Drug Delivery最新文献

Correction. 更正。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-05-14 DOI: 10.1080/10717544.2024.2350273

引用次数: 0

Homotypic cell membrane-camouflaged biomimetic PLGA nanoparticle loading triptolide for the treatment of hepatocellular carcinoma. 用于治疗肝细胞癌的同型细胞膜伪装仿生聚乳酸（PLGA）纳米粒子。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-06-01 DOI: 10.1080/10717544.2024.2354687

Zhe Li, Jinshuai Lan, Ya Wu, Yue Ding, Tong Zhang

{"title":"Homotypic cell membrane-camouflaged biomimetic PLGA nanoparticle loading triptolide for the treatment of hepatocellular carcinoma.","authors":"Zhe Li, Jinshuai Lan, Ya Wu, Yue Ding, Tong Zhang","doi":"10.1080/10717544.2024.2354687","DOIUrl":"10.1080/10717544.2024.2354687","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated death worldwide. Beside early detection, early diagnosis, and early surgery, it is urgent to try new strategies for the treatment of HCC. Triptolide (TPL) has been employed to treat HCC. However, its clinical applications were restricted by the narrow therapeutic window, severe toxicity, and poor water-solubility. In this study, we developed cancer cell membrane-camouflaged biomimetic PLGA nanoparticles loading TPL (TPL@mPLGA) with the homologous targeting property for the treatment of HCC. The TPL@mPLGA was successfully prepared with particle size of 195.5 ± 7.5 nm and zeta potential at -21.5 ± 0.2 mV with good stability. The drug loading (DL) of TPL@mPLGA was 2.94%. After Huh-7 cell membrane coating, the natural Huh-7 cell membrane proteins were found to be retained on TPL@mPLGA, thus endowing the TPL@mPLGA with enhanced accumulation at tumor site, and better anti-tumor activity in vitro and in vivo when compared with TPL or TPL@PLGA. The TPL@mPLGA showed enhanced anti-tumor effects and reduced toxicity of TPL, which could be adopted for the treatment of HCC.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug retention after intradiscal administration. 椎管内给药后的药物滞留

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-10-20 DOI: 10.1080/10717544.2024.2415579

Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P Meij, Jens Thies, Pieter Emans, Fetullah C Öner, George Mihov, Joao Pedro Garcia, Anne S Ulrich, Sibylle Grad, Marianna A Tryfonidou, Hugo van Ingen, Laura B Creemers

{"title":"Drug retention after intradiscal administration.","authors":"Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P Meij, Jens Thies, Pieter Emans, Fetullah C Öner, George Mihov, Joao Pedro Garcia, Anne S Ulrich, Sibylle Grad, Marianna A Tryfonidou, Hugo van Ingen, Laura B Creemers","doi":"10.1080/10717544.2024.2415579","DOIUrl":"10.1080/10717544.2024.2415579","url":null,"abstract":"Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enable the optimization of IVDD therapeutics. Release and retention of an inactive hydrophilic fluorine-19 labeled peptide (19F-P) as model for regenerative peptides was studied in a whole IVD culture model by measuring the 19F-NMR (nuclear magnetic resonance) signal in culture media and IVD tissue extracts. In another set-up, noninvasive near-infrared imaging was used to visualize IR-780, as hydrophobic small molecular drug model, retention upon injection into healthy and degenerative caudal IVDs in a rat model of disk degeneration. Furthermore, IR-780-loaded degradable polyester amide microspheres (PEAM) were injected into healthy and needle pricked degenerative IVDs, subcutaneously, and in knee joints with and without surgically-induced osteoarthritis (OA). Most 19F-P was released from the IVD after 7 days. IR-780 signal intensity declined over a 14-week period after bolus injection, without a difference between healthy and degenerative disks. IR-780 signal declined faster in the skin and knee joints compared to the IVDs. IR-780 delivery by PEAMs enhanced disk retention beyond 16 weeks. Moreover, in degenerated IVDs the IR-780 signal was higher over time than in healthy IVDs while no difference between OA and healthy joints was noted. We conclude that the clearance of peptides and hydrophobic small molecules from the IVD is relatively fast. These results illustrate that development of controlled release formulations should take into account the target anatomical location and local (patho)biology.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the use of local anesthetic extended-release systems in pain management. 局麻药缓释系统在疼痛治疗中的应用进展。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2023-12-21 DOI: 10.1080/10717544.2023.2296349

Yulu Chen, Jingmei Xu, Ping Li, Liyang Shi, Sha Zhang, Qulian Guo, Yong Yang

{"title":"Advances in the use of local anesthetic extended-release systems in pain management.","authors":"Yulu Chen, Jingmei Xu, Ping Li, Liyang Shi, Sha Zhang, Qulian Guo, Yong Yang","doi":"10.1080/10717544.2023.2296349","DOIUrl":"10.1080/10717544.2023.2296349","url":null,"abstract":"Pain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local anesthetics is the limited duration of a single injection. To address this problem, catheters are often placed or combined with other drugs in clinical practice to increase the time that local anesthetics act. However, this method does not meet the needs of clinical analgesics. Therefore, many researchers have worked to develop local anesthetic extended-release types that can be administered in a single dose. In recent years, drug extended-release systems have emerged dramatically due to their long duration and efficacy, providing more possibilities for the application of local anesthetics. This paper summarizes the types of local anesthetic drug delivery systems and their clinical applications, discusses them in the context of relevant studies on local anesthetics, and provides a summary and outlook on the development of local anesthetic extended-release agents.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10763865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin. 撤回声明：双组分聚合物胶束用于多柔比星的 pH 值控制给药。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-06-10 DOI: 10.1080/10717544.2024.2355035

引用次数: 0

Statement of Retraction. 撤回声明。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2023-01-18 DOI: 10.1080/10717544.2022.2157535

引用次数: 0

Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment. 抗生素在自乳化油中的悬浮液是一种新方法，可用于配制含有在水环境中会水解的物质的滴眼液。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-07-11 DOI: 10.1080/10717544.2024.2372279

Katarzyna Krzeminska, Malgorzata Sznitowska, Magdalena Wroblewska, Eliza Wolska, Katarzyna Winnicka

{"title":"Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment.","authors":"Katarzyna Krzeminska, Malgorzata Sznitowska, Magdalena Wroblewska, Eliza Wolska, Katarzyna Winnicka","doi":"10.1080/10717544.2024.2372279","DOIUrl":"10.1080/10717544.2024.2372279","url":null,"abstract":"The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of an antibiotic. CEF or VAN (5% w/w) was suspended in SEO carriers prepared by dissolving surfactants (Tween 20 or Span 80 5% w/w) in Miglyol, castor oil, or olive oil. Formulations with or without sodium citrate (2% w/w) were compared. Six-months or 1-year stability tests were carried out at 40 °C. The content of CEF and VAN was evaluated using HPLC and the potency of the antibiotic was assessed with agar diffusion method. In contact with water, drug particles suspended in SEO dissolved rapidly and o/w emulsion was formed. After 1-year at 40 °C, the content of degradation products was at most 0.5% in CEF and 4.0% in VAN formulations. The agar diffusion assay has shown that CEF and VAN loaded into SEO retained its potency against the sensitive microorganisms comparable to an aqueous solution. Therefore, SEO can be used as a novel carrier for the active substances which may not require improved solubility or absorption but need to be protected from moisture. This is a formulation that can be produced on industrial scale, with no limitation of stability or drug concentration.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genistein transfersome-embedded topical delivery system for skin melanoma treatment: in vitro and ex vivo evaluations. 用于治疗皮肤黑色素瘤的基因istein转移体嵌入式局部给药系统：体外和体内评估。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI: 10.1080/10717544.2024.2372277

Amira Motawea, Sara N Maria, Doaa N Maria, Monica M Jablonski, Mohamed Moustafa Ibrahim

{"title":"Genistein transfersome-embedded topical delivery system for skin melanoma treatment: in vitro and ex vivo evaluations.","authors":"Amira Motawea, Sara N Maria, Doaa N Maria, Monica M Jablonski, Mohamed Moustafa Ibrahim","doi":"10.1080/10717544.2024.2372277","DOIUrl":"10.1080/10717544.2024.2372277","url":null,"abstract":"Skin melanoma is considered the most dangerous form of skin cancer due to its association with high risk of metastasis, high mortality rate and high resistance to different treatment options. Genistein is a natural isoflavonoid with known chemotherapeutic activity. Unfortunately, it has low bioavailability due to its poor aqueous solubility and excessive metabolism. In the current study, genistein was incorporated into transferosomal hydrogel to improve its bioavailability. The prepared transferosomal formulations were characterized regarding: particle size; polydispersity index; zeta potential; encapsulation efficiency; TEM; FTIR; DSC; XRD; in vitro drug release; viscosity; pH; ex vivo anti-tumor activity on 3D skin melanoma spheroids and 1-year stability study at different storage temperatures. The optimized formulation has high encapsulation efficiency with an excellent particle size that will facilitate its penetration through the skin. The transfersomes have a spherical shape with sustained drug release profile. The anti-tumor activity evaluation of genistein transfersome revealed that genistein is a potent chemotherapeutic agent with enhanced penetration ability through the melanoma spheroids when incorporated into transfersomes. Stability study results demonstrate the high physical and chemical stability of our formulations. All these outcomes provide evidence that our genistein transferosomal hydrogel is a promising treatment option for skin melanoma.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective. 基于骨支架的骨肉瘤局部给药：现状与未来展望。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-09-06 DOI: 10.1080/10717544.2024.2391001

Wenqing Liang, Hengguo Long, Hongwei Zhang, Juqin Bai, Bo Jiang, Jiangwei Wang, Lifeng Fu, Wenyi Ming, Jiayi Zhao, Bin Zeng

{"title":"Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective.","authors":"Wenqing Liang, Hengguo Long, Hongwei Zhang, Juqin Bai, Bo Jiang, Jiangwei Wang, Lifeng Fu, Wenyi Ming, Jiayi Zhao, Bin Zeng","doi":"10.1080/10717544.2024.2391001","DOIUrl":"10.1080/10717544.2024.2391001","url":null,"abstract":"A common malignant bone neoplasm in teenagers is Osteosarcoma. Chemotherapy, surgical therapy, and radiation therapy together comprise the usual clinical course of treatment for Osteosarcoma. While Osteosarcoma and other bone tumors are typically treated surgically, however, surgical resection frequently fails to completely eradicate tumors, and in turn becomes the primary reason for postoperative recurrence and metastasis, ultimately leading to a high rate of mortality. Patients still require radiation and/or chemotherapy after surgery to stop the spread of the tumor and its metastases, and both treatments have an adverse influence on the body's organ systems. In the postoperative management of osteosarcoma, bone scaffolds can load cargos (growth factors or drugs) and function as drug delivery systems (DDSs). This review describes the different kinds of bone scaffolds that are currently available and highlights key studies that use scaffolds as DDSs for the treatment of osteosarcomas. The discussion also includes difficulties and perspectives regarding the use of scaffold-based DDSs. The study may serve as a source for outlining efficient and secure postoperative osteosarcoma treatment plans.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11382735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable silica nanoparticles for efficient linear DNA gene delivery. 用于高效线性 DNA 基因递送的可生物降解二氧化硅纳米颗粒。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI: 10.1080/10717544.2024.2385376

Andrés Ramos-Valle, Henning Kirst, Mónica L Fanarraga

{"title":"Biodegradable silica nanoparticles for efficient linear DNA gene delivery.","authors":"Andrés Ramos-Valle, Henning Kirst, Mónica L Fanarraga","doi":"10.1080/10717544.2024.2385376","DOIUrl":"10.1080/10717544.2024.2385376","url":null,"abstract":"Targeting, safety, scalability, and storage stability of vectors are still challenges in the field of nucleic acid delivery for gene therapy. Silica-based nanoparticles have been widely studied as gene carriers, exhibiting key features such as biocompatibility, simplistic synthesis, and enabling easy surface modifications for targeting. However, the ability of the formulation to incorporate DNA is limited, which restricts the number of DNA molecules that can be incorporated into the particle, thereby reducing gene expression. Here we use polymerase chain reaction (PCR)-generated linear DNA molecules to augment the coding sequences of gene-carrying nanoparticles, thereby maximizing nucleic acid loading and minimizing the size of these nanocarriers. This approach results in a remarkable 16-fold increase in protein expression six days post-transfection in cells transfected with particles carrying the linear DNA compared with particles bearing circular plasmid DNA. The study also showed that the use of linear DNA entrapped in DNA@SiO2 resulted in a much more efficient level of gene expression compared to standard transfection reagents. The system developed in this study features simplicity, scalability, and increased transfection efficiency and gene expression over existing approaches, enabled by improved embedment capabilities for linear DNA, compared to conventional methods such as lipids or polymers, which generally show greater transfection efficiency with plasmid DNA. Therefore, this novel methodology can find applications not only in gene therapy but also in research settings for high-throughput gene expression screenings.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0