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Peeping at COPD through the keyhole: time to broaden the view to the complexity of the disease by the heterogeneity of symptoms. 通过 "钥匙孔 "窥视慢性阻塞性肺病：是时候通过症状的异质性来拓宽视野，了解疾病的复杂性了。
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-08-05 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00422-2024
Panaiotis Finamore, Ernesto Crisafulli
{"title":"Peeping at COPD through the keyhole: time to broaden the view to the complexity of the disease by the heterogeneity of symptoms.","authors":"Panaiotis Finamore, Ernesto Crisafulli","doi":"10.1183/23120541.00422-2024","DOIUrl":"10.1183/23120541.00422-2024","url":null,"abstract":"<p><p><b>The assessment of co-occurring nonrespiratory symptoms in COPD allow us to explore the true complexity of the disease and to plan specific integrated, multidimensional care strategies</b> https://bit.ly/4dwdnBQ.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic cough: symptom, sign or disease? 慢性咳嗽：症状、体征还是疾病？
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-08-05 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00449-2024
Alyn Morice
{"title":"Chronic cough: symptom, sign or disease?","authors":"Alyn Morice","doi":"10.1183/23120541.00449-2024","DOIUrl":"10.1183/23120541.00449-2024","url":null,"abstract":"<p><p><b>Heritability can be added to the characteristics of chronic cough, making it a disease in its own right</b> https://bit.ly/3ykD6gB.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotyping of primary graft dysfunction after lung transplantation by in-depth biomarker analysis. 通过深入的生物标志物分析，对肺移植后原发性移植物功能障碍进行表型分析。
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-08-05 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00439-2024
Birger Tielemans, Jan Van Slambrouck, Balin Özsoy, Laurens J Ceulemans
{"title":"Phenotyping of primary graft dysfunction after lung transplantation by in-depth biomarker analysis.","authors":"Birger Tielemans, Jan Van Slambrouck, Balin Özsoy, Laurens J Ceulemans","doi":"10.1183/23120541.00439-2024","DOIUrl":"10.1183/23120541.00439-2024","url":null,"abstract":"<p><p><b>This editorial highlights the importance of research towards PGD-specific biomarkers, suggesting strategic sample collection and advanced analysis techniques to expand our knowledge of PGD mechanisms and potential phenotyping</b> https://bit.ly/3UUElw0.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coughing our guts up: how do we diagnose reflux cough? 把肠子咳出来：如何诊断反流性咳嗽？
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-07-29 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00406-2024
Mengru Zhang, Dominic L Sykes
{"title":"Coughing our guts up: how do we diagnose reflux cough?","authors":"Mengru Zhang, Dominic L Sykes","doi":"10.1183/23120541.00406-2024","DOIUrl":"10.1183/23120541.00406-2024","url":null,"abstract":"<p><p><b>Should Peptest be routinely used in a cough clinic? The answer is yes, but only as part of more intricate workup in which discovering the nature of the reflux is as important as identifying its presence.</b> https://bit.ly/3QkbChb.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: "Azithromycin for sarcoidosis cough: an open-label exploratory clinical trial". Simon D. Fraser, Susannah Thackray-Nocera, Marica Shepherd, Rachel Flockton, Caroline Wright, Wayne Sheedy, Kayleigh Brindle, Alyn H. Morice, Paul M. Kaye, Michael G. Crooks and Simon P. Hart. ERJ Open Res 2020; 6: 00534-2020. 勘误："阿奇霉素治疗肉样瘤病咳嗽：一项开放标签探索性临床试验"。Simon D. Fraser, Susannah Thackray-Nocera, Marica Shepherd, Rachel Flockton, Caroline Wright, Wayne Sheedy, Kayleigh Brindle, Alyn H. Morice, Paul M. Kaye, Michael G. Crooks and Simon P. Hart.ERJ Open Res 2020; 6: 00534-2020.
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-07-29 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.50534-2020
{"title":"Erratum: \"Azithromycin for sarcoidosis cough: an open-label exploratory clinical trial\". Simon D. Fraser, Susannah Thackray-Nocera, Marica Shepherd, Rachel Flockton, Caroline Wright, Wayne Sheedy, Kayleigh Brindle, Alyn H. Morice, Paul M. Kaye, Michael G. Crooks and Simon P. Hart. <i>ERJ Open Res</i> 2020; 6: 00534-2020.","authors":"","doi":"10.1183/23120541.50534-2020","DOIUrl":"https://doi.org/10.1183/23120541.50534-2020","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/23120541.00821-2023.].</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Need for sex-stratified reference values for exhaled nitric oxide as biomarker in chronic cough. 将呼出的一氧化氮作为慢性咳嗽的生物标志物，需要按性别划分参考值。
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-07-29 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00202-2024
Sebastian Riemann, Johnmary T Arinze, Andrei Malinovschi, Guy G Brusselle
{"title":"Need for sex-stratified reference values for exhaled nitric oxide as biomarker in chronic cough.","authors":"Sebastian Riemann, Johnmary T Arinze, Andrei Malinovschi, Guy G Brusselle","doi":"10.1183/23120541.00202-2024","DOIUrl":"10.1183/23120541.00202-2024","url":null,"abstract":"<p><p><b>The implementation of exhaled nitric oxide fraction (<i>F</i> <sub>ENO</sub>) as a biomarker in patients with chronic cough requires sex-stratified <i>F</i> <sub>ENO</sub> reference values in general and sex-stratified cut-off levels in the management of unexplained chronic cough</b> https://bit.ly/3JHi0vb.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Get a move on: physical (in)activity in people with obstructive airway disease. 动起来：阻塞性气道疾病患者的体育（不）活动。
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-07-22 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00305-2024
Angela T Burge, Annemarie L Lee
{"title":"Get a move on: physical (in)activity in people with obstructive airway disease.","authors":"Angela T Burge, Annemarie L Lee","doi":"10.1183/23120541.00305-2024","DOIUrl":"10.1183/23120541.00305-2024","url":null,"abstract":"<p><p><b>A study extended the \"can do, do do\" concept in people with obstructive airways disease to demonstrate different clinical and movement behaviour characteristics based on quadrant classification, and proposed a treatable traits approach to management</b> https://bit.ly/4cOGlN5.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to negative conversion and cardiopulmonary performance in athletes with COVID-19. COVID-19 运动员的阴转阳时间和心肺功能。
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-07-22 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00090-2024
Pasquale Mone, Leonardo Bencivenga, Gaetano Santulli, Giuseppe Rengo, Germano Guerra, Klara Komici
{"title":"Time to negative conversion and cardiopulmonary performance in athletes with COVID-19.","authors":"Pasquale Mone, Leonardo Bencivenga, Gaetano Santulli, Giuseppe Rengo, Germano Guerra, Klara Komici","doi":"10.1183/23120541.00090-2024","DOIUrl":"10.1183/23120541.00090-2024","url":null,"abstract":"<p><p><b>Athletes with longer time to negative conversion for COVID-19 do not present reduction of exercise capacity. However, respiratory and ventilatory parameters are modified.</b> https://bit.ly/3TMdrFL.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low serum double-stranded DNA levels are associated with higher survival rates in severe COPD patients. 血清双链 DNA 水平低与严重慢性阻塞性肺病患者的存活率较高有关。
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-07-15 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00240-2024
Sharyn A Roodenburg, Jorine E Hartman, Ilse A Eichhorn, Dirk-Jan Slebos, Simon D Pouwels
{"title":"Low serum double-stranded DNA levels are associated with higher survival rates in severe COPD patients.","authors":"Sharyn A Roodenburg, Jorine E Hartman, Ilse A Eichhorn, Dirk-Jan Slebos, Simon D Pouwels","doi":"10.1183/23120541.00240-2024","DOIUrl":"10.1183/23120541.00240-2024","url":null,"abstract":"<p><strong>Introduction: </strong>Damage-associated molecular patterns (DAMPs) are endogenous danger signals that alert and activate the immune system upon cellular damage or death. It has previously been shown that DAMP release is increased in patients with COPD, leading to higher levels in extracellular fluids such as serum. In the current study we investigated whether the serum levels of DAMPs were associated with survival rates in COPD patients.</p><p><strong>Methods: </strong>A panel of seven DAMPs, consisting of HMGB1, fibrinogen, α-defensin, heat shock protein 70, S100A8, galectin-9 and double-stranded DNA (dsDNA), was measured in serum of 949 severe COPD patients. Maximally selected rank statistics was used to define cut-off values and a Cox proportional hazards model was used to evaluate the effect of high or low DAMP levels on 4-year survival. For DAMPs that were found to affect survival significantly, baseline characteristics were compared between the two DAMP groups.</p><p><strong>Results: </strong>Out of the seven DAMPs, only dsDNA was significantly associated with 4-year survival. Patients with elevated serum level of dsDNA had higher 4-year mortality rates, lower FEV<sub>1</sub> % predicted values and higher emphysema scores.</p><p><strong>Discussion: </strong>In conclusion, in a clinical cohort of 949 patients with moderate-to-severe COPD, elevated serum levels of dsDNA were associated with a higher risk of death. This study further illustrates the potential role of circulating DAMPs, such as dsDNA, in the progression of COPD. Together, the results of this study suggest that levels of circulating dsDNA might serve as an additional prognostic biomarker for survival in COPD patients.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11247366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To burn or not to burn: similar effects of different types of prenatal tobacco exposure on infant lung function. 烧还是不烧：不同类型的产前烟草暴露对婴儿肺功能的相似影响。
IF 4.3 3区 医学
ERJ Open Research Pub Date : 2024-07-08 eCollection Date: 2024-07-01 DOI: 10.1183/23120541.00294-2024
Brian G Oliver, Paul S Foster
{"title":"To burn or not to burn: similar effects of different types of prenatal tobacco exposure on infant lung function.","authors":"Brian G Oliver, Paul S Foster","doi":"10.1183/23120541.00294-2024","DOIUrl":"10.1183/23120541.00294-2024","url":null,"abstract":"<p><p><b>The first study to describe the harmful effects of snus on the unborn infant provides evidence to help clinicians and mothers collectively to make an informed choice about quitting the use of snus before planning pregnancies</b> https://bit.ly/3vJnBxW.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 4","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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