ERJ Open Research最新文献

{"title":"Respiratory sequelae in patients with bronchial asthma after SARS-CoV-2 pneumonia: a retrospective study in a large academic centre in 2020.","authors":"David Espejo, Florencia Pilia, Christian Romero-Mesones, Inigo Ojanguren, María-Jesús Cruz, Xavier Muñoz","doi":"10.1183/23120541.00510-2024","DOIUrl":"10.1183/23120541.00510-2024","url":null,"abstract":"<p><p><b>Patients with asthma do not present more respiratory sequelae than a control population after SARS-CoV-2 pneumonia. However, patients with asthma do seem to present more symptoms and a distinct involvement of the airway</b> https://bit.ly/47E6Hze.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cough frequency has a high daily variation in patients with chronic cough.","authors":"Alyn Morice, Mitja Alge, Laura Kuett, Simon Hart, Alan Rigby, David Elkayam","doi":"10.1183/23120541.00670-2024","DOIUrl":"10.1183/23120541.00670-2024","url":null,"abstract":"<p><p><b>Continuous cough monitoring using a wearable device analysed by machine learning for automated cough detection has revealed considerable day-to-day variability in cough counts. Single-day recording is thus subject to error.</b> https://bit.ly/3yYCRbX.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A framework for modelling whole-lung and regional transfer factor of the lung for carbon monoxide using hyperpolarised xenon-129 lung magnetic resonance imaging.","authors":"Jemima H Pilgrim-Morris, Laurie J Smith, Helen Marshall, Bilal A Tahir, Guilhem J Collier, Neil J Stewart, Jim M Wild","doi":"10.1183/23120541.00442-2024","DOIUrl":"10.1183/23120541.00442-2024","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary gas exchange is assessed by the transfer factor of the lungs (<i>T</i> _L) for carbon monoxide (<i>T</i> _LCO), and can also be measured with inhaled xenon-129 (¹²⁹Xe) magnetic resonance imaging (MRI). A model has been proposed to estimate <i>T</i> _L from ¹²⁹Xe MRI metrics, but this approach has not been fully validated and does not utilise the spatial information provided by three-dimensional ¹²⁹Xe MRI.</p><p><strong>Methods: </strong>Three models for predicting <i>T</i> _L from ¹²⁹Xe MRI metrics were compared: 1) a previously-published physiology-based model, 2) multivariable linear regression and 3) random forest regression. Models were trained on data from 150 patients with asthma and/or COPD. The random forest model was applied voxel-wise to ¹²⁹Xe images to yield regional <i>T</i> _L maps.</p><p><strong>Results: </strong>Coefficients of the physiological model were found to differ from previously reported values. All models had good prediction accuracy with small mean absolute error (MAE): 1) 1.24±0.15 mmol·min^-1·kPa^-1, 2) 1.01±0.06 mmol·min^-1·kPa^-1, 3) 0.995±0.129 mmol·min^-1·kPa^-1. The random forest model performed well when applied to a validation group of post-COVID-19 patients and healthy volunteers (MAE=0.840 mmol·min^-1·kPa^-1), suggesting good generalisability. The feasibility of producing regional maps of predicted <i>T</i> _L was demonstrated and the whole-lung sum of the <i>T</i> _L maps agreed with measured <i>T</i> _LCO (MAE=1.18 mmol·min^-1·kPa^-1).</p><p><strong>Conclusion: </strong>The best prediction of <i>T</i> _LCO from ¹²⁹Xe MRI metrics was with a random forest regression framework. Applying this model on a voxel-wise level to create parametric <i>T</i> _L maps provides a useful tool for regional visualisation and clinical interpretation of ¹²⁹Xe gas exchange MRI.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falling through the cracks: what happens to survivors of preterm birth?","authors":"Andrew Bush, Anne Greenough, Alvar Agustí, Federico Bianco, Eugenio Baraldi","doi":"10.1183/23120541.00643-2024","DOIUrl":"10.1183/23120541.00643-2024","url":null,"abstract":"<p><p><b>There needs to be increased awareness of the long-term implications of prematurity to ensure optimal follow-up of these babies and design studies to obtain an evidence base for the development of improved guidelines</b> https://bit.ly/46cdVtJ.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological correlates of radiological features of systemic sclerosis interstitial lung disease.","authors":"Elizabeth R Volkmann, Donald P Tashkin, Mei Leng, Grace Hyun J Kim, Jonathan Goldin, Airi Harui, Michael D Roth","doi":"10.1183/23120541.00596-2024","DOIUrl":"10.1183/23120541.00596-2024","url":null,"abstract":"<p><strong>Background and objectives: </strong>The extent and pattern of radiological features (<i>e.g.</i> fibrosis and ground glass) can influence treatment approaches for systemic sclerosis-related interstitial lung disease (SSc-ILD). However, the pathobiology underlying these radiological features is poorly understood and warrants further investigation.</p><p><strong>Methods: </strong>68 proteins were measured in bronchoalveolar lavage (BAL) fluid from 103 SSc-ILD participants in Scleroderma Lung Study I. Quantitative image analysis calculated the extent of fibrosis (QLF) and ground-glass opacity (QGG) from concurrent high-resolution computed tomography (HRCT) scans. The relationship between BAL proteins and quantitative HRCT scores was assessed by univariate and multivariate analyses.</p><p><strong>Results: </strong>QLF scores correlated weakly with the extent of QGG, suggesting two distinct processes. In a univariate analysis, 25 proteins from several biological pathways correlated with QLF scores, including profibrotic factors, tissue remodelling proteins, proteins involved in monocyte/macrophage migration and activation, and proteins linked to inflammation and immune regulation. In contrast, QGG scores correlated with only six proteins, of which four were unique and related to granulocyte activation, mobilisation of bone marrow mesenchymal stem cells and activation of T-cells, B-cells, macrophages and eosinophils. In the multivariate models, interleukin-4, CCL7, receptor activator of nuclear factor-κB and tumour necrosis factor-α were independently associated with QLF, whereas interferon-γ was independently associated with QGG.</p><p><strong>Interpretation: </strong>QLF and QGG represent distinct radiological features of SSc-ILD, a conclusion reinforced by the presence of different biological pathways present within BAL fluid that associate with each. The identified proteins and related biological pathways may represent important therapeutic targets.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: \"Effect of lactoferrin treatment on symptoms and physical performance in long COVID patients: a randomised, double-blind, placebo-controlled trial\". Anne-Lotte Redel, Fatana Miry, Merel Elise Hellemons, Laurien Maria Amarentia Oswald and Gerrit Johannes Braunstahl. <i>ERJ Open Res</i> 2024; 10: 00031-2024.","authors":"","doi":"10.1183/23120541.50031-2024","DOIUrl":"https://doi.org/10.1183/23120541.50031-2024","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/23120541.00031-2024.].</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted DNase treatment of obstructive lung disease: a pilot randomised controlled trial.","authors":"Netsanet A Negewo, Natalie M Niessen, Penelope J Baines, Evan J Williams, Naomi Fibbens, Jodie L Simpson, Vanessa M McDonald, Bronwyn S Berthon, Peter G Gibson, Katherine J Baines","doi":"10.1183/23120541.00347-2024","DOIUrl":"10.1183/23120541.00347-2024","url":null,"abstract":"<p><strong>Background: </strong>Sputum extracellular DNA (eDNA) is associated with disease severity in asthma and COPD and therefore emerging as a potential therapeutic target. The aim of this study was to investigate the effect of 10 days of recombinant human DNase (rhDNase) treatment of eDNA-high asthma and COPD on sputum eDNA levels, neutrophil-related inflammation, lung function and symptoms.</p><p><strong>Methods: </strong>Adults with asthma (n=80) or COPD (n=66) were screened for the presence of high (>20 µg·mL^-1) sputum eDNA and those eligible (n=18 asthma, n=17 COPD) were randomised to a two-period crossover controlled trial consisting of daily nebulised rhDNase (2.5 mg/2.5 mL) or placebo (5 mL 0.9% saline) for 10 days, with a 2-week washout period. The primary outcome was sputum eDNA, and secondary outcomes included sputum neutrophil extracellular trap (NET)-related biomarkers, inflammatory cell counts, lung function and respiratory symptoms.</p><p><strong>Results: </strong>At screening, high eDNA was associated with significantly higher sputum total cell count, sputum colour score and inflammation (HNP1-3, LL-37 and interleukin-1β) in both asthma and COPD compared to low eDNA groups. In asthma, participants with high eDNA were older and had poorer lung function and asthma control compared to low eDNA. Administration of nebulised rhDNase significantly reduced sputum eDNA levels in both asthma (median (Q1-Q3) Pre: 48.4 (22.1-74.1); Post: 17.0 (5.0-31.0) µg·mL^-1; p=0.022) and COPD (median (Q1-Q3) Pre: 39.3 (36.7-55.6); Post: 25.4 (11.3-38.6) µg·mL^-1; p=0.044) compared to placebo. Symptoms, lung function and NET biomarkers remained unchanged. In asthma, there was a reduction in banded blood neutrophils (3.2 (0-7.7) to 0.0 (0.0-1.5); p=0.044).</p><p><strong>Conclusion: </strong>Targeted rhDNase treatment for 10 days effectively reduced sputum eDNA in eDNA-high asthma and COPD.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological effects of high-flow nasal cannula during sustained high-intensity exercise in healthy volunteers: a randomised crossover trial.","authors":"Eduardo Moya-Gallardo, Patricio Garcia-Valdés, Consuelo Marambio-Coloma, Constanza Gutierrez-Escobar, Betsabeth Hernández-Vargas, Carolina Muñoz-Castro, Santiago Riquelme-Sánchez, Joel Moo-Millan, Roque Basoalto, Alejandro Bruhn, Orlando Diaz, L Felipe Damiani","doi":"10.1183/23120541.00482-2024","DOIUrl":"10.1183/23120541.00482-2024","url":null,"abstract":"<p><strong>Introduction: </strong>High-flow nasal cannula (HFNC) has increased exercise capacity in patients with chronic respiratory diseases. However, it remains unknown whether HFNC impacts respiratory physiological variables during exercise. This study aimed to evaluate the effect of HFNC on respiratory physiological variables during sustained high-intensity exercise in healthy volunteers.</p><p><strong>Methods: </strong>We performed a single-centre, open-label, randomised crossover trial to compare HFNC (60 L·min^-1) and Sham-HFNC (2 L·min^-1) interventions during a constant work rate exercise (CWRET) through randomised order. The primary outcome was change in oesophageal pressure (Δ<i>P</i> _oes), and the secondary outcomes were other variables of inspiratory effort, ventilation distribution, ventilatory variables and clinical assessment. We evaluated volunteers at seven time points (baseline=T0; CWRET=T1-T2-T3 (1, 4 and 6 min); cooldown period=T4-T5-T6 (1, 6 and 10 min)) in both interventions.</p><p><strong>Results: </strong>14 healthy volunteers (50% women; age: 22 (21-27) years) were enrolled. Mean differences in Δ<i>P</i> _oes decreased to favour the HFNC intervention compared to Sham-HFNC at T2 (-2.8 cmH₂O; 95% CI -5.3 to -0.3), as well as the simplified oesophageal pressure-time product (sPTP) per minute at T2 (-86.1 cmH₂O·s·min^-1; 95% CI -146.2 to -26.1) and T3 (-79.9 cmH₂O·s·min^-1; 95% CI -142.3 to -17.6). The standard deviation of the Regional Ventilation Delay index was also lower with HFNC compared to Sham-HFNC (T1: -1.38; 95% CI -1.93 to -0.83; T2: -0.71; 95% CI -1.27 to -0.16). There was decreased dyspnoea to favour the HFNC, but sPTP per breath, spatial distribution ventilation indexes, ventilatory variables and clinical assessments were nonsignificant between interventions.</p><p><strong>Conclusion: </strong>HFNC intervention reduces respiratory effort and dyspnoea and improves temporal ventilation distribution in healthy volunteers during CWRET.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERS Congress 2024: highlights from the Thoracic Surgery and Lung Transplantation Assembly.","authors":"Dorina Esendagli, Maria Giovanna Mastromarino, Adriana Valverde Zúñiga, Marcello Migliore, Federica Meloni","doi":"10.1183/23120541.01046-2024","DOIUrl":"10.1183/23120541.01046-2024","url":null,"abstract":"<p><p><b>Assembly 8, which includes groups 8.01 Thoracic surgery and 8.02 Lung transplantation, arranged many interesting sessions for #ERSCongress 2024, and we highlight some of them in this article</b> https://bit.ly/3AgC5Yv.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occluding mucous airway plugs in patients with obstructive lung diseases: a new treatable trait?","authors":"Alvar Agustí, Stefano Aliberti, Francesco Blasi, Marc Miravitlles, Alberto Papi","doi":"10.1183/23120541.00793-2024","DOIUrl":"10.1183/23120541.00793-2024","url":null,"abstract":"<p><p><b>Identifying mucous plugs by chest CT should be considered carefully because it is potentially a treatable trait</b> https://bit.ly/4gyJHFW.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}