Drug Delivery最新文献_第3页

Biodegradable silica nanoparticles for efficient linear DNA gene delivery. 用于高效线性 DNA 基因递送的可生物降解二氧化硅纳米颗粒。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI: 10.1080/10717544.2024.2385376

Andrés Ramos-Valle, Henning Kirst, Mónica L Fanarraga

{"title":"Biodegradable silica nanoparticles for efficient linear DNA gene delivery.","authors":"Andrés Ramos-Valle, Henning Kirst, Mónica L Fanarraga","doi":"10.1080/10717544.2024.2385376","DOIUrl":"10.1080/10717544.2024.2385376","url":null,"abstract":"Targeting, safety, scalability, and storage stability of vectors are still challenges in the field of nucleic acid delivery for gene therapy. Silica-based nanoparticles have been widely studied as gene carriers, exhibiting key features such as biocompatibility, simplistic synthesis, and enabling easy surface modifications for targeting. However, the ability of the formulation to incorporate DNA is limited, which restricts the number of DNA molecules that can be incorporated into the particle, thereby reducing gene expression. Here we use polymerase chain reaction (PCR)-generated linear DNA molecules to augment the coding sequences of gene-carrying nanoparticles, thereby maximizing nucleic acid loading and minimizing the size of these nanocarriers. This approach results in a remarkable 16-fold increase in protein expression six days post-transfection in cells transfected with particles carrying the linear DNA compared with particles bearing circular plasmid DNA. The study also showed that the use of linear DNA entrapped in DNA@SiO2 resulted in a much more efficient level of gene expression compared to standard transfection reagents. The system developed in this study features simplicity, scalability, and increased transfection efficiency and gene expression over existing approaches, enabled by improved embedment capabilities for linear DNA, compared to conventional methods such as lipids or polymers, which generally show greater transfection efficiency with plasmid DNA. Therefore, this novel methodology can find applications not only in gene therapy but also in research settings for high-throughput gene expression screenings.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2385376"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system. 推进烧伤创面治疗：探索水凝胶作为透皮给药系统。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-02-16 DOI: 10.1080/10717544.2023.2300945

MeeiChyn Goh, Meng Du, Wang Rui Peng, Phei Er Saw, Zhiyi Chen

{"title":"Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system.","authors":"MeeiChyn Goh, Meng Du, Wang Rui Peng, Phei Er Saw, Zhiyi Chen","doi":"10.1080/10717544.2023.2300945","DOIUrl":"10.1080/10717544.2023.2300945","url":null,"abstract":"Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative to traditional wound dressings such as gauze. This is primarily attributed to its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering a moist environment that supports effective burn wound healing. Additionally, hydrogel facilitates the penetration of loaded therapeutic agents throughout the wound surface, combating burn wound pathogens through the hydration effect and thereby enhancing the healing process. However, the presence of eschar formation on burn wounds obstructs the passive diffusion of therapeutics, impairing the efficacy of hydrogel as a wound dressing, particularly in cases of severe burns involving deeper tissue damage. This review focuses on exploring the potential of hydrogel as a carrier for transdermal drug delivery in burn wound treatment. Furthermore, strategies aimed at enhancing the transdermal delivery of therapeutic agents from hydrogel to optimize burn wound healing are also discussed.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2300945"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10878343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a drug delivering round window niche implant for cochlear pharmacotherapy. 开发用于人工耳蜗药物治疗的给药圆窗壁龛植入体。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-08-21 DOI: 10.1080/10717544.2024.2392755

Chunjiang Wei, Ziwen Gao, Martina Knabel, Martin Ulbricht, Stefan Senekowitsch, Peter Erfurt, Norman Maggi, Bastian Zwick, Thomas Eickner, Farnaz Matin-Mann, Anne Seidlitz, Thomas Lenarz, Verena Scheper

{"title":"Development of a drug delivering round window niche implant for cochlear pharmacotherapy.","authors":"Chunjiang Wei, Ziwen Gao, Martina Knabel, Martin Ulbricht, Stefan Senekowitsch, Peter Erfurt, Norman Maggi, Bastian Zwick, Thomas Eickner, Farnaz Matin-Mann, Anne Seidlitz, Thomas Lenarz, Verena Scheper","doi":"10.1080/10717544.2024.2392755","DOIUrl":"10.1080/10717544.2024.2392755","url":null,"abstract":"Background: There exists an unfulfilled requirement for effective cochlear pharmacotherapy. Controlled local drug delivery could lead to effective bioavailability. The round window niche (RWN), a cavity in the middle ear, is connected to the cochlea via a membrane through which drug can diffuse. We are developing individualized drug-eluting RWN implants (RNIs). To test their effectiveness in guinea pigs, a commonly used model in cochlear pharmacology studies, it is first necessary to develop guinea pig RNIs (GP-RNI).Methods: Since guinea pigs do not have a RWN such as it is present in humans and to reduce the variables in in vivo studies, a one-size-fits-all GP-RNI model was designed using 12 data sets of Dunkin-Hartley guinea pigs. The model was 3D-printed using silicone. The accuracy and precision of printing, distribution of the sample ingredient dexamethasone (DEX), biocompatibility, bio-efficacy, implantability and drug release were tested in vitro. The GP-RNI efficacy was validated in cochlear implant-traumatized guinea pigs in vivo.Results: The 3D-printed GP-RNI was precise, accurate and fitted in all tested guinea pig RWNs. DEX was homogeneously included in the silicone. The GP-RNI containing 1% DEX was biocompatible, bio-effective and showed a two-phase and sustained DEX release in vitro, while it reduced fibrous tissue growth around the cochlear implant in vivo.Conclusions: We developed a GP-RNI that can be used for precise inner ear drug delivery in guinea pigs, providing a reliable platform for testing the RNI's safety and efficacy, with potential implications for future clinical translation.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2392755"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI: 10.1080/10717544.2024.2392318

引用次数: 0

The recent research progress in the application of the nanozyme-hydrogel composite system for drug delivery. 应用纳米酶-水凝胶复合系统给药的最新研究进展。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1080/10717544.2024.2417986

Haichang Li, Zhenghong Liu, Pu Zhang, Dahong Zhang

{"title":"The recent research progress in the application of the nanozyme-hydrogel composite system for drug delivery.","authors":"Haichang Li, Zhenghong Liu, Pu Zhang, Dahong Zhang","doi":"10.1080/10717544.2024.2417986","DOIUrl":"10.1080/10717544.2024.2417986","url":null,"abstract":"Hydrogels, comprising 3D hydrophilic polymer networks, have emerged as promising biomaterial candidates for emulating the structure of biological tissues and delivering drugs through topical administration with good biocompatibility. Nanozymes can catalyze endogenous biomolecules, thereby initiating or inhibiting in vivo biological processes. A nanozyme-hydrogel composite inherits the biological functions of hydrogels and nanozymes, where the nanozyme serves as the catalytic core and the hydrogel forms the structural scaffold. Moreover, the composite can concentrate nanozymes in targeted lesions and catalyze the binding of a specific group of substrates, resulting in pathological microenvironment remodeling and drug-penetrating barrier impairment. The composite also shields nanozymes to prevent burst release during catalytic production and reduce related toxicity. Currently, the application of these composites has been extended to antibacterial, anti-inflammatory, anticancer, and tissue repair applications. In this review, we elucidate the preparation methods for nanozyme-hydrogel composites, provide compelling evidence of their advantages in drug delivery and provide a comprehensive overview of their biological application.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2417986"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells. 为具有抗结直肠癌细胞增殖活性的牛膝提取物设计壳聚糖结肠输送微/纳米颗粒。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI: 10.1080/10717544.2024.2372285

María de Las Nieves Siles-Sánchez, Irene Fernández-Jalao, Laura Jaime De Pablo, Susana Santoyo

{"title":"Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells.","authors":"María de Las Nieves Siles-Sánchez, Irene Fernández-Jalao, Laura Jaime De Pablo, Susana Santoyo","doi":"10.1080/10717544.2024.2372285","DOIUrl":"10.1080/10717544.2024.2372285","url":null,"abstract":"In this study, chitosan low molecular weight (LCH) and chitosan medium molecular weight (MCH) were employed to encapsulate a yarrow extract rich in chlorogenic acid and dicaffeoylquinic acids (DCQAs) that showed antiproliferative activity against colon adenocarcinoma cells. The design of CH micro/nanoparticles to increase the extract colon delivery was carried out by using two different techniques: ionic gelation and spray drying. Ionic gelation nanoparticles obtained were smaller and presented higher yields values than spray-drying microparticles, but spray-drying microparticles showed the best performance in terms of encapsulation efficiency (EE) (> 94%), also allowing the inclusion of a higher quantity of extract. Spray-drying microparticles designed using LCH with an LCH:extract ratio of 6:1 (1.25 mg/mL) showed a mean diameter of 1.31 ± 0.21 µm and EE values > 93%, for all phenolic compounds studied. The release profile of phenolic compounds included in this formulation, at gastrointestinal pHs (2 and 7.4), showed for most of them a small initial release, followed by an increase at 1 h, with a constant release up to 3 h. Chlorogenic acid presented the higher release values at 3 h (56.91% at pH 2; 44.45% at pH 7.4). DCQAs release at 3 h ranged between 9.01- 40.73%, being higher for 1,5- and 3,4-DCQAs. After gastrointestinal digestion, 67.65% of chlorogenic and most DCQAs remained encapsulated. Therefore, spray-drying microparticles can be proposed as a promising vehicle to increase the colon delivery of yarrow phenolics compounds (mainly chlorogenic acid and DCQAs) previously described as potential agents against colorectal cancer.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2372285"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mannose/stearyl chloride doubly functionalized polyethylenimine as a nucleic acid vaccine carrier to promote macrophage uptake. 甘露糖/硬脂酰氯双功能化聚乙烯亚胺作为核酸疫苗载体，促进巨噬细胞摄取。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1080/10717544.2024.2427138

Lu Bai, Xiaoqi Chen, Chengyu Li, Haijun Zhou, Yantao Li, Jijun Xiao, Fen Zhang, Hua Cheng, Mengmeng Zhou

{"title":"Mannose/stearyl chloride doubly functionalized polyethylenimine as a nucleic acid vaccine carrier to promote macrophage uptake.","authors":"Lu Bai, Xiaoqi Chen, Chengyu Li, Haijun Zhou, Yantao Li, Jijun Xiao, Fen Zhang, Hua Cheng, Mengmeng Zhou","doi":"10.1080/10717544.2024.2427138","DOIUrl":"10.1080/10717544.2024.2427138","url":null,"abstract":"Transmembrane transport remains a significant challenge for nucleic acid vaccine vectors. Promoting the ability of immune cells, such as macrophages, to capture foreign stimuli is also an effective approach to improving cross-presentation. In addition, polyethyleneimine (PEI) has gained attention in the field of nucleic acid vaccine carriers due to its excellent gene transfection efficiency and unique proton buffering effect. However, although high molecular weight PEI exhibits high efficiency, its high-density positive charges make it highly toxic, which limits its application. In this study, mannose/stearyl chloride functionalized polyethylenimine (SA-Man-PEI) was prepared by functionalizing PEI (molecular weight of 25 kDa) with mannose with immunomodulatory and phagocyte targeting effects, and an alkyl hydrophobic chain segment, which could easily promote cell uptake. Moreover, the functionalized-PEI retains a strong proton buffering effect, which helps the carrier escape from the lysosome. The particle sizes of the composite particles formed by SA-Man-PEI and ovalbumin (OVA) were below 200 nm, with good storage stability at both 4 °C and 37 °C. At a drug concentration of 2 μg/mL, the cell survival rate of functionalized-PEI was 19.2% higher than that of unfunctionalized PEI. In vitro macrophage endocytosis experiments showed that SA-Man-PEI could significantly enhance the macrophage uptake of composite particles, compared to unfunctionalized PEI or single-functionalized PEI. This study offers a new approach for developing PEI as a nucleic acid vaccine carrier, which could simultaneously enhance cell targeting and promote cell uptake.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2427138"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of ion-triggered in situ gel containing ketoconazole/hydroxypropyl-β-cyclodextrin for ocular delivery: in vitro and in vivo evaluation. 开发含有酮康唑/羟丙基-β-环糊精的离子触发原位凝胶，用于眼部给药：体外和体内评估。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1080/10717544.2024.2424217

Huiyun Xia, Jingjing Yang, Fei Song, Guojuan Pu, Fudan Dong, Zhen Liang, Junjie Zhang

{"title":"Development of ion-triggered in situ gel containing ketoconazole/hydroxypropyl-β-cyclodextrin for ocular delivery: in vitro and in vivo evaluation.","authors":"Huiyun Xia, Jingjing Yang, Fei Song, Guojuan Pu, Fudan Dong, Zhen Liang, Junjie Zhang","doi":"10.1080/10717544.2024.2424217","DOIUrl":"10.1080/10717544.2024.2424217","url":null,"abstract":"The application of ketoconazole (KET) in ocular drug delivery is restricted by its poor aqueous solubility though its broad-spectrum antifungal activity. The aim of this study is to develop an ion-sensitive in situ gel (ISG) of KET to promote its ocular bioavailability in topical application. The solubility of KET in water was increased by complexation with hydroxypropyl-β-cyclodextrin (HPβCD), then KET-HPβCD inclusion complex (KET-IC) was fabricated into an ion-sensitive ISG triggered by sodium alginate (SA). The in vitro drug release and antifungal activities investigations demonstrated that the KET-IC-ISG formulation increased drug release and anti-fungal activities compared to pure KET. The ex vivo rabbit corneal permeation studied demonstrated higher permeability of KET-IC-ISG formulation (Papp of (6.34 <math><mrow><mo>±</mo></mrow></math>0.21) <math><mrow><mo>×</mo></mrow></math>10-4 cm/h) than pure KET (Papp of (3.09 <math><mrow><mo>±</mo></mrow></math> 0.09) <math><mrow><mo>×</mo></mrow></math>10-4 cm/h). The cytotoxicity assay and the ocular irritation study in rabbits confirmed the KET-IC-ISG safety and well tolerance. The ocular pharmacokinetics of KET in rabbits was investigated and the results showed that the KET-IC-ISG increased its bioavailability in cornea by 47-fold. In conclusion, the KET-IC-ISG system promoted the precorneal retention, the ocular drug bioavailability and the developed formulation is a potential strategy to treat mycotic keratitis.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2424217"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking boundaries: the advancements in transdermal delivery of antibiotics. 打破界限：抗生素透皮给药技术的进步。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-01-19 DOI: 10.1080/10717544.2024.2304251

Ahlam Zaid Alkilani, Rania Hamed, Batool Musleh, Zaina Sharaire

{"title":"Breaking boundaries: the advancements in transdermal delivery of antibiotics.","authors":"Ahlam Zaid Alkilani, Rania Hamed, Batool Musleh, Zaina Sharaire","doi":"10.1080/10717544.2024.2304251","DOIUrl":"10.1080/10717544.2024.2304251","url":null,"abstract":"Transdermal drug delivery systems (TDDS) for antibiotics have seen significant advances in recent years that aimed to improve the efficacy and safety of these drugs. TDDS offer many advantages over other conventional delivery systems such as non-invasiveness, controlled-release pattern, avoidance of first-pass metabolism. The objective of this review is to provide an overview on the recent advances in the TDDS of different groups of antibiotics including β-lactams, tetracyclines, macrolides, and lincosamides, utilized for their effective delivery through the skin and to explore the challenges associated with this field. The majority of antibiotics do not have favorable properties for passive transdermal delivery. Thus, novel strategies have been employed to improve the delivery of antibiotics through the skin, such as the use of nanotechnology (nanoparticles, solid-lipid nanoparticles, nanoemulsions, vesicular carriers, and liposomes) or the physical enhancement techniques like microneedles and ultrasound. In conclusion, the transdermal delivery systems could be a promising method for delivering antibiotics that have the potential to improve patient outcomes and enhance the efficacy of drugs. Further research and development are still needed to explore the potential of delivering more antibiotic drugs by using various transdermal drug delivery approaches.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2304251"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10802811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139502483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in cell membrane-based biomimetic nanodelivery systems for natural products. 基于细胞膜的天然产品仿生纳米输送系统的进展。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-06-03 DOI: 10.1080/10717544.2024.2361169

Yifeng Zhang, Qian Zhang, Chunhong Li, Ziyun Zhou, Hui Lei, Minghua Liu, Dan Zhang

{"title":"Advances in cell membrane-based biomimetic nanodelivery systems for natural products.","authors":"Yifeng Zhang, Qian Zhang, Chunhong Li, Ziyun Zhou, Hui Lei, Minghua Liu, Dan Zhang","doi":"10.1080/10717544.2024.2361169","DOIUrl":"10.1080/10717544.2024.2361169","url":null,"abstract":"Active components of natural products, which include paclitaxel, curcumin, gambogic acid, resveratrol, triptolide and celastrol, have promising anti-inflammatory, antitumor, anti-oxidant, and other pharmacological activities. However, their clinical application is limited due to low solubility, instability, low bioavailability, rapid metabolism, short half-life, and strong off-target toxicity. To overcome these drawbacks, cell membrane-based biomimetic nanosystems have emerged that avoid clearance by the immune system, enhance targeting, and prolong drug circulation, while also improving drug solubility and bioavailability, enhancing drug efficacy, and reducing side effects. This review summarizes recent advances in the preparation and coating of cell membrane-coated biomimetic nanosystems and in their applications to disease for targeted natural products delivery. Current challenges, limitations, and prospects in this field are also discussed, providing a research basis for the development of multifunctional biomimetic nanosystems for natural products.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2361169"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0