eNeuro最新文献_第7页

Temporal Lobectomy Evidence for the Role of the Amygdala in Early Emotional Face and Body Processing.

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-14 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0114-24.2024

Eleanor Moses, Jenna Scambler, Jessica Taubert, Ada H Y Lo, Kate Thompson, Beatrice de Gelder, Alan J Pegna

{"title":"Temporal Lobectomy Evidence for the Role of the Amygdala in Early Emotional Face and Body Processing.","authors":"Eleanor Moses, Jenna Scambler, Jessica Taubert, Ada H Y Lo, Kate Thompson, Beatrice de Gelder, Alan J Pegna","doi":"10.1523/ENEURO.0114-24.2024","DOIUrl":"10.1523/ENEURO.0114-24.2024","url":null,"abstract":"The amygdala is believed to make invaluable contributions to visual emotion processing. Yet how this subcortical body contributes to emotion perception across time is contended. Here, we measured differences in the perceptual processing of emotional stimuli after unilateral temporal lobe and amygdala resection (TLR) in humans, using EEG. Through mass univariate analysis of brain activity, we compared responses to fearful and neutral faces (left TLR N = 8, right TLR N = 8, control N = 8), and fearful and neutral bodies (left TLR N = 9, right TLR N = 9, control N = 9). We found that TLR impaired the early-stage perceptual processing of emotional stimuli seen in the control group. Indeed, in controls a heightened responses to fearful faces was found in the 140-170 ms time window, over temporoparietal electrodes. This effect was also present in the left TLR group but disappeared in the right TLR group. For emotional bodies, brain activity was differentially sensitive to fearful stimuli at 90-120 ms in the control group, but this effect was eliminated in both TLR groups. Collectively, these results reveal the amygdala contributes to the early stages of perceptual processing that discriminate emotional stimuli from neutral stimuli. Further, they emphasize the unique role of the right medial temporal structures such as the amygdala in emotional face perception.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Heterogeneity in Myelin Sheathing Impacts Signaling Reliability and Susceptibility to Injury.

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-14 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0402-24.2025

Afroditi Talidou, Jérémie Lefebvre

{"title":"Spatial Heterogeneity in Myelin Sheathing Impacts Signaling Reliability and Susceptibility to Injury.","authors":"Afroditi Talidou, Jérémie Lefebvre","doi":"10.1523/ENEURO.0402-24.2025","DOIUrl":"10.1523/ENEURO.0402-24.2025","url":null,"abstract":"Axons in the mammalian brain show significant diversity in myelination motifs, displaying spatial heterogeneity in sheathing along individual axons and across brain regions. However, its impact on neural signaling and susceptibility to injury remains poorly understood. To address this, we leveraged cable theory and developed model axons replicating the myelin sheath distributions observed experimentally in different regions of the mouse central nervous system. We examined how the spatial arrangement of myelin affects propagation and predisposition to conduction failure in axons with cortical versus callosal myelination motifs. Our results indicate that regional differences in myelination significantly influence conduction timing and signaling reliability. Sensitivity of action potential propagation to the specific positioning, lengths, and ordering of myelinated and exposed segments reveals non-linear and path-dependent conduction. Furthermore, myelination motifs impact signaling vulnerability to demyelination, with callosal motifs being particularly sensitive to myelin changes. These findings highlight the crucial role of myelinating glia in brain function and disease.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal Properties in the Lateral Habenula and Adult-Newborn Interactions in Virgin Female and Male Mice.

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-14 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0414-24.2025

Cheng-Hsi Wu, Manuel Mameli, Salvatore Lecca

{"title":"Neuronal Properties in the Lateral Habenula and Adult-Newborn Interactions in Virgin Female and Male Mice.","authors":"Cheng-Hsi Wu, Manuel Mameli, Salvatore Lecca","doi":"10.1523/ENEURO.0414-24.2025","DOIUrl":"10.1523/ENEURO.0414-24.2025","url":null,"abstract":"The behavioral interactions between adults and newborns are decisive for the fitness and the survival of offspring across the animal kingdom. In laboratory mice, while virgin females display caregiving behaviors, virgin males are rather neglectful or aggressive toward pups. Despite the importance of these behavioral variations, the underlying neural mechanisms remain poorly understood. Brain regions encoding these behaviors may exhibit sex-dependent functional differences at the baseline. Additionally, these structures might undergo sex-specific plasticity after adults interact with the offspring. Emerging evidence suggests sex-based differences in input connectivity, genetics, and receptor expression of the epithalamic lateral habenula (LHb). Moreover, LHb neuronal activity is instrumental for adult-newborn interactions. However, whether LHb neuronal function varies between sexes and/or undergoes adaptations following interactions with pups has not been fully investigated. In this study, we used in vivo and ex vivo single-cell electrophysiology to examine the basal LHb neuronal activity of virgin female and male mice. In a second set of experiments, we exposed mice to pups and recapitulated sex-based divergent behaviors. Recordings in acute slices showed no alterations in LHb firing properties, regardless of sex or pup exposure. These findings suggest that, although the LHb participates in adult behaviors toward pups, this is not mediated by sex-dependent functional differences or adaptations in the neuronal firing properties. Thus, this study provides new insights into the neural basis of sex-specific adult-newborn behaviors and the role of the LHb in these processes.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Connectivity of the Scene Processing Network at Rest Does Not Reliably Predict Human Behavior on Scene Processing Tasks.

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-12 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0375-24.2024

David M Watson, Timothy J Andrews

{"title":"Functional Connectivity of the Scene Processing Network at Rest Does Not Reliably Predict Human Behavior on Scene Processing Tasks.","authors":"David M Watson, Timothy J Andrews","doi":"10.1523/ENEURO.0375-24.2024","DOIUrl":"10.1523/ENEURO.0375-24.2024","url":null,"abstract":"The perception of scenes is associated with processing in a network of scene-selective regions in the human brain. Prior research has identified a posterior-anterior bias within this network. Posterior scene regions exhibit preferential connectivity with early visual and posterior parietal regions, indicating a role in representing egocentric visual features. In contrast, anterior scene regions demonstrate stronger connectivity with frontoparietal control and default mode networks, suggesting a role in mnemonic processing of locations. Despite these findings, evidence linking connectivity in these regions to cognitive scene processing remains limited. In this preregistered study, we obtained cognitive behavioral measures alongside resting-state fMRI data from a large-scale public dataset to investigate interindividual variation in scene processing abilities relative to the functional connectivity of the scene network. Our results revealed substantial individual differences in scene recognition, spatial memory, and navigational abilities. Resting-state functional connectivity reproduced the posterior-anterior bias within the scene network. However, contrary to our preregistered hypothesis, we did not observe any consistent associations between interindividual variation in this connectivity and behavioral performance. These findings highlight the need for further research to clarify the role of these connections in scene processing, potentially through assessments of functional connectivity during scene-relevant tasks or in naturalistic conditions.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11820959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FAST: Fast, Free, Consistent, and Unsupervised Oligodendrocyte Segmentation and Tracking System. FAST：快速，免费，一致，无监督少突胶质细胞分割和跟踪系统。

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-12 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0025-24.2024

Eunchan Bae, Gregory E Perrin, Virgilio Gonzenbach, Jennifer L Orthmann-Murphy, Russell T Shinohara

{"title":"FAST: Fast, Free, Consistent, and Unsupervised Oligodendrocyte Segmentation and Tracking System.","authors":"Eunchan Bae, Gregory E Perrin, Virgilio Gonzenbach, Jennifer L Orthmann-Murphy, Russell T Shinohara","doi":"10.1523/ENEURO.0025-24.2024","DOIUrl":"10.1523/ENEURO.0025-24.2024","url":null,"abstract":"To develop reparative therapies for neurological disorders like multiple sclerosis (MS), we need to better understand the physiology of loss and replacement of oligodendrocytes, the cells that make myelin and are the target of damage in MS. In vivo two-photon fluorescence microscopy allows direct visualization of oligodendrocytes in the intact brain of transgenic mouse models, promising a deeper understanding of the longitudinal dynamics of replacing oligodendrocytes after damage. However, the task of tracking the fate of individual oligodendrocytes requires extensive effort for manual annotation and is especially challenging in three-dimensional images. While several models exist for annotating cells in two-dimensional images, few models exist to annotate cells in three-dimensional images and even fewer are designed for tracking cells in longitudinal imaging. Notably, existing options often come with a substantial financial investment, being predominantly commercial or confined to proprietary software. Furthermore, the complexity of processes and myelin formed by individual oligodendrocytes can result in the failure of algorithms that are specifically designed for tracking cell bodies alone. Here, we propose a fast, free, consistent, and unsupervised beta-mixture oligodendrocyte segmentation system (FAST) that is written in open-source software, and can segment and track oligodendrocytes in three-dimensional images over time with minimal human input. We showed that the FAST model can segment and track oligodendrocytes similarly to a blinded human observer. Although FAST was developed to apply to our studies on oligodendrocytes, we anticipate that it can be modified to study four-dimensional in vivo data of any brain cell with associated complex processes.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11820958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth Hormone Alters Remapping in the Hippocampal Area CA1 in a Novel Environment.

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-11 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0237-24.2024

Kamilla G Haugland, Sondre Valentin Jordbræk, Erik Knutsen, Kirsten B Kjelstrup, Vegard H Brun

{"title":"Growth Hormone Alters Remapping in the Hippocampal Area CA1 in a Novel Environment.","authors":"Kamilla G Haugland, Sondre Valentin Jordbræk, Erik Knutsen, Kirsten B Kjelstrup, Vegard H Brun","doi":"10.1523/ENEURO.0237-24.2024","DOIUrl":"10.1523/ENEURO.0237-24.2024","url":null,"abstract":"Growth hormone (GH) is a neuromodulator that binds to receptors in the hippocampus and alters synaptic plasticity. A decline in GH levels is associated with normal aging, stress, and disease, and the mechanisms proposed involve the hippocampal circuit plasticity. To see how GH affects the hippocampal neural code, we recorded single neurons in the CA1 region of male Long-Evans rats with locally altered GH levels. Rats received injections of adeno-associated viruses into the hippocampus to make the cells overexpress either GH or an antagonizing mutated GH (aGH). Place cells were recorded in both familiar and novel environments to allow the assessment of pattern separation in the neural representations termed remapping. All the animals showed intact and stable place fields in the familiar environment. In the novel environment, aGH transfection increased the average firing rate, peak rate, and information density of the CA1 place fields. The tendency of global remapping increased in the GH animals compared with the controls, and only place cells of control animals showed significant rate remapping. Our results suggest that GH increases hippocampal sensitivity to novel information. Our findings show that GH is a significant neuromodulator in the hippocampus affecting how place cells represent the environment. These results could help us to understand the mechanisms behind memory impairments in GH deficiency as well as in normal aging.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Targeted Memory Reactivation on Dogs' Visuospatial Memory.

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-11 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0304-20.2024

Henrietta Bolló, Cecília Carreiro, Ivaylo Borislavov Iotchev, Ferenc Gombos, Márta Gácsi, József Topál, Anna Kis

{"title":"The Effect of Targeted Memory Reactivation on Dogs' Visuospatial Memory.","authors":"Henrietta Bolló, Cecília Carreiro, Ivaylo Borislavov Iotchev, Ferenc Gombos, Márta Gácsi, József Topál, Anna Kis","doi":"10.1523/ENEURO.0304-20.2024","DOIUrl":"10.1523/ENEURO.0304-20.2024","url":null,"abstract":"The role of sleep in memory consolidation is a widely discussed but still debated area of research. In light of the fact that memory consolidation during sleep is an evolutionary adaptive function, investigating the same phenomenon in nonhuman model species is highly relevant for its understanding. One such species, which has acquired human-analog sociocognitive skills through convergent evolution, is the domestic dog. Family dogs have surfaced as an outstanding animal model in sleep research, and their learning skills (in a social context) are subject to sleep-dependent memory consolidation. These results, however, are correlational, and the next challenge is to establish causality. In the present study, we aimed to adapt a TMR (targeted memory reactivation) paradigm in dogs and investigate its effect on sleep parameters. Dogs (N = 16) learned new commands associated with different locations and afterward took part in a sleep polysomnography recording when they were re-exposed to one of the previously learned commands. The results did not indicate a cueing benefit on choice performance. However, there was evidence for a decrease in choice latency after sleep, while the density (occurrence/minute) of fast sleep spindles was also notably higher during TMR recordings than adaptation recordings from the same animals and even compared with a larger reference sample from a previous work. Our study provides empirical evidence that TMR is feasible with family dogs, even during a daytime nap. Furthermore, the present study highlights several methodological and conceptual challenges for future research.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":"12 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extended Cognitive Load Induces Fast Neural Responses Leading to Commission Errors.

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-10 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0354-24.2024

Fabio Taddeini, Giulia Avvenuti, Alberto Arturo Vergani, Jacopo Carpaneto, Francesca Setti, Damiana Bergamo, Linda Fiorini, Pietro Pietrini, Emiliano Ricciardi, Giulio Bernardi, Alberto Mazzoni

{"title":"Extended Cognitive Load Induces Fast Neural Responses Leading to Commission Errors.","authors":"Fabio Taddeini, Giulia Avvenuti, Alberto Arturo Vergani, Jacopo Carpaneto, Francesca Setti, Damiana Bergamo, Linda Fiorini, Pietro Pietrini, Emiliano Ricciardi, Giulio Bernardi, Alberto Mazzoni","doi":"10.1523/ENEURO.0354-24.2024","DOIUrl":"10.1523/ENEURO.0354-24.2024","url":null,"abstract":"Extended performance of cognitively demanding tasks induces cognitive fatigue manifested with an overall deterioration of behavioral performance. In particular, long practice with tasks requiring impulse control is typically followed by a decrease in self-control efficiency, leading to performance instability. Here, we show that this is due to changes in activation modalities of key task-related areas occurring if these areas previously underwent intensive use. We investigated in 25 healthy adults the effects of extended practice with high cognitive demand (HCD) tasks on a Go-No Go task and the underlying electroencephalographic (EEG) activity. We compared these effects with those induced by practice with similar, but low cognitive demand (LCD) tasks. HCD tasks were followed by an increase in response inhibition failures. These were correlated with the appearance of a distinct neural signature on fast response trials, characterized by lower levels of beta ([13-30] Hz) EEG activity in the prestimulus period, and by a lack of EEG markers of preresponse processing in frontal areas. Moreover, HCD tasks were followed by a decrease in N200 during correct withholds while LCD tasks were followed instead by a lesser fraction of hits and a decrease in P300, suggesting a decrease in engagement. Overall, these results show that exertion of cognitive control determines the appearance of two distinct modalities of response with different processing speeds, associated with distinct underlying neural activity.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gamma and Theta/Alpha-Band Oscillations in the Electroencephalogram Distinguish the Content of Inner Speech.

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-10 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0297-24.2025

Thomas J Whitford, Kevin M Spencer, Marianthe Godwin, Yoji Hirano, Lawrence Kin-Hei Chung, Wadim Vodovozov, Oren Griffiths, Anthony W F Harris, Mike E Le Pelley, Bradley N Jack

{"title":"Gamma and Theta/Alpha-Band Oscillations in the Electroencephalogram Distinguish the Content of Inner Speech.","authors":"Thomas J Whitford, Kevin M Spencer, Marianthe Godwin, Yoji Hirano, Lawrence Kin-Hei Chung, Wadim Vodovozov, Oren Griffiths, Anthony W F Harris, Mike E Le Pelley, Bradley N Jack","doi":"10.1523/ENEURO.0297-24.2025","DOIUrl":"10.1523/ENEURO.0297-24.2025","url":null,"abstract":"Inner speech refers to the silent production of language in one's mind. As a purely mental action without obvious physical manifestations, inner speech has been notoriously difficult to quantify. To address this issue, the present study repurposed the phenomenon of speaking-induced suppression, wherein overt speech has been consistently shown to elicit reduced auditory evoked potentials compared with externally generated speech, as well as changes in oscillatory activity in gamma and theta frequency bands. Given the functional similarities between inner and overt speech, we used an established experimental protocol to investigate whether similar metrics could be used to distinguish the content of inner speech. Healthy participants (n = 129) produced an inner syllable at a precisely specified time. An audible syllable was concurrently presented which either matched or mismatched the content of the inner syllable. The results revealed that Match and Mismatch conditions could be differentiated on the basis of their evoked oscillations in the gamma, theta, and alpha bands. Notably, there was a gamma-band oscillation in the vicinity of the P2 that differed between the Match and Mismatch conditions, suggesting that \"late\" gamma-band activity may index consciously perceived expectancy violations, or cognitive prediction errors. Regarding the auditory evoked potentials, the N1 component was suppressed in the Match condition while the P2 component was suppressed in the Mismatch condition, replicating previous findings. This study provides support for the existence of \"inner speaking-induced suppression\", and demonstrates that inner syllables can be differentiated based on their influence on the electroencephalographic activity elicited by simultaneously-presented audible syllables.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical HFS-Induced Neo-Hebbian Local Plasticity Enhances Efferent Output Signal and Strengthens Afferent Input Connectivity. hfs诱导的皮层neo-Hebbian局部可塑性增强了传入输出信号，增强了传入输入连通性。

IF 2.7 3区医学

eNeuro Pub Date : 2025-02-10 Print Date: 2025-02-01 DOI: 10.1523/ENEURO.0045-24.2024

Xiao Li, Xue Wang, Xiaohan Hu, Peng Tang, Congping Chen, Ling He, Mengying Chen, Stephen Temitayo Bello, Tao Chen, Xiaoyu Wang, Yin Ting Wong, Wenjian Sun, Xi Chen, Jianan Qu, Jufang He

{"title":"Cortical HFS-Induced Neo-Hebbian Local Plasticity Enhances Efferent Output Signal and Strengthens Afferent Input Connectivity.","authors":"Xiao Li, Xue Wang, Xiaohan Hu, Peng Tang, Congping Chen, Ling He, Mengying Chen, Stephen Temitayo Bello, Tao Chen, Xiaoyu Wang, Yin Ting Wong, Wenjian Sun, Xi Chen, Jianan Qu, Jufang He","doi":"10.1523/ENEURO.0045-24.2024","DOIUrl":"10.1523/ENEURO.0045-24.2024","url":null,"abstract":"High-frequency stimulation (HFS)-induced long-term potentiation (LTP) is generally regarded as a homosynaptic Hebbian-type LTP, where synaptic changes are thought to occur at the synapses that project from the stimulation site and terminate onto the neurons at the recording site. In this study, we first investigated HFS-induced LTP on urethane-anesthetized rats and found that cortical HFS enhances neural responses at the recording site through the strengthening of local connectivity with nearby neurons at the stimulation site rather than through synaptic strengthening at the recording site. This enhanced local connectivity at the stimulation site leads to increased output propagation, resulting in signal potentiation at the recording site. Additionally, we discovered that HFS can also nonspecifically strengthen distant afferent synapses at the HFS site, thereby expanding its impact beyond local neural connections. This form of plasticity exhibits a neo-Hebbian characteristic as it exclusively manifests in the presence of cholecystokinin release, induced by HFS. The cortical HFS-induced local LTP was further supported by a behavioral task, providing additional evidence. Our results unveil a previously overlooked mechanism underlying cortical plasticity: synaptic plasticity is more likely to occur around the soma site of strongly activated cortical neurons rather than solely at their projection terminals.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0