ERJ Open Research最新文献

{"title":"COPD Assessment Test and risk of readmission in patients with bronchiectasis: a prospective cohort study.","authors":"Juan Wang, Xiaoting Chen, Siqi He, Jing Li, Tianyuan Ma, Lu Liu, Lei Zhang, Xiaoning Bu","doi":"10.1183/23120541.00867-2023","DOIUrl":"10.1183/23120541.00867-2023","url":null,"abstract":"<p><strong>Introduction: </strong>Readmission following bronchiectasis exacerbation is a common and challenging clinical problem and few simple predictive tools exist. The COPD Assessment Test (CAT) is an easy-to-use questionnaire. This study aims to evaluate the predictive value of CAT scores in determining the risk of readmission in patients with bronchiectasis exacerbation.</p><p><strong>Methods: </strong>We conducted a prospective cohort study in 106 bronchiectasis patients admitted with exacerbation. All patients completed the CAT at admission and at discharge. Patients were followed-up for 12 months to collect data on readmission. The area under the curve was used to measure the predictive value of CAT at admission, CAT at discharge and change in CAT for readmission due to bronchiectasis exacerbation.</p><p><strong>Results: </strong>46 patients were readmitted for bronchiectasis exacerbation within 12 months. High CAT at admission was an independent risk factor for readmission within 12 months in patients with acute exacerbation of bronchiectasis (hazard ratio 3.201, 95% CI 1.065-9.624; p<0.038) after adjustment for confounding variables. The cut-off value of CAT at admission and CAT at discharge to predict 12-month readmission in patients with acute exacerbation of bronchiectasis was 23.5 (sensitivity 62.2%, specificity 83.6%) and 15.5 (sensitivity 52.2%, specificity 87.0%).</p><p><strong>Conclusions: </strong>CAT at admission is a strong predictor of readmission in patients with bronchiectasis exacerbation.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the learning effect on the 6-min walk distance in adults with long COVID.","authors":"Tess Volckaerts, Kirsten Quadflieg, Chris Burtin, Kevin de Soomer, Ellie Oostveen, Ella Roelant, Iris Verhaegen, David Ruttens, Thérèse S Lapperre, Dirk Vissers","doi":"10.1183/23120541.00708-2023","DOIUrl":"10.1183/23120541.00708-2023","url":null,"abstract":"<p><p><b>There was no learning effect found on 6-min walk distance (6MWD) in patients with long COVID, performing a 6-min walk test twice. However, considerable variation in the difference between the two 6MWDs was observed: only 51% showed an increase.</b> https://bit.ly/3H70G1r.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10788084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic delay in bronchiectasis: an Italian perspective.","authors":"Carlo Chessari, Edoardo Simonetta, Francesco Amati, Mattia Nigro, Anna Stainer, Giovanni Sotgiu, Mariangela Puci, Andrea Gramegna, Francesco Blasi, Letizia Corinna Morlacchi, Agata Alba Maria Domenica Buscemi, Valentina Conio, Vincenzo Sanci, Angelo G Corsico, Paola Faverio, Weronika Michalak, Fabrizio Luppi, Claudia Crimi, Carlo Vancheri, Raffaele Campisi, Maria Rosaria Vulpi, Giovanna Elisiana Carpagnano, Marianna Cicchetti, Kseniia Sekretna, Nicola Scichilone, Salvatore Battaglia, Stefano Aliberti","doi":"10.1183/23120541.00713-2023","DOIUrl":"10.1183/23120541.00713-2023","url":null,"abstract":"<p><p><b>It takes ∼3.5 years to reach a diagnosis of bronchiectasis from onset of symptoms: the long patient's journey in Italy</b> https://bit.ly/46XMWAz.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spray nozzle for topical anaesthesia during flexible bronchoscopy: a randomised controlled trial.","authors":"Chun-Ta Huang, Hsiao-Chen Chou, Hao-Chun Chang, Ching-Yao Yang, Shu-Yung Lin, Lih-Chyun Chang, Tzu-Hsiu Tsai, Chia-Lin Hsu, Jung-Yien Chien, Chao-Chi Ho","doi":"10.1183/23120541.00913-2023","DOIUrl":"10.1183/23120541.00913-2023","url":null,"abstract":"<p><strong>Background: </strong>The effectiveness of using a spray nozzle to deliver lidocaine for superior topical airway anaesthesia during non-sedation flexible bronchoscopy (FB) remains a topic of uncertainty when compared with conventional methods.</p><p><strong>Methods: </strong>Patients referred for FB were randomly assigned to receive topical lidocaine anaesthesia <i>via</i> the bronchoscope's working channel (classical spray (CS) group) or through a washing pipe equipped with a spray nozzle (SN group). The primary outcome was cough rate, defined as the total number of coughs per minute. Secondary outcomes included subjective perceptions of both the patient and operator regarding the FB process. These perceptions were rated on a visual analogue scale, with numerical ratings ranging from 0 to 10.</p><p><strong>Results: </strong>Our study enrolled a total of 126 (61 CS group; 65 SN group) patients. The SN group exhibited a significantly lower median cough rate compared with the CS group (4.5 <i>versus</i> 7.1 counts·min^-1; p=0.021). Patients in the SN group also reported less oropharyngeal discomfort (4.5±2.7 <i>versus</i> 5.6±2.9; p=0.039), better tolerance of the procedure (6.8±2.2 <i>versus</i> 5.7±2.7; p=0.011) and a greater willingness to undergo a repeat FB procedure (7.2±2.7 <i>versus</i> 5.8±3.4; p=0.015) compared with those in the CS group. From the operator's perspective, patient discomfort (2.7±1.7 <i>versus</i> 3.4±2.3; p=0.040) and cough scores (2.3±1.5 <i>versus</i> 3.2±2.4; p=0.013) were lower in the SN group compared with the CS group, with less disruption due to coughing observed among those in the SN group (1.6±1.4 <i>versus</i> 2.3±2.3; p=0.029).</p><p><strong>Conclusions: </strong>This study illustrates that employing a spray nozzle for the delivery of lidocaine provides superior topical airway anaesthesia during non-sedation FB compared with the traditional method.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10926006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial.","authors":"Merete B Long, Hani Abo-Leyah, Yan Hui Giam, Thenmalar Vadiveloo, Rebecca C Hull, Holly R Keir, Thomas Pembridge, Daniela Alferes De Lima, Lilia Delgado, Sarah K Inglis, Chloe Hughes, Amy Gilmour, Marek Gierlinski, Benjamin J M New, Graeme MacLennan, Albena T Dinkova-Kostova, James D Chalmers","doi":"10.1183/23120541.00917-2023","DOIUrl":"10.1183/23120541.00917-2023","url":null,"abstract":"<p><strong>Introduction: </strong>Sulforaphane can induce the transcription factor, Nrf2, promoting antioxidant and anti-inflammatory responses. In this study, hospitalised patients with community-acquired pneumonia (CAP) were treated with stabilised synthetic sulforaphane (SFX-01) to evaluate impact on clinical status and inflammation.</p><p><strong>Methods: </strong>Double-blind, randomised, placebo-controlled trial of SFX-01 (300 mg oral capsule, once daily for 14 days) conducted in Dundee, UK, between November 2020 and May 2021. Patients had radiologically confirmed CAP and CURB-65 (confusion, urea >7 mmol·L^-1, respiratory rate ≥30 breaths·min^-1, blood pressure <90 mmHg (systolic) or ≤60 mmHg (diastolic), age ≥65 years) score ≥1. The primary outcome was the seven-point World Health Organization clinical status scale at day 15. Secondary outcomes included time to clinical improvement, length of stay and mortality. Effects on Nrf2 activity and inflammation were evaluated on days 1, 8 and 15 by measurement of 45 serum cytokines and mRNA sequencing of peripheral blood leukocytes.</p><p><strong>Results: </strong>The trial was terminated prematurely due to futility with 133 patients enrolled. 65 patients were randomised to SFX-01 treatment and 68 patients to placebo. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was the cause of CAP in 103 (77%) cases. SFX-01 treatment did not improve clinical status at day 15 (adjusted OR 0.87, 95% CI 0.41-1.83; p=0.71), time to clinical improvement (adjusted hazard ratio (aHR) 1.02, 95% CI 0.70-1.49), length of stay (aHR 0.84, 95% CI 0.56-1.26) or 28-day mortality (aHR 1.45, 95% CI 0.67-3.16). The expression of Nrf2 targets and pro-inflammatory genes, including interleukin (IL)-6, IL-1β and tumour necrosis factor-α, was not significantly changed by SFX-01 treatment. At days 8 and 15, respectively, 310 and 42 significant differentially expressed genes were identified between groups (false discovery rate adjusted p<0.05, log₂FC >1).</p><p><strong>Conclusion: </strong>SFX-01 treatment did not improve clinical status or modulate key Nrf2 targets in patients with CAP primarily due to SARS-CoV-2 infection.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10926007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home sleep studies in children with neurodisabilities: success rates and parental perception.","authors":"Mihaela Diaconu, Andrew Bush, Hui-Leng Tan","doi":"10.1183/23120541.00630-2023","DOIUrl":"10.1183/23120541.00630-2023","url":null,"abstract":"<p><p><b>Home sleep studies in children with neurodisabilities have a high success rate (85.4% in our cohort), particularly in patients with limited mobility, have the advantage of reducing the burden of hospital admissions and are the family preferred option</b> https://bit.ly/46t8aWN.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10910318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative assessment of sensations and triggers in chronic cough.","authors":"Barnaby Hirons, Katherine Rhatigan, Harini Kesavan, Peter S P Cho, Surinder S Birring","doi":"10.1183/23120541.00923-2023","DOIUrl":"10.1183/23120541.00923-2023","url":null,"abstract":"<p><p><b>Qualitative interviews show a wide range of cough triggers and sensations in patients with refractory chronic cough. Knowledge of these may help us manage this complicated and impactful condition.</b> https://bit.ly/41k9Ot5.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10910352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between upper and lower respiratory disease among patients with primary ciliary dyskinesia: an international study.","authors":"Yin Ting Lam, Jean-François Papon, Mihaela Alexandru, Andreas Anagiotos, Miguel Armengot, Mieke Boon, Andrea Burgess, Doriane Calmes, Suzanne Crowley, Sinan Ahmed D Dheyauldeen, Nagehan Emiralioglu, Ela Erdem Eralp, Christine van Gogh, Yasemin Gokdemir, Eric G Haarman, Amanda Harris, Isolde Hayn, Hasnaa Ismail-Koch, Bülent Karadag, Céline Kempeneers, Elisabeth Kieninger, Sookyung Kim, Natalie Lorent, Ugur Ozcelik, Charlotte Pioch, Johanna Raidt, Ana Reula, Jobst Roehmel, Synne Sperstad Kennelly, Panayiotis Yiallouros, Myrofora Goutaki","doi":"10.1183/23120541.00932-2023","DOIUrl":"10.1183/23120541.00932-2023","url":null,"abstract":"<p><strong>Introduction: </strong>Nearly all patients with primary ciliary dyskinesia (PCD) report ear-nose-throat (ENT) symptoms. However, scarce evidence exists about how ENT symptoms relate to pulmonary disease in PCD. We explored possible associations between upper and lower respiratory disease among patients with PCD in a multicentre study.</p><p><strong>Methods: </strong>We included patients from the ENT Prospective International Cohort (EPIC-PCD). We studied associations of several reported ENT symptoms and chronic rhinosinusitis (defined using patient-reported information and examination findings) with reported sputum production and shortness of breath, using ordinal logistic regression. In a subgroup with available lung function results, we used linear regression to study associations of chronic rhinosinusitis and forced expiratory volume in 1 s (FEV₁) accounting for relevant factors.</p><p><strong>Results: </strong>We included 457 patients (median age 15 years, interquartile range 10-24 years; 54% males). Shortness of breath associated with reported nasal symptoms and ear pain of any frequency, often or daily hearing problems, headache when bending down (OR 2.1, 95% CI 1.29-3.54) and chronic rhinosinusitis (OR 2.3, 95% CI 1.57-3.38) regardless of polyp presence. Sputum production associated with daily reported nasal (OR 2.2, 95% CI 1.20-4.09) and hearing (OR 2.0, 95% CI 1.10-3.64) problems and chronic rhinosinusitis (OR 2.1, 95% CI 1.48-3.07). We did not find any association between chronic rhinosinusitis and FEV₁.</p><p><strong>Conclusion: </strong>Reported upper airway symptoms and signs of chronic rhinosinusitis associated with reported pulmonary symptoms, but not with lung function. Our results emphasise the assessment and management of upper and lower respiratory disease as a common, interdependent entity among patients with PCD.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10910353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-based and vegetarian diets are associated with reduced obstructive sleep apnoea risk.","authors":"Yohannes Adama Melaku, Lijun Zhao, Robert Adams, Danny J Eckert","doi":"10.1183/23120541.00739-2023","DOIUrl":"10.1183/23120541.00739-2023","url":null,"abstract":"<p><strong>Introduction: </strong>Obstructive sleep apnoea (OSA) and obesity commonly coexist. Weight loss and exercise are recommended management options for OSA. However, most of the current evidence on diet and OSA is focused on calorie restriction rather than diet quality. The aim of the present study was to determine the association of plant-based dietary indices (PDI) with OSA risk.</p><p><strong>Methods: </strong>Cross-sectional data from 14 210 participants of the National Health and Nutrition Examination Survey who provided dietary information using the 24-hour recall method were used. PDI - including healthy (hPDI), unhealthy (uPDI) and pro-vegetarian diet index (PVDI) - were determined. OSA risk was determined using the STOP-BANG questionnaire. Logistic regression was used to determine the relationship between dietary indices and OSA risk.</p><p><strong>Results: </strong>Higher adherence to PDI (odds ratio (OR)_{Q5 <i>versus</i> Q1}=0.81; 95% confidence interval (CI): 0.66-1.00), hPDI (OR=0.83; 95% CI: 0.69-1.01) and PVDI (OR=0.84; 95% CI: 0.68-1.05) was inversely associated with OSA risk, whereas higher consumption of an unhealthy plant-based diet (OR=1.22; 95% CI: 1.00-1.49) was positively associated with OSA. Sex differences in estimates were observed for PDI in males (OR=0.71; 95% CI: 0.56-0.90) <i>versus</i> females (OR=0.93; 95% CI: 0.68-1.28), hPDI in males (OR=0.90; 95% CI: 0.68-1.18) <i>versus</i> females (OR=0.77; 95% CI: 0.54-1.09) and uPDI in males (OR=1.13; 95% CI: 0.89-1.44) <i>versus</i> females (OR=1.42; 95% CI: 1.03-1.97) but not for PVDI.</p><p><strong>Conclusions: </strong>Higher adherence to a healthy plant-based diet is associated with reduced OSA risk, while an unhealthy plant-based diet has a positive association. The magnitude of these associations differs by sex. Further longitudinal studies are warranted.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10910314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cluster analysis identifies novel real-world lung disease-pulmonary hypertension sub-phenotypes: implications for treatment response","authors":"Shelsey W. Johnson, Rui-Sheng Wang, Michael R. Winter, K. R. Gillmeyer, Katarina Zeder, E. Klings, Ronald H. Goldstein, R. Wiener, Bradley A Maron","doi":"10.1183/23120541.00959-2023","DOIUrl":"https://doi.org/10.1183/23120541.00959-2023","url":null,"abstract":"Clinical trials repurposing pulmonary arterial hypertension (PAH) therapies to patients with lung disease- or hypoxia-pulmonary hypertension (Group 3 PH) have failed to show a consistent benefit. However, Group 3 PH clinical heterogeneity suggests robust phenotyping may inform detection of treatment-responsive subgroups. We hypothesized that cluster analysis would identify sub-phenotypes with differential responses to oral PAH therapy.Two k-means analyses were performed on a national cohort of U.S. Veterans with Group 3 PH; an inclusive model (I) of all treated patients (n=196) and a hemodynamic model (H) limited to patients with right heart catheterisations (RHC) (n=112). The primary outcome was organ failure or all-cause mortality by cluster. An exploratory analysis evaluated within-cluster treatment effects.Three distinct clusters of Group 3 PH patients were identified. In the “inclusive model” (C1I=43, 21.9%; C2I=102, 52.0%; C3I=51, 26.0%) lung disease and spirometry drove cluster assignment whereas RHC data surpassed the importance of these variables in the hemodynamic model (C1H=44, 39.3%; C2H=43, 38.4%; C3H=25, 22.3%). In the hemodynamic model, compared to C3H, C1Hexperienced the greatest hazard for respiratory failure or death (HR 6.1 [95% CI 3.2, 11.8]). In an exploratory analysis, cluster determined treatment response (p=0.006). Conclusions regarding within-cluster treatment responses were limited by significant differences between select variables in the treated and untreated groups.Cluster analysis identifies novel real-world sub-phenotypes of Group 3 PH patients with distinct clinical trajectories. Future studies may consider this methodologic approach to identify subgroups of heterogeneous patients that may be responsive to existing pulmonary vasodilatory therapies.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140410901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}