Environmental Epidemiology最新文献_第6页

IF 3.6

Environmental Epidemiology Pub Date : 2022-03-31 DOI: 10.1097/EE9.0000000000000206

P. Masselot, T. Ouarda, C. Charron, C. Campagna, É. Lavigne, A. St‐Hilaire, F. Chebana, P. Valois, P. Gosselin

{"title":"Heat-related mortality prediction using low-frequency climate oscillation indices: Case studies of the cities of Montréal and Québec, Canada","authors":"P. Masselot, T. Ouarda, C. Charron, C. Campagna, É. Lavigne, A. St‐Hilaire, F. Chebana, P. Valois, P. Gosselin","doi":"10.1097/EE9.0000000000000206","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000206","url":null,"abstract":"Background: Heat-related mortality is an increasingly important public health burden that is expected to worsen with climate change. In addition to long-term trends, there are also interannual variations in heat-related mortality that are of interest for efficient planning of health services. Large-scale climate patterns have an important influence on summer weather and therefore constitute important tools to understand and predict the variations in heat-related mortality. Methods: In this article, we propose to model summer heat-related mortality using seven climate indices through a two-stage analysis using data covering the period 1981–2018 in two metropolitan areas of the province of Québec (Canada): Montréal and Québec. In the first stage, heat attributable fractions are estimated through a time series regression design and distributed lag nonlinear specification. We consider different definitions of heat. In the second stage, estimated attributable fractions are predicted using climate index curves through a functional linear regression model. Results: Results indicate that the Atlantic Multidecadal Oscillation is the best predictor of heat-related mortality in both Montréal and Québec and that it can predict up to 20% of the interannual variability. Conclusion: We found evidence that one climate index is predictive of summer heat-related mortality. More research is needed with longer time series and in different spatial contexts. The proposed analysis and the results may nonetheless help public health authorities plan for future mortality related to summer heat.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42483865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

PM2.5 composition and disease aggravation in amyotrophic lateral sclerosis 肌萎缩性侧索硬化症中PM2.5成分与疾病加重

IF 3.6

Environmental Epidemiology Pub Date : 2022-03-30 DOI: 10.1097/EE9.0000000000000204

Y. Nunez, A. Boehme, Jeff Goldsmith, Maggie Li, A. van Donkelaar, M. Weisskopf, D. Re, R. Martin, M. Kioumourtzoglou

{"title":"PM2.5 composition and disease aggravation in amyotrophic lateral sclerosis","authors":"Y. Nunez, A. Boehme, Jeff Goldsmith, Maggie Li, A. van Donkelaar, M. Weisskopf, D. Re, R. Martin, M. Kioumourtzoglou","doi":"10.1097/EE9.0000000000000204","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000204","url":null,"abstract":"Background: Long-term exposure to fine particulate matter (PM2.5) has been associated with disease aggravation in amyotrophic lateral sclerosis (ALS). In this study, we characterized long-term exposure to six major PM2.5 components and their individual association with disease aggravation in ALS. Methods: We leveraged 15 years of data from the New York Department of Health Statewide Planning and Research Cooperative System (2000–2014) to calculate annual ALS first hospitalizations in New York State. We used the first hospital admission as a surrogate of disease aggravation and a prediction model to estimate population-weighted annual black carbon, organic matter (OM), nitrate, sulfate, sea salt, and soil concentrations at the county level. We used a multi-pollutant mixed quasi-Poisson model with county-specific random intercepts to estimate rate ratios (RR) of 1-year exposure to each PM2.5 component and disease aggravation in ALS, adjusting for potential confounders. Results: We observed 5,655 first ALS-related hospitalizations. The annual average hospitalization count per county was 6.08 and the average PM2.5 total mass concentration per county was 8.1 μg/m3—below the United States’ National Ambient Air Quality Standard of 12 μg/m3. We found a consistent positive association between ALS aggravation and OM (1.17, 95% confidence intervals [CI], 1.11, 1.24 per standard deviation [SD] increase) and a negative association with soil (RR = 0.91, 95% CI, 0.86, 0.97). Conclusion: Our findings suggest that PM2.5 composition may influence its effect on ALS. We found that annual increases in county-level particulate OM may be associated with disease aggravation in ALS, even at PM2.5 levels below current standards.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41694774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Ambient air pollution during pregnancy and cardiometabolic biomarkers in cord blood 怀孕期间的环境空气污染与脐带血中的心脏代谢生物标志物

IF 3.6

Environmental Epidemiology Pub Date : 2022-03-22 DOI: 10.1097/EE9.0000000000000203

Chloe Friedman, D. Dabelea, L. Bloemsma, D. S. Thomas, J. Peel, J. Adgate, S. Magzamen, S. Martenies, W. Allshouse, A. Starling

{"title":"Ambient air pollution during pregnancy and cardiometabolic biomarkers in cord blood","authors":"Chloe Friedman, D. Dabelea, L. Bloemsma, D. S. Thomas, J. Peel, J. Adgate, S. Magzamen, S. Martenies, W. Allshouse, A. Starling","doi":"10.1097/EE9.0000000000000203","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000203","url":null,"abstract":"Background/Objectives: Prenatal air pollution exposure has been associated with adverse childhood cardiometabolic outcomes. It is unknown whether evidence of metabolic disruption associated with air pollution is identifiable at birth. We examined exposure to prenatal ambient air pollution and cord blood cardiometabolic biomarkers among 812 mother-infant pairs in the Healthy Start study. Methods: Using inverse-distance-weighted interpolation of ambient concentrations obtained from stationary monitors, we estimated daily particulate matter ≤2.5 micrometers (PM2.5) and ozone (O3) concentrations at participant residences. Daily estimates were averaged by trimester, full-pregnancy, and the 7 and 30 days prior to delivery. Associations of air pollution with the following cord blood biomarkers were estimated via multivariable linear regression: glucose, insulin, glucose/insulin ratio (GIR), leptin, high-density lipoprotein (HDL) cholesterol, non-HDL cholesterol, free fatty acids, and triglycerides. Results: In this Denver-based cohort, PM2.5 concentrations were lower than in many US urban areas, but O3 concentrations regularly exceeded federal air quality standards. Higher O3 concentrations during pregnancy were consistently associated with higher insulin and lower GIR in cord blood. For example, an interquartile range increase in full pregnancy O3 (6.3 parts per billion [ppb]) was associated with 0.13 log-µIU/ml (95% confidence interval [CI] = 0.04, 0.22) higher cord blood insulin, after adjusting for PM2.5 and other confounders. We found positive, but generally nonsignificant, associations between PM2.5 and leptin and isolated associations between pollutants during certain exposure periods and lipids. Conclusions: In this cohort with moderately high O3 exposure, prenatal concentrations of O3 were positively associated with cord blood insulin. Future studies should examine the implications for offspring long-term health.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46267379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Erratum: Ambient air pollution associated with lower academic achievement among US children: A nationwide panel study of school districts: Erratum. 勘误表：环境空气污染与美国儿童学业成绩下降有关：一项针对学区的全国性小组研究：勘误表。

IF 3.6

Environmental Epidemiology Pub Date : 2022-02-25 DOI: 10.1097/ee9.0000000000000202

引用次数: 0

Accelerating Research and Policy on PFAS in India 加速印度的PFAS研究和政策

IF 3.6

Environmental Epidemiology Pub Date : 2022-02-22 DOI: 10.1097/ee9.0000000000000199

Ankan Mukherjee Das, R. Janardhanan

引用次数: 2

Joint associations between neighborhood walkability, greenness, and particulate air pollution on cardiovascular mortality among adults with a history of stroke or acute myocardial infarction 在有中风或急性心肌梗死病史的成年人中，社区可步行性、绿色和颗粒物空气污染对心血管死亡率的联合影响

IF 3.6

Environmental Epidemiology Pub Date : 2022-02-18 DOI: 10.1097/EE9.0000000000000200

Noelle S. Liao, S. K. Van Den Eeden, S. Sidney, K. Deosaransingh, J. Schwartz, S. Uong, S. Alexeeff

{"title":"Joint associations between neighborhood walkability, greenness, and particulate air pollution on cardiovascular mortality among adults with a history of stroke or acute myocardial infarction","authors":"Noelle S. Liao, S. K. Van Den Eeden, S. Sidney, K. Deosaransingh, J. Schwartz, S. Uong, S. Alexeeff","doi":"10.1097/EE9.0000000000000200","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000200","url":null,"abstract":"Background: Fine particulate matter (PM2.5) is a known risk factor for cardiovascular disease (CVD). Neighborhood walkability and greenness may also be associated with CVD, but there is limited evidence on their joint or interacting effects with PM2.5. Methods: Cox proportional hazard models were used to estimate the risk of CVD mortality among adults with a history of acute myocardial infarction and/or stroke living in Northern California. We assessed the independent and joint effects of walkability, greenness (Normalized Differentiated Vegetation Index [NDVI]), and PM2.5 at residential addresses, controlling for age, sex, race/ethnicity, comorbidities, BMI, smoking, revascularization, medications, and socioeconomic status. Results: Greenness had a nonlinear association with CVD mortality (P = 0.038), with notably protective effects (HR = 0.87 [95% confidence interval {CI} = 0.78, 0.97]) at higher greenness levels (NDVI ≥ 0.3) and moderate attenuation after adjusting for PM2.5 (HR = 0.92 [95% CI = 0.82, 1.03]) per 0.1 increase in NDVI. Walkability had no independent effect on CVD mortality. PM2.5 had a strong independent effect in models adjusted for greenness and walkability (HR = 1.20 [95% CI = 1.08, 1.33)) per 10 μg/m3 increase in PM2.5. There was an interaction between walkability and PM2.5 (P = 0.037), where PM2.5 had slightly stronger associations in more walkable than less walkable neighborhoods (HR = 1.23 [95% CI = 1.06, 1.42] vs. 1.17 [95% CI = 1.04, 1.32]) per 10 μg/m3 increase in PM2.5. Greenness had no interaction with PM2.5 (P = 0.768) nor walkability (P = 0.385). Conclusions: High greenness may be protective of CVD mortality among adults with CVD history. PM2.5 associated CVD mortality risk varies slightly by level of neighborhood walkability, though these small differences may not be clinically meaningful.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46589821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The P value plot does not provide evidence against air pollution hazards P值图没有提供反对空气污染危害的证据

IF 3.6

Environmental Epidemiology Pub Date : 2022-02-18 DOI: 10.1097/EE9.0000000000000198

D. Hicks

引用次数: 1

Applying the exposome concept to working life health 暴露概念在工作生活健康中的应用

IF 3.6

Environmental Epidemiology Pub Date : 2022-02-17 DOI: 10.1097/EE9.0000000000000185

A. Pronk, Miranda Loh, E. Kuijpers, M. Albin, Jenny Selander, L. Godderis, Manosij Ghosh, Roel C. H. Vermeulen, S. Peters, I. Mehlum, M. Turner, V. Schlünssen, M. Goldberg, M. Kogevinas, Barbara N Harding, S. Solovieva, T. Garani-Papadatos, M. V. van Tongeren, R. Stierum

{"title":"Applying the exposome concept to working life health","authors":"A. Pronk, Miranda Loh, E. Kuijpers, M. Albin, Jenny Selander, L. Godderis, Manosij Ghosh, Roel C. H. Vermeulen, S. Peters, I. Mehlum, M. Turner, V. Schlünssen, M. Goldberg, M. Kogevinas, Barbara N Harding, S. Solovieva, T. Garani-Papadatos, M. V. van Tongeren, R. Stierum","doi":"10.1097/EE9.0000000000000185","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000185","url":null,"abstract":"Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all occupational and related nonoccupational exposures. The latter includes nonoccupational exposures that may be directly or indirectly influenced by or interact with the working life of the individual in their relation to health. The Exposome Project for Health and Occupational Research aims to advance knowledge on the complex working life exposures in relation to disease beyond the single high exposure–single health outcome paradigm, mapping and relating interrelated exposures to inherent biological pathways, key body functions, and health. This will be achieved by combining (1) large-scale harmonization and pooling of existing European cohorts systematically looking at multiple exposures and diseases, with (2) the collection of new high-resolution external and internal exposure data. Methods and tools to characterize the working life exposome will be developed and applied, including sensors, wearables, a harmonized job exposure matrix (EuroJEM), noninvasive biomonitoring, omics, data mining, and (bio)statistics. The toolbox of developed methods and knowledge will be made available to policy makers, occupational health practitioners, and scientists. Advanced knowledge on working life exposures in relation to NCDs will serve as a basis for evidence-based and cost-effective preventive policies and actions. The toolbox will also enable future scientists to further expand the working life exposome knowledge base.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47586093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Prenatal exposure to insecticides and child cardiometabolic risk factors in the VHEMBE birth cohort VHEMBE出生队列中产前暴露于杀虫剂和儿童心脏代谢危险因素

IF 3.6

Environmental Epidemiology Pub Date : 2022-02-11 DOI: 10.1097/EE9.0000000000000196

Joanne Kim, Seungmi Yang, E. Moodie, M. Obida, R. Bornman, B. Eskenazi, J. Chevrier

{"title":"Prenatal exposure to insecticides and child cardiometabolic risk factors in the VHEMBE birth cohort","authors":"Joanne Kim, Seungmi Yang, E. Moodie, M. Obida, R. Bornman, B. Eskenazi, J. Chevrier","doi":"10.1097/EE9.0000000000000196","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000196","url":null,"abstract":"Background: As part of malaria control programs, many countries spray dichlorodiphenyltrichloroethane (DDT) or pyrethroid insecticides inside dwellings in a practice called indoor residual spraying that results in high levels of exposure to local populations. Gestational exposure to these endocrine- and metabolism-disrupting chemicals may influence child cardiometabolic health. Methods: We measured the serum concentration of DDT and dichlorodiphenyldichloroethylene (DDE) and urinary concentration of pyrethroid metabolites (cis-DBCA, cis-DCCA, trans-DCCA, 3-PBA) in peripartum samples collected between August 2012 and December 2013 from 637 women participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE), a birth cohort study based in Limpopo, South Africa. We applied marginal structural models to estimate the relationship between biomarker concentrations and child-size (height and weight), adiposity (body mass index [BMI], body fat percentage, waist circumference) and blood pressure at 5 years of age. Results: Maternal concentrations of all four pyrethroid metabolites were associated with lower adiposity including reduced BMI z-scores, smaller waist circumferences, and decreased body fat percentages. Reductions in BMI z-score were observed only among children of mothers with sufficient energy intake during pregnancy (βcis-DCCA, trans-DCCA=−0.4, 95% confidence interval (CI) = −0.7,−0.1; pinteraction=0.03 and 0.04, respectively) but there was no evidence of effect modification for the other measures of adiposity. Maternal p,p’-DDT concentrations were associated with a reduction in body fat percentage (β = −0.4%, 95% CI = −0.8,−0.0). Conclusions: Gestational exposure to pyrethroids may reduce adiposity in children at 5 years of age.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45296251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Does early life phthalate exposure mediate racial disparities in children’s cognitive abilities? 幼年接触邻苯二甲酸盐是否介导了儿童认知能力的种族差异?

IF 3.6

Environmental Epidemiology Pub Date : 2021-08-23 DOI: 10.1097/EE9.0000000000000205

M. Patti, M. Eliot, Nan Li, K. Yolton, B. Lanphear, Aimin Chen, J. Braun

{"title":"Does early life phthalate exposure mediate racial disparities in children’s cognitive abilities?","authors":"M. Patti, M. Eliot, Nan Li, K. Yolton, B. Lanphear, Aimin Chen, J. Braun","doi":"10.1097/EE9.0000000000000205","DOIUrl":"https://doi.org/10.1097/EE9.0000000000000205","url":null,"abstract":"Background: Early life exposure to phthalates may be associated with reduced cognition. However, it is unknown if disproportionate exposure to phthalates contributes to racial disparities in children’s intellectual abilities. Methods: We used data from 253 mother-child pairs in Cincinnati, OH (the Health Outcomes and Measures of the Environment study, 2003–2006). We measured urinary concentrations of 11 phthalate metabolites twice during pregnancy and up to six times in childhood. We evaluated children’s cognitive abilities at ages 5 and 8 years. Using mediation models, we quantified covariate-adjusted direct and indirect effects of race on children’s Full-Scale Intelligence Quotient (IQ) scores for individual phthalate metabolite concentrations during gestation and childhood. Results: Average IQ scores among Black children (n = 90) were 7.0 points lower (95% confidence interval [CI] = −12, −1.8) than among White children (n = 145) after adjustment for socioeconomic factors. Urinary monobenzyl phthalate and monoethyl phthalate (MEP) concentrations during gestation and childhood were higher among Black than White children. We did not observe evidence that phthalate concentrations mediated the race-IQ association, with the exception of MEP. Childhood MEP concentrations partially mediated the race-IQ association. For instance, each 10-fold increase in MEP concentrations at age 2 years contributed to a 1.9-point disparity in IQ scores between Black and White children (95% CI = −4.7, 0.7). Other phthalate metabolite concentrations during pregnancy or childhood did not mediate the race-IQ association. Conclusions: Despite observing racial disparities in exposure to some phthalates and IQ, we found little evidence that phthalates contribute to IQ disparities.","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"6 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44695288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0