ERJ Open Research最新文献_第4页

ERJ Open Research, list of peer reviewers 2024.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.11001-2025

引用次数: 0

Incidence of acute exacerbations of chronic respiratory disease during pulmonary rehabilitation delivered at home or hospital.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00209-2024

Angela T Burge, Narelle S Cox, Arkash Ponnudurai, Anne E Holland, Janet Bondarenko, Catherine J Hill, Arwel W Jones

引用次数: 0

Two forced expiratory volume in 1 s trajectories with distinct prognoses in pulmonary Langerhans cell histiocytosis.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00864-2024

Amira Benattia, Raphaël Porcher, Constance de Margerie-Mellon, Emmanuella Caradec, Gwenaël Lorillon, Abdellatif Tazi

{"title":"Two forced expiratory volume in 1 s trajectories with distinct prognoses in pulmonary Langerhans cell histiocytosis.","authors":"Amira Benattia, Raphaël Porcher, Constance de Margerie-Mellon, Emmanuella Caradec, Gwenaël Lorillon, Abdellatif Tazi","doi":"10.1183/23120541.00864-2024","DOIUrl":"10.1183/23120541.00864-2024","url":null,"abstract":"Background: Lung function outcomes in pulmonary Langerhans cell histiocytosis (PLCH) patients are variable and difficult to predict. Our goal was to identify different forced expiratory volume in 1 s (FEV1) trajectories in these patients during long-term follow-up.Methods: All newly diagnosed adult PLCH patients seen between January 2004 and April 2018 were eligible for inclusion in our prospective cohort. The primary end-point was the identification of FEV1 trajectories using a joint latent class model for longitudinal and time-to-event data. Internal validation was performed via bootstrapping.Results: Among the 191 patients included (mean age of 39±12 years, 59% females, 96% current smokers), who were followed for a median of 5.1 years (interquartile range 3.2-6.0), two FEV1 trajectories were identified. Patients with trajectory 1 (n=157, 82.2%) were characterised by a normal FEV1 at diagnosis (mean predicted value (pred) of 95±3%) that remained stable over time (annual variation of 0.2% pred, 95% CI -0.8-0.4). Patients with trajectory 2 (n=34, 17.8%) had a decreased initial FEV1 (63±7% pred) and an annual decrease of -1.8% pred (-3.4--0.2). Trajectory 2 was associated with increased mortality (hazard ratio 9.46, 95% CI 1.24-72.2; p=0.03).Conclusions: FEV1 remained stable in most PLCH patients, but the subgroup of patients that experienced a significant decrease in FEV1 over time had a poorer prognosis. These patients should be closely monitored for early therapeutic intervention. These results need to be confirmed in an external validation cohort.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ERJ Open Research at 10 years: charting for the next decade.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00098-2025

Woo-Jung Song, Freddy Frost, Esther Barreiro

引用次数: 0

Contrasting the clinical and biological characteristics of young and old COPD patients.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00671-2024

Marc Vila, Alvar Agustí, Jørgen Vestbo, Bartolome Celli, Borja G Cosio, Edwin K Silverman, Oriol Sibila, Joan Ramon Badía, Per Bakke, Ruth Tal-Singer, William MacNee, Rosa Faner

{"title":"Contrasting the clinical and biological characteristics of young and old COPD patients.","authors":"Marc Vila, Alvar Agustí, Jørgen Vestbo, Bartolome Celli, Borja G Cosio, Edwin K Silverman, Oriol Sibila, Joan Ramon Badía, Per Bakke, Ruth Tal-Singer, William MacNee, Rosa Faner","doi":"10.1183/23120541.00671-2024","DOIUrl":"10.1183/23120541.00671-2024","url":null,"abstract":"Background: The ECLIPSE study was a large, international, prospective, controlled, observational study that included COPD patients (Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 2-4), as well as smoking and non-smoking participants with normal spirometry, aged 40-75 years, who were followed-up regularly for 3 years. Here we sought to contrast the clinical and biological characteristics of young COPD versus controls of similar age and older COPD patients included in ECLIPSE.Methods: We compared 106 young (<50 years) and 488 old (>70 years) COPD patients, as well as 119 young smokers and 92 nonsmoker controls (<50 years) with normal spirometry.Results: Young COPD patients: 1) were more symptomatic than young controls, often reported a family history of chronic bronchitis, emphysema and asthma, as well as a personal history of asthma and bronchitis, and suffered from a similar disease burden to older patients; 2) were at higher risk of substantial forced expiratory volume in 1 s decline over time; and 3) had reduced serum levels of CC16 (a lung-derived anti-inflammatory protein that relates to lung damage) and, at the same time, reduced pro-inflammatory markers compared to older COPD patients.Conclusions: Young COPD patients suffer from significant disease burden, display an altered biomarker and disease progression profile reflected by an accelerated risk of lung function decline highlighting the need for early life diagnosis, prevention approaches and treatment.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of seasonality and treatment on COPD clinical outcomes: IMPACT post hoc analysis.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00583-2024

Gerard J Criner, David A Lipson, Lee Tombs, MeiLan K Han

引用次数: 0

Living with chronic cough: experiences, burden and management in interstitial lung disease - a mixed methods study.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00641-2024

Shirley Quach, Anatasia Newman, Matisse LeBouedec, Renata Mancopes, Diana Hatzoglou, Natya Raghavan, Dina Brooks, Ana Oliveira

引用次数: 0

Sleep apnoea, cognition and aspirin's effects in healthy older people: an ASPREE substudy.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00581-2024

Stephanie A Ward, Robyn L Woods, Matthew T Naughton, Rory Wolfe, Danijela Gasevic, Garun S Hamilton, Walter P Abhayaratna, Katherine Webb, Fergal J O'Donoghue, Nigel Stocks, Ruth E Trevaks, Sharyn M Fitzgerald, Suzanne G Orchard, Christopher M Reid, Elsdon Storey

{"title":"Sleep apnoea, cognition and aspirin's effects in healthy older people: an ASPREE substudy.","authors":"Stephanie A Ward, Robyn L Woods, Matthew T Naughton, Rory Wolfe, Danijela Gasevic, Garun S Hamilton, Walter P Abhayaratna, Katherine Webb, Fergal J O'Donoghue, Nigel Stocks, Ruth E Trevaks, Sharyn M Fitzgerald, Suzanne G Orchard, Christopher M Reid, Elsdon Storey","doi":"10.1183/23120541.00581-2024","DOIUrl":"10.1183/23120541.00581-2024","url":null,"abstract":"Importance: Obstructive sleep apnoea (OSA) may increase the risk of dementia; however, studies have reported variable findings. We investigated if undiagnosed OSA in healthy older adults is associated with cognitive decline, and whether low-dose aspirin could attenuate this.Methods: This was conducted as a substudy of the ASPirin in Reducing Events in the Elderly study. Participants were aged 70 years and above, free of dementia, cardiovascular disease and known OSA. A limited channel home sleep study calculated the oxygen desaturation index. Participants were randomised to daily aspirin 100 mg or placebo. Outcomes were the association of OSA, and the interaction of aspirin with OSA, with change in the Modified Mini-Mental State examination (3MS), a test of global cognition, over 3 years. Secondary outcomes were changes in domain-specific cognitive tests. Analyses were adjusted for relevant demographic, lifestyle and cardiometabolic factors.Results: Mild OSA, detected in 630 (49.0%) participants, and moderate/severe OSA, detected in 405 (31.5%) participants, were associated with lower 3MS scores over 3 years (mild OSA: β -0.58, 95% CI -1.15 to -0.00, p=0.049; moderate/severe OSA: β -0.69, 95% CI -1.32 to -0.05, p=0.035), compared to the 250 (19.5%) participants without OSA. No associations of OSA with decline in domain-specific cognitive tests were observed. Interaction terms were not significant for the effects of aspirin with OSA on change in any cognitive test score.Conclusions: OSA was associated with a small decline in global cognition over 3 years in this healthy older cohort. This decline was not attenuated by aspirin.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible bronchoscopy in the diagnosis of chronic cough causes in non-smoking adults.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00571-2024

Karolina Klimowicz, Marta Dąbrowska, Elżbieta M Grabczak, Katarzyna Białek-Gosk, Olga Truba, Aleksandra Rybka-Frączek, Magdalena Paplińska-Goryca, Patrycja Nejman-Gryz, Agata Cyran, Rafał Krenke

引用次数: 0

Medical hypnosis increases 6-min walking test distance in severe COPD patients: a case-control study.

IF 4.3 3区医学

ERJ Open Research Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.1183/23120541.00795-2024

Christian Straus, Gladys Beuze, Sophie Lavault, Antoine Guerder, Capucine Morélot-Panzini, Jésus Gonzalez-Bermejo, Thomas Similowski

引用次数: 0