Environmental Epidemiology最新文献_第4页

Association between prenatal and childhood PM2.5 exposure and preadolescent anxiety and depressive symptoms 产前和儿童期 PM2.5 暴露与青春期前焦虑和抑郁症状之间的关系

IF 3.6

Environmental Epidemiology Pub Date : 2023-12-15 DOI: 10.1097/EE9.0000000000000283

L. Mcguinn, Iván Gutiérrez-Avila, M. Rosa, Allan C. Just, Brent Coull, I. Kloog, Marcela Tamayo Ortiz, H. Harari, Sandra Martinez, Erika Osorio-Valencia, M. Téllez-Rojo, Daniel N. Klein, Rosalind J. Wright, Robert O. Wright

{"title":"Association between prenatal and childhood PM2.5 exposure and preadolescent anxiety and depressive symptoms","authors":"L. Mcguinn, Iván Gutiérrez-Avila, M. Rosa, Allan C. Just, Brent Coull, I. Kloog, Marcela Tamayo Ortiz, H. Harari, Sandra Martinez, Erika Osorio-Valencia, M. Téllez-Rojo, Daniel N. Klein, Rosalind J. Wright, Robert O. Wright","doi":"10.1097/EE9.0000000000000283","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000283","url":null,"abstract":"Background: Fine particulate matter (PM2.5) exposure has been linked to anxiety and depression in adults; however, there is limited research in the younger populations, in which symptoms often first arise. Methods: We examined the association between early-life PM2.5 exposure and symptoms of anxiety and depression in a cohort of 8–11-year-olds in Mexico City. Anxiety and depressive symptoms were assessed using the Spanish versions of the Revised Children’s Manifest Anxiety Scale and Children’s Depression Inventory. Daily PM2.5 was estimated using a satellite-based exposure model and averaged over several early and recent exposure windows. Linear and logistic regression models were used to estimate the change in symptoms with each 5-µg/m3 increase in PM2.5. Models were adjusted for child’s age, child’s sex, maternal age, maternal socioeconomic status, season of conception, and temperature. Results: Average anxiety and depressive symptom T-scores were 51.0 (range 33–73) and 53.4 (range 44–90), respectively. We observed consistent findings for exposures around the fourth year of life, as this was present for both continuous and dichotomized anxiety symptoms, in both independent exposure models and distributed lag modeling approaches. This window was also observed for elevated depressive symptoms. An additional consistent finding was for PM2.5 exposure during early pregnancy in relation to both clinically elevated anxiety and depressive symptoms, this was seen in both traditional and distributed lag modeling approaches. Conclusion: Both early life and recent PM2.5 exposure were associated with higher mental health symptoms in the child highlighting the role of PM2.5 in the etiology of these conditions.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139000665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Power outages and pediatric unintentional injury hospitalizations in New York State 纽约州停电与儿科意外伤害住院情况

IF 3.6

Environmental Epidemiology Pub Date : 2023-12-14 DOI: 10.1097/EE9.0000000000000287

Alexander J Northrop, Nina M. Flores, V. Do, Perry E. Sheffield, Joan A. Casey

{"title":"Power outages and pediatric unintentional injury hospitalizations in New York State","authors":"Alexander J Northrop, Nina M. Flores, V. Do, Perry E. Sheffield, Joan A. Casey","doi":"10.1097/EE9.0000000000000287","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000287","url":null,"abstract":"Background: In the past decade, electrical power disruptions (outages) have increased in the United States, especially those attributable to weather events. These outages have a range of health impacts but are largely unstudied in children. Here, we investigated the association between outages and unintentional injury hospitalizations, a leading cause of childhood morbidity. Methods: The study setting was New York State (NYS) from 2017 to 2020. Outage exposure was defined as ≥10%, ≥20%, and ≥50% of customers from a power operating locality without power, ascertained from NYS Department of Public Service records and stratified by rural, urban non-New York City (NYC), and NYC regions. Outcome daily block group-level pediatric injury hospitalization data was from the Statewide Planning and Research Cooperative System (SPARCS). We leveraged a case-crossover study design with logistic conditional regression. Results: We identified 23,093 unintentional injury hospitalizations in children <18 years with complete block group and exposure data. Most hospitalizations occurred in urban regions (90%), whereas outages were more likely in rural than urban areas. In urban non-NYC regions, outages ≥4 hours were associated with 30% increased odds of all-cause unintentional injury hospitalizations when ≥50% of customers were without power. Analyses by injury subtype revealed increasing point estimates as the proportion of customers exposed increased. These results, however, had wide confidence intervals. Conclusions: Outage exposure differed significantly across rural, urban non-NYC, and NYC regions across New York. Especially at the highest outage threshold, we observed an increased risk of pediatric unintentional injury hospitalizations.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138974134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between outdoor temperature and fatal police shootings in the United States, 2015–2021 2015-2021 年美国室外温度与警察致命枪击案之间的关系

IF 3.6

Environmental Epidemiology Pub Date : 2023-12-01 DOI: 10.1097/EE9.0000000000000267

Ellen Martinson, Howard Chang, R. D’Souza, S. Ebelt, N. Scovronick

{"title":"Association between outdoor temperature and fatal police shootings in the United States, 2015–2021","authors":"Ellen Martinson, Howard Chang, R. D’Souza, S. Ebelt, N. Scovronick","doi":"10.1097/EE9.0000000000000267","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000267","url":null,"abstract":"Background: Here, we investigate the association between outdoor temperature and fatal police shootings in the United States between 2015 and 2021. Methods: We conducted a time-stratified case-crossover study. Data on fatal police shootings were from the Washington Post’s Fatal Force database and temperature data were from Daymet. Results: A 5°C increase in maximum same-day temperature was associated with a 1.033 (95% CI = 1.002, 1.065) increased odds of a fatal police shooting. In stratified analyses, the strongest associations were observed in victims who were armed (OR, 1.052 [95% CI = 1.017, 1.088), White (OR, 1.052 [95% CI = 1.006, 1.100), or aged 45+ (OR, 1.110 [95% CI = 1.044, 1.181]). In additional subgroup analyses, relative risks were also generally higher among those who were armed. Conclusions: There is evidence of an association between outdoor temperature and fatal police shootings in the United States, particularly when the victims were reported as armed. This study cannot determine if the associations are a result of any specific causes (e.g., increased police aggression or other factors).","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138627698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sociodemographic inequalities in long-term exposure to air pollution, road traffic noise, and greenness: A population-based cohort study of women 长期暴露于空气污染、道路交通噪音和绿化中的社会人口不平等：基于人口的妇女队列研究

IF 3.6

Environmental Epidemiology Pub Date : 2023-12-01 DOI: 10.1097/EE9.0000000000000279

Lara Stucki, Staffan Betnér, Jenny Selander, M. Lõhmus, A. Åkesson, C. Eriksson

{"title":"Sociodemographic inequalities in long-term exposure to air pollution, road traffic noise, and greenness: A population-based cohort study of women","authors":"Lara Stucki, Staffan Betnér, Jenny Selander, M. Lõhmus, A. Åkesson, C. Eriksson","doi":"10.1097/EE9.0000000000000279","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000279","url":null,"abstract":"Background: Recent evidence suggests environmental health inequalities both within and between European countries and socially deprived groups may be more susceptible to pollution. However, evidence is still inconclusive and additional studies are warranted. This study aims to investigate sociodemographic inequalities in long-term residential exposure to air pollution, road traffic noise, and greenness, taking lifestyle and degree of urbanization into account. Methods: In total 20,407 women, born 1914–48 residing in Uppsala County, Sweden, were followed between 1997 and 2017. Time-varying sociodemographic variables were obtained from registers, and questionnaires provided lifestyle information. Generalized estimating equations were used to compute beta-coefficients (β) and 95% confidence intervals (95% CI) for associations between sociodemographic and lifestyle variables and spatial-temporal modeled particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), road traffic noise and greenness. All models were additionally stratified by urbanization type. Results: Urban area residency was the most important predictor of high exposure to air pollution and noise, and to low greenness. For instance, β for NO2 was −2.92 (95% CI = −3.00, −2.83) and −3.10 (95% CI = −3.18, −3.01) µg/m3 in suburban and rural areas, respectively, compared with urban areas. For greenness, the opposite held true with corresponding β of 0.059 (95% CI = 0.056, 0.062) and 0.095 (95% CI = 0.092, 0.098). Within urban areas, elderly, unmarried and well-educated women had the highest environmental burden. However, less pronounced, and even reversed associations were found in suburban and rural areas. Conclusion: This study provides evidence of a mixed pattern of environmental health inequalities across sociodemographic groups in urban areas.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of urban trees and total vegetation on asthma development in children 城市树木和全部植被对儿童哮喘发展的影响

IF 3.6

Environmental Epidemiology Pub Date : 2023-11-16 DOI: 10.1097/EE9.0000000000000280

Louise Duquesne, Elhadji Anassour Laouan Sidi, C. Plante, Ying Liu, Naizhuo Zhao, Éric Lavigne, Kate Zinszer, Rita Sousa-Silva, Michel Fournier, Paul J. Villeneuve, David J. Kaiser, A. Smargiassi

{"title":"The influence of urban trees and total vegetation on asthma development in children","authors":"Louise Duquesne, Elhadji Anassour Laouan Sidi, C. Plante, Ying Liu, Naizhuo Zhao, Éric Lavigne, Kate Zinszer, Rita Sousa-Silva, Michel Fournier, Paul J. Villeneuve, David J. Kaiser, A. Smargiassi","doi":"10.1097/EE9.0000000000000280","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000280","url":null,"abstract":"Objective: We aimed to assess whether the influence of urban vegetation on asthma development in children (<13 years) varies by type (e.g., total vegetation, tree type, and grass) and season. Methods: We used a cohort of all children born in Montreal, Canada, between 2000 and 2015. Children and cases were identified from linked medico-administrative databases. Exposure to residential vegetation was estimated using the Normalized Difference Vegetation Index (NDVI) for total vegetation and using the total area covered by deciduous and evergreen crowns for trees in 250 m buffers centered on residential postal codes. Seasonal variations in vegetation were modeled by setting values to zero on days outside of pollen and leaf-on seasons. Cox models with vegetation exposures, age as a time axis, and adjusted for sex, material deprivation, and health region were used to estimate hazard ratios (HR) for asthma development. Results: We followed 352,946 children for a total of 1,732,064 person-years and identified 30,816 incident cases of asthma. While annual vegetation (total and trees) measures did not appear to be associated with asthma development, models for pollen and leaf-on seasons yielded significant nonlinear associations. The risk of developing asthma was lower in children exposed to high levels (>33,300 m2) of deciduous crown area for the leaf-on season (HR = 0.69; 95% confidence interval [CI] = 0.67, 0.72) and increased for the pollen season (HR = 1.07; 95% CI =1.02, 1.12), compared with unexposed children. Similar results were found with the Normalized Difference Vegetation Index. Conclusion: The relationship between urban vegetation and childhood asthma development is nonlinear and influenced by vegetation characteristics, from protective during the leaf-on season to harmful during the pollen season.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139270152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015 2003-2015 年北卡罗来纳州出生队列中妊娠期每周接触细颗粒物、臭氧和二氧化氮与早产之间的关系

IF 3.6

Environmental Epidemiology Pub Date : 2023-11-15 DOI: 10.1097/EE9.0000000000000278

A. Krajewski, T. Luben, Joshua L. Warren, K. Rappazzo

{"title":"Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015","authors":"A. Krajewski, T. Luben, Joshua L. Warren, K. Rappazzo","doi":"10.1097/EE9.0000000000000278","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000278","url":null,"abstract":"Background: Preterm birth (PTB; <37 weeks completed gestation) is associated with exposure to air pollution, though variability in association magnitude and direction across exposure windows exists. We evaluated associations between weekly gestational exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) with PTB in a North Carolina Birth Cohort from 2003 to 2015 (N = 1,367,517). Methods: Daily average PM2.5 and daily 8-hour maximum NO2 concentration estimates were obtained from a hybrid ensemble model with a spatial resolution of 1 km2. Daily 8-hour maximum census tract-level concentration estimates for O3 were obtained from the EPA’s Fused Air Quality Surface Using Downscaling model. Air pollutant concentrations were linked by census tract to residential address at delivery and averaged across each week of pregnancy. Modified Poisson regression models with robust errors were used to estimate risk differences (RD [95% confidence intervals (CI)]) for an interquartile range increase in pollutants per 10,000 births, adjusted for potential confounders. Results: Associations were similar in magnitude across weeks. We observed positive associations for PM2.5 and O3 exposures, but generally null associations with NO2. RDs ranged from 15 (95% CI = 11, 18) to 32 (27, 37) per 10,000 births for PM2.5; from −7 (−14, −1) to 0 (−5, 4) for NO2; and from 4 (1, 7) to 13 (10, 16) for O3. Conclusion: Our results show that increased PM2.5 exposure is associated with an increased risk of PTB across gestational weeks, and these associations persist in multipollutant models with NO2 and/or O3.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139272528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose–response analysis of protracted absorbed organ dose and site-specific cancer incidence in Sweden after the Chernobyl nuclear power plant accident 瑞典切尔诺贝利核电站事故后器官长时间吸收剂量与部位特异性癌症发病率的剂量-反应分析

Environmental Epidemiology Pub Date : 2023-11-02 DOI: 10.1097/ee9.0000000000000277

Martin Tondel, Tobias Nordquist, Mats Isaksson, Christopher Rääf, Robert Wålinder

{"title":"Dose–response analysis of protracted absorbed organ dose and site-specific cancer incidence in Sweden after the Chernobyl nuclear power plant accident","authors":"Martin Tondel, Tobias Nordquist, Mats Isaksson, Christopher Rääf, Robert Wålinder","doi":"10.1097/ee9.0000000000000277","DOIUrl":"https://doi.org/10.1097/ee9.0000000000000277","url":null,"abstract":"Background: Adult males in Sweden exhibit an increased risk of cancer associated with an increased absorbed dose to the colon from the Chernobyl accident. Methods: A closed cohort, with information on hunter status, included all individuals living in northern Sweden in 1986. Complete annual information on exposure to 137 Cs at the dwelling coordinate was available for a total of 2,104,101 individuals. A nested case-control method with four controls matched for year of cancer diagnosis and year of birth, was used. Individual absorbed organ doses were calculated between 1986 and 2020 including external and internal exposure. Hazard ratios (HR) per mGy with 95% confidence intervals (95% CI) were calculated using conditional logistic regression adjusted for rural/nonrural habitat, education level and pre-Chernobyl cancer incidence 1980 to 1985. A total of 161,325 cancer cases in males and 144,439 in females were included. Results: The adjusted HR per mGy for all cancer sites combined was 1.027 (95% CI = 1.022, 1.031) in males and 1.011 (95% CI = 1.006, 1.017) in females. In a post hoc analysis accounting for both remaining confounding from hunter lifestyle and the pre-Chernobyl cancer incidence by county, the adjusted HR per mGy for all cancer sites combined was 1.014 (95% CI = 1.009, 1.019) in males and 1.000 (95% CI = 0.994, 1.006) in females. The post hoc analysis suggested an increased risk of cancer in the colon, pancreas, and stomach, respectively, in males, and lymphoma in females. Conclusions: Increased cancer risk estimates were found for some specific cancer sites but remaining uncontrolled confounding due to hunter lifestyle could not be ruled out.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135933398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residential mobility in pregnancy and potential exposure misclassification of air pollution, temperature, and greenness 怀孕期间的居住流动性和潜在暴露的空气污染、温度和绿化的错误分类

Environmental Epidemiology Pub Date : 2023-10-26 DOI: 10.1097/ee9.0000000000000273

Seulkee Heo, Yelena Afanasyeva, Leonardo Trasande, Michelle L. Bell, Akhgar Ghassabian

{"title":"Residential mobility in pregnancy and potential exposure misclassification of air pollution, temperature, and greenness","authors":"Seulkee Heo, Yelena Afanasyeva, Leonardo Trasande, Michelle L. Bell, Akhgar Ghassabian","doi":"10.1097/ee9.0000000000000273","DOIUrl":"https://doi.org/10.1097/ee9.0000000000000273","url":null,"abstract":"Introduction: Epidemiological studies commonly use residential addresses at birth to estimate exposures throughout pregnancy, ignoring residential mobility. Lack of consideration for residential mobility during pregnancy might lead to exposure misclassification that should be addressed in environmental epidemiology. Methods: We investigated potential exposure misclassification from estimating exposure during pregnancy by residence at delivery utilizing a prospective cohort of pregnant women in New York, United States (n = 1899; 2016–2019). We calculated exposure during pregnancy corresponding to each address for fine particles (PM 2.5 ), temperature, and greenness (Enhanced Vegetation Index [EVI]). Results: Twenty-two percent of participants moved at least once during pregnancy; 82.3% of movers changed residences during the second or third trimesters. Participants with better health, lower parity, and higher socioeconomic status were more likely to move. Exposures based on address at delivery rather than residential history overestimated exposure for PM 2.5 (exposure error: range −5.7 to 4.6 µg/m 3 , average −0.6 µg/m 3 ) and EVI (range −0.305 to 0.307, average −0.013), but not temperature. Overestimations were significantly larger for mothers with higher socioeconomic status. Our findings indicate that the error for prenatal exposure can occur when residential mobility is not considered and is disproportional by maternal characteristics. Conclusions: Epidemiological studies should consider residential mobility in exposure assessments based on geolocation when possible, and results based on mother’s residence at birth should be interpreted with understanding of potential differential exposure misclassification.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136377336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal serum per- and polyfluoroalkyl substances during pregnancy and breastfeeding duration: Erratum 妊娠期和哺乳期母亲血清中全氟烷基和多氟烷基物质:勘误

Environmental Epidemiology Pub Date : 2023-10-26 DOI: 10.1097/ee9.0000000000000276

引用次数: 0

Associations between prenatal blood metals and vitamins and cord blood peptide hormone concentrations 产前血液中金属和维生素与脐带血肽类激素浓度之间的关系

IF 3.6

Environmental Epidemiology Pub Date : 2023-10-19 DOI: 10.1097/EE9.0000000000000275

Anna R. Smith, Pi-I. D. Lin, S. Rifas-Shiman, K. Switkowski, A. Fleisch, R. O. Wright, Brent Coull, E. Oken, M. Hivert, Andres Cardenas

{"title":"Associations between prenatal blood metals and vitamins and cord blood peptide hormone concentrations","authors":"Anna R. Smith, Pi-I. D. Lin, S. Rifas-Shiman, K. Switkowski, A. Fleisch, R. O. Wright, Brent Coull, E. Oken, M. Hivert, Andres Cardenas","doi":"10.1097/EE9.0000000000000275","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000275","url":null,"abstract":"Background: Nonessential metals have endocrine-disrupting properties, interfere with cellular processes, generate reactive oxygen, and deplete antioxidants, while essential metals and vitamins act as antioxidants. The extent to which prenatal metals and vitamins are associated with cord blood hormones involved in maternal and fetal metabolic and growth processes is unknown. Methods: We measured six nonessential (arsenic, barium, cadmium, cesium, lead, and mercury) and four essential (magnesium, manganese, selenium, and zinc) metals and trace elements, and two vitamins (B12 and folate) in first-trimester blood from participants in the longitudinal prebirth Project Viva cohort, who were recruited between 1999 and 2002 in eastern Massachusetts. We measured adiponectin, C-peptide, insulin-like growth factor (IGF)-1, IGF-2, IGF binding protein (IGFBP)-3, insulin, and leptin concentrations in cord blood (~n = 695). We used covariate-adjusted quantile g-computation for mixtures and linear regression for individual exposures to estimate associations with cord blood peptide hormones. Results: The essential metal mixture (magnesium, manganese, selenium, and zinc) was associated with higher IGF-1 (β = 3.20 ng/ml per quartile; 95% CI = 0.39, 6.01), IGF-2 (β = 10.93 ng/ml; 95% CI = 0.08, 21.79), and leptin (β = 1.03 ng/ml; 95% CI = 0.25, 1.80). Magnesium was associated with higher leptin (β = 2.90 ng/ml; 95% CI = 0.89, 4.91), while B12 was associated with lower adiponectin, IGF-2, and leptin but higher C-peptide. Other individual nonessential metals were associated with cord blood hormones. Conclusions: Our findings suggest that some prenatal metals and vitamins are associated with cord blood hormones, which may influence growth and development.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0