血小板-淋巴细胞比率、中性粒细胞-淋巴细胞比率及其在2型糖尿病中的动态变化:一项中国队列研究。

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2022-08-01 Epub Date: 2022-09-26 DOI:10.1080/07435800.2022.2127757

Canjia Zhang, Huan Chen, Shangxin Cui, Yeli Lin, Yongqiang Liang, Ping Zhao, Changyi Wang, Shan Xu, Xiaolin Peng, Hongen Chen, Li Wang, Dan Zhao, Ming Zhang, Dongsheng Hu, Yanmei Lou, Fulan Hu

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引用次数: 3

摘要

背景:本研究旨在探讨血小板-淋巴细胞比率(PLR)和中性粒细胞-淋巴细胞比率(NLR)与2型糖尿病(T2DM)的关系及其动态变化(∆PLR，∆NLR)。方法:本研究招募了41439名在首次健康检查中被诊断为无T2DM的个体，并完成了至少一次随访。采用Cox回归模型分析NLR、PLR、∆PLR、∆NLR与T2DM风险的关系，并建立相应的风险比(hr)和95%置信区间(CIs)。结果:PLR与T2DM风险呈线性反向剂量-反应模式，在模型3中调整年龄、性别、BMI、TG、TC、HDL-C、FPG、ALT、AST、心率、吸烟、糖尿病家族史和饮酒基线后，Q2、Q3和Q4与Q1对应的hr和95% ci分别为0.81(0.72、0.90)、0.71(0.63、0.80)和0.56(0.49、0.64)(p趋势< 0.001)。结论:较高的PLR可以降低2型糖尿病的风险。NLR增大可增加T2DM风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China.

Background: This study aimed at investigating the relationships between Platelet-Lymphocyte ratio (PLR) and Neutrophil-Lymphocyte ratio (NLR) and their dynamic changes (∆PLR, ∆NLR) with type 2 diabetes mellitus (T2DM) in a Chinese cohort study.

Methods: This study recruited 41,439 individuals who were diagnosed without T2DM at first health examination and completed at least one follow-up. The relationships between NLR, PLR, ∆PLR, ∆NLR and T2DM risk were analyzed using the Cox regression model with corresponding Hazard Ratios (HRs) and 95% Confidence Intervals (CIs).

Results: PLR exhibited significant correlation with T2DM risk in a linear reverse dose-response pattern, the corresponding HRs and 95% CIs were 0.81 (0.72, 0.90), 0.71 (0.63, 0.80) and 0.56 (0.49, 0.64) respectively (P_trend < 0.001) for Q2, Q3 and Q4 vs Q1 after adjusting for age, gender, BMI, TG, TC, HDL-C, FPG, ALT, AST, heart rate, smoking, family history of diabetes, and alcohol consumption at baseline in Model 3. The significance remained in subgroups of women, <45 years, ≥45 years, BMI ≥ 24, with fatty liver disease, without fatty liver disease and normotension. Comparing with the largest decrease group of NLR (∆NLR < -0.32), the risk of T2DM increased for -0.003 ≤ ∆NLR < 0.31 (HR 1.17, 95% CI 1.01-1.36) and ∆NLR ≥ 0.31 (HR 1.23, 95% CI 1.06-1.43).

Conclusions: Higher PLR could reduce the risk of T2DM. Larger increase of NLR could increase T2DM risk.

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.