Simon Proctor, Nathan J Cheetham, Julia R B Brown, Vicky Bowyer, Barbara Toson, Nicholas R Harvey, Guy Leschziner, Desaline Joseph, Alexander Hammers, Carole H Sudre, Claire J Steves, Sutapa Mukherjee, Emma L Duncan
{"title":"大流行的睡眠障碍：疾病时间更长，更疲劳，但SARS-CoV-2的影响很小。","authors":"Simon Proctor, Nathan J Cheetham, Julia R B Brown, Vicky Bowyer, Barbara Toson, Nicholas R Harvey, Guy Leschziner, Desaline Joseph, Alexander Hammers, Carole H Sudre, Claire J Steves, Sutapa Mukherjee, Emma L Duncan","doi":"10.1183/23120541.00975-2024","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic disturbed sleep globally in both infected and uninfected individuals. Prolonged symptoms (particularly fatigue) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (post-COVID 2019 syndrome (PCS)) remain a health issue. Whether there is a relationship between PCS and sleep disturbance is largely unknown, with most studies lacking uninfected controls. We assessed sleep behaviours in a large UK cohort, analysing sleep disruption, fatigue, SARS-CoV-2 infection and symptom duration.</p><p><strong>Methods: </strong>UK adults previously recruited from the King's College London ZOE COVID Symptom Study to the COVID Symptom Study Biobank, with prospective symptom logging and SARS-CoV-2 testing, were invited to complete online validated questionnaires for sleep (Pittsburgh Sleep Quality Index, Sleep Condition Indicator, the STOP-Bang Questionnaire and Epworth Sleepiness Scale), fatigue (Chalder Fatigue Scale) and mental health (Generalised Anxiety Disorder 2 scale and Patient Health Questionnaire 2). Data were analysed considering SARS-CoV-2 infection, symptom duration and co-morbidities, including mental health.</p><p><strong>Results: </strong>Questionnaires were completed by 3833 of 8355 participants (2089 infected, 1721 uninfected, 23 unknown). Individuals with longer (<i>versus</i> shorter) symptom duration had poorer sleep scores for multiple questionnaires, but SARS-CoV-2 infection had no independent effect on sleep. However, previously infected (<i>versus</i> uninfected) individuals had greater fatigue, over a year since infection. Longer symptom duration, poorer sleep scores and greater fatigue were also associated with higher contemporaneous levels of anxiety and depression; however, an independent effect of prior SARS-CoV-2 infection on fatigue remained after adjustment. Higher body mass index, greater age and prior co-morbidities also independently worsened sleep scores.</p><p><strong>Conclusions: </strong>Sleep disturbance contributes to prolonged symptom reporting, irrespective of SARS-CoV-2 infection. Proven sleep interventions may help individuals with post-pandemic fatigue, including PCS.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257144/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pandemic-disordered sleep: longer illness and more fatigue but little SARS-CoV-2 effect.\",\"authors\":\"Simon Proctor, Nathan J Cheetham, Julia R B Brown, Vicky Bowyer, Barbara Toson, Nicholas R Harvey, Guy Leschziner, Desaline Joseph, Alexander Hammers, Carole H Sudre, Claire J Steves, Sutapa Mukherjee, Emma L Duncan\",\"doi\":\"10.1183/23120541.00975-2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The COVID-19 pandemic disturbed sleep globally in both infected and uninfected individuals. Prolonged symptoms (particularly fatigue) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (post-COVID 2019 syndrome (PCS)) remain a health issue. Whether there is a relationship between PCS and sleep disturbance is largely unknown, with most studies lacking uninfected controls. We assessed sleep behaviours in a large UK cohort, analysing sleep disruption, fatigue, SARS-CoV-2 infection and symptom duration.</p><p><strong>Methods: </strong>UK adults previously recruited from the King's College London ZOE COVID Symptom Study to the COVID Symptom Study Biobank, with prospective symptom logging and SARS-CoV-2 testing, were invited to complete online validated questionnaires for sleep (Pittsburgh Sleep Quality Index, Sleep Condition Indicator, the STOP-Bang Questionnaire and Epworth Sleepiness Scale), fatigue (Chalder Fatigue Scale) and mental health (Generalised Anxiety Disorder 2 scale and Patient Health Questionnaire 2). Data were analysed considering SARS-CoV-2 infection, symptom duration and co-morbidities, including mental health.</p><p><strong>Results: </strong>Questionnaires were completed by 3833 of 8355 participants (2089 infected, 1721 uninfected, 23 unknown). Individuals with longer (<i>versus</i> shorter) symptom duration had poorer sleep scores for multiple questionnaires, but SARS-CoV-2 infection had no independent effect on sleep. However, previously infected (<i>versus</i> uninfected) individuals had greater fatigue, over a year since infection. Longer symptom duration, poorer sleep scores and greater fatigue were also associated with higher contemporaneous levels of anxiety and depression; however, an independent effect of prior SARS-CoV-2 infection on fatigue remained after adjustment. Higher body mass index, greater age and prior co-morbidities also independently worsened sleep scores.</p><p><strong>Conclusions: </strong>Sleep disturbance contributes to prolonged symptom reporting, irrespective of SARS-CoV-2 infection. Proven sleep interventions may help individuals with post-pandemic fatigue, including PCS.</p>\",\"PeriodicalId\":11739,\"journal\":{\"name\":\"ERJ Open Research\",\"volume\":\"11 4\",\"pages\":\"\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257144/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ERJ Open Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1183/23120541.00975-2024\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ERJ Open Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1183/23120541.00975-2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Pandemic-disordered sleep: longer illness and more fatigue but little SARS-CoV-2 effect.
Background: The COVID-19 pandemic disturbed sleep globally in both infected and uninfected individuals. Prolonged symptoms (particularly fatigue) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (post-COVID 2019 syndrome (PCS)) remain a health issue. Whether there is a relationship between PCS and sleep disturbance is largely unknown, with most studies lacking uninfected controls. We assessed sleep behaviours in a large UK cohort, analysing sleep disruption, fatigue, SARS-CoV-2 infection and symptom duration.
Methods: UK adults previously recruited from the King's College London ZOE COVID Symptom Study to the COVID Symptom Study Biobank, with prospective symptom logging and SARS-CoV-2 testing, were invited to complete online validated questionnaires for sleep (Pittsburgh Sleep Quality Index, Sleep Condition Indicator, the STOP-Bang Questionnaire and Epworth Sleepiness Scale), fatigue (Chalder Fatigue Scale) and mental health (Generalised Anxiety Disorder 2 scale and Patient Health Questionnaire 2). Data were analysed considering SARS-CoV-2 infection, symptom duration and co-morbidities, including mental health.
Results: Questionnaires were completed by 3833 of 8355 participants (2089 infected, 1721 uninfected, 23 unknown). Individuals with longer (versus shorter) symptom duration had poorer sleep scores for multiple questionnaires, but SARS-CoV-2 infection had no independent effect on sleep. However, previously infected (versus uninfected) individuals had greater fatigue, over a year since infection. Longer symptom duration, poorer sleep scores and greater fatigue were also associated with higher contemporaneous levels of anxiety and depression; however, an independent effect of prior SARS-CoV-2 infection on fatigue remained after adjustment. Higher body mass index, greater age and prior co-morbidities also independently worsened sleep scores.
Conclusions: Sleep disturbance contributes to prolonged symptom reporting, irrespective of SARS-CoV-2 infection. Proven sleep interventions may help individuals with post-pandemic fatigue, including PCS.
期刊介绍：
ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
