Endocrine Research最新文献_第8页

Lipoprotein(a) and Hyperinsulinemia in Healthy Normal-weight, Prepubertal Mexican Children. 正常体重墨西哥青春期前健康儿童的脂蛋白(a)和高胰岛素血症

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-08-01 Epub Date: 2021-02-08 DOI: 10.1080/07435800.2021.1881966

Martha Rodríguez-Moran, Claudia I Gamboa-Gómez, Lucia Preza-Rodríguez, Fernando Guerrero-Romero

{"title":"Lipoprotein(a) and Hyperinsulinemia in Healthy Normal-weight, Prepubertal Mexican Children.","authors":"Martha Rodríguez-Moran, Claudia I Gamboa-Gómez, Lucia Preza-Rodríguez, Fernando Guerrero-Romero","doi":"10.1080/07435800.2021.1881966","DOIUrl":"https://doi.org/10.1080/07435800.2021.1881966","url":null,"abstract":"Background. Given the numerous gaps in our knowledge about the biological interactions of lipoprotein(a) [Lp(a)], we determined whether Lp(a) was associated with hyperinsulinemia in healthy normal-weight, prepubertal children.Methods. A total of 131 healthy normal-weight Mexican children aged 6 to 9 years at Tanner stage 1 who were born appropriate for gestational age were enrolled in a case-control study. Children with hyperinsulinemia were allocated into the case group (n = 32), and children with normal insulin levels were allocated into the control group (n = 99). Birth weight, age, and body mass index were matching criteria. Multivariate logistic regression analysis was used to compute the odds ratio (OR) between Lp(a) and both hyperinsulinemia and insulin resistance. Furthermore, a multivariate linear regression analysis was performed to evaluate the association between Lp(a) and both insulin levels and HOMA-IR. Both models were adjusted by sex, age, birth weight, and body mass index.Results. The median (25-75 percentile) serum levels of Lp(a) [20.0 (13.7-29.6) versus 14.6 (10.6-26.7) mg/dL, p = .003] and insulin [24.5 (6.0-30) versus 7.9 (4.3-9.0) µU/L, p < .0005] were higher in the case group than in the control group. The logistic regression analysis showed that Lp(a) was associated with hyperinsulinemia (OR 5.86; 95%CI 2.5-13.6, p < .0005) and insulin resistance (OR 2.01; 95%CI 1.1-9.9, p = .004). In addition, the linear regression analysis showed a significant association between serum Lp(a) and insulin levels (β 11.1; 95%CI 1.8-10.9, p < .0001) and the HOMA-IR index (β 2.606; 95%CI 2.3-2.9, p < .0005).Conclusion. Lp(a) was associated with hyperinsulinemia and insulin resistance in healthy normal-weight, prepubertal children.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 3","pages":"87-91"},"PeriodicalIF":2.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1881966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25343722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of the Effectiveness of Adult Height Prediction Methods in Children with Growth Hormone Deficiency. 成人身高预测方法在生长激素缺乏症儿童中的有效性比较。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-08-01 Epub Date: 2021-04-26 DOI: 10.1080/07435800.2021.1916029

İbrahim Mert Erbaş, Zeynep Ölmez, Ahu Paketçi, Korcan Demir, Ece Böber, Ayhan Abacı

{"title":"Comparison of the Effectiveness of Adult Height Prediction Methods in Children with Growth Hormone Deficiency.","authors":"İbrahim Mert Erbaş, Zeynep Ölmez, Ahu Paketçi, Korcan Demir, Ece Böber, Ayhan Abacı","doi":"10.1080/07435800.2021.1916029","DOIUrl":"https://doi.org/10.1080/07435800.2021.1916029","url":null,"abstract":"Background: In patients with growth hormone (GH) deficiency, the prediction of adult height before initiation of GH treatment can be helpful to guide clinicians and families. However, data regarding the effectiveness of prediction methods in such patients are limited.Objective: We aimed to investigate the accuracy of the three most used adult height prediction methods [Bayley-Pinneau (BP), Roche-Wainer-Thissen (RWT), and Tanner-Whitehouse 2 (TW2)] by comparing their results with the near-adult height (NAH) data of children treated with GH.Methods: A single-center retrospective study was conducted including patients treated with somatotropin due to GH deficiency. Bone age radiographs were reread by three authors. Adult height predictions were made using BP, RWT, and TW2 methods for each patient.Results: Forty-nine patients with GH deficiency [median age at diagnosis 10.8 (9.2-12.0) years, 63.3% girls, 69.4% prepubertal] were included. Median differences between predicted adult height (PAH) and NAH standard deviation (SD) scores were -0.5, 0.0, and 0.3 for BP, RWT, and TW2 methods, respectively. The rates of PAH within ±1 SD score of NAH were 54.7%, 62.3%, and 77.4% for BP, TW2, and RWT methods, respectively. RWT was the most accurate method in girls, however, it showed a similar efficiency with TW2 in prepubertal patients or those with delayed bone age between 1-2 years, independent of gender.Conclusions: We found that RWT and TW2 methods may be preferable rather than the BP method for predicting adult height in patients with a diagnosis of GH deficiency.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 3","pages":"140-147"},"PeriodicalIF":2.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1916029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38909241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The association between insulin-like growth factor 1 levels within reference range and early postoperative remission rate in patients with Cushing's disease. 参考范围内胰岛素样生长因子1水平与库欣病患者术后早期缓解率的关系

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-08-01 Epub Date: 2021-02-09 DOI: 10.1080/07435800.2021.1883056

Emre Gezer, Berrin Çetinarslan, Alev Selek, Zeynep Cantürk, Mehmet Sözen, Özlem Elen, Canan Baydemir, Burak Çabuk, Savaş Ceylan

{"title":"The association between insulin-like growth factor 1 levels within reference range and early postoperative remission rate in patients with Cushing's disease.","authors":"Emre Gezer, Berrin Çetinarslan, Alev Selek, Zeynep Cantürk, Mehmet Sözen, Özlem Elen, Canan Baydemir, Burak Çabuk, Savaş Ceylan","doi":"10.1080/07435800.2021.1883056","DOIUrl":"https://doi.org/10.1080/07435800.2021.1883056","url":null,"abstract":"Introduction: The relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) and glucocorticoids (GC) was examined in various studies. Long-term GC treatment was shown to decrease GH concentration and, interestingly, to increase IGF-1 concentration. We performed a retrospective study in order to examine how preoperative IGF-1 concentrations vary within the reference range and if tertiles of age- and sex-adjusted normal IGF-1 are predictive for early postoperative remission in the patients with Cushing's Disease (CD).Patients and methods: Patients diagnosed with CD were retrospectively evaluated. After the exclusion of 67 patients, a final cohort of 250 CD patients were included. Age- and sex-adjusted normal IGF-1 levels were divided into tertiles (T1, T2 and T3). Early postoperative remission was defined as a nadir morning cortisol concentration measured within the first 3 consecutive days following surgery of less than 5 µg/dL (138 nmol/L).Results: Early postoperative remission rate was the lowest in T1 and highest in T3; 49.1% (n = 28) versus 77.3% (n = 75), p = .001, respectively. Binary logistic regression analysis showed the remission rate in T3 was three times higher than that in T1 (p = .003). Cortisol and ACTH concentration were significantly higher and GH concentrations were significantly lower in T1 compared to those in the other two tertiles.Conclusions: As the first study evaluating the correlation between early postoperative remission rate in patients with CD and the tertiles of normal age- and sex-adjusted IGF-1 levels, we have shown that higher IGF-1 levels could predict better outcome in CD.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 3","pages":"92-98"},"PeriodicalIF":2.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1883056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25350627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Involvement of β-catenin in Androgen-induced Mesenchymal Transition of Breast MDA-MB-453 Cancer Cells. β-连环蛋白参与雄激素诱导的乳腺MDA-MB-453癌细胞间质转化。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-08-01 Epub Date: 2021-03-11 DOI: 10.1080/07435800.2021.1895829

Mamoun Ahram, Randa Bawadi, Mohammad S Abdullah, Dana B Alsafadi, Haneen Abaza, Sallam Abdallah, Ebtihal Mustafa

{"title":"Involvement of β-catenin in Androgen-induced Mesenchymal Transition of Breast MDA-MB-453 Cancer Cells.","authors":"Mamoun Ahram, Randa Bawadi, Mohammad S Abdullah, Dana B Alsafadi, Haneen Abaza, Sallam Abdallah, Ebtihal Mustafa","doi":"10.1080/07435800.2021.1895829","DOIUrl":"https://doi.org/10.1080/07435800.2021.1895829","url":null,"abstract":"Purpose The cellular and molecular dynamics of DHT-induced EMT in MDA-MB-453 cells were investigated.Methods:PCR arrays were used to examine the expression of EMT-regulatory genes. Immunoblotting was used to detect protein levels and confirm protein-protein interaction following immunoprecipitation. Immunofluorescence was used to observe rearrangement of the actin cytoskeleton and cell morphology. Cell migration was assessed by transwell assayResults: Change of cell morphology was concomitant with increased cell migration after treating cells with DHT. Exposure of cells to DHT for one hour was sufficient to induce changes in cell morphology and actin cytoskeleton after 72 hours indicating altered gene expression. A long-term lasting nuclear translocation of AR was observed after a short exposure of cells to DHT. Investigating the expression of 84 EMT-related genes revealed down-expression of β-catenin, N-cadherin, and TCF-4 and increased expression of Slug, all of which were confirmed at the protein level. Yet, not only early interaction of AR and β-catenin was observed following AR activation, inhibition of β-catenin blocked DHT-induced mesenchymal transition and migration. Wnt signaling was found to be partially important in DHT-induced morphological alteration. The mesenchymal transition of cells could be induced by treating cells with an inhibitor of glycogen synthase kinase-3β, an enzyme that inhibits β-catenin; this morphological transition could be reversed by antagonizing AR suggesting that AR functions downstream of β-catenin.Conclusions: These results suggest that MDA-MB-453 cells undergo partial EMT induced by DHT, β-catenin is critical for this phenotypic change, and AR probably reciprocally mediates the mesenchymal transition of these cells upon activation of GSK-3 β.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 3","pages":"114-128"},"PeriodicalIF":2.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1895829","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25462902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Influence of Glucocorticoid Receptor on Sex Differences of Gene Expression Profile in Skeletal Muscle. 糖皮质激素受体对骨骼肌基因表达谱性别差异的影响。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-08-01 Epub Date: 2021-02-16 DOI: 10.1080/07435800.2021.1884874

Noritada Yoshikawa, Aya Oda, Hiroki Yamazaki, Motohisa Yamamoto, Akiko Kuribara-Souta, Masaaki Uehara, Hirotoshi Tanaka

{"title":"The Influence of Glucocorticoid Receptor on Sex Differences of Gene Expression Profile in Skeletal Muscle.","authors":"Noritada Yoshikawa, Aya Oda, Hiroki Yamazaki, Motohisa Yamamoto, Akiko Kuribara-Souta, Masaaki Uehara, Hirotoshi Tanaka","doi":"10.1080/07435800.2021.1884874","DOIUrl":"https://doi.org/10.1080/07435800.2021.1884874","url":null,"abstract":"Skeletal muscle functions as a locomotory system and maintains whole-body metabolism. Sex differences in such skeletal muscle morphology and function have been documented; however, their underlying mechanisms remain elusive. Glucocorticoids are adrenocortical hormones maintaining homeostasis, including regulating whole-body energy metabolism in addition to stress response. In skeletal muscle, glucocorticoids can reduce the synthesis of muscle proteins and simultaneously accelerate the breakdown of proteins to regulate skeletal muscle mass and energy metabolism via a transcription factor glucocorticoid receptor (GR). We herein evaluated the related contributions of the GR to sex differences of gene expression profiles in skeletal muscle using GR-floxed (GRf/f) and skeletal muscle-specific GR knockout (GRmKO) mice. There were no differences in GR mRNA and protein expression levels in gastrocnemius muscle between males and females. A DNA microarray analysis using gastrocnemius muscle from GRf/f and GRmKO mice revealed that, although most gene expression levels were identical in both sexes, genes related to cholesterol and apolipoprotein synthesis and fatty acid biosynthesis and the immunological system were predominantly expressed in males and females, respectively, in GRf/f but not in GRmKO mice. Moreover, many genes were up-regulated in response to starvation in GRf/f but not in GRmKO mice, many of which were sex-independent and functioned to maintain homeostasis, while genes that showed sex dominance related to a variety of functions. Although the genes expressed in skeletal muscle may be predominantly sex-independent, sex-dominant genes may relate to sex differences in energy metabolism and the immune system and could be controlled by the GR.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 3","pages":"99-113"},"PeriodicalIF":2.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1884874","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25372524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Relationship between Functional miR-143/145 Cluster Variants and Susceptibility to Type 2 Diabetes Mellitus: A Preliminary Case-Control Study and Bioinformatics Analyses. 功能性miR-143/145聚类变异与2型糖尿病易感性的关系:初步病例对照研究和生物信息学分析

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-08-01 Epub Date: 2021-04-17 DOI: 10.1080/07435800.2021.1914079

Danial Jahantigh, Fariba Mirani Sargazi, Saman Sargazi, Ramin Saravani, Saeedeh Ghazaey Zidanloo, Milad Heidari Nia, Maryam Piri

{"title":"Relationship between Functional miR-143/145 Cluster Variants and Susceptibility to Type 2 Diabetes Mellitus: A Preliminary Case-Control Study and Bioinformatics Analyses.","authors":"Danial Jahantigh, Fariba Mirani Sargazi, Saman Sargazi, Ramin Saravani, Saeedeh Ghazaey Zidanloo, Milad Heidari Nia, Maryam Piri","doi":"10.1080/07435800.2021.1914079","DOIUrl":"https://doi.org/10.1080/07435800.2021.1914079","url":null,"abstract":"Purpose: To investigate the link between two variants (rs4705342 and rs4705343) in the promoter of the miR-143/145 cluster with Type 2 diabetes mellitus (T2DM) risk. Methods:A total of 1200 subjects were genotyped using the ARMS-PCR method. Results: The rs4705342 variant enhanced the risk of T2DM under codominant CC (OR = 3.24; 95% CI: 1.89-5.60), recessive TT+TC (OR = 3.02; 95% CI: 1.77-5.17), and dominant TC+CC (OR = 1.35; 95% CI: 1.08-1.71) genetic models. Individuals carrying the C allele of rs4705342 conferred a 1.43 fold increased risk of T2DM. As regards rs4705343, decreased risk of T2DM was observed under codominant TC (OR = 0.53; 95% CI: 0.42-0.67), over-dominant TT+CC (OR = 0.51; 95% CI: 0.40-0.64), and dominant TC+CC (OR = 0.59; 95% CI: 0.48-0.75) models. Haplotype analysis of the variants showed a 1.941-fold increased risk of T2DM regarding the C T combination. Significant associations were noticed between different haplotypes and lipid indices of T2DM patients. There were no notable changes in p-values after adjustment for BMI. Computational analysis revealed that miR143 and/or miR145 target important genes involved in glucose and lipid metabolism. Conclusions: Functional miR-143/145 variants might influence the risk of T2DM. Hence, clarifying the precise regulatory mechanisms of gene expression in the development of T2DM will significantly guide researchers to find a novel target for therapeutic intervention.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 3","pages":"129-139"},"PeriodicalIF":2.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1914079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38887822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

The Value of Historical Height Loss for Detecting Vertebral Fractures in Postmenopausal Women in China. 中国绝经后妇女椎体骨折的历史身高损失价值

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-10-12 DOI: 10.1080/07435800.2020.1827263

Rong Chen, Shuying Liu, Meng Huang, Yangna Ou, Wei Liu, Rongrong Cui, Lingqing Yuan, Zhongjian Xie, Zhifeng Sheng, Hong Liu

{"title":"The Value of Historical Height Loss for Detecting Vertebral Fractures in Postmenopausal Women in China.","authors":"Rong Chen, Shuying Liu, Meng Huang, Yangna Ou, Wei Liu, Rongrong Cui, Lingqing Yuan, Zhongjian Xie, Zhifeng Sheng, Hong Liu","doi":"10.1080/07435800.2020.1827263","DOIUrl":"https://doi.org/10.1080/07435800.2020.1827263","url":null,"abstract":"Objectives: The diagnosis and management of osteoporosis and osteoporotic fractures are challenging in rural and underdeveloped areas of China because medical resources are inaccessible; thus, a simple and accurate method is essential for the detection of vertebral fractures. We aimed to examine the relationship between historical height loss (HHL) and vertebral fractures in postmenopausal Chinese women.Material and methods: A cross-sectional study of 255 postmenopausal women aged 50 years or older was conducted in September 2017. Demographic data, including self-reported tallest historical height and current height were analyzed. Vertebral fractures were assessed using X-ray radiography and HHL thresholds were examined using specificity and sensitivity testing.Results: The average age of the 255 participants was 66.3 ± 9.0 years and their mean HHL was 3.5 ± 2.8 cm. The 24 women who were found to have vertebral fractures were older, had more years since menopause (YSM), and a larger HHL compared to those without vertebral fractures. Logistic regression analysis showed that age was a better predictor of vertebral fractures than HHL was, and the cutoff age for detecting vertebral fractures was 71 years, with an area under the receiver operating characteristic curve of 0.750.Conclusions: Although the women in this study with vertebral fractures had a greater height loss than those without fractures, it was apparent that age, rather than HHL, is the best way to determine who is most likely to develop vertebral fractures.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 1","pages":"14-19"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2020.1827263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38579621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MTHFR Polymorphisms in Girls with Anorexia Nervosa: Implications on Body Weight. 神经性厌食症女孩的MTHFR多态性:对体重的影响。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2021-01-28 DOI: 10.1080/07435800.2021.1879845

Areti Augoulea, Eleni Armeni, Evangelia Deligeoroglou, Stavroula A Paschou, Georgios Papadimitriou, Evgenia Stergioti, Vassilios Karountzos, Artemis Tsitsika, Konstantinos Panoulis, Emmanuel Economou, Irene Lambrinoudaki

{"title":"MTHFR Polymorphisms in Girls with Anorexia Nervosa: Implications on Body Weight.","authors":"Areti Augoulea, Eleni Armeni, Evangelia Deligeoroglou, Stavroula A Paschou, Georgios Papadimitriou, Evgenia Stergioti, Vassilios Karountzos, Artemis Tsitsika, Konstantinos Panoulis, Emmanuel Economou, Irene Lambrinoudaki","doi":"10.1080/07435800.2021.1879845","DOIUrl":"https://doi.org/10.1080/07435800.2021.1879845","url":null,"abstract":"The development of atypical vs typical anorexia nervosa (AN) might be explained by the genetic background. We assessed the link between the subtypes of AN and the genetic polymorphisms of the thrombotic panel and the methyltetrahydrofolate reductase (MTHFR) gene. This cross-sectional pilot study recruited 48 girls with AN and 10 age-matched control girls with normal menstruation. We recorded anthropometric parameters and obtained blood samples for genotyping and hormonal assessment. Classification of AN was performed according to the DSM-V criteria. Girls with AN had 2.66 times higher odds of carrying at least one genetic polymorphism from the MTHFR panel (C677T and A1298C) compared with girls without AN (OR = 2.660, p-value = 0.041; CI 95% 1.057-6.720). The presence of atypical vs typical AN was associated independently with the presence of any of the assessed MTHFR polymorphisms (C677T, OR = 4.929, 95% CI 1.076-22.579, p-value = 0.040; A1298C, OR = 0.097, 95% CI 0.011-0.866, p-value = 0.037) in age and estrogen adjusted models. The atypical presentation of AN is mainly linked with higher prevalence of the MTHFR C677T and lower prevalence of the A1298C polymorphism.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 2","pages":"80-85"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2021.1879845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38870416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum thyroid stimulating hormone level for predicting utility of thyroid uptake and scan. 血清促甲状腺激素水平预测甲状腺摄取和扫描的效用。

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-09-02 DOI: 10.1080/07435800.2020.1810064

Lauren Buehler, Alireza Movahed, Keren Zhou, M Cecilia Lansang

{"title":"Serum thyroid stimulating hormone level for predicting utility of thyroid uptake and scan.","authors":"Lauren Buehler, Alireza Movahed, Keren Zhou, M Cecilia Lansang","doi":"10.1080/07435800.2020.1810064","DOIUrl":"https://doi.org/10.1080/07435800.2020.1810064","url":null,"abstract":"Background: Thyroid uptake and scan (TUS) is a clinical tool used for differentiation of thyrotoxicosis etiologies. Although guidelines recommend ordering a TUS for evaluation of low TSH levels, no specific value is defined. This study aimed to determine a TSH cutoff at which TUSs yield a greater likelihood of successful determination of etiology to avoid unnecessary testing.Methods: This was a retrospective study on 137 patients seen by an endocrinologist who underwent TUS for evaluation of low TSH (<0.4 μU/mL). A receiver operating curve analysis was performed to determine the TSH cutoff with maximal sensitivity and specificity for prediction of diagnostic utility.Results: Ninety percent of TUSs (n = 123) led to a diagnosis, while 10% (n = 14) were inconclusive or normal. Diagnoses included Graves' diseases (52%), toxic multinodular goiter (19%), thyroiditis (12%), and solitary toxic adenoma (7%). The median TSH value was 0.008 μU/mL (IQR 0.005, 0.011), and the median free T4 value was 1.7 μU/mL (IQR 1.3, 2.8). The ROC analysis produced an area under the curve of 0.86. The optimal TSH cutoff value was 0.02 μU/mL (sensitivity 80%, specificity 93%) for prediction of diagnostic yield.Conclusion: This study demonstrates that TSH is a useful predictor of the utility of TUS in yielding an etiology of thyrotoxicosis. Our analysis showed that TUS had a greater likelihood of determining an etiology when TSH was ≤0.02 μU/mL. This information can help clinicians avoid unnecessary cost and patient time burden when TUS is unlikely to aid in determining the etiology of thyrotoxicosis.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 1","pages":"10-13"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2020.1810064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38335796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silencing of Long Non-coding RNA ENST00000606790.1 Inhibits the Malignant Behaviors of Papillary Thyroid Carcinoma through the PI3K/AKT Pathway. 长链非编码RNA ENST00000606790.1的沉默通过PI3K/AKT通路抑制甲状腺乳头状癌的恶性行为

IF 2.1 4区医学

Endocrine Research Pub Date : 2021-02-01 Epub Date: 2020-08-13 DOI: 10.1080/07435800.2020.1804928

Zhihua Zuo, Ling Liu, Bin Song, Juan Tan, Dafa Ding, Yibing Lu

{"title":"Silencing of Long Non-coding RNA ENST00000606790.1 Inhibits the Malignant Behaviors of Papillary Thyroid Carcinoma through the PI3K/AKT Pathway.","authors":"Zhihua Zuo, Ling Liu, Bin Song, Juan Tan, Dafa Ding, Yibing Lu","doi":"10.1080/07435800.2020.1804928","DOIUrl":"https://doi.org/10.1080/07435800.2020.1804928","url":null,"abstract":"Purpose: This study aimed to investigate the role and mechanism of lncRNA ENST00000606790.1 (ENST) in promoting the progression of papillary thyroid carcinoma (PTC).Methods: The expression of ENST in human PTC and normal para-cancerous thyroid (NPTC) tissues or cell lines was determined by RT-qPCR. Cell growth was determined by CCK8 assay. Cell colony formation was determined by cell colony formation assay. Cell cycle analysis was performed by staining cells with PI (Propidium Iodide). Cell invasion was assessed by transwell assay. Protein expression was examined by western-blot. siRNA was constructed to inhibit the expression of ENST. 740-Y-P was used to activate PI3K. The correlation between ENST expression and clinical outcomes was analyzed.Results: ENST was significantly up-regulated in PTC tissues or PTC cell lines (PTC and IHH4 cell lines), compared to NPTC tissues or normal cell lines, respectively. High expression of ENST was strongly correlated to lymph node metastasis and tumor size at diagnosis. Silencing of ENST significantly inhibited cell growth and colony formation, arrested the cell cycle at G2/M phase, upregulated the expression of CHK1, downregulated the expression of CDC25C, and inhibited cell invasion. Silencing of ENST significantly down-regulated the expression of PI3K, p-PI3K, AKT, and p-AKT in IHH4 cells. Furthermore, treatment with the PI3K activator 740-Y-P partially abolished the effect of silencing of ENST on PTC cells.Conclusions: Overall, our results demonstrated that ENST can promote PTC progression by activating the PI3K/AKT signaling pathway, suggesting that ENST can serve as a potential biomarker and new therapeutic target for patients with PTC.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"46 1","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435800.2020.1804928","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38259894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2