The utility of spirometry and single breath gas transfer measurements to identify low total lung capacity.

IF 4 3区医学 Q1 RESPIRATORY SYSTEM

ERJ Open Research Pub Date : 2025-09-08 eCollection Date: 2025-09-01 DOI:10.1183/23120541.00038-2025

Ben Knox-Brown, Chara Alexiou, Sanja Stanojevic, Karl P Sylvester

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Abstract

Background: Measurement of total lung capacity (TLC) requires large and expensive equipment. We aimed to investigate whether spirometric restriction and low alveolar volume measured by single breath gas transfer (V _A) can be used to identify those with a low TLC.

Methods: We retrospectively analysed data from adults referred to Cambridge University Hospitals between January 2016 and December 2023. We investigated the utility of spirometric restriction (forced vital capacity (FVC) < lower limit of normal (LLN) with forced expiratory volume in 1 s /FVC ≥LLN) and reduced V _A (pleth V _A to identify TLC_pleth

Results: Data from 7923 patients were included. The majority (94%) of patients were of European ancestry, 51% were female. Mean age was 58 years. 11% of patients had a TLC_pleth V _A pleth pleth V _A pleth V _A pleth

Conclusions: A FVC in the healthy range is an effective tool for ruling out restriction. Low V _A can be used to accurately identify those with a low TLC, negating the need for formal measurement of static lung volumes when identifying restrictive lung disease.

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利用肺活量测定法和单次呼吸气体转移测量来识别低总肺活量。

背景：全肺容量（TLC）的测量需要大型和昂贵的设备。我们的目的是研究单次呼吸气体传输（va）测量的肺泡容积和呼吸受限是否可以用于鉴别TLC低的患者。方法：我们回顾性分析2016年1月至2023年12月在剑桥大学医院转诊的成人数据。我们研究了肺活量限制(用力肺活量（FVC) <正常下限（LLN），用力呼气量为1 s /FVC≥LLN）和降低V A（容积V A）识别tlpleth的有效性。大多数（94%）患者为欧洲血统，51%为女性。平均年龄58岁。结论：健康范围内的FVC是排除限制的有效工具。低V A可用于准确识别低TLC患者，在识别限制性肺部疾病时无需正式测量静态肺容积。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ERJ Open Research Medicine-Pulmonary and Respiratory Medicine

CiteScore

6.20

自引率

4.30%

发文量

273

审稿时长

8 weeks

期刊介绍： ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.