Environmental Epidemiology最新文献

筛选
英文 中文
The association between time spent outdoors during daylight and mortality among participants of the Adventist Health Study 2 Cohort. 在基督复临健康研究2队列参与者中,白天在户外度过的时间与死亡率之间的关系。
IF 3.3
Environmental Epidemiology Pub Date : 2025-05-28 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000401
Noor Nazeeh, Michael J Orlich, Gina Segovia-Siapco, Gary E Fraser, David Shavlik
{"title":"The association between time spent outdoors during daylight and mortality among participants of the Adventist Health Study 2 Cohort.","authors":"Noor Nazeeh, Michael J Orlich, Gina Segovia-Siapco, Gary E Fraser, David Shavlik","doi":"10.1097/EE9.0000000000000401","DOIUrl":"10.1097/EE9.0000000000000401","url":null,"abstract":"<p><strong>Background: </strong>Prolonged exposure to sunlight increases the risk of skin cancer. However, multiple sunlight-related health benefits have been identified. The overall effect of sun exposure on mortality remains inconclusive. This study investigated the association between daylight exposure and mortality (all-cause and cause-specific: cancer, cardiovascular disease (CVD), and noncancer non-CVD mortalities).</p><p><strong>Methods: </strong>This study utilized the Adventist Health Study (AHS) 2 cohort of North America. Sun exposure was defined using time spent outdoors during daylight in warmer and cooler months. Mortality outcomes were identified through 2015. Multivariable Cox regression was used to examine the association between sun exposure and mortality.</p><p><strong>Results: </strong>This study included 83,205 AHS-2 participants enrolled between 2002 and 2007. We observed nonlinear (reverse J-shaped) associations between time outdoors in warmer months and the risks of all-cause, CVD, and noncancer non-CVD mortalities. Compared with spending 30 min/day during daylight in warmer months, spending 2 hours/day was associated with a lower risk of all-cause (hazard ratio: 0.90; 95% confidence interval = 0.86, 0.93), CVD (0.89; 0.83, 0.95), and noncancer non-CVD mortalities (0.83; 0.78, 0.89), but was not significantly associated with cancer mortality risk (1.02; 0.93, 1.13) after adjusting for physical activity and important confounders. All associations were weaker with the time spent outdoors in cooler months.</p><p><strong>Conclusions: </strong>Moderate time outdoors in daylight during warmer months could be associated with lower risks of all-cause, CVD, and noncancer non-CVD mortality; however, there was no clear evidence of an association with cancer mortality. Epidemiological studies need to investigate the balance between sun exposure's health benefits and risks.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e401"},"PeriodicalIF":3.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association of multiple built environment factors with a clinical measure of grip strength. 多种建筑环境因素与握力临床测量的关联。
IF 3.3
Environmental Epidemiology Pub Date : 2025-05-28 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000391
Millie Baghela, Jaclyn Parks, Parveen Bhatti
{"title":"The association of multiple built environment factors with a clinical measure of grip strength.","authors":"Millie Baghela, Jaclyn Parks, Parveen Bhatti","doi":"10.1097/EE9.0000000000000391","DOIUrl":"10.1097/EE9.0000000000000391","url":null,"abstract":"<p><strong>Background: </strong>Population-level interventions that promote healthy aging through modifications to the built environment are likely to be more effective than individual-level interventions. Few studies have examined the influence of multiple built environment factors on measures of healthy aging.</p><p><strong>Objectives: </strong>We leveraged detailed data from a population-based cohort study to examine how multiple aspects of the built environment were associated with grip strength, a well-accepted measure of age-related health status.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted among 15,068 participants of the British Columbia Generations Project. Geospatial measures of air pollution (PM<sub>2.5</sub>, SO<sub>2</sub>, and NO<sub>2</sub>), greenness, light-at-night, and walkability were linked to participant residential postal codes. Grip strength was measured using a digital hydraulic hand dynamometer. Logistic regression analyses were used to estimate the odds of having sex-specific clinically weak measures of grip strength in association with each built environment factor. The other built environment factors, demographics, and lifestyle factors were evaluated as confounders.</p><p><strong>Results: </strong>Increased SO<sub>2</sub> and greenness were statistically significantly associated with increased and decreased odds of having clinically weak grip strength, respectively, after adjusting for demographic, lifestyle, and other built environment factors.</p><p><strong>Conclusion: </strong>Our findings suggest that built environment factors are compelling targets for improving age-related health, though the mechanisms underlying associations with these factors, particularly greenness, remain uncertain.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e391"},"PeriodicalIF":3.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Road traffic noise and incident ischemic heart disease, myocardial infarction, and stroke: A systematic review and meta-analysis. 道路交通噪音与缺血性心脏病、心肌梗死和中风的发生:一项系统回顾和荟萃分析。
IF 3.3
Environmental Epidemiology Pub Date : 2025-05-28 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000400
Göran Pershagen, Andrei Pyko, Gunn Marit Aasvang, Mikael Ögren, Pekka Tiittanen, Timo Lanki, Mette Sørensen
{"title":"Road traffic noise and incident ischemic heart disease, myocardial infarction, and stroke: A systematic review and meta-analysis.","authors":"Göran Pershagen, Andrei Pyko, Gunn Marit Aasvang, Mikael Ögren, Pekka Tiittanen, Timo Lanki, Mette Sørensen","doi":"10.1097/EE9.0000000000000400","DOIUrl":"10.1097/EE9.0000000000000400","url":null,"abstract":"<p><strong>Background: </strong>This systematic review aimed to estimate relative risks for incident ischemic heart disease (IHD), myocardial infarction (MI), and stroke in relation to long-term road traffic noise exposure and to evaluate exposure-response functions.</p><p><strong>Methods: </strong>We systematically searched databases for longitudinal studies in humans on incident IHD, MI, and/or stroke, including quantitative estimates on individual exposure to residential road traffic noise based on validated models or measurements. Risk of bias was evaluated in each study based on predefined criteria. Pooled linear exposure-response functions were generated from random-effect models in meta-analyses of study-specific risk estimates. Restricted cubic spline models were used to capture potential nonlinear associations.</p><p><strong>Results: </strong>Twenty eligible studies were identified based on more than 8.4 million individuals, mostly from Europe, including between 160,000 and 240,000 cases for each of the outcomes. Pooled relative risk estimates were 1.017 (95% confidence interval [CI]: 0.990, 1.044) for IHD, 1.029 (95% CI: 1.011, 1.048) for MI, and 1.025 (95% CI: 1.009, 1.041) for stroke per 10 dB L<sub>den</sub> in road traffic noise exposure. Risk estimates appeared higher in combined analyses of studies with a low risk of exposure assessment bias. Restricted cubic spline analyses of these studies showed clear risk increases with exposure for all three cardiovascular outcomes.</p><p><strong>Conclusions: </strong>The evidence indicates that long-term exposure to road traffic noise increases the incidence of IHD, including MI, and stroke. Given the abundant exposure, traffic noise is a cardiovascular risk factor of public health importance. High-quality assessment of noise exposure appears essential for the risk estimation.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e400"},"PeriodicalIF":3.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A good move for health?: Analyzing urban exposure trajectories of residential relocation and mental health in populations in Bradford. 一个有益健康的举动?:分析布拉德福德地区居民的城市暴露轨迹和心理健康状况。
IF 3.3
Environmental Epidemiology Pub Date : 2025-05-23 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000397
Mikel Subiza-Pérez, Teumzghi F Mebrahtu, Kimon Krenz, Aidan Watmuff, Tiffany Yang, Laura Vaughan, John Wright, Rosemary R C McEachan
{"title":"A good move for health?: Analyzing urban exposure trajectories of residential relocation and mental health in populations in Bradford.","authors":"Mikel Subiza-Pérez, Teumzghi F Mebrahtu, Kimon Krenz, Aidan Watmuff, Tiffany Yang, Laura Vaughan, John Wright, Rosemary R C McEachan","doi":"10.1097/EE9.0000000000000397","DOIUrl":"10.1097/EE9.0000000000000397","url":null,"abstract":"<p><p>Residential relocation can be leveraged as a natural experiment. This study examined the changes in environmental exposures due to residential relocation in two samples of within-city movers in Bradford (UK); 2089 residents (66% women, mean [SD] age, 47.80 [19.88] years) with preexisting common mental disorders-related prescriptions and 12,699 residents (60% women, mean [SD] age, 42.47 [17.40] years) without the same prescriptions at baseline (January-April 2021). Study data were extracted from National Health Service health records. The outcome was the presence of an active prescription for anxiolytics or antidepressants (yes/no) 1 year after relocation (January-April 2022). Change scores were calculated for several exposures, including the normalized difference vegetation index, distance decay to green spaces, coarse (PM<sub>10</sub>) and fine particulate matter (PM<sub>2.5</sub>), and nitrogen dioxide (NO<sub>2</sub>) at pre- and postmove addresses. Logistic regression models were used for each change score exposure, adjusting for covariates selected using a direct acyclic graph validated against the data. Participants without prescriptions at baseline were likely to relocate to less green and less polluted areas compared with those with preexisting medication. A total of 15% of participants without prescriptions at baseline had an active prescription at follow-up. For these, increases in normalized difference vegetation index were associated with lower odds of having active prescriptions at follow-up [OR (odds ratio) = 0.93 (95% confidence interval [CI] = 0.88, 0.98), <i>P</i> = 0.007], whereas increases in PM<sub>2.5</sub> [OR = 1.1 (95% CI = 1.04, 1.16), <i>P</i> < 0.001] and PM<sub>10</sub> [OR = 1.12 (95% CI = 1.06-1.19), <i>P</i> < 0.001] concentrations were associated with higher odds. Changes in environmental exposures due to residential relocation showed an influence on mental health only for those participants without active prescriptions in the baseline.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e397"},"PeriodicalIF":3.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early life exposure to fine particulate matter and fine motor function, attentional function, and working memory among Spanish school-aged children. 西班牙学龄儿童早期接触细颗粒物与精细运动功能、注意力功能和工作记忆的关系。
IF 4.2
Environmental Epidemiology Pub Date : 2025-05-14 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000396
Kristina W Whitworth, Aitana Lertxundi, Mingze Yuan, Alison Rector-Houze, Wei-Jen Chen, Mònica Guxens, Jordi Julvez, Michael Swartz, Elaine Symanski, Antonia Valentin, Carmen Iniguez, Llúcia L González-Safont, Jesús Ibarluzea
{"title":"Early life exposure to fine particulate matter and fine motor function, attentional function, and working memory among Spanish school-aged children.","authors":"Kristina W Whitworth, Aitana Lertxundi, Mingze Yuan, Alison Rector-Houze, Wei-Jen Chen, Mònica Guxens, Jordi Julvez, Michael Swartz, Elaine Symanski, Antonia Valentin, Carmen Iniguez, Llúcia L González-Safont, Jesús Ibarluzea","doi":"10.1097/EE9.0000000000000396","DOIUrl":"10.1097/EE9.0000000000000396","url":null,"abstract":"<p><strong>Background: </strong>Evidence of the association between fine particulate matter (PM<sub>2.5</sub>) exposure and child neuropsychological function is equivocal. We examined early life PM<sub>2.5</sub> exposure in relation to fine motor function, attention, and working memory in early childhood.</p><p><strong>Methods: </strong>We used data from the Spanish INfancia y Medio Ambiente Project, 2003-2008. Exposure to PM<sub>2.5</sub> (μg/m<sup>3</sup>) was assessed using spatiotemporal land-use random forest models and assigned based on residential address histories. Around age six, children completed the finger tapping test, attentional network test (ANT), and n-back task to evaluate fine motor speed, attention, and working memory, respectively. A total of 1,310 children had data from at least one neuropsychological assessment. General linear models were applied to assess associations between average prenatal and postnatal PM<sub>2.5</sub> with each outcome. Distributed lag nonlinear models were used to explore refined periods of susceptibility to PM<sub>2.5</sub>. We reported β estimates and 99% credible intervals (CrI) representing the change in each outcome per 5-μg/m<sup>3</sup> increase in PM<sub>2.5</sub>.</p><p><strong>Results: </strong>Prenatal PM<sub>2.5</sub> exposure was associated with decreased mean hit reaction time (HRT) (β = -21.82; 99% CrI = -64.1, 20.4) and HRT-standard error (β = -9.7; 99% CrI = -30.3, 10.9) on the ANT but estimates were imprecise. Postnatal PM<sub>2.5</sub> was associated with reduced mean HRT on the n-back task (β = -39.4; 99% CrI = -115.1, 26.3). We observed sensitive periods of exposure in the postnatal period associated with both better and worse performance on the finger-tapping test and ANT.</p><p><strong>Conclusions: </strong>We found limited evidence to support an association between PM<sub>2.5</sub> exposure and fine motor function, attentional function, or working memory in school-aged children.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e396"},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air pollution, greenspace, and metabolic syndrome in older Czech and Swiss populations. 捷克和瑞士老年人的空气污染、绿地和代谢综合征。
IF 4.2
Environmental Epidemiology Pub Date : 2025-05-08 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000393
Andrea Dalecká, Ayoung Jeong, Daniel Szabó, Balint Tamasi, Medea Imboden, Emmanuel Schaffner, Dirk Keidel, Youchen Shen, Mark Nieuwenhuijsen, Marta Cirach, Kees de Hoogh, Jelle Vlaanderen, Roel Vermeulen, Annette Peters, Erik Melén, Anne Peasey, Martin Bobák, Hynek Pikhart, Nicole Probst-Hensch
{"title":"Air pollution, greenspace, and metabolic syndrome in older Czech and Swiss populations.","authors":"Andrea Dalecká, Ayoung Jeong, Daniel Szabó, Balint Tamasi, Medea Imboden, Emmanuel Schaffner, Dirk Keidel, Youchen Shen, Mark Nieuwenhuijsen, Marta Cirach, Kees de Hoogh, Jelle Vlaanderen, Roel Vermeulen, Annette Peters, Erik Melén, Anne Peasey, Martin Bobák, Hynek Pikhart, Nicole Probst-Hensch","doi":"10.1097/EE9.0000000000000393","DOIUrl":"10.1097/EE9.0000000000000393","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of metabolic syndrome (MetS) has increased rapidly, with considerable variation between European countries. The study examined the relationship between air pollutants, greenspace, and MetS and its components in the Czech and Swiss populations.</p><p><strong>Methods: </strong>Cross-sectional data from the Czech Health, Alcohol and Psychosocial Factors in Eastern Europe (HAPIEE) (n = 4,931) and the Swiss cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) (n = 4,422) cohorts included participants aged 44-73 years. MetS was defined as abdominal obesity plus two additional components (hypertension, diabetes, low high-density lipoprotein cholesterol, and elevated triglycerides). Annual mean concentrations of PM<sub>10</sub>, PM<sub>2.5</sub>, NO<sub>2</sub>, and greenspace (defined as the annual mean of normalized difference vegetation index within 500 m) were assigned to the individual residential level. We estimated odds ratios (OR) using multivariable logistic regressions with cluster-robust standard error, controlling for multiple confounders.</p><p><strong>Results: </strong>The prevalence of MetS was significantly higher in the Czech (51.1%) compared with Swiss (35.8%) population as were the concentration means of PM<sub>10</sub> and PM<sub>2.5</sub>. In HAPIEE, a 5 μg/m<sup>3</sup> increase in PM<sub>2.5</sub> was associated with 14% higher odds of MetS (OR = 1.14; 95% confidence interval [CI] = 1.01, 1.28). In SAPALDIA, no evidence was found for the associations between air pollutants and MetS (e.g. OR = 1.01; 95% CI = 0.90, 1.13 for PM<sub>2.5</sub>). No protective effects of normalized difference vegetation index on MetS were observed. Upon inspection of MetS components, PM<sub>2.5</sub> and PM<sub>10</sub> exposures were associated with higher odds of hypertension and elevated triglycerides in HAPIEE only, while PM<sub>2.5</sub>, PM<sub>10,</sub> and NO<sub>2</sub> were associated with higher odds of diabetes in SAPALDIA only.</p><p><strong>Conclusion: </strong>Individuals with higher exposures to PM<sub>2.5</sub> may be at higher risk of MetS. The differential associations with MetS components between the cohorts deserve further investigation.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e393"},"PeriodicalIF":4.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extreme heat and hospital admissions in older adults: A small-area analysis in the Greater Boston metropolitan area. 极端高温和老年人住院:大波士顿市区的小区域分析。
IF 4.2
Environmental Epidemiology Pub Date : 2025-05-06 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000395
Youn Soo Jung, Ernani Choma, Scott Delaney, Daniel Mork, Michelle Audirac, Danielle Braun, William Kessler, Brent Coull, Kari Nadeau, Antonella Zanobetti
{"title":"Extreme heat and hospital admissions in older adults: A small-area analysis in the Greater Boston metropolitan area.","authors":"Youn Soo Jung, Ernani Choma, Scott Delaney, Daniel Mork, Michelle Audirac, Danielle Braun, William Kessler, Brent Coull, Kari Nadeau, Antonella Zanobetti","doi":"10.1097/EE9.0000000000000395","DOIUrl":"10.1097/EE9.0000000000000395","url":null,"abstract":"<p><p>Extreme heat (EH) is a leading cause of weather-related fatalities in the United States. In Massachusetts, average temperatures have increased by 1.9 °C since the 20th century, higher than the global average increase of 1.1 °C. EH disproportionately impacts communities, exacerbating social inequities. This study examined the risks of heat-related hospitalizations in each small area of the Greater Boston Metropolitan Area using Medicare data (2000-2016). EH events included daily heat index (HI), days with an HI above the 90th percentile, and heat waves (≥2 consecutive EH days). We applied a case-crossover design to estimate area-specific associations between EH and hospitalizations and assessed effect modifications by an individual (age ≥85, sex, Medicaid dual eligibility) and ZIP-code characteristics (green space, poverty, educational attainment, and household income). Results were pooled using random effects meta-analysis. Area-specific analysis revealed higher hospitalization risks in Boston compared with surrounding areas. Pooled results indicated heat-related hospitalizations increased by 9.0% (95% CI = 5.7, 12.3) per 10 °C rise in HI, 14.4% (95% CI = 8.8, 20.3) on EH days, and 17.9% (95% CI = 11.1, 25.1) during heat waves. Risks were more pronounced in Boston, and some indications of elevated risk among males and residents in low-income, low-education areas. These findings underscore that heat-related health risks may be different across the level of geographic units and suggest the need for targeted public health strategies to mitigate the impacts of EH.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e395"},"PeriodicalIF":4.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association of prenatal ambient air pollution with placental epigenetic gestational age at birth. 产前环境空气污染与出生时胎盘表观遗传胎龄的关系。
IF 3.8
Environmental Epidemiology Pub Date : 2025-05-05 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000384
Zhengting He, Ashley Y Song, Rose Schrott, Jason I Feinberg, Kelly M Bakulski, Kelly S Benke, Lisa A Croen, Irva Hertz-Picciotto, Rebecca J Schmidt, Kristen Lyall, Craig J Newschaffer, M Daniele Fallin, Heather E Volk, Christine Ladd-Acosta
{"title":"The association of prenatal ambient air pollution with placental epigenetic gestational age at birth.","authors":"Zhengting He, Ashley Y Song, Rose Schrott, Jason I Feinberg, Kelly M Bakulski, Kelly S Benke, Lisa A Croen, Irva Hertz-Picciotto, Rebecca J Schmidt, Kristen Lyall, Craig J Newschaffer, M Daniele Fallin, Heather E Volk, Christine Ladd-Acosta","doi":"10.1097/EE9.0000000000000384","DOIUrl":"10.1097/EE9.0000000000000384","url":null,"abstract":"<p><strong>Background: </strong>Prenatal air pollutants have been associated with adverse birth outcomes, and DNA methylation (DNAm) changes in placenta may contribute to these associations. DNAm-based epigenetic gestational age (GA) estimators are emerging biomarkers for aging/biological age that can reflect early-life exposures and predict long-term health outcomes. We leveraged 103 mother-offspring pairs from the Early Autism Risk Longitudinal Investigation cohort to assess associations between prenatal air pollution and placental epigenetic GA at birth.</p><p><strong>Methods: </strong>Prenatal air pollution concentrations (NO<sub>2</sub>, O<sub>3</sub>, PM<sub>2.5</sub>, and PM<sub>10</sub>) were estimated from weekly data from monitoring stations near maternal residence and calculated for preconception and pregnancy periods. DNAm from fetal-side placenta samples was measured on Illumina HumanMethylation450 BeadChip. Epigenetic GA was computed using Lee's robust placenta clock algorithm. GA acceleration/deceleration was the residual of predicted epigenetic GA on chronologic GA, adjusted (intrinsic) or unadjusted (extrinsic) for cell type proportions. We used linear regressions to examine associations between average air pollution levels in each period and GA acceleration/deceleration, and weekly distributed lag models to examine critical exposure windows.</p><p><strong>Results: </strong>Higher pregnancy average O<sub>3</sub> and PM<sub>10</sub> exposures were associated with decelerated intrinsic (β = -0.65 and -0.79) and extrinsic GA (β = -0.69 and -0.74) at birth (per 10-unit increment). Trimester-specific analyses revealed higher O<sub>3</sub> and PM<sub>10</sub> exposures in trimesters 2 to 3 associated with decelerated GA at birth. Weekly distributed lag models suggested pregnancy weeks 21 to 31 and 21 to 29 were critical windows of O<sub>3</sub> and PM<sub>10</sub> exposures, respectively.</p><p><strong>Conclusions: </strong>Prenatal air pollution exposures, especially during mid- to late-pregnancy, were associated with lower biological maturity at birth.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e384"},"PeriodicalIF":3.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compound drought and heatwave extreme weather events: Mortality risk in individuals with chronic respiratory disease. 复合干旱和热浪极端天气事件:慢性呼吸道疾病患者的死亡风险。
IF 3.3
Environmental Epidemiology Pub Date : 2025-05-01 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000389
Austin Rau, Arianne K Baldomero, Jesse E Bell, Jared Rennie, Chris H Wendt, Gillian A M Tarr, Bruce H Alexander, Jesse D Berman
{"title":"Compound drought and heatwave extreme weather events: Mortality risk in individuals with chronic respiratory disease.","authors":"Austin Rau, Arianne K Baldomero, Jesse E Bell, Jared Rennie, Chris H Wendt, Gillian A M Tarr, Bruce H Alexander, Jesse D Berman","doi":"10.1097/EE9.0000000000000389","DOIUrl":"10.1097/EE9.0000000000000389","url":null,"abstract":"<p><strong>Background: </strong>Compound extreme weather events are severe weather conditions that can jointly magnify human health risks beyond any single event alone. Drought and heatwaves are extreme weather conditions associated with adverse health, but their combined impact is poorly understood.</p><p><strong>Methods: </strong>We designed a case-crossover study to estimate heatwave-associated mortality stratified by drought conditions in 183,725 US Veteran patients (2016-2021) with chronic obstructive pulmonary disease (COPD). A conditional logistic regression with distributed lag models was applied. Droughts were categorized into binary and categorical metrics, and we further explored the timing of heatwaves as a risk factor.</p><p><strong>Results: </strong>Our results indicate that drought amplifies heatwaves with hotter temperatures and longer durations during drought conditions, and the percentage of mortality attributable to heatwaves during drought was 7.41% (95% confidence interval [CI]: 2.91, 12.28) compared with 2.91% (95% CI: 0.00, 4.76) for heatwaves during nondrought conditions. Heatwaves that occurred during drought conditions in the late warm season had a larger association with mortality compared with late-season heatwaves during nondrought conditions, 7.41% (95% CI: 1.96, 13.04) of mortality events and 0.99% (95% CI: -1.01, 3.85) of mortality events attributable to these exposures, respectively.</p><p><strong>Conclusion: </strong>Compound drought and heatwave events trend toward increased mortality risk among patients with COPD and present a growing human health threat under climate change. Existing heat warnings and vulnerability maps may include drought conditions to better capture heat-related public health risks.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e389"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beneath the smoke: Understanding the public health impacts of the Los Angeles urban wildfires. 烟雾之下:了解洛杉矶城市野火对公众健康的影响。
IF 4.2
Environmental Epidemiology Pub Date : 2025-04-28 eCollection Date: 2025-06-01 DOI: 10.1097/EE9.0000000000000388
Tarik Benmarhnia, Nicole A Errett, Joan A Casey
{"title":"Beneath the smoke: Understanding the public health impacts of the Los Angeles urban wildfires.","authors":"Tarik Benmarhnia, Nicole A Errett, Joan A Casey","doi":"10.1097/EE9.0000000000000388","DOIUrl":"10.1097/EE9.0000000000000388","url":null,"abstract":"","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 3","pages":"e388"},"PeriodicalIF":4.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书