Environmental Epidemiology最新文献

{"title":"Weather, air pollution, and migraine: A case-time series analysis examining environmental exposures and transient health outcomes recorded via smartphone application.","authors":"Andrea E Portt, Antonio Gasparrini, Erjia Ge, Christine Lay, Hong Chen, Peter M Smith","doi":"10.1097/EE9.0000000000000475","DOIUrl":"10.1097/EE9.0000000000000475","url":null,"abstract":"<p><strong>Background: </strong>Most studies of environmental exposures and migraine have been limited to weather or single-pollutant models and aggregate outcome measures. We estimated the associations between multiple environmental exposures and migraine events captured using a smartphone application (app) in the province of Ontario, Canada.</p><p><strong>Methods: </strong>We obtained Ontario-wide local daily weather and pollution estimates for 2017-2019 from Environment and Climate Change Canada. The Migraine Buddy app team provided records from research-consenting users. Associations between environmental exposures and migraine attack onsets were examined with case-time series lagged multipollutant models, accounting for demographic and temporal covariates.</p><p><strong>Results: </strong>We analyzed 69,808 migraine attacks reported by 7418 participants in Ontario, Canada. Overall cumulative estimates for 0-3 days suggested increased odds for migraine attacks with higher nitrogen dioxide (NO₂) and ozone (O₃), drops in barometric pressure, and cold winter temperatures. No association was observed for PM_2.5. Positive associations with NO₂ and O₃ were strongest 1 and 2 days after exposures, while associations with barometric pressure changes and cold winter temperatures were strongest on the first day. Estimates for warmer summer temperatures suggested a complex temporal pattern, with positive same-day association followed by 3 days of negative associations.</p><p><strong>Conclusion: </strong>This study presents a novel examination of the associations between air pollution and migraine attacks using small-area exposures, smartphone data, and the case-time series method. Onset of migraine was associated with higher NO₂ and O₃, colder winter weather, and positive and negative changes in barometric pressure.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 3","pages":"e475"},"PeriodicalIF":4.2,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147867259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community severance and mental health-related hospital visits in New York City.","authors":"Jaime Benavides, Gali Cohen, Jeff Goldsmith, Marianthi-Anna Kioumourtzoglou","doi":"10.1097/EE9.0000000000000482","DOIUrl":"10.1097/EE9.0000000000000482","url":null,"abstract":"<p><strong>Background: </strong>Mental health disorders are more prevalent in urban areas; urban living has been linked to increased risk of anxiety, mood, and schizophrenia disorders. These associations may be partially explained by the social and physical urban environment. While traffic-related exposures such as air pollution and noise have been linked to adverse mental health outcomes, the role of road infrastructure and traffic in severing communities and breaking down the social fabric-termed community severance-remains understudied.</p><p><strong>Methods: </strong>We conducted ZIP code-level analyses (2011-2014) to investigate the association between mental health hospital visits and community severance in New York City (NYC), using annual counts of mood-, anxiety-, adjustment-, and schizophrenia-related hospital visits from the New York State Department of Health Statewide Planning and Research Cooperative System database. Community severance was quantified using the community severance index (CSI). We employed generalized additive mixed models to characterize potentially nonlinear associations, adjusting for potential confounders. In secondary analyses, we further adjusted for black carbon to obtain traffic pollution-independent CSI estimates and evaluated potential effect modification by age through stratified analyses.</p><p><strong>Results: </strong>Each interquartile range increase in CSI was associated with higher rates of schizophrenia-related hospital visits (rate ratio [RR] = 1.13, 95% confidence interval [CI] = 1.00, 1.27). Associations for mood (RR = 1.07; 95% CI = 0.98, 1.16), anxiety (RR = 1.06; 95% CI = 0.99, 1.14), and adjustment disorders (RR = 1.07; 95% CI = 0.97, 1.19) were also positive. Results were similar after black carbon adjustment. We found no clear evidence of effect modification by age.</p><p><strong>Conclusion: </strong>Our findings indicate an association between higher levels of community severance and schizophrenia-related hospital visits in urban areas, independent of traffic-related air pollution.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 3","pages":"e482"},"PeriodicalIF":4.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyanobacterial bloom occurrence and emergency department visits for asthma or wheeze, Wisconsin, 2017-2019.","authors":"Amy M Lavery, Jordan Murray, Audrey F Pennington, Blake A Schaeffer, Bridget N Seegers, Elizabeth D Hilborn, Keith A Loftin, Stephen Scroggins, Lorraine C Backer","doi":"10.1097/EE9.0000000000000439","DOIUrl":"10.1097/EE9.0000000000000439","url":null,"abstract":"<p><strong>Background: </strong>Cyanobacterial harmful algal blooms (cyanoHABs) pose risks to human and animal health.</p><p><strong>Methods: </strong>We investigated the relationship between cyanoHABs and asthma or wheeze-related emergency department (ED) visits near three Wisconsin cities (Green Bay, Madison, and Oshkosh) during 2017-2019. CyanoHAB exposure was approximated using the Cyanobacterial Assessment Network remotely sensed satellite indicator of cyanobacterial biomass, a chlorophyl algorithm (Chl_BS) aggregated by water-adjacent ZIP Code Tabulation Areas (ZCTA), and distance weighted from the nearest waterbody. Weekly counts of ED visits for asthma or wheeze were aggregated by ZCTA. Poisson generalized linear models estimated the association between the weekly number of ED visits and weekly Chl_BS, adjusting for maximum temperature, dewpoint, fine particulate matter (PM_2.5), month, and correlation within ZCTA.</p><p><strong>Results: </strong>During 2017-2019, 7,057 ED visits for asthma or wheeze occurred in the study area (42 ZCTAs). Peaks in Chl_BS occurred between June and October, with higher values in Lake Winnebago and Lake Mendota compared to Green Bay. Chl_BS was not associated with ED visits for asthma or wheeze (adjusted rate ratio = 1.00, 95% confidence interval = 0.99, 1.00), and the presence of onshore winds did not change this result. Monthly aggregations of ED visits and Chl_BS showed a monotonic trend between increasing Chl_BS and ED visits during July-September.</p><p><strong>Conclusion: </strong>This study demonstrates the utility of remote sensing data in environmental health research. Future studies could explore individual-level exposure and outcomes to refine health risks associated with cyanoHABs.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 3","pages":"e439"},"PeriodicalIF":4.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When does algorithmic complexity add causal value in environmental epidemiology?","authors":"Perla Simons, Salvador Diaz, Antonio Garcia Loureiro, Isaac Zablah","doi":"10.1097/EE9.0000000000000483","DOIUrl":"10.1097/EE9.0000000000000483","url":null,"abstract":"","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 3","pages":"e483"},"PeriodicalIF":4.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution from livestock farms and lung function decline in neighboring residents over 7 years.","authors":"Warner van Kersen, Myrna M T de Rooij, Bernadette Aalders, Kaitlin Prins, Floor Borlée, Joris C Yzermans, Joke W B van der Giessen, Dick Heederik, Mary B Rice, Lidwien A M Smit","doi":"10.1097/EE9.0000000000000479","DOIUrl":"10.1097/EE9.0000000000000479","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal studies investigating air pollution from livestock farms and respiratory health effects in neighboring residents are lacking. The aim of this study was to assess the relationship between residential livestock farm exposures and lung function decline over a 7-year period in people living in livestock-dense rural areas in the Netherlands.</p><p><strong>Methods: </strong>Spirometry was performed in 2014/2015 and 2021/2022 for 847 adults (28-80 years of age at follow-up). We analyzed the annual rate of change in forced expiratory volume in 1 second (FEV₁), forced vital capacity (FVC), tiffeneau index (FEV₁/FVC) , peak expiratory flow, and maximal mid-expiratory flow in relation to long-term exposure to livestock farming-emitted endotoxin and particulate matter <10 µm (PM₁₀) at the home address, which was predicted by dispersion modeling at baseline. Data analysis was performed using generalized additive models with nonlinear terms for exposure, adjusting for potential confounders.</p><p><strong>Results: </strong>No associations were identified between residential exposure to livestock-related endotoxin or PM₁₀ and the annual rate of change in lung function (<i>P</i> > 0.05). Adjusted models showed that participants with a farm childhood had larger annual decreases in FEV₁ (-5.63 ml/year, <i>P</i> = 0.018) and maximal mid-expiratory flow (-11.15 ml/second per year, <i>P</i> = 0.032), compared with those without a farm childhood. However, average baseline spirometry was higher in participants with a farm childhood compared with those without.</p><p><strong>Conclusion: </strong>Our longitudinal study did not find evidence for a relationship between air pollution from livestock farms and lung function decline in neighboring residents. Longitudinal studies with a greater number of observations across the life course are needed to gain deeper insights into lung function trajectories and to assess the impact of livestock-related air pollution in rural populations.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 3","pages":"e479"},"PeriodicalIF":4.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption of antioxidant-rich foods attenuates respiratory and cardiovascular health effects in a population highly exposed to air pollution.","authors":"Adeladza Kofi Amegah, Kelvin Yeboah, Evans Quarshie, Divine Onyekachi Benjamin, Patricia Amonoo, Patrick Attey-Yeboah, Saverio Stranges, Ngianga-Bakwin Kandala","doi":"10.1097/EE9.0000000000000477","DOIUrl":"10.1097/EE9.0000000000000477","url":null,"abstract":"<p><strong>Background: </strong>Diet and nutrition have shown promise in attenuating air pollution health effects. However, to date, no study has been conducted in an occupationally exposed population who experience high levels of very complex air pollution mixtures on a daily basis.</p><p><strong>Objectives: </strong>We therefore evaluated the effectiveness of regular consumption of antioxidant-rich foods in attenuating respiratory and cardiovascular health effects among street vendors in Accra, Ghana.</p><p><strong>Methods: </strong>We used a quasi-experimental design of 12-month duration, assigning 307 street vendors to either an intervention group (n = 155) to receive a weekly supply of antioxidant-rich foods or a control group (n = 152) who maintained their usual dietary pattern. Participants regularly consuming antioxidant-rich foods were assigned to the intervention group, with those consuming less of these foods assigned to the control group.</p><p><strong>Results: </strong>In the multivariable ordinal multinomial logistic regression model controlling for age, gender, educational level, and body mass index, the intervention participants were found to have reduced odds of cough (adjusted odds ratio [AOR] = 0.45; 95% CI: 0.33, 0.63), difficulty breathing (AOR = 0.40; 95% CI: 0.25, 0.65), irregular heartbeat (AOR = 0.08; 95% CI: 0.05, 0.13), and hospital visits (AOR = 0.34; 95% CI: 0.16, 0.72) compared with the control participants. Surprisingly, we observed a decline in lung function among the intervention participants compared with the control participants.</p><p><strong>Conclusions: </strong>We found regular consumption of antioxidant-rich foods to attenuate adverse air pollution health effects among this vulnerable population. Risk communication among this group and other outdoor workers should emphasize this nutrition intervention.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 3","pages":"e477"},"PeriodicalIF":4.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure metrics for smoke waves from wildland fires and their associations with preterm birth in California.","authors":"Sally Picciotto, Nathan R Pavlovic, Frederick W Lurmann, ShihMing Huang, Elizabeth M Noth, Rachel Morello-Frosch, Amy M Padula","doi":"10.1097/EE9.0000000000000470","DOIUrl":"10.1097/EE9.0000000000000470","url":null,"abstract":"<p><p>Wildland fire smoke has been linked to preterm birth, but the relative contributions of exposure frequency, duration, and intensity remain unclear. We defined a smoke wave as two or more consecutive days with wildfire-specific particulate matter of aerodynamic diameter ≤ 2.5 microns concentrations exceeding thresholds (5 and 20 μg/m³) and assessed the associations of preterm birth with several different metrics of exposure based on smoke waves experienced during pregnancy. These exposure metrics emphasized different aspects of exposure: intensity was always included via the threshold concentrations but was particularly emphasized in metrics quantifying the average or maximum concentration during smoke waves; frequency was considered in the count of smoke waves experienced; and duration was emphasized in metrics quantifying the total number of smoke wave days or the maximum length of a single smoke wave. Finally, all three aspects contribute to the cumulative exposure during smoke waves. We used Cox proportional hazards models to compare pregnancies at the same gestational age, adjusting for season of conception, health insurance type, and birthing parents' age, education level, race/ethnicity, and smoking status. Increases in each exposure metric were associated with higher hazards of preterm birth. For example, an increase of 3 smoke waves based on a 5 μg/m³ threshold was associated with a hazard ratio of 1.02 (95% confidence interval: 1.01, 1.02), and an increase of 10 smoke wave days based on a 20 μg/m³ threshold was associated with a hazard ratio of 1.03 (1.02, 1.05). Metrics incorporating duration or frequency of smoke waves showed stronger associations with preterm birth than those focusing mainly on intensity.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e470"},"PeriodicalIF":4.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of one-carbon metabolism variants in the associations between perfluoroalkyl substances exposure and birth size in the Taiwan Birth Panel Study.","authors":"Chih-Fu Wei, Mei-Huei Chen, Ching-Chun Lin, Tzu-Pin Lu, Chia-Yang Chen, Wu-Shiun Hsieh, Pau-Chung Chen","doi":"10.1097/EE9.0000000000000472","DOIUrl":"10.1097/EE9.0000000000000472","url":null,"abstract":"<p><strong>Background: </strong>One-carbon metabolism (OCM) is crucial for fetal development, while perfluoroalkyl substances (PFAS) are associated with adverse birth outcomes and lower folate levels. PFAS may compete with folate for receptors, and OCM genes regulate folate metabolism; however, no study examined if OCM variants modified PFAS-birth outcome associations. The study investigated the relationship between OCM variants, prenatal PFAS exposure, and birth outcomes.</p><p><strong>Methods: </strong>We analyzed birth weight and head circumference data from 338 mother-infant pairs in the Taiwan Birth Panel Study. Cord blood concentrations of four PFAS were measured using ultra-performance liquid chromatography-tandem mass spectrometry. Infant genotypes were assessed with the Taiwan Biobank Array, and we focused on five single-nucleotide polymorphisms related to OCM reported in previous literature. Gene-environment interactions were assessed using generalized linear regression and two mixture modeling approaches: quantile g-computation and Bayesian Kernel Machine Regression.</p><p><strong>Results: </strong>Prenatal perfluorooctane sulfonate and perfluoroundecanoic acid exposure were associated with lower birth weight, and PFAS mixture exposure was associated with lower birth weight. PFAS exposure-birth weight associations were more obvious among those with reference genotypes. Different PFAS mixture-birth weight associations were observed across <i>MTHFR</i> rs1801133 and genotypes, and there were stronger inverse associations among individuals with <i>MTHFD1</i> rs2236225 GG genotype. Associations between prenatal PFAS exposure and birth outcomes also differed by <i>MTR</i> rs1805087, <i>MTRR</i> rs1801394, and <i>CBS</i> rs234714 genotypes. In addition, we observed a stronger perfluorooctane sulfonate-head circumference association among participants with <i>MTHFR</i> rs1801133 GG genotype.</p><p><strong>Conclusion: </strong>Genetic variants in OCM pathways modified the associations between prenatal individual PFAS, mixture PFAS exposure, and reduced birth weight and head circumference.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e472"},"PeriodicalIF":4.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of endometrial tissue PFAS concentrations using serum levels, demographic, and reproductive factors: Findings from the Investigating Mixtures of Pollutants and Endometriosis in Tissue (IMPLANT) study.","authors":"Maggie K Fuzak Nunziato, Helen B Chin, Jenna R Krall, Morgan Reynolds, Kurunthachalam Kannan, Anna Z Pollack","doi":"10.1097/EE9.0000000000000476","DOIUrl":"10.1097/EE9.0000000000000476","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyfluoroalkyl substances (PFAS) accumulate in reproductive tissues, yet most studies rely on serum measurements. It remains unclear whether serum concentrations adequately reflect levels in target tissues. We evaluated whether serum PFAS predicts endometrial tissue concentrations and examined associations with endometriosis.</p><p><strong>Methods: </strong>The Investigating Mixtures of Pollutants and Endometriosis in Tissue study included 433 reproductive-aged women undergoing laparoscopy or laparotomy in Salt Lake City, Utah, and San Francisco, California. Nine PFAS-perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), perfluoroheptanoic acid (PFHpA), and perfluorooctane sulfonamide (PFOSA)-were quantified in matched serum (ng/mL) and endometrial tissue (ng/g) using high-performance liquid chromatography with tandem mass spectrometry. Values below the limit of detection were multiply imputed. Linear regression estimated log-transformed tissue concentrations from serum PFAS and covariates. Logistic regression estimated odds ratios (ORs) for endometriosis. Composite variables were created by summing log-transformed concentrations of short-chain PFAS (<8 carbons: PFHpA, PFHxS, PFOA, and PFOS) and long-chain PFAS (≥8 carbons: PFNA, PFDA, PFUnDA, PFDoDA, and PFOSA).</p><p><strong>Results: </strong>Serum PFAS was moderately associated with tissue levels, with the strongest performance for PFOS (R² = 0.46) and PFHxS (R² = 0.37). Model fit was low for longer-chain compounds (e.g., PFUnDA R² = 0.09, PFDoDA R² = 0.07). Serum PFOA (OR = 3.38, 95% CI = 1.08, 10.59) and PFNA (OR = 3.12, 95% CI = 1.15, 8.45) were significantly associated with endometriosis, whereas corresponding tissue-based estimates were attenuated. The serum long-chain composite was associated with increased odds of endometriosis (OR = 2.74, 95% CI = 1.15, 6.59), while the short-chain composite showed no association.</p><p><strong>Conclusions: </strong>Serum PFAS minimally reflect endometrial tissue burden, with variability by chain length. While serum remains practical for large studies, tissue-based measures may provide more accurate estimates of exposure in tissue. These findings inform PFAS-endometriosis research and may extend to other gynecologic conditions.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e476"},"PeriodicalIF":4.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary nontuberculous mycobacterial infection is associated with urinary molybdenum concentrations in a bronchiectasis cohort.","authors":"Christopher S Semancik, Alexander Ganninger, Chevalia Robinson, Sandra Cooper-Bennett, Jonathan Fintzi, Kevin Fennelly, D Rebecca Prevots, Ettie M Lipner","doi":"10.1097/EE9.0000000000000468","DOIUrl":"10.1097/EE9.0000000000000468","url":null,"abstract":"<p><strong>Background: </strong>Epidemiologic studies have demonstrated an association between trace metals in source water and water distribution systems and nontuberculous mycobacterial (NTM) pulmonary infection and disease. Specifically, molybdenum has been strongly associated with <i>Mycobacterium abscessus</i> and <i>Mycobacterium avium complex</i> infection and disease in multiple epidemiologic studies. We aimed to determine if urinary molybdenum, chromium, and manganese concentrations were associated with pulmonary NTM infection in a bronchiectasis patient cohort.</p><p><strong>Methods: </strong>We enrolled 120 consecutive adult bronchiectasis patients participating in a bronchiectasis natural history study. We collected one urine sample per patient during routine visits and sent samples to the Centers for Disease Control and Prevention for trace metal testing. We defined three patient subgroups: (1) current NTM infection, (2) previous NTM infection, and (3) never NTM infection. Logistic regression models adjusted for age, racial/ethnic group, and cavitary disease status were used to test for differences between metal concentrations across infection statuses.</p><p><strong>Results: </strong>Forty-six (38%) patients were currently infected with NTM, 46 (38%) were previously infected, and 28 (23%) were never infected. For each increase of one standard deviation of the logarithm of molybdenum concentration, the odds of current versus never NTM infection increased significantly by 14% [odds ratio (OR) = 1.14, 95% confidence interval (CI) = 1.02, 1.28], while manganese and chromium did not exhibit significant associations.</p><p><strong>Conclusions: </strong>This clinical study is the first to examine the relationship between trace metals and pulmonary NTM infections. These findings support those from prior population-based studies.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e468"},"PeriodicalIF":4.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13016183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}