IF 2.6 3区医学

eNeuro Pub Date : 2026-09-03 Print Date: 2026-09-01 DOI: 10.1523/ENEURO.0064-26.2026

Benjamin J Seicol, Amelie Valles-Jane, Anna Kohler, Elisabeth Glowatzki, Megan B Wood

{"title":"Machine Learning-Guided Video Analysis Identifies Sound-Evoked Pain-Related Behaviors from Facial Grimace and Body Cues in Mice.","authors":"Benjamin J Seicol, Amelie Valles-Jane, Anna Kohler, Elisabeth Glowatzki, Megan B Wood","doi":"10.1523/ENEURO.0064-26.2026","DOIUrl":"10.1523/ENEURO.0064-26.2026","url":null,"abstract":"Humans can experience sound-evoked pain, either from extremely loud sounds or in cases of pain hyperacusis from typically tolerable sounds. However, the mechanisms underlying sound-evoked pain remain poorly understood. Developing behavioral methods to measure sound-evoked pain in animal models is critical for elucidating these mechanisms. Here, a machine learning-based approach was developed to measure sound-evoked pain in freely moving mice of both sexes by analyzing facial grimace and body position from video recordings during sound exposure. Facial grimace, a commonly used method to detect pain in mice, and body position, which can be used to measure postural and movement changes that also indicate pain, were both quantified using a deep neural network model trained to extract established facial and body features from video recorded by a single camera. To validate the model's capability to detect pain, a known painful state, migraine induced by the injection of the neuropeptide calcitonin gene-related peptide (CGRP), was used. Using this machine learning-based approach, the ability to quantify a pain response from CGRP-induced migraine, distinct from baseline behavior, was demonstrated, resulting in a defined pain threshold. Sound exposures at high intensities elicited significant changes in facial grimace and body position, in comparison, surpassing the pain threshold calculated from CGRP-induced migraine. These behavioral changes were absent in Tmie-knock-out mice, which lack functional sound transduction in the cochlea. This automated, high-throughput framework enables objective and sensitive analysis of pain-related behavior providing a foundation for future studies investigating the peripheral and central mechanisms of sound-evoked pain.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct Roles of Directional and Positional Experience in De Novo Visuomotor Learning. 定向和位置经验在新生视觉运动学习中的独特作用。

IF 2.6 3区医学

eNeuro Pub Date : 2026-09-02 Print Date: 2026-09-01 DOI: 10.1523/ENEURO.0001-26.2026

Tomoya Kawano, Shota Hagio

{"title":"Distinct Roles of Directional and Positional Experience in De Novo Visuomotor Learning.","authors":"Tomoya Kawano, Shota Hagio","doi":"10.1523/ENEURO.0001-26.2026","DOIUrl":"10.1523/ENEURO.0001-26.2026","url":null,"abstract":"Humans can flexibly acquire entirely new sensorimotor mappings, a process known as de novo motor learning. A central challenge in de novo motor learning is that the learner must discover a viable solution from scratch within a highly redundant control space, without predefined task constraints. Understanding what types of sensorimotor information contribute to the formation of accurate motor behavior in such situations is therefore critical for explaining how novel sensorimotor skills are acquired. While previous studies have suggested that novel visuomotor mappings can be formed based on movement direction and target position, it remains unclear how these two types of information contribute to the learning process. To address this question, we trained 25 human participants (13 males and 12 females) to learn arbitrary joystick-to-cursor mapping. We then employed a generalization paradigm to selectively restrict learning experience to either movement direction or target position. Three distinct target conditions were designed: one emphasized target position (P), another emphasized movement direction (D), and a third (P&D) encouraged learning of both components separately. Results showed direction experience reduced initial direction error, whereas the lack of position experience was associated with increased final position error. However, in the P&D condition, combining these experiences did not yield additive generalization. Instead, endpoint accuracy was positively correlated with the alignment between direction- and position-based outputs in the redundant control space. These results suggest that accurate formation of a novel sensorimotor map depends on the coordinated use of directional and positional experiences.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scene Perception-Memory Pairing Extends to the Superior Parietal Cortex. 场景感知-记忆配对延伸至上顶叶皮层。

IF 2.6 3区医学

eNeuro Pub Date : 2026-09-01 DOI: 10.1523/ENEURO.0155-26.2026

Runhan Nicole Tang, Dominika Panek, Leila H Barkoff, Catriona L Scrivener, Edward H Silson, Adam Steel

{"title":"Scene Perception-Memory Pairing Extends to the Superior Parietal Cortex.","authors":"Runhan Nicole Tang, Dominika Panek, Leila H Barkoff, Catriona L Scrivener, Edward H Silson, Adam Steel","doi":"10.1523/ENEURO.0155-26.2026","DOIUrl":"10.1523/ENEURO.0155-26.2026","url":null,"abstract":"Visual scene analysis relies on a set of scene-selective regions in the posterior cerebral cortex (OPA, PPA, MPA), with a paired memory-responsive counterpart located in the anterior (LPMA, VPMA) or overlapping (MPMA) cortex. The interaction between these pairs of regions is thought to integrate visual input with mnemonic context. Recently, a fourth scene perception area in the superior parietal cortex (the superior place area, SPA) was identified, with a proposed role in visually guided navigation. Whether this region also has an anterior paired memory region is currently unknown. Across two independent fMRI datasets (total N = 24, 14 females) using static or dynamic stimuli and distinct memory tasks, we show that recalling visual scenes evokes robust responses in a region immediately anterior and dorsal to SPA (referred to here as the superior place memory area, SPMA). During resting-state fMRI, SPA preferentially coupled with the other scene perception areas, while SPMA preferentially coupled with the other place memory areas. At the whole-brain level, seed-based connectivity revealed that SPA sits at the confluence of four processing streams spanning regions implicated in egocentric scene perception, map-based navigation, perspective taking, and goal-directed movement. These findings extend the perception-memory motif associated with visual scene processing to a fourth cortical surface. The widespread anatomical coupling between scene perception and memory processes reflects the importance of this interaction for flexible, context-grounded navigation.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Corticosterone Administration Induced Affective Disturbances, But Did Not Alter Consolidated Active Avoidance Coping or Neuronal Activation Level, in Male Long-Evans Rats. 在雄性Long-Evans大鼠中，慢性皮质酮管理诱导情感性障碍，但没有改变巩固的主动回避应对或神经元激活水平。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-28 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0085-26.2026

Zhi Hui Kang, Chun-Hui Chang

{"title":"Chronic Corticosterone Administration Induced Affective Disturbances, But Did Not Alter Consolidated Active Avoidance Coping or Neuronal Activation Level, in Male Long-Evans Rats.","authors":"Zhi Hui Kang, Chun-Hui Chang","doi":"10.1523/ENEURO.0085-26.2026","DOIUrl":"10.1523/ENEURO.0085-26.2026","url":null,"abstract":"Stress is a major risk factor for various psychiatric disorders. Activation of the hypothalamic-pituitary-adrenal axis increases cortisol release, whereas prolonged glucocorticoid exposure has been linked to cognitive impairment and mood disorders. In this study, we examined whether chronic corticosterone administration alters emotional states, active coping strategies, and associated neuronal activation in rats. Male Long-Evans rats were trained in a lever-press task to avoid signaled footshocks and then assigned into control or corticosterone-treated groups, with the latter receiving daily corticosterone injections for 21 consecutive days. Afterward, emotional states were assessed using the elevated plus maze (EPM), forced swim test (FST), and sucrose preference test (SPT). Finally, the animals were retested for their active avoidance behavior, while neuronal activation levels in related brain areas were evaluated. Our results showed that chronic corticosterone administration led to decrease in body weight and deteriorated fur condition over time. The stressed rats showed hypolocomotion in EPM but no changes in anxiety-like behavior, increased despair-like behavior in FST, and developed anhedonia in SPT. Despite these emotional alterations, active avoidance performance and freezing behavior were not affected. Consistently, analyses of numbers of c-Fos-positive neurons in the prelimbic cortex, infralimbic cortex, nucleus accumbens core, nucleus accumbens shell, dorsal CA3, and basolateral amygdala did not differ between groups. Together, our results suggested that chronic corticosterone administration induced physical deterioration. These animals were less active and developed behavioral despair and anhedonia, but did not alter their coping strategies to threat-related signals.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13631773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Neural Basis of Avoidance Learning and Its Relation to Safety Processing. 回避学习的神经基础及其与安全加工的关系。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-26 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0170-26.2026

Lieselotte Claes, Patrick A F Laing, Trevor Steward, Kim L Felmingham, Bram Vervliet, Christopher G Davey, Bradford Moffat, Rebecca K Glarin, Ben J Harrison

{"title":"The Neural Basis of Avoidance Learning and Its Relation to Safety Processing.","authors":"Lieselotte Claes, Patrick A F Laing, Trevor Steward, Kim L Felmingham, Bram Vervliet, Christopher G Davey, Bradford Moffat, Rebecca K Glarin, Ben J Harrison","doi":"10.1523/ENEURO.0170-26.2026","DOIUrl":"10.1523/ENEURO.0170-26.2026","url":null,"abstract":"Persistent avoidance plays a major role in maintaining anxiety disorders. The few studies that have explored the neural basis of avoidance have predominantly examined established avoidance behaviors rather than the learning processes that establish avoidance responses. We aimed to characterize the temporal dynamics and neural mechanisms of avoidance learning using a novel paradigm combined with 7 tesla fMRI in 82 healthy participants (37 male and 45 female). Participants were first conditioned to two threat stimuli and a compound safety stimulus. Next, they were trained to avoid one threat stimulus while the other remained unavoidable. Behavioral data confirmed accurate learning of task contingencies. Successful avoidance was associated with prominent activation of the ventromedial prefrontal cortex (vmPFC), posterior cingulate cortex (PCC), and ventrolateral prefrontal cortex compared with unsuccessful avoidance, with additional nucleus accumbens and orbitofrontal cortex engagement when compared with safety learning (P FDR whole-brain corrected). Critically, early compared with late avoidance learning was distinctly associated with activation of midbrain-striatal circuits, including the periaqueductal gray (PAG), mediodorsal thalamus, substantia nigra, and anterior insular cortex-regions associated with threat processing and learning-related signaling. These findings suggest that initial avoidance learning relies on subcortical threat-responsive and learning-related circuits, whereas established avoidance responses engage cortical safety-processing regions. This dissociation parallels recent findings in safety learning and provides novel mechanistic insights for interventions targeting maladaptive avoidance patterns.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lhx2 Regulates Distinct Dendritic Architecture of Pyramidal Neurons across Primary Sensory Areas. Lhx2调节主要感觉区锥体神经元的树突结构。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-26 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0103-26.2026

Achintya Srivastava, Deyl S Djama, Dipanjana Banerjee, Shubha Tole, Leena Ali Ibrahim

{"title":"Lhx2 Regulates Distinct Dendritic Architecture of Pyramidal Neurons across Primary Sensory Areas.","authors":"Achintya Srivastava, Deyl S Djama, Dipanjana Banerjee, Shubha Tole, Leena Ali Ibrahim","doi":"10.1523/ENEURO.0103-26.2026","DOIUrl":"10.1523/ENEURO.0103-26.2026","url":null,"abstract":"Distinct neocortical regions subserve different sensory functions, yet the cellular features that distinguish neurons across cortical areas remain poorly understood. Layer (L)2/3 pyramidal neurons (PyNs) are generated at similar developmental times throughout the cortex, but whether their morphological and functional properties are shaped by areal identity programs is unclear. Here, we compared L2/3 PyNs in mouse primary somatosensory (S1) and primary visual (V1) cortices (both male and female). We observed pronounced areal differences where V1 neurons exhibited smaller and less complex dendritic arbors and displayed increased intrinsic excitability relative to their counterparts in S1. These differences were present in both juvenile and adult stages, indicating that they emerge early and persist over time. Given prior evidence implicating the transcription factor LHX2 in dendritic arborization, we tested its contribution to these differences. Loss of Lhx2 in E15.5 V1 progenitors did not alter neuronal morphology in V1, in contrast to our previous findings in S1. We found that E15.5 progenitors display lower levels of LHX2 protein in V1 than in S1; therefore, we overexpressed Lhx2 in V1 progenitors and found increased dendritic branching complexity in V1 L2/3 PyNs. Together, these findings identify LHX2 as a molecular regulator that contributes to area-specific structural differentiation of L2/3 PyNs. Our results show that PyNs arising from different regions of the dorsal pallium diverge in morphology and physiology according to the cortical area, suggesting that regionally patterned transcriptional programs help establish functional specialization across the neocortex.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippocampal Gene Expression in Zebra Finches Reveals Sex- and Subregion-Specific Topographies. 斑胸草雀海马基因表达揭示了性别和亚区域特异性地形。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0121-26.2026

Alexander C Taylor, Chinweike N Asogwa, Changjiu Zhao, Farrah N Madison

{"title":"Hippocampal Gene Expression in Zebra Finches Reveals Sex- and Subregion-Specific Topographies.","authors":"Alexander C Taylor, Chinweike N Asogwa, Changjiu Zhao, Farrah N Madison","doi":"10.1523/ENEURO.0121-26.2026","DOIUrl":"10.1523/ENEURO.0121-26.2026","url":null,"abstract":"The hippocampus is a highly evolutionarily conserved brain region that supports spatial memory, stress responses, and social behavior across vertebrates. While mammalian hippocampal transcriptomics have been extensively characterized, comparative data from the avian hippocampus remain limited. Using RNA sequencing, we characterized hippocampal gene expression in zebra finches (Taeniopygia guttata) across sex, rostral-caudal subregions, and acute social conditions (Paired, Separated, Unpaired). Although acute social conditions produced only modest transcriptional effects, with 32 differentially expressed genes (DEGs) reaching significance, robust differential gene expression emerged across sex (2,148 DEGs) and rostral-caudal subregion (2,259 DEGs). Notably, 28% of sex-biased DEGs mapped to the Z chromosome, consistent with incomplete dosage compensation in the avian brain. Gene Ontology enrichment across sex highlighted SMAD signaling and transforming growth factor beta (TGF-β)/activin pathway regulation as repeated organizational features of the zebra finch hippocampal transcriptome. Region-specific DEGs converged on themes of membrane excitability and synaptic plasticity, while social condition effects were sex- and subregion-specific, with females demonstrating a more pronounced transcriptional response to pair bonding and mate separation than males, particularly in the caudal hippocampus. These findings establish a foundational molecular reference for the zebra finch hippocampus and position the songbird as a comparative model for investigating how sex, neuroanatomical subregion, and social context interact at the molecular level to shape hippocampal function across vertebrates.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148600794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0362-25.2026

Matthew J Kourakis, Yishen Miao, Erin D Newman-Smith, Kerrianne Ryan, William C Smith

{"title":"Similarities between Ciona Dorsal Motor Ganglion and Vertebrate Cerebellum: Did a Chordate Ancestor Already Show D/V Subdivision within a Hindbrain Precursor?","authors":"Matthew J Kourakis, Yishen Miao, Erin D Newman-Smith, Kerrianne Ryan, William C Smith","doi":"10.1523/ENEURO.0362-25.2026","DOIUrl":"10.1523/ENEURO.0362-25.2026","url":null,"abstract":"The cerebellum, a major structure of the vertebrate central nervous system, forms the dorsal region of the hindbrain. While evidence from connectomics, neuron classification, and gene expression analyses suggests that the major CNS divisions of forebrain, midbrain, hindbrain, and spinal cord predate the vertebrate/tunicate divergence, it is unknown if the subdivision of the hindbrain into a cerebellum, or cerebellum precursor structure, does as well. In fact, conflicting views exist over whether even the most basal vertebrates, the cyclostomes, have a cerebellum homolog. We report here that the motor ganglion (MG), a structure that has been homologized to the vertebrate hindbrain in the chordate Ciona (a tunicate), has functionally distinct dorsal and ventral domains, similar to the generalized hindbrain of vertebrates. In Ciona, the dorsal MG functions as an ascending relay and processing center for peripheral sensory neurons, while the ventral domain processes and relays descending sensorimotor commands. These differences are reflected in distinct neuron classes present in the two domains, as well as in gene expression. While the dorsal MG of Ciona and HB of vertebrates differ in function and complexity, they share a number of similarities. Thus, while it is likely that the cerebellum proper evolved within vertebrates, our findings support the hypothesis that a simpler, dorsally positioned antecedent was present before the tunicate-vertebrate divergence.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":"13 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13509005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats. 大鼠高通量空间导航测试的并行自动化系统。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0415-25.2026

Violet T Saathoff, Josiah A Quinn, Zhana D Prince, Charles I O'Leary, Anna K Gillespie

{"title":"A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.","authors":"Violet T Saathoff, Josiah A Quinn, Zhana D Prince, Charles I O'Leary, Anna K Gillespie","doi":"10.1523/ENEURO.0415-25.2026","DOIUrl":"10.1523/ENEURO.0415-25.2026","url":null,"abstract":"Spatial navigation tasks for rodents have been an extremely useful tool for studying cognitive processes for decades but are often laborious to administer and sensitive to experimenter-induced variability. To address these limitations, we have developed a parallelized maze system which runs four highly flexible maze environments simultaneously with automated reward delivery, enabling reduced experimenter involvement, increased throughput, and streamlined data collection. Further, our software tracks subject performance and manages the progression through a preset curriculum as subjects learn, reducing experimenter error and ensuring comparable learning curves across cohorts. Equipped with IR beam break-based reward ports, peristaltic pumps for liquid reward delivery, and overhead video tracking, our current maze accessories can be flexibly reconfigured to enable a vast array of behavioral tasks and support a wide range of experimental questions. Pilot cohorts of young (4-8 months) and aged (28-32 months) male and female rats demonstrate that this apparatus enables the efficient training of a series of increasingly difficult visually cued and memory-dependent spatial navigation task variants across a wide range of performance abilities.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Platelet-Derived Growth Factor B-Modified Nanoparticles in Enhancing Pericyte Activation for Acute Ischemic Stroke. 血小板衍生生长因子- b修饰纳米颗粒增强急性缺血性卒中周细胞活化的治疗潜力。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0404-25.2026

Satoshi Karashima, Koichi Arimura, Ryusuke Hatae, Soh Takagishi, Sayoko Narahara, Takahito Kawano, Shunya Tanaka, Ryota Kurogi, Akira Nakamizo, Masaharu Murata, Koji Yoshimoto

{"title":"Therapeutic Potential of Platelet-Derived Growth Factor B-Modified Nanoparticles in Enhancing Pericyte Activation for Acute Ischemic Stroke.","authors":"Satoshi Karashima, Koichi Arimura, Ryusuke Hatae, Soh Takagishi, Sayoko Narahara, Takahito Kawano, Shunya Tanaka, Ryota Kurogi, Akira Nakamizo, Masaharu Murata, Koji Yoshimoto","doi":"10.1523/ENEURO.0404-25.2026","DOIUrl":"10.1523/ENEURO.0404-25.2026","url":null,"abstract":"Platelet-derived growth factor subunit B (PDGF-B) signaling plays a critical role in pericyte activation and neurovascular repair following ischemic injury. Although enhancing PDGF-B signaling in pericytes represents a promising therapeutic strategy for ischemic stroke, practical approaches have not yet been developed. In this study, we evaluated the therapeutic efficacy and underlying mechanisms of PDGF-B-modified heat shock protein nanoparticles (PDGF-B HSPNPs) in a transient middle cerebral artery occlusion mouse model of either sex. Mice were treated with single intravenous injection of PDGF-B HSPNPs immediately after reperfusion, and infarct volume and motor function were assessed. To investigate cellular effects, flow cytometric analysis of brain-derived single-cell suspensions was performed 3 d after treatment to quantify platelet-derived growth factor receptor β-positive pericytes. Our results demonstrate that PDGF-B HSPNPs administration significantly reduced infarct volume and improved motor function, accompanied by enhanced activation of pericytes in the peri-infarct region. These findings suggest that PDGF-B HSPNPs represent a promising therapeutic approach for the treatment of ischemic stroke.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13509415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148600743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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