Endocrine Research最新文献

{"title":"Association between the Extent of Peripheral Blood DNA Methylation of <i>HIF3A</i> and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study.","authors":"Genki Mizuno,&nbsp;Hiroya Yamada,&nbsp;Eiji Munetsuna,&nbsp;Mirai Yamazaki,&nbsp;Yoshitaka Ando,&nbsp;Ryosuke Fujii,&nbsp;Yoshiki Tsuboi,&nbsp;Atsushi Teshigawara,&nbsp;Itsuki Kageyama,&nbsp;Keisuke Osakabe,&nbsp;Keiko Sugimoto,&nbsp;Hiroaki Ishikawa,&nbsp;Naohiro Ichino,&nbsp;Yoshiji Ohta,&nbsp;Koji Ohashi,&nbsp;Shuji Hashimoto,&nbsp;Koji Suzuki","doi":"10.1080/07435800.2022.2121967","DOIUrl":"https://doi.org/10.1080/07435800.2022.2121967","url":null,"abstract":"<p><strong>Introduction: </strong>DNA methylation in the CpG sites of intron 1 of <i>HIF3A</i> is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of <i>HIF3A</i> and BMI or adiposity parameters in the Japanese population.</p><p><strong>Method: </strong>DNA methylation of <i>HIF3A</i> was quantified via pyrosequencing.</p><p><strong>Result: </strong>DNA methylation of <i>HIF3A</i> differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers.</p><p><strong>Conclusion: </strong>Peripheral blood DNA methylation at the CpG site (cg27146050) of <i>HIF3A</i> correlated with VAT thickness in Japanese women.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"130-137"},"PeriodicalIF":2.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40355471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robert I. Gregerman, MD (1930-2021). An Editorial Reminiscence.","authors":"Michael S Katz,&nbsp;Paul J Davis","doi":"10.1080/07435800.2022.2120893","DOIUrl":"https://doi.org/10.1080/07435800.2022.2120893","url":null,"abstract":"Robert I. Gregerman, MD, a luminary in endocrine research and a pioneering investigator of the metabolic aspects of aging, died October 6, 2021, in San Antonio, Texas, at age 91 years. At the time of his death, following a protracted illness, he was at home, with family and hospice care members by his side. Dr. Gregerman leaves behind a distinguished legacy of academic accomplishment embodied in 60 years of innovative contributions to the medical literature and in generations of trainees who have themselves become leaders in the fields of endocrinology and biomedical gerontology. Robert (Bob) Gregerman (Figure 1) will be remembered as among the inaugural group of gifted scientists presciently recruited by Nathan W. Shock, PhD (1907– 1989), to “grow” the first inter-disciplinary program on aging research at the National Institutes of Health (NIH). In 1956, as a newly minted commissioned officer in the United States Public Health Service (USPHS), Bob arrived at Dr. Shock’s brainchild, then known as the Gerontology Branch of the National Heart Institute and a uniquely creative hybrid of a research enterprise–operating administratively as a unit within the NIH, housed on the grounds of the Baltimore City Hospitals (BCH) and affiliated academically with the Johns Hopkins University School of Medicine several miles away. By 1961, Bob had become the founding chief of the Endocrine Section within the Gerontology Branch, which in 1968 moved into its own NIH-financed building, designated the Gerontology Research Center (GRC), on the BCH campus, and subsequently matured into the intramural research program of the National Institute on Aging (NIA) established in 1974. Bob Gregerman’s laboratory at the GRC remained at the forefront of investigations into the endocrinology of aging for another two decades, during which time he was promoted to Professor of Medicine at Johns Hopkins. Then, in 1994, following retirement from the USPHS he moved with his wife Marjorie to San Antonio, Texas (Figure 2), to direct the research programs of the San Antonio Geriatric Research, Education and Clinical Center (GRECC) at the Audie L. Murphy Memorial Veterans Hospital, and with an appointment as Professor of Medicine at the affiliated University of Texas Health Science Center at San Antonio (UTHSCSA). In San Antonio, he extended the research inquiries he had long pursued in Baltimore, until formal retirement in 2011 afforded him time and opportunity for his favored activities, namely, visiting the UTHSCSA medical library to keep abreast of the literature and conferring with former trainees and colleagues over advances in the biology and endocrinology of aging. Many years earlier, he had written, “my field always serves as a reminder of the finiteness of time.” In the last years of his life (Figure 3), then, when his scientific endeavors, and his delight in pursuing them, did recede under the assaults of time, it likely came to him with regret but as no great surprise. For tho","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"95-103"},"PeriodicalIF":2.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40356885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China.","authors":"Canjia Zhang,&nbsp;Huan Chen,&nbsp;Shangxin Cui,&nbsp;Yeli Lin,&nbsp;Yongqiang Liang,&nbsp;Ping Zhao,&nbsp;Changyi Wang,&nbsp;Shan Xu,&nbsp;Xiaolin Peng,&nbsp;Hongen Chen,&nbsp;Li Wang,&nbsp;Dan Zhao,&nbsp;Ming Zhang,&nbsp;Dongsheng Hu,&nbsp;Yanmei Lou,&nbsp;Fulan Hu","doi":"10.1080/07435800.2022.2127757","DOIUrl":"https://doi.org/10.1080/07435800.2022.2127757","url":null,"abstract":"<p><strong>Background: </strong>This study aimed at investigating the relationships between Platelet-Lymphocyte ratio (PLR) and Neutrophil-Lymphocyte ratio (NLR) and their dynamic changes (∆PLR, ∆NLR) with type 2 diabetes mellitus (T2DM) in a Chinese cohort study.</p><p><strong>Methods: </strong>This study recruited 41,439 individuals who were diagnosed without T2DM at first health examination and completed at least one follow-up. The relationships between NLR, PLR, ∆PLR, ∆NLR and T2DM risk were analyzed using the Cox regression model with corresponding Hazard Ratios (HRs) and 95% Confidence Intervals (CIs).</p><p><strong>Results: </strong>PLR exhibited significant correlation with T2DM risk in a linear reverse dose-response pattern, the corresponding HRs and 95% CIs were 0.81 (0.72, 0.90), 0.71 (0.63, 0.80) and 0.56 (0.49, 0.64) respectively (<i>P</i>_trend < 0.001) for Q2, Q3 and Q4 vs Q1 after adjusting for age, gender, BMI, TG, TC, HDL-C, FPG, ALT, AST, heart rate, smoking, family history of diabetes, and alcohol consumption at baseline in Model 3. The significance remained in subgroups of women, <45 years, ≥45 years, BMI ≥ 24, with fatty liver disease, without fatty liver disease and normotension. Comparing with the largest decrease group of NLR (∆NLR < -0.32), the risk of T2DM increased for -0.003 ≤ ∆NLR < 0.31 (HR 1.17, 95% CI 1.01-1.36) and ∆NLR ≥ 0.31 (HR 1.23, 95% CI 1.06-1.43).</p><p><strong>Conclusions: </strong>Higher PLR could reduce the risk of T2DM. Larger increase of NLR could increase T2DM risk.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"138-152"},"PeriodicalIF":2.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40376328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are We Only Detecting the Tip of the Iceberg? A Nationwide Study on Primary Aldosteronism with up to 8-Year Follow-up","authors":"Hrafnhildur Gunnarsdóttir, G. Jónsdóttir, G. Birgisson, Jon Gudmundsson, H. Sigurjonsdottir","doi":"10.1080/07435800.2022.2068572","DOIUrl":"https://doi.org/10.1080/07435800.2022.2068572","url":null,"abstract":"ABSTRACT Background Long-term follow-up studies on primary aldosteronism (PA) are lacking. Objective We aim to review results of diagnostic procedures and histopathology for patients diagnosed during 2012–2016 in Iceland, compare unilateral (UD) and bilateral disease (BD) and assess treatment response. Methods Thirty-two patients aged 28–88 were diagnosed and treated according to guidelines. Results The majority had BD. Everyone needed potassium supplementation at case detection. We saw a reduction in systolic blood pressure (p < .001, both groups), antihypertensive agents (p = .002 UD and p = .04 BD) and potassium supplementation (p < .001, both groups). Conclusion Similar treatment response was seen in both subgroups. Ratio of hypokalemia and number of cases indicates severe PA underdiagnosis in Iceland.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"104 - 112"},"PeriodicalIF":2.1,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44786403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Triglycerides and Glucose Index Is Associated with Mild Cognitive Impairment in Older Adults","authors":"Y. Weyman-Vela, L. Simental‐Mendía, Abelardo Camacho-Luis, C. Gamboa-Gómez, F. Guerrero‐Romero","doi":"10.1080/07435800.2022.2061508","DOIUrl":"https://doi.org/10.1080/07435800.2022.2061508","url":null,"abstract":"ABSTRACT Background It has been reported that insulin resistance is related to cognitive decline. The triglycerides and glucose (TyG) index, is a reliable and inexpensive surrogate test for detecting insulin resistance. Aims The goal of this study was to evaluate the association between the TyG index and the mild cognitive impairment (MCI) in older adults. Methods A total of 135 individuals, men and women aged 60 to 90 years, were enrolled in a case and control study. Individuals with a diagnosis of MCI (n = 65) were allocated into the case group and compared with individuals without MCI (n = 70) in the control group. Alcohol intake, diabetes duration ≥5 years, diagnoses of cerebrovascular disease, brain injury, folic acid deficiency, dementia, moderate or severe CI, major depressive disorders, and thyroid disease were exclusion criteria. Results Individuals in the case group exhibited higher waist circumference (97.9 ± 13.9 versus 93.5 ± 13.0, p = .001) and TyG index (5.0 ± 0.3 versus 4.1 ± 0.2, p = .001) than individuals in the control group. The TyG index ≥4.68 (OR 6.91; 95% CI 2.05–11.68) and waist circumference (OR 1.03; 95% CI 1.01–1.06) were positively associated with MCI, while education level (OR 0.44; 95% CI 0.30–0.61), occupation (OR 0.75; 95% CI 0.59–0.61), and exercise (OR 0.34; 95% CI 0.22–0.52) were inversely associated with MCI. After controlling for sex, age, waist circumference, education level, occupation, and exercise, a TyG index ≥4.68 remained significantly associated with MCI (OR 2.97; 95% CI 1.12–14.71). Conclusion The TyG index is independently associated with the presence of MCI in older people.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"89 - 93"},"PeriodicalIF":2.1,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44206684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between the Lipid Accumulation Product and Beta-cell Function in Korean Adults with or without Type 2 Diabetes Mellitus: The 2015 Korea National Health and Nutrition Examination Survey","authors":"Hye-eun Cho, Seung-Bum Yang, M. Gi, J. A. Cha, S. Park, Hyun Yoon","doi":"10.1080/07435800.2022.2053540","DOIUrl":"https://doi.org/10.1080/07435800.2022.2053540","url":null,"abstract":"ABSTRACT Aims This study was conducted to assess the relationship between the lipid accumulation product index (LAP) and the homeostasis model assessment for insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in Korean adults with or without type 2 diabetes mellitus (T2DM). Materials and Methods The study was carried out using data from the 2015 Korean National Health and Nutrition Examination Survey (KNHANES) and included 4,922 adults aged 20 or older. Results There were several key findings. First, in overall population, after adjusting for related variables, HOMA-IR (p < .001) and HOMA-B (p < .001) level were positively associated with quartiles of LAP. Second, in non-T2DM group, HOMA-IR (p < .001) and HOMA-B level (p < .001) were positively associated with quartiles of LAP. Third, in T2DM group, HOMA-IR (p < .001) level was positively associated with the quartiles of LAP, but HOMA-B (p = .153) level was not significant. In addition, HOMA-B level was increased with an increasing metabolic syndrome component in non-T2DM (p < .001) but not in T2DM (p = .267). Conclusions LAP was positively associated with both HOMA-IR and HOMA-B in non-diabetic Korean adults. However, LAP was positively associated with HOMA-IR in Korean adults with T2DM, while the association with HOMA-B was not significant.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"80 - 88"},"PeriodicalIF":2.1,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42040886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serologic Testing for Celiac Disease in Graves' Hyperthyroidism: Should We Act Early?","authors":"Hande Demirdere,&nbsp;Ozge Telci Caklili,&nbsp;Sema Yarman","doi":"10.1080/07435800.2021.1959607","DOIUrl":"https://doi.org/10.1080/07435800.2021.1959607","url":null,"abstract":"<p><strong>Background: </strong>The general practice is to screen patients with autoimmune thyroid disease for celiac disease (CD); however, optimal timing for CD screening for patients with Graves'Disease (GD) has not been identified yet. The aim of the study was to show whether positive celiac antibodies persist after euthyroidism is achieved.</p><p><strong>Materials and methods: </strong>Serum samples were collected from 35 patients with GD (23 female and 12 male) who applied to the endocrine outpatient clinic. Patients and healthy controls were screened for CD with IgG and IgA antigliadin antibodies (IgG - AGA and IgA - AGA), IgA endomysial antibody (IgA-EMA) and IgA tissue transglutaminase antibody (IgA anti-tTG). These antibodies were reevaluated when patients were euthyroid under antithyroid therapy. Small intestine biopsy was offered to the patients who remained antibody positive after being euthyroid.</p><p><strong>Results: </strong>Screening 35 patients with GD revealed positive results for IgA-AGA (<i>n</i> = 6/35, 17%), IgG-AGA (<i>n</i> = 9/35, 26%), IgA-EmA (<i>n</i> = 2/35, 6%) and IgA-tTG (<i>n</i> = 2/35, 6%). No patient had multiple antibodies positive. Selective IgA deficiency was not detected in patients and controls. When patients were euthyroid, baseline positive IgA-AGA, IgG-AGA, and IgA-EmA became negative, while positive anti-tTG persisted in two patients. Endoscopic duodenal biopsy showed a normal villi/crypts ratio in these patients. None of the controls had positive antibodies.</p><p><strong>Conclusion: </strong>Due to possibility of false seropositivity of celiac antibodies in patients with Graves' thyrotoxicosis, one should defer testing for CD until euthyroidism has been achieved.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"26-31"},"PeriodicalIF":2.1,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39297707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Circulating Adiponectin and Heart Rate Recovery in Women with Polycystic Ovarian Syndrome.","authors":"Wenjiang Sun,&nbsp;Guanghui Liu,&nbsp;Bin Liu","doi":"10.1080/07435800.2021.2011908","DOIUrl":"https://doi.org/10.1080/07435800.2021.2011908","url":null,"abstract":"<p><strong>Context: </strong>Adiponectin (APN) is reported to be correlated closely with autonomic nervous function in different clinical settings. Heart rate recovery (HRR) is a noninvasive and readily obtainable indicator, which reflects the coordinated interplay between parasympathetic reactivation and sympathetic withdrawal.</p><p><strong>Objective: </strong>This study aimed to investigate the relationship between serum APN and HRR in polycystic ovarian syndrome (PCOS) women.</p><p><strong>Design: </strong>Eighty-nine PCOS women were enrolled and divided into two groups. Women with HRR values slower than 12 beats were defined as Blunted HRR Group. APN levels were compared between Blunted HRR Group and Normal HRR Group. Multivariate logistic regression analysis and multiple linear regression analysis were performed to determine which clinical variables were independently associated with HRR and APN levels, respectively.</p><p><strong>Results: </strong>Twenty-three women were categorized into Blunted HRR Group, in which APN level was significantly lower than Normal HRR Group. Age, body mass index, hypertension, and APN were independent factors of attenuated HRR in PCOS women. Meanwhile, multiple linear regression analysis showed age, dyslipidemia, and homeostasis model assessment-insulin resistance (HOMA-IR) were closely associated with APN levels in PCOS women.</p><p><strong>Conclusions: </strong>Our findings suggested that decreased APN concentration was closely associated with HRR blunt in PCOS women. Further studies are needed to explore the underlying interactions between APN and autonomic nervous function.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 2","pages":"56-63"},"PeriodicalIF":2.1,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39946437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Insulin Use And Increased Mortality In Patients With COVID-19 And Diabetes: A Meta-Analysis.","authors":"Wanteng Wang,&nbsp;Yu Sun,&nbsp;Shuai Wang,&nbsp;Yunbo Sun","doi":"10.1080/07435800.2021.1967376","DOIUrl":"https://doi.org/10.1080/07435800.2021.1967376","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to review observational studies on the effect of insulin use and mortality in patients with COVID-19 and diabetes.</p><p><strong>Methods: </strong>A systematic literature search was performed using the PubMed, Medline, EMBASE, and Cochrane Library databases. The meta-analysis was performed using a random effects model, and I² was applied to evaluate heterogeneity. Sensitivity and subgroup analyses were also performed.</p><p><strong>Results: </strong>Overall, 1,338 patients over six studies were ultimately included. Insulin use was related to a higher risk of death in diabetic patients with COVID-19 compared to those who did not use insulin (odds ratio: 2.59, 95% confidence interval: 1.66-4.05; P < .0001; I²: 57%).</p><p><strong>Conclusions: </strong>This meta-analysis revealed a correlation between insulin usage and increased mortality in diabetic patients with COVID-19. These results showed that insulin requirement in patients with COVID-19 and diabetes might indicate a poor prognosis.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"32-38"},"PeriodicalIF":2.1,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39325007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible Contributions of Nongenomic Actions of Thyroid Hormones to the Vasculopathic Complex of COVID-19 Infection.","authors":"Paul J Davis,&nbsp;Hung-Yun Lin,&nbsp;Aleck Hercbergs,&nbsp;Kelly A Keating,&nbsp;Shaker A Mousa","doi":"10.1080/07435800.2021.1972307","DOIUrl":"https://doi.org/10.1080/07435800.2021.1972307","url":null,"abstract":"<p><strong>Background: </strong>Integrin αvβ3 is a cell membrane structural protein whose extracellular domain contains a receptor for L-thyroxine (T4). The integrin is expressed in rapidly dividing cells and its internalization is prompted by T4. The protein binds viruses and we have raised the possibility elsewhere that action of free T4 (FT4)-when he latter is increased in the nonthyroidal illness syndrome (NTIS) known to complicate COVID-19 infecction-may enhance cellular uptke of SARS-CoV-2 and its receptor.</p><p><strong>Objective: </strong>Because T4 also acts nongenomically via the integrin to promote platelet aggregation and angiogenesis, we suggest here that T4 may contribute to the coagulopathy and endothelial abnormalities that can develop in COVID-19 infections, particularly when the lung is primary affected.</p><p><strong>Discussion and conclusions: </strong>Elevated FT4 has been described in the NTIS of COVID-19 patients and may be associated with increased illness severity, but the finding of FT4 elevation is inconsistent in the NTIS literature. Circulating 3,5',3'-triiodo-L-thyronine (reverse T3, rT3) are frequently elevated in NTIS. Thought to be biologically inactive, rT3in fact stimulates cancer cell proliferation via avb3 and also may increase actin polymerization. We propose here that rT3 in the NTIS complicating systemic COVIF-19 infection may support coagulation and disordered blood vessel formation via actin polymerization.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"39-44"},"PeriodicalIF":2.1,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39621830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}