ERJ Open Research最新文献

{"title":"<i>IL1RL1</i> variant may affect the response to type 2 biologics in patients with severe asthma.","authors":"Kenta Nishi, Hisako Matsumoto, Hironobu Sunadome, Tadao Nagasaki, Tsuyoshi Oguma, Noriyuki Tashima, Yusuke Hayashi, Satoru Terada, Kyohei Morita, Chie Yoshimura, Yasuo Nishizaka, Akiko Sano, Takashi Iwanaga, Hiroyuki Sano, Ryuta Haraguchi, Yuji Tohda, Takahisa Kawaguchi, Fumihiko Matsuda, Toyohiro Hirai","doi":"10.1183/23120541.00448-2024","DOIUrl":"10.1183/23120541.00448-2024","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a heterogeneous disease with variable response to treatment. Genetic backgrounds are involved in the severity of type 2 asthma, but their effects on responses to biologics remain unknown. This study aimed to clarify the role of genetic factors in response to biologics in patients with severe asthma.</p><p><strong>Methods: </strong>Adults with severe asthma receiving biologics were enrolled in this multicentre, observational, real-world study. The responses to biologics were evaluated using Physicians' Global Evaluation of Treatment Effectiveness (GETE). Optimal biologic for each patient was also determined based on the best GETE score for the biologic used or currently used biologic. Three single nucleotide polymorphisms (<i>IL1RL1</i>, rs1420101; <i>IL4RA</i>, rs8832; and <i>TSLP</i> rs1837253) were examined.</p><p><strong>Results: </strong>Among the 113 patients analysed, 53 (46.9%) had an excellent GETE score for at least one biologic. These patients with an excellent GETE score for at least one biologic, particularly for benralizumab, had the risk genotype of rs1420101 more frequently than the remaining patients, independent of the clinical demographics. Regarding the optimal biologic for each patient, anti-IL-5 drugs were optimal for patients with the rs1420101 TT or rs8832 GG genotype. Furthermore, dupilumab was similarly effective, regardless of the risk genotypes examined in this study.</p><p><strong>Conclusion: </strong><i>IL1RL1</i> rs1420101 TT genotype and/or <i>IL4RA</i> rs8832 GG genotype may predict an excellent or optimal response to biologic therapy in each patient, particularly to anti-interleukin-5 targeted therapy. The elucidation of genetic predisposition may improve the management of severe asthma in the era of biologics.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital markers of asthma exacerbations: a systematic review.","authors":"Brenda Cokorudy, Jeff Harrison, Amy Hai Yan Chan","doi":"10.1183/23120541.00014-2024","DOIUrl":"10.1183/23120541.00014-2024","url":null,"abstract":"<p><strong>Background and objective: </strong>With the increase in use of digital technologies, there is growing interest in digital markers, where technology is used to detect early markers of disease deterioration. The aim of this systematic review is to summarise the evidence relating to digital markers of asthma exacerbations.</p><p><strong>Methods: </strong>A systematic search of the following databases was conducted, using key search terms relating to asthma, digital and exacerbations: Ovid MEDLINE, EMBASE, Psycinfo, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials. Studies that aimed to explore the relationship between any digitally measured marker and asthma exacerbations using any form of portable digital sensor technology were included.</p><p><strong>Results: </strong>23 papers were included. The digital markers related to five key categories: environmental, physiological, medication, lung function and breath-related parameters. The most commonly studied marker was lung function, which was reported in over half (13 out of 23) of the papers. However, studies were conflicting in terms of the use of lung function parameters as a predictor of asthma exacerbations. Medication parameters were measured in over a third of the studies (10 out of 23) with a focus on short-acting β-agonist (SABA) use as a marker of exacerbations. Only four and two studies measured heart rate and cough, respectively; however, both parameters were positively associated with exacerbations in all reported studies.</p><p><strong>Conclusion: </strong>Several digital markers are associated with asthma exacerbations. This suggests a potential role for using parameters such as heart rate, SABA use and, potentially, cough as digital markers of asthma exacerbations.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: \"Influence of physical activity on the prognosis of COPD patients: the HADO.2 score - health, activity, dyspnoea and obstruction\". Cristóbal Esteban, Nere Larrea, Amaia Aramburu, Javier Moraza, Leyre Chasco, Myriam Aburto, Susana Aizpiri, Rafael Golpe and José M. Quintana. <i>ERJ Open Res</i> 2024; 10: 00488-2023.","authors":"","doi":"10.1183/23120541.50488-2023","DOIUrl":"https://doi.org/10.1183/23120541.50488-2023","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/23120541.00488-2023.].</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma.","authors":"Amir Hossein Alizadeh Bahmani, Susanne J H Vijverberg, Simone Hashimoto, Christine Wolff, Catarina Almqvist, Lizan D Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Anna M Hedman, Michael Kabesch, Leyre López-Fernández, Aletta D Kraneveld, Anne H Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Barbara S Dierdorp, Tamara Dekker, Nariman K A Metwally, Jan Willem Duitman, René Lutter, Paul Brinkman, Mahmoud I Abdel-Aziz, Anke H Maitland-van der Zee","doi":"10.1183/23120541.00222-2024","DOIUrl":"10.1183/23120541.00222-2024","url":null,"abstract":"<p><strong>Background: </strong>Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. We aimed to investigate the association between blood inflammatory parameters and asthma burden in children with moderate-to-severe asthma.</p><p><strong>Methods: </strong>Blood inflammatory parameters (eosinophil and neutrophil counts and inflammatory mediators using multiplex immunoassay technology) were measured in children (6-17 years) with moderate-to-severe asthma from the SysPharmPediA cohort across four European countries. Based upon low/high blood eosinophil (LBE/HBE) counts of </≥0.3×10⁹·L^-1, respectively and low/high blood neutrophil (LBN/HBN) counts of </≥4×10⁹·L^-1, respectively, mixed (HBE-HBN), eosinophilic (HBE-LBN), neutrophilic (LBE-HBN) and paucigranulocytic (LBE-LBN) phenotypes were defined. Inflammatory mediator profiles and burden of disease (asthma control status, exacerbations and school days missed in the past year) were compared between phenotypes using adjusted logistic regression models.</p><p><strong>Results: </strong>Among 126 included children (41% girls and mean (sd) age of 11.94 (2.76)), 22%, 44%, 11% and 23% were classified as mixed, eosinophilic, neutrophilic and paucigranulocytic phenotypes, respectively. Neutrophilic children had the lowest lung function (forced expiratory volume in 1 s % predicted pre-salbutamol) compared with other groups. Children with mixed asthma were most often uncontrolled and had the highest asthma-related school absence in the past year. Interleukin (IL)-6 and matrix metalloproteinase-9 levels were significantly higher in patients with mixed or neutrophilic asthma, whereas tissue inhibitor of metalloproteinase-2 was lower in patients with neutrophilic asthma compared with eosinophilic or paucigranulocytic asthma. IL-5 was increased in eosinophilic group compared with the neutrophilic and paucigranulocytic groups, irrespective of the chosen cut-off for eosinophilia.</p><p><strong>Conclusion: </strong>Differences in asthma burden-related clinical expression and distinct blood inflammatory mediator profiles were found between phenotypes, highlighting implications for optimising personalised treatment and management strategies in children with moderate-to-severe asthma.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease.","authors":"Linh T Ngo, Michaella J Rekowski, Devin C Koestler, Takafumi Yorozuya, Atsushi Saito, Imaan Azeem, Alexis Harrison, M Kristen Demoruelle, Jonathan Boomer, Bryant R England, Paul Wolters, Philip L Molyneaux, Mario Castro, Joyce S Lee, Joshua J Solomon, Koji Koronuma, Michael P Washburn, Scott M Matson","doi":"10.1183/23120541.00192-2024","DOIUrl":"10.1183/23120541.00192-2024","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic interstitial pneumonias (IIPs), such as idiopathic pulmonary fibrosis and interstitial pneumonia with autoimmune features, present diagnostic and therapeutic challenges due to their heterogeneous nature. This study aimed to identify intrinsic molecular signatures within the lung microenvironment of these IIPs through proteomic analysis of bronchoalveolar lavage fluid (BALF).</p><p><strong>Methods: </strong>Patients with IIP (n=23) underwent comprehensive clinical evaluation including pre-treatment bronchoscopy and were compared with controls without lung disease (n=5). Proteomic profiling of BALF was conducted using label-free quantitative methods. Unsupervised cluster analyses identified protein expression profiles that were then analysed to predict survival outcomes and investigate associated pathways.</p><p><strong>Results: </strong>Proteomic profiling successfully differentiated IIP from controls. k-means clustering based on protein expression revealed three distinct IIP clusters, which were not associated with age, smoking history, or baseline pulmonary function. These clusters had unique survival trajectories and provided more accurate survival predictions than the Gender Age Physiology index (concordance index 0.794 <i>versus</i> 0.709). The cluster with the worst prognosis featured decreased inflammatory signalling and complement activation, with pathway analysis highlighting altered immune response pathways related to immunoglobulin production and B-cell-mediated immunity.</p><p><strong>Conclusions: </strong>The unsupervised clustering of BALF proteomics provided a novel stratification of IIP patients, with potential implications for prognostic and therapeutic targeting. The identified molecular phenotypes underscore the diversity within the IIP classification and the potential importance of personalised treatments for these conditions. Future validation in larger, multi-ethnic cohorts is essential to confirm these findings and to explore their utility in clinical decision-making for patients with IIP.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintenance oral steroids are not required in severe asthma.","authors":"Emma Rebecca Graham, Chellan Eames, Wint Soe, Lauren Fox, Ciara Whitfield, Sumita Kerley, Ma Pantaleon, Jodi McCreery, Peter Cook, Anna Freeman, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Paddy Dennison, Anneliese Day, J J Hudson-Colby, Nadia Zarif, Hitasha Rupani","doi":"10.1183/23120541.00568-2024","DOIUrl":"10.1183/23120541.00568-2024","url":null,"abstract":"<p><p><b>Protocol-guided multidisciplinary team supported steroid weaning is effective in reducing maintenance OCS use in most biologic-naïve patients with severe asthma, supporting the concept that maintenance OCS are inappropriate treatments for severe asthma</b> https://bit.ly/4cgrJEL.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definition of sinonasal and otological exacerbation in patients with primary ciliary dyskinesia: an expert consensus.","authors":"Myrofora Goutaki, Yin Ting Lam, Andreas Anagiotos, Miguel Armengot, Andrea Burgess, Raewyn Campbell, Mathilde Carlier, Nathalie Caversaccio, Neil K Chadha, Berat Demir, Sinan Ahmed D Dheyauldeen, Onder Gunaydin, Amanda Harris, Isolde Hayn, Deniz Inal-Ince, Eric Levi, Trini Lopez Fernandez, Jane S Lucas, Bernard Maitre, Anne-Lise M L Poirrier, Lynne Schofield, Kazuhiko Takeuchi, Christine van Gogh, Nikolaus E Wolter, Jean-François Papon","doi":"10.1183/23120541.00218-2024","DOIUrl":"10.1183/23120541.00218-2024","url":null,"abstract":"<p><strong>Background: </strong>Recurrent infections of the nose, sinuses and ears are common problems for people with primary ciliary dyskinesia. While pulmonary exacerbations in primary ciliary dyskinesia are defined, there is no definition for ear-nose-throat exacerbations, a potential outcome for research and clinical trials.</p><p><strong>Methods: </strong>We set up an expert panel of 24 ear-nose-throat specialists, respiratory physicians, other healthcare professionals and patients to develop consensus definitions of sinonasal and otological exacerbations in children and adults with primary ciliary dyskinesia for research settings. We reviewed the literature and used a modified Delphi approach with four electronic surveys.</p><p><strong>Results: </strong>Definitions for both sinonasal and otological exacerbations are based on a combination of major and minor criteria, requiring three major or two major and at least two minor criteria each. Major criteria for a sinonasal exacerbation are 1) reported acute increase in nasal discharge or change in colour, 2) reported acute pain or sensitivity in the sinus regions and 3) mucopurulent discharge on examination. Minor criteria include reported symptoms, examination signs, doctor's decision to treat and improvement after at least 14 days. Major criteria for the otological exacerbation are 1) reported acute ear pain or sensitivity, 2) reported acute ear discharge, 3) ear discharge on examination and 4) signs of otitis media in otoscopy. Minor criteria are reported acute hearing problems, signs of acute complication, and doctor's decision to treat.</p><p><strong>Conclusion: </strong>These definitions might offer a useful outcome measure for primary ciliary dyskinesia research in different settings. They should be validated in future studies and trials together with other potential outcomes, to assess their usability.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early career member highlights from the 22nd ERS Lung Science Conference: development of chronic lung diseases - from life-spanning mechanisms to preventive therapy.","authors":"Cheng-Yu Wu, María Camila Melo-Narváez, Sara Cuevas-Ocaña","doi":"10.1183/23120541.00659-2024","DOIUrl":"10.1183/23120541.00659-2024","url":null,"abstract":"<p><p><b>ERJOR: In case you missed the #LSC2024, this work highlights some of the new key points that were discussed at the @EuroRespSoc Lung Science Conference about #COPD & #IPF by @SaraOcana1 @danielchengyuwu @cami93melo @EarlyCareerERS @ERSpublications #ERJOR</b> https://bit.ly/4cbMjpS.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical remission among severe asthmatics on monoclonal antibody therapy: real-world outcomes at 2 years.","authors":"Fred Fyles, Rachel Burton, Amy Nuttall, Hannah Joplin, Laura Watkins, Hassan Burhan","doi":"10.1183/23120541.00261-2024","DOIUrl":"10.1183/23120541.00261-2024","url":null,"abstract":"<p><p><b>Real-world data suggest clinical remission is a feasible treatment goal of monoclonal antibody therapy. Evidence of ongoing response post-12 months may be used to inform treatment decisions. Further work is needed to standardise criteria for remission.</b> https://bit.ly/4cA6TkG.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-frequency percussive ventilation in acute respiratory failure.","authors":"Andrea Bruni, Giuseppe Neri, Gianmaria Cammarota, Vincenzo Bosco, Eugenio Biamonte, Letizia Troisi, Annalisa Boscolo, Paolo Navalesi, Federico Longhini, Eugenio Garofalo","doi":"10.1183/23120541.00401-2024","DOIUrl":"10.1183/23120541.00401-2024","url":null,"abstract":"<p><strong>Introduction: </strong>High-frequency percussive ventilation (HFPV) is a ventilation mode characterised by high-frequency breaths. This study investigated the impact of HFPV on gas exchange and clinical outcomes in acute respiratory failure (ARF) patients during spontaneous breathing, noninvasive ventilation (NIV) and invasive mechanical ventilation (iMV).</p><p><strong>Methods: </strong>This systematic review included randomised and nonrandomised studies up to August 2023. Inclusion criteria focused on adult ARF patients, HFPV application, comparisons with other ventilation modes, and outcomes related to oxygenation and clinical parameters. A pooled data analysis was performed comparing HFPV with iMV concerning gas exchange, pulmonary infection and mortality.</p><p><strong>Results: </strong>Of the 51 identified records, 29 met the inclusion criteria. HFPV was safely and effectively applied to ARF patients during spontaneous breathing or NIV, improving oxygenation. For patients who underwent iMV, HFPV significantly enhanced oxygenation and the arterial partial pressure of carbon dioxide, reduced pulmonary infection occurrence and improved survival. Barotrauma rates were not elevated with HFPV, and haemodynamic stability remained unaffected. HFPV was also utilised in patients undergoing extracorporeal membrane oxygenation, resulting in improved lung recruitment and oxygenation.</p><p><strong>Conclusion: </strong>HFPV had favourable effects on physiological and certain clinical outcomes in ARF patients. However, the overall evidence quality remains weak, necessitating large-scale randomised controlled trials for definitive conclusions.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"10 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}