Drug Delivery最新文献_第3页

In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma. 负载PHT-427抑制剂的聚合纳米颗粒在头颈部鳞状细胞癌中的体内抗肿瘤活性。

IF 6.5 2区医学

Drug Delivery Pub Date : 2025-12-01 Epub Date: 2025-01-09 DOI: 10.1080/10717544.2024.2449376

Joaquín Yanes-Díaz, Raquel Palao-Suay, Francisca Inmaculada Camacho-Castañeda, Juan Riestra-Ayora, María Rosa Aguilar, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez

{"title":"In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma.","authors":"Joaquín Yanes-Díaz, Raquel Palao-Suay, Francisca Inmaculada Camacho-Castañeda, Juan Riestra-Ayora, María Rosa Aguilar, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez","doi":"10.1080/10717544.2024.2449376","DOIUrl":"10.1080/10717544.2024.2449376","url":null,"abstract":"Recent studies on head and neck squamous cell carcinoma (HNSCC) tumorigenesis have revealed several dysregulated molecular pathways. The phosphatidylinositol-3-kinase (PI3K) signaling pathway is frequently activated in HNSCC, making it an attractive target for therapies. PHT-427 is a dual inhibitor of PI3K and the mammalian target of AKT/PDK1. This study evaluates the anticancer efficacy of the inhibitor PHT-427 loaded into polymeric nanoparticles (NP) based on α-TOS (NP-427) administered by intratumoral injection into a hypopharyngeal squamous cell carcinoma (FaDu cells) heterotopic xenograft mouse model. The nanocarrier system, based on block copolymers of N-vinylpyrrolidone (VP) and a methacrylic derivative of α-TOS (MTOS), was synthesized, and PHT-427 was loaded into the delivery system. First, we evaluated the effect of NP-427 on tumor growth by measuring tumor volume, mouse weight, survival, and the development of tumor ulceration and necrosis. In addition, we measured PI3KCA/AKT/PDK1 gene expression, PI3KCA/AKT/PDK1 protein levels, Epidermal Growth Factor Receptor (EGFR), and angiogenesis in the tumor tissue. PHT-427 encapsulation increased drug efficacy and safety, as demonstrated by decreased tumor volume, reduced PI3K/AKT/PDK1 pathway expression, and improved antitumor activity and necrosis induction in the mouse xenograft model. EGFR and angiogenesis marker (Factor VIII) expression were significantly lower in the NP-427 group compared to other experimental groups. Administration of encapsulated PHT-427 at the tumor sites proves promising for HNSCC therapy.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"32 1","pages":"2449376"},"PeriodicalIF":6.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11727052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incorporation of doxorubicin into plant-derived nanovesicles: process monitoring and activity assessment. 阿霉素并入植物源性纳米囊泡：过程监测和活性评估。

IF 6.5 2区医学

Drug Delivery Pub Date : 2025-12-01 Epub Date: 2024-12-11 DOI: 10.1080/10717544.2024.2439272

Aleksandra Steć, Monika Targońska, Shishir Jaikishan, Rui Chen, Piotr Mucha, Grzegorz S Czyrski, Jacek Jasiecki, Agata Płoska, Andrea Heinz, Susanne K Wiedmer, Leszek Kalinowski, Krzysztof Waleron, Bartosz Wielgomas, Szymon Dziomba

{"title":"Incorporation of doxorubicin into plant-derived nanovesicles: process monitoring and activity assessment.","authors":"Aleksandra Steć, Monika Targońska, Shishir Jaikishan, Rui Chen, Piotr Mucha, Grzegorz S Czyrski, Jacek Jasiecki, Agata Płoska, Andrea Heinz, Susanne K Wiedmer, Leszek Kalinowski, Krzysztof Waleron, Bartosz Wielgomas, Szymon Dziomba","doi":"10.1080/10717544.2024.2439272","DOIUrl":"10.1080/10717544.2024.2439272","url":null,"abstract":"Extracellular vesicles (EVs) are an experimental class of drug carriers. Alternative sources of EVs are currently being explored to overcome limitations related to their manufacturing from mesenchymal stem cells. In this work, Citrus limon-derived EVs were tested as carriers for the widely used chemotherapeutic drug - doxorubicin (DOX). Capillary electrophoresis (CE) and nanoplasmonic sensing (NPS) were developed for the quality control of DOX-EV preparations. It was found that the CE method enables simultaneous detection of free and incorporated DOX and allows assessing the stability of the preparations and the drug leakage. NPS, on the other hand, demonstrated that DOX is accumulated in the interfacial region of the carrier. The activity of DOX-loaded EVs was tested on HeLa (cervical cancer cells) and HEK293T (human embryonic kidney cells) cell lines. It was found that DOX incorporation into plant-derived EVs virtually does not affect the drug's cytotoxicity to HeLa cells but significantly decreases DOX activity against HEK293T cell line.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"32 1","pages":"2439272"},"PeriodicalIF":6.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effect of pH-sensitive PEGylated RG3-chitosan prodrug nanoparticles encapsulated celastrol on pancreatic cancer.

IF 6.5 2区医学

Drug Delivery Pub Date : 2025-12-01 Epub Date: 2025-02-16 DOI: 10.1080/10717544.2025.2464189

Zheng Zhang, Jiaxing Wang, Xiaofang Li, Lingzhou Zhao, Junwei Zhao, Mengjiao Su, Xiangxiang Wu, Huahui Zeng

{"title":"Synergistic effect of pH-sensitive PEGylated RG3-chitosan prodrug nanoparticles encapsulated celastrol on pancreatic cancer.","authors":"Zheng Zhang, Jiaxing Wang, Xiaofang Li, Lingzhou Zhao, Junwei Zhao, Mengjiao Su, Xiangxiang Wu, Huahui Zeng","doi":"10.1080/10717544.2025.2464189","DOIUrl":"10.1080/10717544.2025.2464189","url":null,"abstract":"Celastrol (Cel) is a potential anticancer therapeutic candidate, but its limited practical applicability is due to its low solubility, poor tumor selectivity, and cytotoxicity. Clinically, ginsenoside Rg3 (RG3) is typically combined with chemotherapy to enhance antitumor effects and reduce side effects. Herein, we developed novel pH-sensitive prodrug nanoparticles (NPs) containing RG3 and Cel for the synergistic treatment of pancreatic cancer (PC). Amphiphilic prodrug, a PEGylated chitosan oligosaccharide coupled with RG3 via Schiff base bond, was self-assembled with hydrophobic Cel into NPs with drug loadings of 2.12% (Cel) and 1.63% (RG3). NPs exhibited a suitable particle size of 124.01 nm, zeta potential of -39.89 mV and good physical stability. In addition, NPs also showed a controlled drug release when the Schiff base bonds were hydrolyzed in the acidic environment. In Pan02 tumor-bearing mice, NPs exhibited a high accumulation in tumor tissues and prolonged blood circulation time. Furthermore, NPs could more effectively inhibit tumor growth and reduce systemic toxicity, compared with the free Cel, RG3, prodrug, and Cel + RG3. The results indicated that the NPs could provide a safe and promising nanoplatform for PC therapy.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"32 1","pages":"2464189"},"PeriodicalIF":6.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug retention after intradiscal administration. 椎管内给药后的药物滞留

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-10-20 DOI: 10.1080/10717544.2024.2415579

Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P Meij, Jens Thies, Pieter Emans, Fetullah C Öner, George Mihov, Joao Pedro Garcia, Anne S Ulrich, Sibylle Grad, Marianna A Tryfonidou, Hugo van Ingen, Laura B Creemers

{"title":"Drug retention after intradiscal administration.","authors":"Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P Meij, Jens Thies, Pieter Emans, Fetullah C Öner, George Mihov, Joao Pedro Garcia, Anne S Ulrich, Sibylle Grad, Marianna A Tryfonidou, Hugo van Ingen, Laura B Creemers","doi":"10.1080/10717544.2024.2415579","DOIUrl":"10.1080/10717544.2024.2415579","url":null,"abstract":"Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enable the optimization of IVDD therapeutics. Release and retention of an inactive hydrophilic fluorine-19 labeled peptide (19F-P) as model for regenerative peptides was studied in a whole IVD culture model by measuring the 19F-NMR (nuclear magnetic resonance) signal in culture media and IVD tissue extracts. In another set-up, noninvasive near-infrared imaging was used to visualize IR-780, as hydrophobic small molecular drug model, retention upon injection into healthy and degenerative caudal IVDs in a rat model of disk degeneration. Furthermore, IR-780-loaded degradable polyester amide microspheres (PEAM) were injected into healthy and needle pricked degenerative IVDs, subcutaneously, and in knee joints with and without surgically-induced osteoarthritis (OA). Most 19F-P was released from the IVD after 7 days. IR-780 signal intensity declined over a 14-week period after bolus injection, without a difference between healthy and degenerative disks. IR-780 signal declined faster in the skin and knee joints compared to the IVDs. IR-780 delivery by PEAMs enhanced disk retention beyond 16 weeks. Moreover, in degenerated IVDs the IR-780 signal was higher over time than in healthy IVDs while no difference between OA and healthy joints was noted. We conclude that the clearance of peptides and hydrophobic small molecules from the IVD is relatively fast. These results illustrate that development of controlled release formulations should take into account the target anatomical location and local (patho)biology.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2415579"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-05-14 DOI: 10.1080/10717544.2024.2350273

引用次数: 0

Homotypic cell membrane-camouflaged biomimetic PLGA nanoparticle loading triptolide for the treatment of hepatocellular carcinoma. 用于治疗肝细胞癌的同型细胞膜伪装仿生聚乳酸（PLGA）纳米粒子。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-06-01 DOI: 10.1080/10717544.2024.2354687

Zhe Li, Jinshuai Lan, Ya Wu, Yue Ding, Tong Zhang

{"title":"Homotypic cell membrane-camouflaged biomimetic PLGA nanoparticle loading triptolide for the treatment of hepatocellular carcinoma.","authors":"Zhe Li, Jinshuai Lan, Ya Wu, Yue Ding, Tong Zhang","doi":"10.1080/10717544.2024.2354687","DOIUrl":"10.1080/10717544.2024.2354687","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated death worldwide. Beside early detection, early diagnosis, and early surgery, it is urgent to try new strategies for the treatment of HCC. Triptolide (TPL) has been employed to treat HCC. However, its clinical applications were restricted by the narrow therapeutic window, severe toxicity, and poor water-solubility. In this study, we developed cancer cell membrane-camouflaged biomimetic PLGA nanoparticles loading TPL (TPL@mPLGA) with the homologous targeting property for the treatment of HCC. The TPL@mPLGA was successfully prepared with particle size of 195.5 ± 7.5 nm and zeta potential at -21.5 ± 0.2 mV with good stability. The drug loading (DL) of TPL@mPLGA was 2.94%. After Huh-7 cell membrane coating, the natural Huh-7 cell membrane proteins were found to be retained on TPL@mPLGA, thus endowing the TPL@mPLGA with enhanced accumulation at tumor site, and better anti-tumor activity in vitro and in vivo when compared with TPL or TPL@PLGA. The TPL@mPLGA showed enhanced anti-tumor effects and reduced toxicity of TPL, which could be adopted for the treatment of HCC.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2354687"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction. 撤回声明。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2023-01-18 DOI: 10.1080/10717544.2022.2157535

引用次数: 0

Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport. 固定会改变肿瘤组织的物理特性，从而调节纳米药物的运输。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1080/10717544.2024.2430528

John D Martin, Fotios Mpekris, Vikash P Chauhan, Margaret R Martin, Megan E Walsh, Matthew D Stuber, Donald M McDonald, Fan Yuan, Triantafyllos Stylianopoulos, Rakesh K Jain

{"title":"Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport.","authors":"John D Martin, Fotios Mpekris, Vikash P Chauhan, Margaret R Martin, Megan E Walsh, Matthew D Stuber, Donald M McDonald, Fan Yuan, Triantafyllos Stylianopoulos, Rakesh K Jain","doi":"10.1080/10717544.2024.2430528","DOIUrl":"10.1080/10717544.2024.2430528","url":null,"abstract":"To have the desired therapeutic effect, nanomedicines and macromolecular medications must move from the site of injection to the site of action, without having adverse effects. Transvascular transport is a critical step of this navigation, as exemplified by the Enhanced Permeability and Retention (EPR) effect in solid tumors, not found in normal organs. Numerous studies have concluded that passive, diffusion- and convection-based transport predominates over active, cellular mechanisms in this effect. However, recent work using a new approach reevaluated this principle by comparing tumors with or without fixation and concluded the opposite. Here, we address the controversy generated by this new approach by reporting evidence from experimental investigations and computer simulations that separate the contributions of active and passive transport. Our findings indicate that tissue fixation reduces passive transport as well as active transport, indicating the need for new methods to distinguish the relative contributions of passive and active transport.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2430528"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective. 基于骨支架的骨肉瘤局部给药：现状与未来展望。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-09-06 DOI: 10.1080/10717544.2024.2391001

Wenqing Liang, Hengguo Long, Hongwei Zhang, Juqin Bai, Bo Jiang, Jiangwei Wang, Lifeng Fu, Wenyi Ming, Jiayi Zhao, Bin Zeng

{"title":"Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective.","authors":"Wenqing Liang, Hengguo Long, Hongwei Zhang, Juqin Bai, Bo Jiang, Jiangwei Wang, Lifeng Fu, Wenyi Ming, Jiayi Zhao, Bin Zeng","doi":"10.1080/10717544.2024.2391001","DOIUrl":"10.1080/10717544.2024.2391001","url":null,"abstract":"A common malignant bone neoplasm in teenagers is Osteosarcoma. Chemotherapy, surgical therapy, and radiation therapy together comprise the usual clinical course of treatment for Osteosarcoma. While Osteosarcoma and other bone tumors are typically treated surgically, however, surgical resection frequently fails to completely eradicate tumors, and in turn becomes the primary reason for postoperative recurrence and metastasis, ultimately leading to a high rate of mortality. Patients still require radiation and/or chemotherapy after surgery to stop the spread of the tumor and its metastases, and both treatments have an adverse influence on the body's organ systems. In the postoperative management of osteosarcoma, bone scaffolds can load cargos (growth factors or drugs) and function as drug delivery systems (DDSs). This review describes the different kinds of bone scaffolds that are currently available and highlights key studies that use scaffolds as DDSs for the treatment of osteosarcomas. The discussion also includes difficulties and perspectives regarding the use of scaffold-based DDSs. The study may serve as a source for outlining efficient and secure postoperative osteosarcoma treatment plans.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2391001"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11382735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the use of local anesthetic extended-release systems in pain management. 局麻药缓释系统在疼痛治疗中的应用进展。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2023-12-21 DOI: 10.1080/10717544.2023.2296349

Yulu Chen, Jingmei Xu, Ping Li, Liyang Shi, Sha Zhang, Qulian Guo, Yong Yang

{"title":"Advances in the use of local anesthetic extended-release systems in pain management.","authors":"Yulu Chen, Jingmei Xu, Ping Li, Liyang Shi, Sha Zhang, Qulian Guo, Yong Yang","doi":"10.1080/10717544.2023.2296349","DOIUrl":"10.1080/10717544.2023.2296349","url":null,"abstract":"Pain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local anesthetics is the limited duration of a single injection. To address this problem, catheters are often placed or combined with other drugs in clinical practice to increase the time that local anesthetics act. However, this method does not meet the needs of clinical analgesics. Therefore, many researchers have worked to develop local anesthetic extended-release types that can be administered in a single dose. In recent years, drug extended-release systems have emerged dramatically due to their long duration and efficacy, providing more possibilities for the application of local anesthetics. This paper summarizes the types of local anesthetic drug delivery systems and their clinical applications, discusses them in the context of relevant studies on local anesthetics, and provides a summary and outlook on the development of local anesthetic extended-release agents.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2296349"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10763865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0