IF 2.6 3区医学

eNeuro Pub Date : 2026-08-26 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0103-26.2026

Achintya Srivastava, Deyl S Djama, Dipanjana Banerjee, Shubha Tole, Leena Ali Ibrahim

{"title":"Lhx2 Regulates Distinct Dendritic Architecture of Pyramidal Neurons across Primary Sensory Areas.","authors":"Achintya Srivastava, Deyl S Djama, Dipanjana Banerjee, Shubha Tole, Leena Ali Ibrahim","doi":"10.1523/ENEURO.0103-26.2026","DOIUrl":"10.1523/ENEURO.0103-26.2026","url":null,"abstract":"Distinct neocortical regions subserve different sensory functions, yet the cellular features that distinguish neurons across cortical areas remain poorly understood. Layer (L)2/3 pyramidal neurons (PyNs) are generated at similar developmental times throughout the cortex, but whether their morphological and functional properties are shaped by areal identity programs is unclear. Here, we compared L2/3 PyNs in mouse primary somatosensory (S1) and primary visual (V1) cortices (both male and female). We observed pronounced areal differences where V1 neurons exhibited smaller and less complex dendritic arbors and displayed increased intrinsic excitability relative to their counterparts in S1. These differences were present in both juvenile and adult stages, indicating that they emerge early and persist over time. Given prior evidence implicating the transcription factor LHX2 in dendritic arborization, we tested its contribution to these differences. Loss of Lhx2 in E15.5 V1 progenitors did not alter neuronal morphology in V1, in contrast to our previous findings in S1. We found that E15.5 progenitors display lower levels of LHX2 protein in V1 than in S1; therefore, we overexpressed Lhx2 in V1 progenitors and found increased dendritic branching complexity in V1 L2/3 PyNs. Together, these findings identify LHX2 as a molecular regulator that contributes to area-specific structural differentiation of L2/3 PyNs. Our results show that PyNs arising from different regions of the dorsal pallium diverge in morphology and physiology according to the cortical area, suggesting that regionally patterned transcriptional programs help establish functional specialization across the neocortex.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippocampal Gene Expression in Zebra Finches Reveals Sex- and Subregion-Specific Topographies. 斑胸草雀海马基因表达揭示了性别和亚区域特异性地形。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0121-26.2026

Alexander C Taylor, Chinweike N Asogwa, Changjiu Zhao, Farrah N Madison

{"title":"Hippocampal Gene Expression in Zebra Finches Reveals Sex- and Subregion-Specific Topographies.","authors":"Alexander C Taylor, Chinweike N Asogwa, Changjiu Zhao, Farrah N Madison","doi":"10.1523/ENEURO.0121-26.2026","DOIUrl":"10.1523/ENEURO.0121-26.2026","url":null,"abstract":"The hippocampus is a highly evolutionarily conserved brain region that supports spatial memory, stress responses, and social behavior across vertebrates. While mammalian hippocampal transcriptomics have been extensively characterized, comparative data from the avian hippocampus remain limited. Using RNA sequencing, we characterized hippocampal gene expression in zebra finches (Taeniopygia guttata) across sex, rostral-caudal subregions, and acute social conditions (Paired, Separated, Unpaired). Although acute social conditions produced only modest transcriptional effects, with 32 differentially expressed genes (DEGs) reaching significance, robust differential gene expression emerged across sex (2,148 DEGs) and rostral-caudal subregion (2,259 DEGs). Notably, 28% of sex-biased DEGs mapped to the Z chromosome, consistent with incomplete dosage compensation in the avian brain. Gene Ontology enrichment across sex highlighted SMAD signaling and transforming growth factor beta (TGF-β)/activin pathway regulation as repeated organizational features of the zebra finch hippocampal transcriptome. Region-specific DEGs converged on themes of membrane excitability and synaptic plasticity, while social condition effects were sex- and subregion-specific, with females demonstrating a more pronounced transcriptional response to pair bonding and mate separation than males, particularly in the caudal hippocampus. These findings establish a foundational molecular reference for the zebra finch hippocampus and position the songbird as a comparative model for investigating how sex, neuroanatomical subregion, and social context interact at the molecular level to shape hippocampal function across vertebrates.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148600794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0362-25.2026

Matthew J Kourakis, Yishen Miao, Erin D Newman-Smith, Kerrianne Ryan, William C Smith

{"title":"Similarities between Ciona Dorsal Motor Ganglion and Vertebrate Cerebellum: Did a Chordate Ancestor Already Show D/V Subdivision within a Hindbrain Precursor?","authors":"Matthew J Kourakis, Yishen Miao, Erin D Newman-Smith, Kerrianne Ryan, William C Smith","doi":"10.1523/ENEURO.0362-25.2026","DOIUrl":"10.1523/ENEURO.0362-25.2026","url":null,"abstract":"The cerebellum, a major structure of the vertebrate central nervous system, forms the dorsal region of the hindbrain. While evidence from connectomics, neuron classification, and gene expression analyses suggests that the major CNS divisions of forebrain, midbrain, hindbrain, and spinal cord predate the vertebrate/tunicate divergence, it is unknown if the subdivision of the hindbrain into a cerebellum, or cerebellum precursor structure, does as well. In fact, conflicting views exist over whether even the most basal vertebrates, the cyclostomes, have a cerebellum homolog. We report here that the motor ganglion (MG), a structure that has been homologized to the vertebrate hindbrain in the chordate Ciona (a tunicate), has functionally distinct dorsal and ventral domains, similar to the generalized hindbrain of vertebrates. In Ciona, the dorsal MG functions as an ascending relay and processing center for peripheral sensory neurons, while the ventral domain processes and relays descending sensorimotor commands. These differences are reflected in distinct neuron classes present in the two domains, as well as in gene expression. While the dorsal MG of Ciona and HB of vertebrates differ in function and complexity, they share a number of similarities. Thus, while it is likely that the cerebellum proper evolved within vertebrates, our findings support the hypothesis that a simpler, dorsally positioned antecedent was present before the tunicate-vertebrate divergence.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":"13 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13509005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats. 大鼠高通量空间导航测试的并行自动化系统。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0415-25.2026

Violet T Saathoff, Josiah A Quinn, Zhana D Prince, Charles I O'Leary, Anna K Gillespie

{"title":"A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.","authors":"Violet T Saathoff, Josiah A Quinn, Zhana D Prince, Charles I O'Leary, Anna K Gillespie","doi":"10.1523/ENEURO.0415-25.2026","DOIUrl":"10.1523/ENEURO.0415-25.2026","url":null,"abstract":"Spatial navigation tasks for rodents have been an extremely useful tool for studying cognitive processes for decades but are often laborious to administer and sensitive to experimenter-induced variability. To address these limitations, we have developed a parallelized maze system which runs four highly flexible maze environments simultaneously with automated reward delivery, enabling reduced experimenter involvement, increased throughput, and streamlined data collection. Further, our software tracks subject performance and manages the progression through a preset curriculum as subjects learn, reducing experimenter error and ensuring comparable learning curves across cohorts. Equipped with IR beam break-based reward ports, peristaltic pumps for liquid reward delivery, and overhead video tracking, our current maze accessories can be flexibly reconfigured to enable a vast array of behavioral tasks and support a wide range of experimental questions. Pilot cohorts of young (4-8 months) and aged (28-32 months) male and female rats demonstrate that this apparatus enables the efficient training of a series of increasingly difficult visually cued and memory-dependent spatial navigation task variants across a wide range of performance abilities.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Platelet-Derived Growth Factor B-Modified Nanoparticles in Enhancing Pericyte Activation for Acute Ischemic Stroke. 血小板衍生生长因子- b修饰纳米颗粒增强急性缺血性卒中周细胞活化的治疗潜力。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0404-25.2026

Satoshi Karashima, Koichi Arimura, Ryusuke Hatae, Soh Takagishi, Sayoko Narahara, Takahito Kawano, Shunya Tanaka, Ryota Kurogi, Akira Nakamizo, Masaharu Murata, Koji Yoshimoto

{"title":"Therapeutic Potential of Platelet-Derived Growth Factor B-Modified Nanoparticles in Enhancing Pericyte Activation for Acute Ischemic Stroke.","authors":"Satoshi Karashima, Koichi Arimura, Ryusuke Hatae, Soh Takagishi, Sayoko Narahara, Takahito Kawano, Shunya Tanaka, Ryota Kurogi, Akira Nakamizo, Masaharu Murata, Koji Yoshimoto","doi":"10.1523/ENEURO.0404-25.2026","DOIUrl":"10.1523/ENEURO.0404-25.2026","url":null,"abstract":"Platelet-derived growth factor subunit B (PDGF-B) signaling plays a critical role in pericyte activation and neurovascular repair following ischemic injury. Although enhancing PDGF-B signaling in pericytes represents a promising therapeutic strategy for ischemic stroke, practical approaches have not yet been developed. In this study, we evaluated the therapeutic efficacy and underlying mechanisms of PDGF-B-modified heat shock protein nanoparticles (PDGF-B HSPNPs) in a transient middle cerebral artery occlusion mouse model of either sex. Mice were treated with single intravenous injection of PDGF-B HSPNPs immediately after reperfusion, and infarct volume and motor function were assessed. To investigate cellular effects, flow cytometric analysis of brain-derived single-cell suspensions was performed 3 d after treatment to quantify platelet-derived growth factor receptor β-positive pericytes. Our results demonstrate that PDGF-B HSPNPs administration significantly reduced infarct volume and improved motor function, accompanied by enhanced activation of pericytes in the peri-infarct region. These findings suggest that PDGF-B HSPNPs represent a promising therapeutic approach for the treatment of ischemic stroke.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13509415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148600743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive Transcranial Magnetic Stimulation over Right PMd Does Not Affect the Stability of Rhythmic Bimanual Finger Movements. 反复经颅磁刺激右PMd不影响有节奏的双手手指运动的稳定性。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0026-26.2026

Ronan Denyer, Anjana Rajendran, Cristina Rubino, Lara A Boyd

{"title":"Repetitive Transcranial Magnetic Stimulation over Right PMd Does Not Affect the Stability of Rhythmic Bimanual Finger Movements.","authors":"Ronan Denyer, Anjana Rajendran, Cristina Rubino, Lara A Boyd","doi":"10.1523/ENEURO.0026-26.2026","DOIUrl":"10.1523/ENEURO.0026-26.2026","url":null,"abstract":"How the brain controls rhythmic asymmetric bimanual movements remains an enduring question in neuroscience. Prior research suggests that the right dorsal premotor cortex (PMd) is essential for maintaining asymmetric bimanual rhythmic finger-tapping patterns. However, such findings have not fully accounted for evidence showing that asymmetric movements impose greater cognitive control demands than symmetric ones. Thus, previously observed disruptions following transient disruption of right PMd may reflect impaired cognitive control rather than motor processes specific to asymmetry. To test this, we manipulated cognitive control demands during bimanual tapping by having participants synchronize movements with regularly flickering visual stimuli. Switching from spatially congruent to symbolic cues reduces tapping stability similarly to switching from symmetric to asymmetric patterns, providing a platform to test the cognitive control hypothesis. Right PMd was targeted with 1 Hz repetitive transcranial magnetic stimulation (rTMS) intended to transiently reduce excitability. Participants (15 females, 13 males) completed symmetric and asymmetric tapping tasks across multiple frequencies. Performance was compared with a sham session. Contrary to expectations, rTMS-related alterations in tapping stability and accuracy were not dependent on movement symmetry or cognitive control demands. Instead, no detectable behavioral effect of rTMS was observed under the present stimulation and testing conditions. These results indicate that asymmetric rhythmic tapping can be maintained after rTMS over right PMd, although lacking direct measures of PMd target engagement limits conclusions regarding cortical perturbation effectiveness. Future work incorporating concurrent neural measures can determine the mechanisms underlying this null effect.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":"13 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pretraining for Large-Scale Functional Connectome Fingerprinting Supports Generalization and Transfer Learning in Functional Neuroimaging. 大规模功能连接体指纹识别的预训练支持功能神经成像的泛化和迁移学习。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0370-25.2026

Mattson Ogg, Lindsey Kitchell

{"title":"Pretraining for Large-Scale Functional Connectome Fingerprinting Supports Generalization and Transfer Learning in Functional Neuroimaging.","authors":"Mattson Ogg, Lindsey Kitchell","doi":"10.1523/ENEURO.0370-25.2026","DOIUrl":"10.1523/ENEURO.0370-25.2026","url":null,"abstract":"Functional MRI (fMRI) currently supports a limited application space stemming from modest dataset sizes, large interindividual variability, and heterogeneity among scanning protocols. These constraints have made it difficult for fMRI researchers to take full advantage of modern deep-learning tools that have revolutionized other fields such as NLP, speech transcription, and image recognition. To help address these issues, we scaled up functional connectome fingerprinting as a neural network pretraining task, drawing inspiration from speaker recognition research, to learn a generalizable representation of brain function. This approach achieves strong performance for neural fingerprinting on a previously unseen scale, across multiple public fMRI datasets (individual recognition from held-out scan sessions, 93% on MPI-Leipzig, 94% on NKI-Rockland, 73% on OASIS-3, and 99% on HCP). Performance is maintained even when evaluation scan duration is truncated to <2 min. We show that this representation can also generalize to support accurate neural fingerprinting for completely new datasets and participants of either sex not used in training. Finally, we demonstrate that the representation learned by the network encodes features related to individual variability that partially transfers to new tasks. These results support the development of scalable transfer-learning approaches for future clinical and cognitive neuroimaging applications.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148619117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Generation Neural Mass Models Reproduce Features of Speech Processing. 下一代神经质量模型再现语音处理特征。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0379-25.2026

Andrew Shannon, David Andrew William Barton, Martin Homer, Conor Houghton

{"title":"Next-Generation Neural Mass Models Reproduce Features of Speech Processing.","authors":"Andrew Shannon, David Andrew William Barton, Martin Homer, Conor Houghton","doi":"10.1523/ENEURO.0379-25.2026","DOIUrl":"10.1523/ENEURO.0379-25.2026","url":null,"abstract":"Segregation of speech into syllables is a key step in neural speech processing. It relies on the alignment of neural activity with the rhythmic structure of speech. Two competing hypotheses explain this \"neural speech tracking\", phase-resetting and evoked responses. While phenomenological modeling of these hypotheses has been successful, we still lack understanding of the underlying cortical circuits. To investigate these mechanisms, we evaluate whether a biophysical next-generation neural mass model (NMM) can reproduce several features of neural speech tracking, using phenomenological models of the competing hypotheses as algorithmic baselines. We investigate the models' dynamics with four tests: recreating in silico an EEG experiment that identified a correlation between tracking strength and phoneme sharpness, computing the phase concentration metric, testing the effect of varying syllabic rates, and evaluating the inter event phase coherence (IEPC) across phoneme onsets. While all of the models that we study reproduce the sharpness-tuned rhythmic speech tracking, the evoked model requires a pre-processed acoustic edge impulse stimulus. We demonstrate that the NMM is performing thresholded phase-resetting triggered by sharp onsets in the continuous speech envelope. This produces cross-frequency nested oscillations that qualitatively match an experimentally-observed dual-peak signature in the IEPC. Our results indicate that the biophysical NMM provides a mechanistic bridge between generic oscillatory dynamics in cortical populations and the cognitive computations of speech tracking. Indeed, the nonlinear dynamics of the NMM offer an explanation for how peak-rate event representations in auditory cortex activity arise in response to continuous acoustic input.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Narrowly and Broadly Tuned Peripheral Gustatory Neurons Cooperate to Encode Three Behaviorally Relevant Stimulus Categories. 窄调和宽调外周味觉神经元合作编码三种行为相关的刺激类别。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0306-25.2026

Tao Huang, Robin F Krimm

{"title":"Narrowly and Broadly Tuned Peripheral Gustatory Neurons Cooperate to Encode Three Behaviorally Relevant Stimulus Categories.","authors":"Tao Huang, Robin F Krimm","doi":"10.1523/ENEURO.0306-25.2026","DOIUrl":"10.1523/ENEURO.0306-25.2026","url":null,"abstract":"Peripheral taste neurons vary in tuning breadth; some respond selectively to a single stimulus (narrowly tuned), and others respond to multiple stimuli (broadly tuned). How these differences contribute to taste coding remains unclear. We recorded calcium responses from 280 geniculate ganglion neurons to five or seven taste stimuli in male and female mice. Using five stimuli, 47% of neurons were narrowly tuned, while 53% responded to multiple stimuli. Hierarchical cluster analysis revealed five functional groups with five stimuli and six with seven stimuli, suggesting that the number of clusters is sensitive to the stimulus set rather than representing a fixed number of biologically distinct taste neuron \"types.\" Principal component analysis revealed three stimulus categories: (1) bitter, sour, and nonsodium salts (aversive), (2) sucrose and umami (caloric/appetitive), and (3) sodium salts (sodium-specific). Both narrowly tuned and broadly tuned neurons within a single category contributed to this categorization. In contrast, 40% of the neurons were broadly tuned across categories and did not cluster with specific stimulus types. These cross-category neurons were more likely to exhibit mixture subadditivity-lower than additive responses-suggesting they could have a distinct role in encoding intensity or chemical context. Finally, we show Type II taste bud cells are required for representing these categories and mediating mixture subadditivity between sweet and sour stimuli. These results suggest peripheral gustatory neurons primarily function to categorize taste stimuli into three groups. Furthermore, differing roles for narrowly tuned and broadly tuned neurons may be a key organizing principle of peripheral taste representation.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13631774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strain-Dependent Network Activity Differences Underlie Social Decision-Making in Male Mice. 品系依赖的网络活动差异是雄性小鼠社会决策的基础。

IF 2.6 3区医学

eNeuro Pub Date : 2026-08-24 Print Date: 2026-08-01 DOI: 10.1523/ENEURO.0207-26.2026

Elizabeth Illescas-Huerta, Andrea Villamizar, Meghan Cum, Nancy Padilla-Coreano

{"title":"Strain-Dependent Network Activity Differences Underlie Social Decision-Making in Male Mice.","authors":"Elizabeth Illescas-Huerta, Andrea Villamizar, Meghan Cum, Nancy Padilla-Coreano","doi":"10.1523/ENEURO.0207-26.2026","DOIUrl":"10.1523/ENEURO.0207-26.2026","url":null,"abstract":"Adaptive social behavior requires balancing self-interest with the welfare of others, a core axiom of social decision-making that determines whether actions are selfish or prosocial. Although the medial prefrontal cortex (mPFC) has been implicated in prosocial behavior, the broader cortical-subcortical networks that arbitrate between selfish and prosocial actions remain poorly understood. Moreover, most studies of social decision-making (at both the single-region and circuit levels) have focused on inbred C57BL/6 mice, leaving unclear whether similar neural mechanisms operate across genetically diverse populations. Here, we combined a social decision-making task with c-Fos mapping to examine activity across distributed cortical and subcortical regions in inbred C57BL/6 and outbred CD1 male mice during prosocial and selfish choices. We found that CD1 mice exhibited a stronger bias toward selfish behavior, whereas C57BL/6 mice were more prosocial. This behavioral divergence was associated with elevated c-Fos activity in the mPFC and nucleus accumbens core (NAcC) in CD1 mice compared with C57BL/6 mice, with mPFC activity positively correlating with selfish choices. At the network level, social decision-making selectively recruited coordinated activity among the distinct mPFC subregions, ventral tegmental area (VTA), and NAcC. Importantly, prosocial and selfish individuals exhibited distinct prefrontal-subcortical network configurations during social decision-making. Together, these findings identify distributed cortical-subcortical network dynamics underlying social choice bias and suggest that differences in the neural architecture associated with prosocial and selfish behavior are influenced by strain in male mice.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":"13 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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