{"title":"A novel colonoscope with an extra-wide field of view increases polyp detection rate compared with standard colonoscope: Prospective model-based trial.","authors":"Horst Neuhaus, Tanja Nowak, Arthur Schmidt","doi":"10.1055/a-2422-9502","DOIUrl":"https://doi.org/10.1055/a-2422-9502","url":null,"abstract":"<p><p><b>Background and study aims</b> Colonoscopy, the gold standard for early detection of colorectal cancer, may miss polyps especially those hidden behind folds. This prospective study compared polyp detection and performance of a novel colonoscope with extra-wide field of view (EFOV) of 230 degrees (partially retrograde) to a standard colonoscope (SC, 170 degrees) in a colon model. <b>Patients and methods</b> A 3D printed colon model was used featuring 12 polyps placed throughout different colon segments, with several located on the proximal side of haustral folds. Endoscopists were instructed to identify polyps, first inserting the SC immediately followed by the EFOV device, and to place a snare to simulate a polypectomy. A standardized survey was used to record operator impressions. <b>Results</b> Twenty-nine experienced endoscopists participated in this study. On average, 5.3 vs 9.6 polyps were detected with the standard and EFOV colonoscopes, respectively ( <i>P</i> < 0.001). Five of 29 operators (17.2%) detected all 12 polyps with the EFOV device, whereas no operator detected all polyps with the SC. The success rate for snare placement was 100% for both endoscopes with similar times (mean of 14 vs 15 seconds for SC and EFOV, respectively). EFOV handling and optical performance were rated as equally good or better by all endoscopists. <b>Conclusions</b> Use of a colonoscope with novel optics significantly improved polyp detection compared with a standard colonoscope in this non-randomized model-based study, with favorable performance and usability ratings for the EFOV instrument. Clinical studies are needed to confirm these encouraging preliminary results.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 10","pages":"E1230-E1236"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benedetto Mangiavillano, Daryl Ramai, Michel Kahaleh, Amy Tyberg, Haroon Shahid, Avik Sarkar, Jayanta Samanta, Jahnvi Dhar, Michiel Bronswijk, Schalk Van der Merwe, Abdul Kouanda, Hyun Ji, Sun-Chuan Dai, Pierre Deprez, Jorge Vargas-Madrigal, Giuseppe Vanella, Roberto Leone, Paolo Giorgio Arcidiacono, Carlos Robles-Medranda, Juan Alcivar Vasquez, Martha Arevalo-Mora, Alessandro Fugazza, Christopher Ko, John Morris, Andrea Lisotti, Pietro Fusaroli, Amaninder Dhaliwal, Massimiliano Mutignani, Edoardo Forti, Irene Cottone, Alberto Larghi, Gianenrico Rizzatti, Domenico Galasso, Carmelo Barbera, Francesco Maria Di Matteo, Serena Stigliano, Cecilia Binda, Carlo Fabbri, Khanh Do-Cong Pham, Roberto Di Mitri, Michele Amata, Stefano Francesco Crinó, Andrew Ofosu, Luca De Luca, Abed Al-Lehibi, Francesco Auriemma, Danilo Paduano, Federica Calabrese, Carmine Gentile, Cesare Hassan, Alessandro Repici, Antonio Facciorusso
{"title":"Correction: Outcomes of lumen apposing metal stent placement in patients with surgically altered anatomy: Multicenter international experience.","authors":"Benedetto Mangiavillano, Daryl Ramai, Michel Kahaleh, Amy Tyberg, Haroon Shahid, Avik Sarkar, Jayanta Samanta, Jahnvi Dhar, Michiel Bronswijk, Schalk Van der Merwe, Abdul Kouanda, Hyun Ji, Sun-Chuan Dai, Pierre Deprez, Jorge Vargas-Madrigal, Giuseppe Vanella, Roberto Leone, Paolo Giorgio Arcidiacono, Carlos Robles-Medranda, Juan Alcivar Vasquez, Martha Arevalo-Mora, Alessandro Fugazza, Christopher Ko, John Morris, Andrea Lisotti, Pietro Fusaroli, Amaninder Dhaliwal, Massimiliano Mutignani, Edoardo Forti, Irene Cottone, Alberto Larghi, Gianenrico Rizzatti, Domenico Galasso, Carmelo Barbera, Francesco Maria Di Matteo, Serena Stigliano, Cecilia Binda, Carlo Fabbri, Khanh Do-Cong Pham, Roberto Di Mitri, Michele Amata, Stefano Francesco Crinó, Andrew Ofosu, Luca De Luca, Abed Al-Lehibi, Francesco Auriemma, Danilo Paduano, Federica Calabrese, Carmine Gentile, Cesare Hassan, Alessandro Repici, Antonio Facciorusso","doi":"10.1055/a-2447-4371","DOIUrl":"https://doi.org/10.1055/a-2447-4371","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/a-2411-1814.].</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 10","pages":"C8"},"PeriodicalIF":2.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaofei Wang, Bingqing Bai, Qiming Huang, Yuanyuan Fang, Chenyu Zhang, Xinwen Chen, Jianglong Hong, Lei Jie, Hao Ding, Cui Hu, Hongye Li, Yang Li, Xiaochang Liu, Rutao Hong, Junjun Bao, Qiao Mei
{"title":"Real-world evidence comparing early and late pancreatic stent placement to prevent post-ERCP pancreatitis.","authors":"Shaofei Wang, Bingqing Bai, Qiming Huang, Yuanyuan Fang, Chenyu Zhang, Xinwen Chen, Jianglong Hong, Lei Jie, Hao Ding, Cui Hu, Hongye Li, Yang Li, Xiaochang Liu, Rutao Hong, Junjun Bao, Qiao Mei","doi":"10.1055/a-2409-1285","DOIUrl":"https://doi.org/10.1055/a-2409-1285","url":null,"abstract":"<p><p><b>Background and study aims</b> Pancreatic stenting effectively lowers the occurrence of post-ERCP pancreatitis (PEP) and reduces its severity. However, limited research has been conducted to determine the optimal timing for pancreatic stent placement. Our objective was to evaluate whether early pancreatic stent placement (EPSP) is more effective than late pancreatic stent placement (LPSP) in preventing PEP among patients with naive papilla. <b>Patients and methods</b> We conducted a retrospective cohort study that analyzed 590 patients with difficult biliary cannulation using the pancreatic guidewire technique, who were divided into EPSP and LPSP groups. In the EPSP group, a pancreatic stent was placed immediately before/after endoscopic retrograde cholangiography (ERC) or endoscopic sphincterotomy (EST). Conversely, in the LPSP group, a pancreatic stent was placed after partial/all completion of major endoscopic procedures. <b>Results</b> From November 2017 to May 2023, 385 patients were in the EPSP group and 205 in the LPSP group. EPSP was associated with a decreased PEP occurrence compared with LPSP (2.9% vs. 7.3%; <i>P</i> = 0.012). Similarly, hyperamylasemia was lower in the EPSP group (19.7% vs. 27.8%; <i>P</i> = 0.026). Furthermore, sensitivity analysis using multivariable analysis and propensity score-matched (PSM) analysis also validated these findings. <b>Conclusions</b> Early pancreatic stent placement reduced the incidence of PEP and hyperamylasemia compared with late pancreatic stent placement. Our findings favor pancreatic stenting immediately before/after ERC or EST.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 10","pages":"E1162-E1170"},"PeriodicalIF":2.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness and safety of a new clip for delivery using a duodenoscope for bleeding after endoscopic sphincterotomy.","authors":"Atsushi Yamaguchi, Hiroki Kamada, Shigeaki Semba, Naohiro Kato, Yasuhiro Okuda, Yuji Teraoka, Takeshi Mizumoto, Yuzuru Tamaru, Tsuyoshi Hatakeyama, Hirotaka Kouno, Shigeto Yoshida","doi":"10.1055/a-2420-2419","DOIUrl":"https://doi.org/10.1055/a-2420-2419","url":null,"abstract":"<p><p><b>Background and study aims</b> Hemostasis for post-endoscopic sphincterotomy (post-EST) bleeding involves no standard strategy. New clips designed for delivery using the duodenoscope (SureClip, Micro-Tech, Nanjing, China) have been utilized for gastrointestinal bleeding hemostasis and bleeding prevention after polypectomy and papillectomy. We retrospectively analyzed the effectiveness and safety of SureClip for post-EST bleeding. <b>Patients and methods</b> Of 608 patients with endoscopic sphincterotomy (EST), 41 cases (6.7%) experienced post-EST bleeding from 2019 to 2023. Of these patients, 24 underwent hemostasis by SureClip, and the success rate of complete hemostasis and complication by hemostasis by SureClip was analyzed. <b>Results</b> In 12 and 12 patients with urgent and delayed bleeding, 11 (91.7%) and 11 (91.7%) had successful hemostasis, respectively. In addition, missed patients achieved complete hemostasis with additional transcatheter arterial embolization and balloon compression, respectively. No complications were observed, including perforation, pancreatitis, and clipping bile duct and pancreatic duct by mistake. <b>Conclusions</b> Hemostasis with SureClip is safe, effective, and not expensive for post-EST bleeding. It could be the first choice for hemostasis in patients with post-EST bleeding refractory to balloon compression.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 10","pages":"E1190-E1195"},"PeriodicalIF":2.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sen Verhoeve, Cynthia Verloop, Marco Bruno, Valeska Terpstra, Lydi Van Driel, Lars Perk, Lieke Hol
{"title":"Efficacy of EUS-guided keyhole biopsies in diagnosing subepithelial lesions of the upper gastrointestinal tract.","authors":"Sen Verhoeve, Cynthia Verloop, Marco Bruno, Valeska Terpstra, Lydi Van Driel, Lars Perk, Lieke Hol","doi":"10.1055/a-2417-0580","DOIUrl":"https://doi.org/10.1055/a-2417-0580","url":null,"abstract":"<p><p><b>Background and study aims</b> Tissue acquisition is required for diagnosis of subepithelial lesions (SELs). However, obtaining adequate tissue remains challenging. This study investigated an EUS-guided technique using a forceps to create a channel and take multiple biopsies from the center of the lesion, therefore called endoscopic ultrasound-guided keyhole biopsy (EUS-KB). <b>Patients and methods</b> A retrospective cohort study was conducted in 56 patients with SELs in the upper gastrointestinal tract who were scheduled to undergo EUS-KB. The primary aim was to assess diagnostic yield, defined as the percentage of procedures where EUS-KB resulted in a definitive histopathological diagnosis. Furthermore, factors influencing diagnostic yield were investigated. Additional outcomes included technical success and adverse events. <b>Results</b> Technical success was achieved in 55 of 60 biopsies (91.7%). EUS-KB provided a diagnosis in 44 of 55 biopsies (80.0%), histology mostly showing gastrointestinal stromal tumor or leiomyoma. The diagnostic yield was not significantly influenced by the size or location of the SEL. Adverse events occurred in one patient (1.7%). <b>Conclusions</b> EUS-KB is a feasible and safe technique for obtaining a classifying diagnosis for SELs in the upper gastrointestinal tract. It could offer an alternative diagnostic modality, especially in lesions smaller than 20 mm.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 10","pages":"E1183-E1189"},"PeriodicalIF":2.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Umar Hayat, Yakub I Khan, Duane Deivert, Joshua Obuch, Athar Altaf, John Boger, Faisal Kamal, David L Diehl
{"title":"Combined antegrade and retrograde dilation (CARD) for management of complete esophageal obstruction: Multicenter case series.","authors":"Umar Hayat, Yakub I Khan, Duane Deivert, Joshua Obuch, Athar Altaf, John Boger, Faisal Kamal, David L Diehl","doi":"10.1055/a-2422-8792","DOIUrl":"https://doi.org/10.1055/a-2422-8792","url":null,"abstract":"<p><p><b>Background and study aims</b> Complete esophageal obstruction (CEO) is a rare complication of radiation therapy for esophageal or head and neck cancers and can be challenging to manage endoscopically. A rendezvous approach by combined anterograde and retrograde endoscopic dilation (CARD) can be used to re-establish luminal integrity in such cases. Our study aimed to review our experience with patients with CEOs managed by CARD. <b>Patients and methods</b> Six patients who had CARD for CEO were reviewed. The primary outcomes were immediate technical and clinical success of CARD. Secondary outcomes were adverse events (AEs) associated with the procedure and continued dependency on the percutaneous endoscopic gastrostomy (PEG)-or jejunostomy tube. <b>Results</b> The mean age was 59 years (range 38-83). Five patients had CEO secondary to neoadjuvant chemoradiotherapy for esophageal cancer, and one patient had complete obstruction secondary to neck trauma. CARD was technically successful in five patients (86%). Two patients had AEs. One had pneumomediastinum requiring no intervention, while the other had bilateral pneumothorax requiring chest tube placement. The median follow-up duration of repeated dilations to maintain liminal patency was 20 months. Four patients had improvement in dysphagia, tolerating oral intake, and mouth secretions after the procedure, with a mean functional oral intake scale (FOIS) score > 3 and an overall success rate of 83%. <b>Conclusions</b> The CARD approach to re-establish esophageal luminal patency in CEO is a safer alternative to high-risk blind antegrade dilation or an invasive surgical approach. It is usually technically feasible with improved swallowing ability in most patients.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 10","pages":"E1199-E1205"},"PeriodicalIF":2.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Karsenti, Rodica Gincul, Arthur Belle, Ariane Vienne, Emmanuel Weiss, Geoffroy Vanbiervliet, Olivier Gronier
{"title":"Antibiotic prophylaxis in digestive endoscopy: Guidelines from the French Society of Digestive Endoscopy.","authors":"David Karsenti, Rodica Gincul, Arthur Belle, Ariane Vienne, Emmanuel Weiss, Geoffroy Vanbiervliet, Olivier Gronier","doi":"10.1055/a-2415-9414","DOIUrl":"https://doi.org/10.1055/a-2415-9414","url":null,"abstract":"<p><p>Digestive endoscopy is a highly dynamic medical discipline, with the recent adoption of new endoscopic procedures. However, comprehensive guidelines on the role of antibiotic prophylaxis in these new procedures have been lacking for many years. The Guidelines Commission of the French Society of Digestive Endoscopy (SFED) convened in 2023 to establish guidelines on antibiotic prophylaxis in digestive endoscopy for all digestive endoscopic procedures, based on literature data up to September 1, 2023. This article summarizes these new guidelines and describes the literature review that fed into them.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 10","pages":"E1171-E1182"},"PeriodicalIF":2.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Corey S Miller, Magali Lecavalier-Barsoum, Kim Ma, Miriam Santos Dutra, Youri Kaitoukov, Boris Bahoric, Nada Tomic, Francine Dinelle, Shirin Enger, Gerald Batist, Stephen Yang, Donald Laporta, Petr Kavan, Anand Sahai, David Roberge, David Donath
{"title":"Feasibility and safety of endoscopic ultrasound-guided diffusing alpha emitter radiation therapy for advanced pancreatic cancer: Preliminary data.","authors":"Corey S Miller, Magali Lecavalier-Barsoum, Kim Ma, Miriam Santos Dutra, Youri Kaitoukov, Boris Bahoric, Nada Tomic, Francine Dinelle, Shirin Enger, Gerald Batist, Stephen Yang, Donald Laporta, Petr Kavan, Anand Sahai, David Roberge, David Donath","doi":"10.1055/a-2379-1591","DOIUrl":"https://doi.org/10.1055/a-2379-1591","url":null,"abstract":"<p><p><b>Background and study aims</b> Pancreatic cancer is a devastating disease with limited locoregional treatment options. Diffusing alpha-emitter radiation therapy (Alpha DaRT), a novel cancer treatment using alpha-particle interstitial radiotherapy, may help address this challenge. The aim of this study was to evaluate the feasibility and safety of endoscopic ultrasound (EUS)-guided Alpha DaRT for advanced pancreatic cancer. <b>Patients and methods</b> Patients with inoperable locally advanced or metastatic pancreatic adenocarcinoma were treated with EUS-guided Alpha DaRT insertion. The Alpha DaRT sources were delivered into pancreatic tumors using a standard EUS needle with a novel proprietary applicator. Adverse events (AEs) were assessed based on the Common Terminology Criteria for Adverse Events version 5.0. Tumor response was evaluated by imaging 4 to 6 weeks post treatment. <b>Results</b> The first five patients were treated between March and September 2023. The procedure was technically successful in all cases, with Alpha DaRT sources inserted into the target tumor. Estimated gross tumor volume coverage ranged from 8% to 44%. Fourteen AEs were reported among three patients. Four were serious AEs, none of which was associated with the treatment, but rather, with disease progression or medical assistance in dying. Only two AEs (mild) were deemed possibly related to the study device. At the 35-day visit, two patients had progressive disease and three had stable disease, with one of the latter showing partial response 2 months post procedure. <b>Conclusions</b> Preliminary results from this first-in-human trial indicate that EUS-guided Alpha DaRT treatment for unresectable pancreatic cancer is feasible and safe, with no device-associated serious AEs. Further investigation of this promising novel modality is underway.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 10","pages":"E1085-E1091"},"PeriodicalIF":2.2,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}