产前血液中金属和维生素与脐带血肽类激素浓度之间的关系

IF 3.3 Q2 ENVIRONMENTAL SCIENCES
Anna R. Smith, Pi-I. D. Lin, S. Rifas-Shiman, K. Switkowski, A. Fleisch, R. O. Wright, Brent Coull, E. Oken, M. Hivert, Andres Cardenas
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引用次数: 0

摘要

背景:非必需金属具有干扰内分泌、干扰细胞过程、产生活性氧和消耗抗氧化剂的特性,而必需金属和维生素则具有抗氧化剂的作用。产前金属和维生素与参与母体和胎儿代谢和生长过程的脐带血激素的关联程度尚不清楚。研究方法我们测量了六种非必需(砷、钡、镉、铯、铅和汞)和四种必需(镁、锰、硒和锌)金属和微量元素以及两种维生素(B12 和叶酸)在产前脐带血中的含量。我们测量了脐带血中的脂肪连素、C 肽、胰岛素样生长因子 (IGF)-1、IGF-2、IGF 结合蛋白 (IGFBP)-3、胰岛素和瘦素浓度(~n = 695)。我们对混合物采用协变量调整量级 g 计算,对单个暴露采用线性回归来估计与脐带血肽类激素的关系。结果必需金属混合物(镁、锰、硒和锌)与较高的 IGF-1(β = 3.20 ng/ml/四分位数;95% CI = 0.39,6.01)、IGF-2(β = 10.93 ng/ml;95% CI = 0.08,21.79)和瘦素(β = 1.03 ng/ml;95% CI = 0.25,1.80)相关。镁与瘦素的升高有关(β = 2.90 ng/ml; 95% CI = 0.89, 4.91),而 B12 与较低的脂肪连接素、IGF-2 和瘦素有关,但与较高的 C 肽有关。其他非必需金属也与脐带血激素有关。结论:我们的研究结果表明,某些产前金属和维生素与脐带血激素有关,而脐带血激素可能会影响生长和发育。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between prenatal blood metals and vitamins and cord blood peptide hormone concentrations
Background: Nonessential metals have endocrine-disrupting properties, interfere with cellular processes, generate reactive oxygen, and deplete antioxidants, while essential metals and vitamins act as antioxidants. The extent to which prenatal metals and vitamins are associated with cord blood hormones involved in maternal and fetal metabolic and growth processes is unknown. Methods: We measured six nonessential (arsenic, barium, cadmium, cesium, lead, and mercury) and four essential (magnesium, manganese, selenium, and zinc) metals and trace elements, and two vitamins (B12 and folate) in first-trimester blood from participants in the longitudinal prebirth Project Viva cohort, who were recruited between 1999 and 2002 in eastern Massachusetts. We measured adiponectin, C-peptide, insulin-like growth factor (IGF)-1, IGF-2, IGF binding protein (IGFBP)-3, insulin, and leptin concentrations in cord blood (~n = 695). We used covariate-adjusted quantile g-computation for mixtures and linear regression for individual exposures to estimate associations with cord blood peptide hormones. Results: The essential metal mixture (magnesium, manganese, selenium, and zinc) was associated with higher IGF-1 (β = 3.20 ng/ml per quartile; 95% CI = 0.39, 6.01), IGF-2 (β = 10.93 ng/ml; 95% CI = 0.08, 21.79), and leptin (β = 1.03 ng/ml; 95% CI = 0.25, 1.80). Magnesium was associated with higher leptin (β = 2.90 ng/ml; 95% CI = 0.89, 4.91), while B12 was associated with lower adiponectin, IGF-2, and leptin but higher C-peptide. Other individual nonessential metals were associated with cord blood hormones. Conclusions: Our findings suggest that some prenatal metals and vitamins are associated with cord blood hormones, which may influence growth and development.
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来源期刊
Environmental Epidemiology
Environmental Epidemiology Medicine-Public Health, Environmental and Occupational Health
CiteScore
5.70
自引率
2.80%
发文量
71
审稿时长
25 weeks
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