Endocrine Research最新文献_第8页

Relationship between Functional miR-143/145 Cluster Variants and Susceptibility to Type 2 Diabetes Mellitus: A Preliminary Case-Control Study and Bioinformatics Analyses. 功能性miR-143/145聚类变异与2型糖尿病易感性的关系:初步病例对照研究和生物信息学分析

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-08-01 Epub Date: 2021-04-17 DOI: 10.1080/07435800.2021.1914079

Danial Jahantigh, Fariba Mirani Sargazi, Saman Sargazi, Ramin Saravani, Saeedeh Ghazaey Zidanloo, Milad Heidari Nia, Maryam Piri

{"title":"Relationship between Functional miR-143/145 Cluster Variants and Susceptibility to Type 2 Diabetes Mellitus: A Preliminary Case-Control Study and Bioinformatics Analyses.","authors":"Danial Jahantigh, Fariba Mirani Sargazi, Saman Sargazi, Ramin Saravani, Saeedeh Ghazaey Zidanloo, Milad Heidari Nia, Maryam Piri","doi":"10.1080/07435800.2021.1914079","DOIUrl":"https://doi.org/10.1080/07435800.2021.1914079","url":null,"abstract":"Purpose: To investigate the link between two variants (rs4705342 and rs4705343) in the promoter of the miR-143/145 cluster with Type 2 diabetes mellitus (T2DM) risk. Methods:A total of 1200 subjects were genotyped using the ARMS-PCR method. Results: The rs4705342 variant enhanced the risk of T2DM under codominant CC (OR = 3.24; 95% CI: 1.89-5.60), recessive TT+TC (OR = 3.02; 95% CI: 1.77-5.17), and dominant TC+CC (OR = 1.35; 95% CI: 1.08-1.71) genetic models. Individuals carrying the C allele of rs4705342 conferred a 1.43 fold increased risk of T2DM. As regards rs4705343, decreased risk of T2DM was observed under codominant TC (OR = 0.53; 95% CI: 0.42-0.67), over-dominant TT+CC (OR = 0.51; 95% CI: 0.40-0.64), and dominant TC+CC (OR = 0.59; 95% CI: 0.48-0.75) models. Haplotype analysis of the variants showed a 1.941-fold increased risk of T2DM regarding the C T combination. Significant associations were noticed between different haplotypes and lipid indices of T2DM patients. There were no notable changes in p-values after adjustment for BMI. Computational analysis revealed that miR143 and/or miR145 target important genes involved in glucose and lipid metabolism. Conclusions: Functional miR-143/145 variants might influence the risk of T2DM. Hence, clarifying the precise regulatory mechanisms of gene expression in the development of T2DM will significantly guide researchers to find a novel target for therapeutic intervention.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 3","pages":"129-139"},"PeriodicalIF":2.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1914079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38887822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

The Value of Historical Height Loss for Detecting Vertebral Fractures in Postmenopausal Women in China. 中国绝经后妇女椎体骨折的历史身高损失价值

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-10-12 DOI: 10.1080/07435800.2020.1827263

Rong Chen, Shuying Liu, Meng Huang, Yangna Ou, Wei Liu, Rongrong Cui, Lingqing Yuan, Zhongjian Xie, Zhifeng Sheng, Hong Liu

{"title":"The Value of Historical Height Loss for Detecting Vertebral Fractures in Postmenopausal Women in China.","authors":"Rong Chen, Shuying Liu, Meng Huang, Yangna Ou, Wei Liu, Rongrong Cui, Lingqing Yuan, Zhongjian Xie, Zhifeng Sheng, Hong Liu","doi":"10.1080/07435800.2020.1827263","DOIUrl":"https://doi.org/10.1080/07435800.2020.1827263","url":null,"abstract":"Objectives: The diagnosis and management of osteoporosis and osteoporotic fractures are challenging in rural and underdeveloped areas of China because medical resources are inaccessible; thus, a simple and accurate method is essential for the detection of vertebral fractures. We aimed to examine the relationship between historical height loss (HHL) and vertebral fractures in postmenopausal Chinese women.Material and methods: A cross-sectional study of 255 postmenopausal women aged 50 years or older was conducted in September 2017. Demographic data, including self-reported tallest historical height and current height were analyzed. Vertebral fractures were assessed using X-ray radiography and HHL thresholds were examined using specificity and sensitivity testing.Results: The average age of the 255 participants was 66.3 ± 9.0 years and their mean HHL was 3.5 ± 2.8 cm. The 24 women who were found to have vertebral fractures were older, had more years since menopause (YSM), and a larger HHL compared to those without vertebral fractures. Logistic regression analysis showed that age was a better predictor of vertebral fractures than HHL was, and the cutoff age for detecting vertebral fractures was 71 years, with an area under the receiver operating characteristic curve of 0.750.Conclusions: Although the women in this study with vertebral fractures had a greater height loss than those without fractures, it was apparent that age, rather than HHL, is the best way to determine who is most likely to develop vertebral fractures.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 1","pages":"14-19"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2020.1827263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38579621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MTHFR Polymorphisms in Girls with Anorexia Nervosa: Implications on Body Weight. 神经性厌食症女孩的MTHFR多态性:对体重的影响。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2021-01-28 DOI: 10.1080/07435800.2021.1879845

Areti Augoulea, Eleni Armeni, Evangelia Deligeoroglou, Stavroula A Paschou, Georgios Papadimitriou, Evgenia Stergioti, Vassilios Karountzos, Artemis Tsitsika, Konstantinos Panoulis, Emmanuel Economou, Irene Lambrinoudaki

{"title":"MTHFR Polymorphisms in Girls with Anorexia Nervosa: Implications on Body Weight.","authors":"Areti Augoulea, Eleni Armeni, Evangelia Deligeoroglou, Stavroula A Paschou, Georgios Papadimitriou, Evgenia Stergioti, Vassilios Karountzos, Artemis Tsitsika, Konstantinos Panoulis, Emmanuel Economou, Irene Lambrinoudaki","doi":"10.1080/07435800.2021.1879845","DOIUrl":"https://doi.org/10.1080/07435800.2021.1879845","url":null,"abstract":"The development of atypical vs typical anorexia nervosa (AN) might be explained by the genetic background. We assessed the link between the subtypes of AN and the genetic polymorphisms of the thrombotic panel and the methyltetrahydrofolate reductase (MTHFR) gene. This cross-sectional pilot study recruited 48 girls with AN and 10 age-matched control girls with normal menstruation. We recorded anthropometric parameters and obtained blood samples for genotyping and hormonal assessment. Classification of AN was performed according to the DSM-V criteria. Girls with AN had 2.66 times higher odds of carrying at least one genetic polymorphism from the MTHFR panel (C677T and A1298C) compared with girls without AN (OR = 2.660, p-value = 0.041; CI 95% 1.057-6.720). The presence of atypical vs typical AN was associated independently with the presence of any of the assessed MTHFR polymorphisms (C677T, OR = 4.929, 95% CI 1.076-22.579, p-value = 0.040; A1298C, OR = 0.097, 95% CI 0.011-0.866, p-value = 0.037) in age and estrogen adjusted models. The atypical presentation of AN is mainly linked with higher prevalence of the MTHFR C677T and lower prevalence of the A1298C polymorphism.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 2","pages":"80-85"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1879845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38870416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum thyroid stimulating hormone level for predicting utility of thyroid uptake and scan. 血清促甲状腺激素水平预测甲状腺摄取和扫描的效用。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-09-02 DOI: 10.1080/07435800.2020.1810064

Lauren Buehler, Alireza Movahed, Keren Zhou, M Cecilia Lansang

{"title":"Serum thyroid stimulating hormone level for predicting utility of thyroid uptake and scan.","authors":"Lauren Buehler, Alireza Movahed, Keren Zhou, M Cecilia Lansang","doi":"10.1080/07435800.2020.1810064","DOIUrl":"https://doi.org/10.1080/07435800.2020.1810064","url":null,"abstract":"Background: Thyroid uptake and scan (TUS) is a clinical tool used for differentiation of thyrotoxicosis etiologies. Although guidelines recommend ordering a TUS for evaluation of low TSH levels, no specific value is defined. This study aimed to determine a TSH cutoff at which TUSs yield a greater likelihood of successful determination of etiology to avoid unnecessary testing.Methods: This was a retrospective study on 137 patients seen by an endocrinologist who underwent TUS for evaluation of low TSH (<0.4 μU/mL). A receiver operating curve analysis was performed to determine the TSH cutoff with maximal sensitivity and specificity for prediction of diagnostic utility.Results: Ninety percent of TUSs (n = 123) led to a diagnosis, while 10% (n = 14) were inconclusive or normal. Diagnoses included Graves' diseases (52%), toxic multinodular goiter (19%), thyroiditis (12%), and solitary toxic adenoma (7%). The median TSH value was 0.008 μU/mL (IQR 0.005, 0.011), and the median free T4 value was 1.7 μU/mL (IQR 1.3, 2.8). The ROC analysis produced an area under the curve of 0.86. The optimal TSH cutoff value was 0.02 μU/mL (sensitivity 80%, specificity 93%) for prediction of diagnostic yield.Conclusion: This study demonstrates that TSH is a useful predictor of the utility of TUS in yielding an etiology of thyrotoxicosis. Our analysis showed that TUS had a greater likelihood of determining an etiology when TSH was ≤0.02 μU/mL. This information can help clinicians avoid unnecessary cost and patient time burden when TUS is unlikely to aid in determining the etiology of thyrotoxicosis.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 1","pages":"10-13"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2020.1810064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38335796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silencing of Long Non-coding RNA ENST00000606790.1 Inhibits the Malignant Behaviors of Papillary Thyroid Carcinoma through the PI3K/AKT Pathway. 长链非编码RNA ENST00000606790.1的沉默通过PI3K/AKT通路抑制甲状腺乳头状癌的恶性行为

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-08-13 DOI: 10.1080/07435800.2020.1804928

Zhihua Zuo, Ling Liu, Bin Song, Juan Tan, Dafa Ding, Yibing Lu

{"title":"Silencing of Long Non-coding RNA ENST00000606790.1 Inhibits the Malignant Behaviors of Papillary Thyroid Carcinoma through the PI3K/AKT Pathway.","authors":"Zhihua Zuo, Ling Liu, Bin Song, Juan Tan, Dafa Ding, Yibing Lu","doi":"10.1080/07435800.2020.1804928","DOIUrl":"https://doi.org/10.1080/07435800.2020.1804928","url":null,"abstract":"Purpose: This study aimed to investigate the role and mechanism of lncRNA ENST00000606790.1 (ENST) in promoting the progression of papillary thyroid carcinoma (PTC).Methods: The expression of ENST in human PTC and normal para-cancerous thyroid (NPTC) tissues or cell lines was determined by RT-qPCR. Cell growth was determined by CCK8 assay. Cell colony formation was determined by cell colony formation assay. Cell cycle analysis was performed by staining cells with PI (Propidium Iodide). Cell invasion was assessed by transwell assay. Protein expression was examined by western-blot. siRNA was constructed to inhibit the expression of ENST. 740-Y-P was used to activate PI3K. The correlation between ENST expression and clinical outcomes was analyzed.Results: ENST was significantly up-regulated in PTC tissues or PTC cell lines (PTC and IHH4 cell lines), compared to NPTC tissues or normal cell lines, respectively. High expression of ENST was strongly correlated to lymph node metastasis and tumor size at diagnosis. Silencing of ENST significantly inhibited cell growth and colony formation, arrested the cell cycle at G2/M phase, upregulated the expression of CHK1, downregulated the expression of CDC25C, and inhibited cell invasion. Silencing of ENST significantly down-regulated the expression of PI3K, p-PI3K, AKT, and p-AKT in IHH4 cells. Furthermore, treatment with the PI3K activator 740-Y-P partially abolished the effect of silencing of ENST on PTC cells.Conclusions: Overall, our results demonstrated that ENST can promote PTC progression by activating the PI3K/AKT signaling pathway, suggesting that ENST can serve as a potential biomarker and new therapeutic target for patients with PTC.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 1","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2020.1804928","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38259894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Insulin Use and Poor COVID-19 Outcomes among Diabetes Patients: Association Not Necessarily Causation. 糖尿病患者胰岛素使用与COVID-19预后不良:相关性不一定是因果关系

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2021-03-08 DOI: 10.1080/07435800.2021.1894821

Shayan Riahi, Kevin Bryan Lo, Catherine Anastasopoulou, Janani Rangaswami

{"title":"Insulin Use and Poor COVID-19 Outcomes among Diabetes Patients: Association Not Necessarily Causation.","authors":"Shayan Riahi, Kevin Bryan Lo, Catherine Anastasopoulou, Janani Rangaswami","doi":"10.1080/07435800.2021.1894821","DOIUrl":"https://doi.org/10.1080/07435800.2021.1894821","url":null,"abstract":"Our study looked at the relationship between insulin use and clinical outcomes in COVID-19. A response to our article, written by Dr. Chia Sing Kow and Dr. Syed Shahzad Hasan raised a few questions. They mentioned our use of hemoglobin A1c may be inaccurate as the patients in our study had high rates of CKD or ESRD which could alter the hemoglobin A1c levels. However due to the limitations of our patient population and perhaps in a lot of other sample populations in the real-world setting, it was the most feasible way to represent glucose control.The writers also suggested that the use of metformin, a potential confounder, was also not adjusted for. This should be considered in future research but addition of too many variables in a regression model may lead to less reliability of results for our study.The letter writers also suggested that the results of our paper may lead to misinterpretation by readers and may influence providers to not use insulin therapy for their patients when necessary due to fear of worse outcomes in the setting of COVID-19. We reiterated that it is very important that the data not be misinterpreted, and that nowhere in our paper did we imply or suggest that patients who need insulin therapy to treat their diabetes should not receive proper therapy due to the association we delineated in our paper. Instead, more careful surveillance of patients with advanced diabetes is needed especially when admitted with COVID-19.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 2","pages":"53-54"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1894821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25449860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Expression of Concern: The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. 关注表达:维生素D和月见草油共同补充对维生素D缺乏多囊卵巢综合征妇女的脂质谱和氧化应激生物标志物的影响:一项随机、双盲、安慰剂对照试验。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-11-04 DOI: 10.1080/07435800.2020.1843877

引用次数: 0

Impact of Acutely Increased Endogenous- and Exogenous Ketone Bodies on FGF21 Levels in Humans. 内源性和外源性酮体急剧增加对人体内FGF21水平的影响。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-10-19 DOI: 10.1080/07435800.2020.1831015

Esben Stistrup Lauritzen, Mads Vandsted Svart, Thomas Voss, Niels Møller, Mette Bjerre

{"title":"Impact of Acutely Increased Endogenous- and Exogenous Ketone Bodies on FGF21 Levels in Humans.","authors":"Esben Stistrup Lauritzen, Mads Vandsted Svart, Thomas Voss, Niels Møller, Mette Bjerre","doi":"10.1080/07435800.2020.1831015","DOIUrl":"https://doi.org/10.1080/07435800.2020.1831015","url":null,"abstract":"Purpose: Fibroblast growth factor (FGF) 21 is a circulating hormone with metabolic regulatory importance. In mice, FGF21 increases in response to a ketogenic diet and fasting. In humans, a similar increase is only observed after prolonged starvation. We aim to study the acute effects of ketone bodies on circulating FGF21 levels in humans.Methods: Participants from three randomized, placebo-controlled crossover studies, with increased endogenous or exogenous ketone bodies, were included. Study 1: patients with type 1 diabetes (T1D) (n = 9) were investigated after a) insulin deprivation and lipopolysaccharide (LPS) injection and b) insulin-controlled euglycemia. Study 2: patients with T1D (n = 9) were investigated after a) total insulin deprivation for 9 hours and b) insulin-controlled euglycemia. Study 3: Healthy adults (n = 9) were examined during a) 3-hydroxybutyrate (OHB) infusion and b) saline infusion. Plasma FGF21 was measured with immunoassay in serial samples.Results: Circulating OHB levels were significantly increased to 1.3, 1.5, and 5.5 mmol/l in the three studies, but no correlations with FGF21 levels were found. Also, no correlations between FGF21, insulin, or glucagon were found. Insulin deprivation and LPS injection resulted in increased plasma FGF21 levels at t = 120 min (p = .005) which normalized at t = 240 min.Conclusion: We found no correlation between circulating FGF21 levels and levels of ketone bodies. This suggests that it is not ketosis per se which controls FGF21 production, but instead a rather more complex regulatory mechanism.Trial registration: clinicaltrials.gov ID number: Study 1: NCT02157155 (5/6-2014), study 2: NCT02077348 (4/3-2014), and study 3: NCT02357550 (6/2-2015).","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 1","pages":"20-27"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2020.1831015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38504691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Insulin Treatment May Not Be Associated with Increased Mortality in Patients with COVID-19 and Concurrent Diabetes. 胰岛素治疗可能与COVID-19合并糖尿病患者死亡率增加无关

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2021-02-26 DOI: 10.1080/07435800.2021.1892748

Chia Siang Kow, Syed Shahzad Hasan

引用次数: 3

Editor's Comment. Caution: The Intersection of Diabetes and COVID-19. 编者评论。警告:糖尿病与COVID-19的交叉。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2021-03-17 DOI: 10.1080/07435800.2021.1894820

Arthur Chernoff

引用次数: 0