Drug Delivery最新文献

{"title":"Extracellular payload release from non-internalizing antibody-drug conjugates: mechanisms and linker technologies.","authors":"Chenxi Feng, Rui Lou, Shipeng Chen, Furong Lin, Jiaqi Ge, Yuwen Zhang, Chaolong Lin, Chenghao Huang","doi":"10.1080/10717544.2026.2645769","DOIUrl":"10.1080/10717544.2026.2645769","url":null,"abstract":"<p><p>Antibody‒drug conjugates (ADCs) have taken on a significant role in precision oncology. These molecules, referred to as 'biological missiles', can deliver cytotoxic drugs directly to cancer cells. Traditional ADCs rely on endocytosis and intracellular release of payloads, but this approach becomes complicated due to issues like antigen loss, tumor heterogeneity, and impaired endocytosis, leading to therapeutic resistance. To address these challenges, noninternalizing ADCs have been developed, utilizing extracellular payload release methods. These structures employ advanced linker technologies to ensure stability in vivo and selective activation in the tumor microenvironment, achieving effective cytotoxic diffusion among tumor cells through the 'bystander effect'. This review discusses the evolution from early linker designs to complex methods based on tumor-specific conditions or external triggers. It also examines the categories of noninternalizing ADC linkers and the latest developments in clinical research, exploring prospects for enhancing the efficacy and safety of ADCs in oncology applications.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2645769"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine-based cancer immunotherapy: translational barriers, mechanistic strategies, and future perspectives.","authors":"Xiaoman Suo, Yingnan Liu, Guofang Zhang, Yang Li","doi":"10.1080/10717544.2026.2679846","DOIUrl":"10.1080/10717544.2026.2679846","url":null,"abstract":"<p><p>Nanomedicine-based cancer immunotherapy integrates nanotechnology with immune modulation, representing a promising strategy to improve both the efficacy and safety of cancer treatment. Despite substantial preclinical potential, clinical translation is hindered by interconnected challenges in pharmacology, pharmacodynamics, and long-term safety. This mechanism-oriented prospective analyzes translational bottlenecks, pharmacological uncertainty from biomolecular corona, suboptimal pharmacodynamics due to tumor barriers, and metabolism/excretion affecting biosafety. Using a concept-driven framework, we link nano-bio interactions to clinical outcomes within a 'barrier-strategy' paradigm. Corresponding strategies such as mechanism-driven design, AI-assisted optimization, and advanced delivery systems are discussed, with emphasis on safety-by-design principles. Collectively, this perspective provides a forward-looking roadmap for future research, underscoring the importance of integrated technologies, advanced translational models, and scalable manufacturing to fully realize the clinical potential of nanoimmunotherapy.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2679846"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A liposome-hydrogel composite ameliorates UVB-induced mouse skin photoaging through integrated antioxidant and extracellular matrix remodeling pathways.","authors":"Yifan Liu, Kejia Chen, Jin Pei, Qi Song, Xinlu Wang, Chuhan Ma, Yao Li, Liangping Yu","doi":"10.1080/10717544.2026.2708405","DOIUrl":"10.1080/10717544.2026.2708405","url":null,"abstract":"<p><p>Skin photoaging, predominantly caused by chronic ultraviolet B (UVB) exposure, is characterized by oxidative stress, collagen degradation, and disruption of the skin barrier. Deer placenta polypeptides (DPP) are rich in bioactive amino acids (AAs); however, their antioxidant and dermo-protective effects remain insufficiently elucidated, and their topical application is limited by enzymatic instability and poor transdermal permeability. To overcome these limitations, we developed a liposome-hydrogel composite delivery system to enhance the stability, skin penetration, and bioactivity of DPP. DPP obtained <i>via</i> enzymatic hydrolysis exhibited a favorable AA profile, free radical-scavenging activity, and a low molecular weight distribution (3-14 kDa). DPP-loaded liposomes (DPP-LIP) demonstrated high encapsulation efficiency, uniform nanosize, and effective preservation of bioactivity. Incorporation of DPP-LIP into a sodium alginate (SA) hydrogel yielded a composite formulation (DPP-LIP-SA) with sustained-release properties and a 2.7-fold enhancement in transdermal permeation. In a UVB-induced photoaging mouse model, topical administration of DPP-LIP-SA markedly alleviated oxidative stress, inflammatory responses, DNA damage, and extracellular matrix degradation. Mechanistically, DPP-LIP-SA treatment activated the Nrf2/HO-1 antioxidant pathway, inhibited TLR4/MyD88/NF-κB-mediated inflammatory signaling, reduced reactive oxygen species accumulation and lipid peroxidation, and restored extracellular matrix homeostasis by promoting collagen synthesis while suppressing MMP-mediated collagen degradation. Collectively, these findings identify DPP as a potent bioactive peptide resource with intrinsic antioxidant and reparative properties and demonstrate that integration of nanocarriers with hydrogel matrices substantially enhances dermal bioavailability. This composite delivery platform shows strong potential as a peptide-based topical strategy for preventing and treating skin photoaging.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2708405"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/10717544.2026.2722432","DOIUrl":"10.1080/10717544.2026.2722432","url":null,"abstract":"","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2722432"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis.","authors":"Yanfang Liu, Nan Luo, Xin Xi, Jinxia Hou, Xiaolu Li, Mingdeng Xia, Tao Yu, Yanyan Yang, Yong Liu","doi":"10.1080/10717544.2026.2627689","DOIUrl":"10.1080/10717544.2026.2627689","url":null,"abstract":"<p><p>Atherosclerosis, a chronic inflammatory disease, is pathologically associated with mitochondrial dysfunction. Mitochondria contribute to oxidative stress, vascular endothelial dysfunction, and chronic inflammatory cascades through pathways such as dynamic imbalance, abnormal epigenetic regulation, disruption of multi-organelle communication, and dysregulation of cell death signaling. Targeting mitochondria has therefore emerged as a promising therapeutic strategy beyond conventional treatments , which often fail to address this underlying pathology. Recent advances in nanomaterials enable precise mitochondrial intervention. Although conventional therapies such as statins and anti-inflammatory drugs can partially mitigate symptoms, they do not directly correct mitochondrial abnormalities and are often limited by systemic side effects. Recent progress in nanotechnology has enabled the development of mitochondria-targeted delivery systems, including liposomes, polymeric nanoparticles, and biomimetic carriers. These platforms enhance mitochondrial accumulation by incorporating targeting motifs or exploiting the negative mitochondrial membrane potential and specific interactions with outer membrane proteins. Among these, TPP⁺-modified liposomes can target the mitochondrial matrix via electrostatic interactions, effectively delivering drugs such as coenzyme Q10 to mitochondria, offering notable clinical potential. Moreover, Szeto-Schiller 31, which targets mitochondrial electron transport chain repair and reduces the secretion of inflammatory cytokines, has entered Phase II clinical trials. This review discusses the mechanistic role of mitochondrial dysfunction in atherosclerosis and evaluates the application of mitochondria-targeted delivery systems in atherosclerosis therapy. It also highlights the challenges these systems face, including issues related to delivery efficiency, biosafety, and targeting specificity. By linking molecular mechanisms with translational innovation, it highlights the significant potential of mitochondrial-targeted therapies.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2627689"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microalgae as novel drug-delivery system for biomedical field.","authors":"Yueyou Dai, Dandan Guo, Aifang Li, Wei Chen, Yi Yang, Shuxuan Li, Lianhe Yang, Shuying Feng","doi":"10.1080/10717544.2026.2616930","DOIUrl":"10.1080/10717544.2026.2616930","url":null,"abstract":"<p><p>Currently, increasing attention is being paid to the extraction and utilization of materials with special biological activities in nature or for medical applications. Owing to their unique biological characteristics and diverse application potential, microalgae are among the most promising materials in the field of biomedicine. Because of their diverse morphology and readily functionalizable surface, they can efficiently carry drugs and achieve targeted drug release. This can avoid major challenges of other methods related to toxicity, biocompatibility, and immunogenicity, which is important for the treatment of various diseases, particularly those related to hypoxia. Despite the distinct advantages of microalgae over other biomaterials, several challenges persist in their practical application. Herein, we comprehensively describe the current state of research on the microalgae drug-delivery system (MDDS). In particular, we explore various microalgae-based strategies and methods to improve the load capacity and stability of DDS, and to achieve target positioning and tracking. With further research on microalgae, their application prospects in DDSs will broaden. In the future, researchers will continue to explore the features and advantages of microalgae; develop more efficient, safe, and accurate DDSs; and provide more options for clinical treatments. Continued progress in microalgal cultivation technology and reduction in large-scale production costs will expand the clinical applications of MDDSs.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2616930"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements and challenges in ophthalmic microneedles to treat eye diseases.","authors":"Yongdeok Jo, Chaimae Gouya, William F Mieler, Jennifer J Kang-Mieler","doi":"10.1080/10717544.2026.2617688","DOIUrl":"10.1080/10717544.2026.2617688","url":null,"abstract":"<p><p>By 2050, more than 61 million people worldwide are expected to lose their vision due to conditions like age-related macular degeneration, glaucoma, diabetic retinopathy, and uveitis (Bourne et al. 2021). This anticipated rise highlights the urgent need for more effective treatment options. While progress continues in developing new pharmacological agents, treating ocular diseases with these therapies remains particularly challenging due to the eye's unique and complex anatomy. This is largely due to the limitations of current drug delivery methods, including systemic administration, topical delivery application, transscleral/periocular drug delivery, and intravitreal injections, which are associated with low bioavailability, side effects, and rapid drug clearance. Given these challenges, microneedles have emerged as a promising alternative. Their minimally invasive nature and ability to precisely target the anterior and posterior segments make them well suited for enhancing therapeutic outcomes while reducing systemic exposure and potential side effects, as well as improving patient adherence (Kang-Mieler et al. 2017; Gadziński et al. 2022). The purpose of this review is to discuss recent advancements, key challenges, and strategies for microneedle-based ocular drug delivery systems, with an emphasis on their potential to treat both anterior and posterior eye diseases.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2617688"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential of mesoporous silica nanoparticles: balancing biomedical applications and safety concerns.","authors":"Yingze Hou, Can Zhu, Zhean Shen, Desheng Cao, Liangyu Wei, Jiyu Yang, Chaoyue Shi, Meiqian Wu, Songyun Zheng, Yan Chen, Xianchun Zhou","doi":"10.1080/10717544.2026.2624186","DOIUrl":"10.1080/10717544.2026.2624186","url":null,"abstract":"<p><p>Mesoporous silica nanoparticles (MSNs) have garnered significant attention across various disciplines, including chemistry, physics, and materials science, owing to their distinctive properties and functionalities. Numerous studies have demonstrated that MSNs possess several advantageous characteristics, such as tunable pore sizes, excellent biocompatibility, and a high specific surface area. These attributes render mesoporous silica nanoparticles promising for diverse applications in medical fields, including in vivo targeting, drug delivery, and disease diagnosis. Nevertheless, recent research has indicated that mesoporous silica may induce cellular and tissue toxicity in humans, necessitating further evaluation of its long-term safety. Additionally, parameters such as the shape, particle size, and surface modification of MSNs require careful control to enhance their biodegradability, regulate the circulation time of nanomaterials within the body, and mitigate the immunogenicity of mesoporous silica, thereby facilitating the clinical translation of mesoporous silica nanoparticles. This article reviews the advancements in research concerning the use of mesoporous silica nanomaterials in targeted therapy, drug delivery, and tissue engineering. This work evaluates the potential applications of mesoporous silica materials in the biomedical sector and delineates future research directions for MSNs by examining and summarizing their biological toxicity and associated risks.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2624186"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A macrophage-mimetic nanocarrier co-loaded with geraniol and FK13-a1 for MRSA-induced acute lung injury.","authors":"Haonan Li, Binghong Xu, Junguang Liang, Tao Hu, Tingting Wu, Liqin Lai, Xuan Zou, Ziquan Lv, Xiangjie Yao, Xiaobao Jin, Yinghua Xu, Shuiqing Gui, Xuemei Lu","doi":"10.1080/10717544.2026.2626104","DOIUrl":"10.1080/10717544.2026.2626104","url":null,"abstract":"<p><p>Current clinical strategies for Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)-induced acute lung injury (ALI) predominantly focus on single-approach interventions such as anti-inflammatory therapy. However, due to the complex, multi-pathway pathological network underlying the disease, targeting a single pathway often yields suboptimal therapeutic outcomes. Consequently, there is a pressing need to develop innovative drug delivery systems capable of systematically addressing this intricate pathological process. Geraniol, a naturally derived monoterpene alcohol, exhibits multiple pharmacological activities including antimicrobial, antioxidant, and organ-protective effects, while the antimicrobial peptide (AMP) FK13-a1 demonstrates broad-spectrum antibacterial, anti-inflammatory, and immunomodulatory functions. Recognizing their complementary mechanisms of action, we innovatively propose a synergistic therapeutic strategy combining geraniol with FK13-a1. To enhance targeting precision, we engineered a biomimetic delivery system by coating nanomaterials with macrophage membranes via tyramine linkage, enabling specific homing to pulmonary inflammatory sites. Guided by this design concept, we successfully fabricated the biomimetic nanodrug Tyr-MM@PLGA/G+F and conducted systematic characterization using multiple analytical techniques. Through established <i>in vitro</i> and <i>in vivo</i> infection models, we evaluated the therapeutic efficacy of this nanosystem. Results demonstrated that Tyr-MM@PLGA/G+F actively targets ALI lesion sites, achieving precise co-delivery and synergistic action of geraniol and FK13-a1 at the pathological foci, thereby significantly enhancing treatment outcomes. This study not only validates the remarkable efficacy of this composite nanosystem against ALI but also provides novel insights and experimental evidence for targeted therapy of this condition.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2626104"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun PVP/HPBCD nanofiber topical drug delivery platform for enhanced skin permeability and anti-pollution bioactivity of <i>Artocarpus altilis</i> extract.","authors":"Chun-Yin Yang, Chih-Hua Tseng, Feng-Lin Yen","doi":"10.1080/10717544.2025.2610654","DOIUrl":"10.1080/10717544.2025.2610654","url":null,"abstract":"<p><p><i>Artocarpus altilis</i> methanolic extract (AAM) exhibits potent protective effects against particulate matter (PM)-induced skin damage; however, its poor aqueous solubility and limited skin permeability restrict its topical bioavailability. To overcome these limitations, we developed a polymer-based drug delivery system by fabricating electrospun nanofibers composed of polyvinylpyrrolidone (PVP), hydroxypropyl-<i>β</i>-cyclodextrin (HPBCD), and AAM. The optimized formulation engineering strategy enhanced AAM solubility via increased surface area, reduced crystallinity, and hydrogen bonding interactions with HPBCD/PVP. The nanofiber matrix also provided an occlusive effect, improving skin hydration and facilitating transdermal diffusion through the stratum corneum. In vitro studies demonstrated improved cellular uptake, greater permeability, and enhanced antioxidant activity, leading to superior anti-pollution efficacy compared to raw AAM in a PM-induced HaCaT keratinocyte model. These results highlight AAM-loaded electrospun nanofibers (ANFs) as a biodegradable, and environmentally sustainable platform for delivering plant-derived bioactive ingredient, offering high potential for advanced topical formulations targeting pollution-induced skin aging.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2610654"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}