{"title":"Post-endoscopy esophageal adenocarcinoma and root cause analysis in Auckland, New Zealand.","authors":"Seong Shin, Dongyeon Kang, Russell S Walmsley","doi":"10.1055/a-2676-3883","DOIUrl":"https://doi.org/10.1055/a-2676-3883","url":null,"abstract":"<p><strong>Background and study aims: </strong>Post-endoscopy esophageal adenocarcinomas (PEEC) challenge timely diagnosis of esophageal adenocarcinomas (OAs). This study aimed to determine prevalence of PEECs in Auckland region and elucidate the most plausible causes through a root-cause analysis framework.</p><p><strong>Patients and methods: </strong>OA cases diagnosed in Auckland from 2013 to 2022 were retrieved from the New Zealand Cancer Registry (NZCR). Electronic clinical data were collected via the Regional Clinical Portal software. The primary outcome was PEEC prevalence, defined as OA diagnosed 6 to 36 months following an esophagogastroduodenoscopy (EGD) that failed to detect the cancer. Identified PEECs were classified into six categories.</p><p><strong>Results: </strong>Among 633 OA cases, 45 (7.1%) were PEECs. A higher prevalence of PEEC was observed in patients with Barrett's esophagus (BE) (18.1% vs 2.7%), undergoing surveillance EGDs (52.6% vs 3.6%) and with early-stage cancers. Root-cause analysis delineated the PEEC causes, classified as follows: A (17.8%): lesion was identified, endoscopic assessment was adequate, follow-up was appropriately planned and executed, yet PEEC developed; B (17.8%): follow-up was delayed due to administrative factors; C (22.2%): follow-up decisions were inappropriate; D (22.2%): inadequate endoscopic assessment; E (11.1%): lesion was unidentified despite adequate assessment; and F (8.9%): lesion was unidentified and assessment was inadequate. Categories B, C, D, and F comprised 71.1% of cases deemed potentially avoidable.</p><p><strong>Conclusions: </strong>Auckland's PEEC prevalence aligns with international post-endoscopy upper gastrointestinal cancer rates. Root-cause analysis underscores that a significant proportion of PEECs may be preventable with improved clinical practice.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26763883"},"PeriodicalIF":2.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristoffer Mazanti Cold, Amaan Ali, Lars Konge, Flemming Bjerrum, Laurence Lovat, Omer Ahmad
{"title":"Author reply to letter to the editor: From fragmentation to frameworks: Standardizing AI in gastrointestinal endoscopy.","authors":"Kristoffer Mazanti Cold, Amaan Ali, Lars Konge, Flemming Bjerrum, Laurence Lovat, Omer Ahmad","doi":"10.1055/a-2695-2884","DOIUrl":"https://doi.org/10.1055/a-2695-2884","url":null,"abstract":"","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26952884"},"PeriodicalIF":2.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Urgency for standardized protocols to improve clinical implementation of artificial intelligence in endoscopic diagnostics.","authors":"Ulrik Deding, Benedicte Schelde-Olesen, Ervin Toth, Anastasios Koulaouzidis","doi":"10.1055/a-2695-2841","DOIUrl":"https://doi.org/10.1055/a-2695-2841","url":null,"abstract":"","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26952841"},"PeriodicalIF":2.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-reflux barrier competency can be estimated by gastric folds stretching during intragastric insufflation without special equipment.","authors":"Hidenori Tanaka, Haruhiro Inoue, Yuto Shimamura, Masachika Saino, Kei Ushikubo, Miyuki Iwasaki, Kazuki Yamamoto, Yohei Nishikawa, Ippei Tanaka, Mayo Tanabe, Satoshi Abiko, Gantuya Boldbaatar, Manabu Onimaru, Shiro Oka","doi":"10.1055/a-2697-7690","DOIUrl":"https://doi.org/10.1055/a-2697-7690","url":null,"abstract":"<p><strong>Background and study aims: </strong>Although the endoscopic pressure study integrated system (EPSIS) is useful to evaluate competency of lower esophageal sphincter as a major part of the anti-reflux barrier, its availability is limited. This study aimed to assess whether gastric fold stretching during insufflation can predict intragastric pressure (IGP) without special equipment.</p><p><strong>Patients and methods: </strong>A retrospective analysis included 33 patients who underwent esophagogastroduodenoscopy and EPSIS between June and July 2024. Gastric fold stretching along the greater curvature at the level of the cardia, observed in a retroflex view during insufflation, was compared with EPSIS results by reviewing recorded videos. Time ranges were defined as follows, and IGP was measured at the end of each range: Time range 1, until the ratio of longitudinal fold thickness to the groove width between folds reached 1:2; Time range 2, until the ratio reached 1:4; and Time range 3, until the folds or mucosal ridges were almost flattened. Variability was assessed using the coefficient of variation (CV), calculated as the standard deviation divided by the mean.</p><p><strong>Results: </strong>Time ranges 1, 2, and 3 were fully observed in 100%, 97%, and 70% of patients, respectively. Mean IGPs at the end of Time ranges 1, 2, and 3 were 8.9, 11.1, and 17.7 mmHg, with CVs of 0.32, 0.28, and 0.08, respectively.</p><p><strong>Conclusions: </strong>Flattening of gastric folds or mucosal ridges during insufflation is a reliable predictor of IGP. This finding may help identify patients with anti-reflux barrier dysfunction during regular endoscopic examination.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26977690"},"PeriodicalIF":2.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amber-red color imaging makes the dissection line more evident during gastric endoscopic submucosal dissection.","authors":"Kohei Funasaka, Ryoji Miyahara, Noriyuki Horiguchi, Hyuga Yamada, Keishi Koyama, Gakushi Komura, Seiya Hagihara, Hijiri Sugiyama, Mizuki Ariga, Mitsuo Nagasaka, Eizaburo Ohno, Teiji Kuzuya, Yoshiki Hirooka","doi":"10.1055/a-2694-7445","DOIUrl":"10.1055/a-2694-7445","url":null,"abstract":"<p><strong>Background and study aims: </strong>Local injection of a small amount of blue dye into the submucosa can facilitate recognizing the dissection line in endoscopic submucosal dissection (ESD). Amber-red color imaging (ACI), which hardly affects the submucosal blue color, is suitable for the entire ESD. This study aimed to clarify characteristics of ACI during ESD.</p><p><strong>Patients and methods: </strong>Nine endoscopic images were selected during submucosal dissection in four cases of gastric ESD to evaluate endoscopic ACI and white light imaging (WLI). Visibility of the dissection line and the submucosal vessel were evaluated by eight endoscopists using a 5-point Likert scale. The blue submucosal area of each endoscopic image and color signal surrounding the submucosa were compared between ACI and WLI. In addition, the color signals in gradient dilutions of blue solutions were compared in ex vivo experiments.</p><p><strong>Results: </strong>Visibility of the dissection line was better in ACI than in WLI and visibility of the submucosal vessels was slightly better in ACI. The size ratio of the blue area in ACI and WLI (i.e., ACI/WLI) ranged from 0.53 to 0.65, indicating that the blue area in the ACI was narrower. The red signal intensity of the surroundings with respect to the submucosa was greater in ACI than in WLI, which was related to the narrower blue area in ACI. Ex vivo experiments corroborated this observation.</p><p><strong>Conclusions: </strong>ACI highlights the submucosa in blue only where sufficient solution is injected, which facilitates recognition of the dissection line during ESD.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26947445"},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differences in complications between colonoscopy and esophagogastroduodenoscopy in Japan using large-scale health insurance claims data.","authors":"Naohisa Yoshida, Hideki Ishikawa, Michihro Mutoh, Naoto Iwai, Reo Kobayashi, Ken Inoue, Ryohei Hirose, Osamu Dohi, Yoshito Itoh, Azusa Yoda, Ayako Maeda-Minami, Yasunari Mano","doi":"10.1055/a-2689-6049","DOIUrl":"10.1055/a-2689-6049","url":null,"abstract":"<p><strong>Background and study aims: </strong>Analyses of colonoscopy (CS) and esophagogastroduodenoscopy (EGD) complications is crucial for further promoting use of endoscopy. This study analyzed rates of severe complications of CS compared with those of EGD using big data.</p><p><strong>Patients and methods: </strong>As a study population, we retrospectively used commercially anonymized health insurance claims data covering 3,050,954 patients from January 2010 to December 2020. Patients ≥ 50 years old who underwent CS or EGD without treatment were included in the study. The main outcomes were differences in rates of hemorrhage, perforation, and fatal events between EGD and CS, and risk factors of each complication comparing CS with EGD.</p><p><strong>Results: </strong>Among 290,470 CSs (male: 182,910, female: 107,560, median age [range]: 58 [50-75]) and 726,075 EGDs (male: 412,365, female: 313,710, 58 [50-75]), rates of hemorrhage, perforation, and fatal events for EGD and CS were 0.0069% vs. 0.0069% ( <i>P</i> = 0.558), 0.0006% vs. 0.0024% ( <i>P</i> = 0.008), and 0.00028% vs. 0.00034% ( <i>P</i> = 0.648), respectively. Rates of hemorrhage for cases aged 50 to 64 and 65 to 75 years were 0.0059% vs. 0.0110% ( <i>P</i> = 0.042) for EGD and 0.0061% vs. 0.0108% for CS ( <i>P</i> = 0.264). Risks of hemorrhage for comparing CS to EGD were significant for biopsy (adjusted odds ratio [aOR] 95% confidence interval [CI] 2.75 [1.15-6.21]; <i>P</i> = 0.017) and antithrombotics (aOR 12.48; 95% CI 1.80-247.14; <i>P</i> = 0.026). Those for perforation were significant for ages 50 to 64 years (aOR 9.58; 95% CI 2.17-66.10; <i>P</i> = 0.006) and male sex (11.76 [1.85-222.65], <i>P</i> = 0.025).</p><p><strong>Conclusions: </strong>Compared with EGD, CS had a higher rate of perforation but not hemorrhage. Complication rates in CS did not differ by age.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26896049"},"PeriodicalIF":2.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dennis Yang, Ernesto Robalino Gonzaga, Muhammad Khalid Hasan, Arvind Julius Trindade, Mark Radlinski, Rebecca A Burbridge, Jeffrey Mosko, Pushpak Taunk, Salmaan Jawaid, Mohamed O Othman, David L Diehl, Harshit S Khara, Quin Liu, Srinivas Gaddam, Harry Aslanian, Shailendra S Chauhan, Amrita Sethi, John Poneros, Jason Samarasena, Ali M Ahmed, Uzma D Siddiqui, Dennis Chen, Moamen Gabr, Andrew Y Wang
{"title":"Minimum standards for training in colorectal endoscopic mucosal resection among advanced endoscopy trainees.","authors":"Dennis Yang, Ernesto Robalino Gonzaga, Muhammad Khalid Hasan, Arvind Julius Trindade, Mark Radlinski, Rebecca A Burbridge, Jeffrey Mosko, Pushpak Taunk, Salmaan Jawaid, Mohamed O Othman, David L Diehl, Harshit S Khara, Quin Liu, Srinivas Gaddam, Harry Aslanian, Shailendra S Chauhan, Amrita Sethi, John Poneros, Jason Samarasena, Ali M Ahmed, Uzma D Siddiqui, Dennis Chen, Moamen Gabr, Andrew Y Wang","doi":"10.1055/a-2683-9906","DOIUrl":"10.1055/a-2683-9906","url":null,"abstract":"<p><strong>Background and study aims: </strong>Data on colorectal endoscopic mucosal resection (C-EMR) training during advanced endoscopy fellowship remain limited. We aimed to determine the number of procedures required by an \"average\" advanced endoscopy trainee (AET) to achieve competence in cognitive and technical C-EMR skills.</p><p><strong>Methods: </strong>AETs from advanced endoscopy training programs (AETPs) were graded on every C-EMR using a standardized assessment tool. Cumulative sum (CUSUM) analysis was used to generate individual and aggregate learning curves to estimate the minimum number of cases required to achieve competence for overall, technical, and cognitive components of C-EMR. AETs completed a self-assessment questionnaire on C-EMR competence at the end of their training.</p><p><strong>Results: </strong>A total of 22 AETs among 16 AETPs participated in this study. Nineteen AETs (86%) reported formal training in C-EMR with a mean number of 32 ± 22 cases prior to their AETP. In aggregate, 637 C-EMRs were performed (median of 32 per AET; interquartile range 17-45). Learning curve analyses revealed substantial variability in minimum volume of procedures needed to attain competence across different C-EMR skills (range: 19-39). A minimum of 19 cases were required to achieve overall competence using the global assessment score. All AETs reported feeling comfortable performing C-EMR independently at the end of AETP, yet only three (14%) achieved competence in their overall performance.</p><p><strong>Conclusions: </strong>The relatively low number of C-EMRs performed by many AETs may be insufficient to achieve competence. The estimated thresholds for an average AET to achieve competence in C-EMR provide a framework for AETPs in determining the minimal standards for case volume exposure during training.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26839906"},"PeriodicalIF":2.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}