Environmental Epidemiology最新文献

{"title":"Sector-specific Long-term Associations Between Transportation, Industrial, and Residential Combustion Air Pollutant Mixtures (PM_2.5, SO₂, NO₂, O₃) and Neurological Disease-related Mortality in Canada.","authors":"Kimberly Mitchell, Chris Hebbern, Annalise Ferro, Toyib Olaniyan, Tanya Christidis, Jasmine D Cakmak, Mathieu Rouleau, Angelos T Anastasopolos, Ivana Popadic, Markey Johnson, Naizhuo Zhao, Michael Tjepkema, Sabit Cakmak","doi":"10.1097/EE9.0000000000000467","DOIUrl":"10.1097/EE9.0000000000000467","url":null,"abstract":"<p><strong>Background: </strong>Improving air quality requires addressing sector-specific air pollution (SSAP). This study examined the relationship between long-term SSAP and Alzheimer's disease and dementia mortality in Canada, and whether associations were modified by neighborhood greenness, educational attainment, and material deprivation.</p><p><strong>Methods: </strong>We used data from the 2006 Canadian Census Health and Environment Cohort with mortality follow-up through 2019, linked to the Canadian Vital Statistics-Death database. Annual exposures to ambient air pollutants (i.e., PM_2.5, SO₂, NO₂, and O₃) from multiple sectors were estimated using the Global Environmental Multiscale-Modelling Air Quality and Chemistry model (10 km resolution) with sector-specific contributions anchored to 2015 emissions profiles. Quantile g-computation models were used to estimate hazard ratios (HRs) for Alzheimer's disease and dementia per quartile increase in SSAP.</p><p><strong>Results: </strong>Alzheimer's disease mortality was most strongly associated with SSAP from residential fuel combustion (RES: HR = 1.29; 95% CI: 1.16, 1.43), and was also positively associated with emissions from on-road transportation (HR = 1.22; 95% CI: 1.12, 1.32), ore and mineral industries (ORE: HR = 1.17, 95% CI: 1.10, 1.24), air-marine-rail transportation (HR = 1.12; 95% CI: 1.06, 1.18), and manufacturing (MAN: HR = 1.06; 95% CI: 1.01, 1.11), while inverse associations were observed for the oil and gas sector (HR = 0.85; 95% CI: 0.81, 0.88). Dementia mortality was positively associated with oil and gas (HR = 1.06; 95% CI: 1.03, 1.09), and inversely associated with air-marine-rail transportation (HR = 0.88; 95% CI: 0.85, 0.92) and ORE (HR = 0.89; 95% CI: 0.85, 0.92). Associations were generally stronger in lower greenness areas and among individuals with lower educational attainment, although heterogeneity by sector was observed.</p><p><strong>Conclusion: </strong>SSAP mixtures were associated with Alzheimer's disease and dementia mortality in Canada. The direction and magnitude of associations varied by sector and by environmental and sociodemographic context, supporting the value of targeted, sector-specific mitigation strategies to reduce neurodegenerative mortality risk.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e467"},"PeriodicalIF":4.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147498006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of mid-childhood per- and polyfluoroalkyl substances and early childhood metals with mid-childhood antibody titers.","authors":"Anna Smith, Pi-I D Lin, Sheryl L Rifas-Shiman, Diane R Gold, Abby F Fleisch, Marie-France Hivert, Emily Oken, Andres Cardenas","doi":"10.1097/EE9.0000000000000471","DOIUrl":"10.1097/EE9.0000000000000471","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyfluoroalkyl substances (PFAS) and nonessential metals impair immune responses, while essential metals promote immune maintenance. We evaluated associations of childhood PFAS and metal mixtures with measles, mumps, rubella (MMR), pertussis, diphtheria, and tetanus antibody titers.</p><p><strong>Methods: </strong>We measured mid-childhood (age 7.7 years, interquartile range 7.4, 8.4) plasma PFAS (perfluorooctanoate, perfluorooctane sulfonate, perfluorodecanoate, perfluorohexane sulfonate, 2-(N-methyl-perfluorooctane sulfonamide) acetate, and perfluorononanoate) and early childhood (3.2 years, interquartile range 3.0, 3.5) blood levels of nonessential (arsenic, barium, cadmium, cesium, lead, mercury, strontium, and tin), and essential (cobalt, copper, magnesium, manganese, molybdenum, selenium, and zinc) metals in children from the Project Viva cohort, recruited prenatally between 1999 and 2000 in Massachusetts, United States. We measured plasma MMR, pertussis, diphtheria, and tetanus titers, and the analytical sample of children with all measurements ranged from n = 493-507 for PFAS and n = 179-185 for metals analyses. We used adjusted quantile g-computation and regression models to estimate mixture- and individual PFAS or metal associations, respectively.</p><p><strong>Results: </strong>Approximately 48% of the children were female, and children received their last MMR or diphtheria, tetanus, pertussis vaccination dose about 3 years before blood antibody titer collection. Contrary to our hypothesis, a one-quartile increase in the mid-childhood PFAS mixture was associated with higher mid-childhood measles [β = 0.06 antibody (Ab) index, 95% confidence interval (CI): 0.02, 0.1], rubella (β = 2.6 IU/mL, 95% CI: 0.5, 4.8), pertussis (log-β = 0.2 IU/mL, 95% CI: 0.2, 0.5), and tetanus (log-β = 0.2 IU/mL, 95% CI: 0.04, 0.4) antibody titers. A one-quartile increase in the early childhood essential metals mixture was associated with lower mid-childhood rubella antibody titers (β = -4.9 IU/mL, 95% CI: -9.0, -0.8). Individual PFAS and metals were associated with pertussis, diphtheria, and tetanus antibody titers in directions contrary to our initial hypotheses.</p><p><strong>Conclusions: </strong>Our results suggest that mid-childhood blood PFAS and early childhood metals may influence antibody titers, although additional prospective studies are needed.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e471"},"PeriodicalIF":4.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12991553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring pathways between residential greenness and antepartum stillbirth: A mediation analysis.","authors":"Dario Ezequiel Elias, Marcia Furquim de Almeida, Rossana Pulcineli Vieira Francisco, Hillegonda Maria Dutilh Novaes, Lays Janaina Prazeres Marques, Regina Schultz, Mara Sandra Hoshida, Zilda Pereira da Silva, Osmara Alves Dos Santos, Gerusa Maria Figueiredo, Rafael Junqueira Buralli, Gabriella Ferreira Demarque, Clarisse Martins Machado, Luciana Regina Meireles, Rodrigo Melim Zerbinati, Andrés Jimenez Galisteo Junior, Laura Cunha Rodrigues, Nelson Gouveia, Gizelton Pereira Alencar","doi":"10.1097/EE9.0000000000000469","DOIUrl":"10.1097/EE9.0000000000000469","url":null,"abstract":"<p><strong>Background: </strong>Antepartum stillbirth is an important public health issue. This study aimed to identify mediation pathways from the vegetation greenness surrounding the maternal residence to antepartum stillbirth, through stillbirth risk factors.</p><p><strong>Methods: </strong>This study is part of the FetRisks project-a population-based case-control study of stillbirth and live births in 14 public hospitals in the Municipality of São Paulo, Brazil (December 2019-December 2023). We estimated vegetation greenness using the median value of the normalized difference vegetation index (NDVI) obtained from satellite images from the study period, considering buffer radii around the residences between 50 and 500 m. We used penalized logistic regressions to select maternal, placental, fetal, and neighborhood characteristics. Based on these data, we built a Bayesian network and performed counterfactual mediation analyses.</p><p><strong>Results: </strong>We analyzed 248 antepartum stillbirths (cases) and 301 live births (controls). The maternal residence of 19.4% (48/248) of cases and 30.9% (93/301) of controls had a median NDVI within a buffer radius of 150 m (NDVI-150m) greater than 0.104. Women living in residences with a median NDVI-150m greater than 0.104 had a lower risk of antepartum stillbirth (odds ratio: 0.50; 95% confidence interval [CI]: 0.33, 0.76). Fetal growth restriction and placental inflammatory signs mediated 38.5% (natural indirect effect: -0.0604; 95% CI: -0.0916, -0.0292) and 14.7% (natural indirect effect: -0.0230; 95% CI: -0.0412, -0.0047) of the effect of a median NDVI-150m greater than 0.104 on antepartum stillbirth, respectively.</p><p><strong>Conclusion: </strong>Higher residential vegetation greenness showed protective indirect effects on antepartum stillbirth partially through a lower risk of fetal growth restriction and placental inflammatory signs.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e469"},"PeriodicalIF":4.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Neighborhood walkability and sedentary behaviors among US adults: Erratum.","authors":"Yangyang Deng, Mohammad Moniruzzaman, Breanna Rogers, Jinani Jayasekera, Lu Hu, Tomoki Nakaya, Eran Ben-Joseph, David Berrigan, Charles E Matthews, Kosuke Tamura","doi":"10.1097/EE9.0000000000000466","DOIUrl":"10.1097/EE9.0000000000000466","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/EE9.0000000000000453.].</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e466"},"PeriodicalIF":4.2,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12911987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to per- and polyfluoroalkyl substances and risk of autism spectrum disorder in the California Central Valley, 2004-2010.","authors":"Katherine Osborne, Zeyan Liew, Xin Cui, Douglas I Walker, Dean P Jones, YuYuan Lin, Karl O'Sharkey, Julia E Heck, Kimberly C Paul, Beate Ritz","doi":"10.1097/EE9.0000000000000464","DOIUrl":"10.1097/EE9.0000000000000464","url":null,"abstract":"<p><strong>Background: </strong>There is mixed evidence regarding the association between per- and polyfluoroalkyl substances (PFAS) and autism spectrum disorder (ASD).</p><p><strong>Methods: </strong>We matched 294 ASD cases to 286 controls by sex, birth year, and exposure to selected pesticides and air pollution. All participants were born in the California Central Valley from 2004 to 2010. Using high-resolution metabolomic profiling, three PFAS were measured in >60% of maternal serum samples: perfluorooctanoic acid (PFOA), perfluorohexanesulfonic acid, and perfluorooctane sulfonate (PFOS). Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using logistic regression to examine relationships between PFAS and ASD. Nonlinear associations were examined using restricted cubic spline regression, and a quantile-based g-computation approach was utilized to examine the association between a PFAS mixture and ASD.</p><p><strong>Results: </strong>We found an elevated aOR for ASD comparing the highest to the lowest PFOA exposure quartile (aOR = 1.71; 95% CI = 0.96, 3.06); this was not seen with perfluorohexanesulfonic acid or PFOS. We saw a <i>J</i>-shaped exposure-outcome relationship for PFOA. No apparent associations were found for the PFAS mixture and ASD. Maternal education modified associations for PFOA and PFOS; among children of mothers with lower education levels, the highest PFOA quartile was strongly associated with ASD compared with the lowest quartile (aOR = 2.97; 95% CI = 1.43, 6.18). This association was not seen with higher education levels (aOR = 0.62; 95% CI = 0.24, 1.64).</p><p><strong>Conclusions: </strong>We found that prenatal exposure to PFOA was associated with ASD in children, particularly among mothers with lower education levels. Larger studies are warranted to replicate our findings.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e464"},"PeriodicalIF":4.2,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of gestational maternal urinary concentrations of individual and mixtures of parabens with cognition in 7.5-month-old infants.","authors":"Nicholas Cragoe, Megan Woodbury, Sa Shen, Andréa Aguiar, Antonia M Calafat, Julianne Cook Botelho, Susan L Schantz","doi":"10.1097/EE9.0000000000000463","DOIUrl":"10.1097/EE9.0000000000000463","url":null,"abstract":"<p><strong>Background: </strong>Few studies have assessed the impact of gestational paraben exposure on neurodevelopment. We evaluated associations of gestational exposure to three parabens with infant cognition at 7.5 months using a visual recognition memory task.</p><p><strong>Methods: </strong>Parabens were quantified in urine samples pooled from five time-point collections across pregnancy. Cognition was measured using infrared eye-tracking. Infants (n = 310) were shown two identical faces (familiarization), followed by the familiar face paired with a novel face (test trials). Covariate-adjusted generalized linear regression assessed associations of each individual paraben with four cognitive outcomes. Quantile g-computation assessed associations of the paraben mixture with the outcomes. Stratified models assessed the moderation by infant sex.</p><p><strong>Results: </strong>Mothers were mostly white and college-educated with incomes >$50,000/year. Ethylparaben was associated with changes in attention with shorter familiarization time in females (per interquartile range [IQR] increase β = -0.015; 95% confidence interval [CI] = -0.034, 0.000), but longer familiarization time in males (per IQR increase β = 0.010; 95% CI = 0.000, 0.015), as well as longer run duration (slower information processing) in females (per IQR increase β = 0.015; 95% CI = 0.000, 0.029). Propylparaben was associated with a lower shift rate, also indicating slower information processing (per IQR increase β = -0.016; 95% CI = -0.032, 0.027) in females. In contrast, the paraben mixture was associated with longer run duration (per IQR increase β = 0.317; 95% CI = -0.020, 0.654), but higher novelty preference (improved memory) (per IQR increase β = 0.029, 95% CI = 0.002, 0.056) and higher shift rate (faster processing) (per IQR increase β = 0.027; 95% CI = 0.000, 0.054) in males.</p><p><strong>Conclusion: </strong>Parabens were associated with changes in infant cognition, with patterns of association differing by sex and cognitive domain, and when parabens were considered individually versus as a mixture.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e463"},"PeriodicalIF":4.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12889505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toenail metal concentrations and kidney health among young people at risk of chronic kidney disease of uncertain etiology.","authors":"Samantha M Hall, Birgit Claus Henn, Selene Vences Brown, Juan José Amador Velázquez, Damaris López Pilarte, Magaly Rosario Amador Sánchez, Juan José Amador Sánchez, Yirong Yuan, Jocelyn Fimbres, Kathryn M Rodgers, Brian P Jackson, Maria Argos, Luis Carvalho, Madeleine K Scammell, David J Friedman, Daniel R Brooks, Jessica H Leibler","doi":"10.1097/EE9.0000000000000461","DOIUrl":"10.1097/EE9.0000000000000461","url":null,"abstract":"<p><strong>Background: </strong>Metal exposure is a hypothesized risk factor for chronic kidney disease of uncertain etiology, an ongoing epidemic in Central America, yet metal biomonitoring data in this region are scant.</p><p><strong>Methods: </strong>We measured metal toenail concentrations using inductively coupled plasma mass spectrometry and calculated estimated glomerular filtration rate (eGFR) in a cohort of Nicaraguans 14-31 years (n = 297; 49% female; data collected in 2023). We used multivariable linear and ordinal regression and Bayesian kernel machine regression to examine individual element and mixture associations of arsenic, cadmium, mercury, nickel, lead, and uranium with eGFR.</p><p><strong>Results: </strong>The middle tertile of nickel was associated with -6.92 ml/min/1.73 m² reduction in eGFR (95% confidence intervals [CI] = -10.7, -3.12) compared to the lowest tertile, suggesting a \"<i>U</i>-shaped\" association. The highest tertile of arsenic was associated with -4.25 ml/min/1.73 m² eGFR reduction (95% CI = -8.42, -0.07) compared to the lowest tertile. Associations between other metals and eGFR were not detected. We observed no evidence of higher-order interactions or joint effects of the metal mixture on eGFR.</p><p><strong>Conclusions: </strong>In this sample of young people in a high-chronic kidney disease of uncertain etiology-risk region, nickel and arsenic were independently associated with reduced eGFR, but other metals and their mixture were not. This finding supports targeted metals biomonitoring and source investigation.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 2","pages":"e461"},"PeriodicalIF":4.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12889388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climatic determinants of antibiotic use in Southern Thailand: Retrospective longitudinal study during 2021 to 2023.","authors":"Tanavij Pannoi, Sukrit Sawangppon, Wen-Chi Pan","doi":"10.1097/EE9.0000000000000460","DOIUrl":"10.1097/EE9.0000000000000460","url":null,"abstract":"<p><strong>Background: </strong>Antibiotic consumption is influenced by multiple factors, including environmental conditions. In tropical regions, climate variability may contribute to seasonal patterns of infectious diseases and prescribing behaviors. This study examined the association between climatic variables and antibiotic use in a tertiary hospital in southern Thailand.</p><p><strong>Methods: </strong>We analyzed 7,696 prescriptions of tetracyclines (n = 971), beta-lactams and penicillins (n = 4,208), and macrolides (n = 2,517) dispensed from 2021 to 2023. Defined daily doses (DDDs) were modeled using generalized additive models and distributed lag nonlinear models to assess associations with temperature, humidity, and rainfall, incorporating delayed and nonlinear effects.</p><p><strong>Results: </strong>Tetracycline use peaked in January with over 120 DDDs/biweek and declined sharply thereafter. Distributed lag nonlinear models revealed a 45-60% increase in tetracycline use following temperature drops of ≥2 °C after 3-4 biweeks. Beta-lactam use rose by 20-30% in response to rising temperatures within 1-2 biweeks. Macrolide prescribing decreased by up to 25% in periods of high humidity (>80%) and increased with sudden temperature fluctuations. Increased rainfall (>100 mm/biweek) was significantly associated with higher beta-lactam DDDs.</p><p><strong>Conclusion: </strong>Climatic factors influence antibiotic consumption patterns in class-specific ways. Incorporating environmental surveillance into antimicrobial stewardship programs may improve preparedness and resource allocation. Further multicenter studies are needed to confirm these findings and assess pathogen-specific implications.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 1","pages":"e460"},"PeriodicalIF":3.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood walkability and sedentary behaviors among US adults.","authors":"Yangyang Deng, Mohammad Moniruzzaman, Breanna Rogers, Jinani Jayasekera, Lu Hu, Tomoki Nakaya, Eran Ben-Joseph, David Berrigan, Charles E Matthews, Kosuke Tamura","doi":"10.1097/EE9.0000000000000453","DOIUrl":"10.1097/EE9.0000000000000453","url":null,"abstract":"<p><strong>Background: </strong>It remains unclear whether individuals living in more walkable neighborhoods spend less time engaging in domain-specific sedentary behaviors, which vary by certain groups. Therefore, this study aimed to examine the associations between neighborhood walkability and total and domain-specific sedentary behavior, and to explore how this relationship varied by sociodemographic factors.</p><p><strong>Methods: </strong>Participants from AmeriSpeak who completed up to two activities completed over time in 24-hours in 2019 were included. Sedentary behavior outcomes (hours/day) included: (1) total sedentary behavior and (2) domain-specific sedentary behaviors (leisure, work, household, transport, personal, and other sedentary activities). Neighborhood walkability index was classified into four groups (least walkable [referent], below average, above average, and most walkable). Weighted generalized linear regression models were used to examine the associations, adjusting for covariates. Subsequently, such associations were stratified by sociodemographic factors.</p><p><strong>Results: </strong>Compared with the least walkable neighborhoods, below average, above average, and most walkable neighborhoods were positively associated with longer total sedentary behavior time (β = 0.53, 95% confidence interval [CI] = 0.06, 1.01; β = 0.78, 95% CI = 0.29, 1.27; and β = 1.40, 95% CI = 0.75, 2.05, respectively). For domain-specific sedentary behavior, neighborhoods with below average, above average, and most walkable neighborhoods were positively related to work sedentary behavior. However, neighborhood walkability was not related to other domain-specific sedentary behaviors. Lastly, adults aged 20-39 living in more walkable neighborhoods spent longer total sedentary behavior and work-related sedentary behavior.</p><p><strong>Conclusion: </strong>Residents living in highly walkable neighborhoods engaged in more total sedentary behavior and work-related sedentary time. Future research should explore how neighborhood environments collectively influence sedentary behavior.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 1","pages":"e453"},"PeriodicalIF":4.2,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal exposures and their interactions with the dietary inflammatory index on inflammatory biomarkers in Mexican adolescents.","authors":"Yanelli Rodríguez-Carmona, Ana Baylin, Peter X K Song, Edward Ruiz-Narvaez, Cindy W Leung, James R Hebert, Nitin Shivappa, Michael D Wirth, Alejandra Cantoral, John D Meeker, Niladri Basu, Martha María Tellez-Rojo, Karen E Peterson, Sung Kyun Park","doi":"10.1097/EE9.0000000000000458","DOIUrl":"10.1097/EE9.0000000000000458","url":null,"abstract":"<p><strong>Background: </strong>Heavy metals, like lead, arsenic, and cadmium, are linked to increased inflammation even in early life; however, anti-inflammatory diets may offset these effects.</p><p><strong>Methods: </strong>We evaluated associations between heavy metals and inflammatory biomarkers, and potential effect modification by diet in 399 adolescents aged 10 to 18 at baseline who attended two study visits 2 years apart (773 observations). At baseline, blood lead, urinary arsenic, and cadmium concentrations were measured, and the Children's Dietary Inflammatory Index (C-DII) was calculated. Fasting serum interleukin (IL)-4, IL-10, IL-1β, IL-6, IL-8, high-sensitivity C-reactive protein, and tumor necrosis factor-alpha were measured for both visits. Generalized estimating equation models were fit to assess associations between metal concentrations and repeatedly measured inflammatory biomarkers, adjusting for study visit and baseline sociodemographic and lifestyle variables. Effect modification by diet was assessed by including metal and C-DII tertiles interaction terms.</p><p><strong>Results: </strong>At baseline, the median age was 13.6 years, 50.4% were females, and 51.1% had a low socioeconomic status. Overall, there were no associations between metals and inflammatory markers in the entire population. In the most anti-inflammatory diet group (C-DII T1), higher blood lead was associated with higher IL-4, IL-1β, IL-6, and IL-8 levels, whereas for the most pro-inflammatory diet (C-DII T3), these associations were inverse (<i>P</i>-trend <0.05). Contrarily, higher urinary arsenic was associated with lower IL-4, IL-6, and IL-8 levels in the anti-inflammatory diet group and positively associated with these cytokines in the pro-inflammatory diet group (<i>P</i>-trend <0.05).</p><p><strong>Conclusion: </strong>Anti-inflammatory diets may modify adolescents' inflammatory response to lead and arsenic. Heavy metal toxicity mitigation by anti-inflammatory diets requires further research.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"10 1","pages":"e458"},"PeriodicalIF":4.2,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}