, p<0.001), with increases mainly seen in older age groups. The increase was less pronounced for males (IRR 1.3, 95% CI 1.1-1.4, p<0.001). There were considerable geographical differences, with age- and sex-adjusted NTM IRs being 10-40% higher in countryside, provincial and catchment municipalities than in the capital.</p><p><strong>Conclusion: </strong>Age, sex and geography are essential determinants in NTM epidemiology. We found that rates of pulmonary NTM have been increasing, particularly in older females, while changes for males were less pronounced. Finally, we observed considerable geographical differences in NTM IRs in Denmark, with higher rates in less populated municipalities.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate recovery after the 6-min walk test in people with bronchiectasis.","authors":"Juan Antonio Sáez-Pérez, Ane Arbillaga-Etxarri, Victoria Alcaraz-Serrano, Elena Gimeno-Santos, Antoni Torres, Beatriz Herrero-Cortina","doi":"10.1183/23120541.00694-2024","DOIUrl":"10.1183/23120541.00694-2024","url":null,"abstract":"<p><strong>Background: </strong>The cardiac autonomic response to exercise and during recovery has been poorly explored in bronchiectasis.</p><p><strong>Methods: </strong>A longitudinal study was conducted in adults with bronchiectasis. Sociodemographic and clinical data were collected at baseline and after 12 months of follow-up. The heart rate recovery after the first (HRR₁) and second minute (HRR₂) of recovery in the six-min walk test (6MWT) was estimated in both assessments. Adjusted regression models were used to identify predictors of a delayed HRR₁ (HRR₁≤14).</p><p><strong>Results: </strong>104 participants with a mean±sd age of 64±13 years and mostly women (67%) were included. A delayed HRR₁ after the baseline 6MWT was identified in 36% of participants. These participants presented a higher proportion of males, increased body mass index, higher disease severity, more likely to require hospitalisation, more impact on quality of life, lower exercise capacity, lower heart rate at the end of the 6MWT and lower HRR₂. Disease severity (β, 95% CI) (moderate and severe <i>versus</i> mild, -0.47 (-0.94 to -0.01)) and distance walked (0.34 (0.11 to 0.56)) were the independent variables associated with HRR₁. Of the 45 participants who completed the entire follow-up period, 24% exhibited delayed HRR₁. The presence of at least two exacerbations during the follow-up period (OR 16.89, 95% CI 1.44 to 197.48) was the only predictor of a delayed HRR₁ in the assessment completed at the end of the study.</p><p><strong>Conclusion: </strong>HRR₁ is related to disease severity and is mainly affected by having severe exacerbations in people with bronchiectasis.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and survival of interstitial lung diseases in the UK in 2010-2019.","authors":"Francesca Gonnelli, Neva Eleangovan, Ursie Smith, Heath Heatley, Vidya Navarantam, Tamera J Corte, David B Price, Victoria Carter, Martina Bonifazi, Caitlin C Fermoyle, Richard Hubbard","doi":"10.1183/23120541.00823-2024","DOIUrl":"10.1183/23120541.00823-2024","url":null,"abstract":"<p><strong>Background: </strong>With the introduction of the antifibrotic drugs targeting progressive pulmonary fibroses, it becomes imperative to provide reliable contemporary estimates of the most common interstitial lung diseases. We aimed to provide contemporary estimates of the incidence and survival of idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and connective tissue disease-associated interstitial lung disease (CTD-ILDs), and to compare their survival to that of the general population. To do this we have used data extracted from the Optimum Patient Care Research Database (OPCRD).</p><p><strong>Methods: </strong>In this matched cohort study, we extracted incident cases of HP, CTD-ILD and IPF, and age and sex matched controls for each case, for the years 2010-2019. We calculated annual incidence rates and analysed incidence trends over time using segmented regression modelling. We estimated survival for cases and controls using the Kaplan-Meier model.</p><p><strong>Results: </strong>We extracted data for 18 914 incident cases of interstitial lung diseases between 2010 and 2019 from the OPRCD. Incidence rates varied across the different diseases, with rates of 18.12, 7.96 and 2.63 per 100 000 person-years for IPF, CTD-ILD and HP, respectively. 5-year survival for IPF, CTD-ILD and HP was 40%, 54% and 66%, respectively, and this was generally ∼50% lower than that of the general population.</p><p><strong>Conclusion: </strong>Our population-based study emphasises the considerable burden of interstitial lung diseases, with >20 000 new cases diagnosed each year in the UK, many of whom will be eligible for antifibrotic drugs.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}