Endocrine Research最新文献

{"title":"Predictive Value of LncRNA LINC01184 in Papillary Thyroid Cancer Development and Prognosis and Its Regulatory Effect on Cellular Processes.","authors":"Yi Sun, Wanping Hu, Jianyuan Huang, Zhi Liu","doi":"10.1080/07435800.2025.2495274","DOIUrl":"https://doi.org/10.1080/07435800.2025.2495274","url":null,"abstract":"<p><strong>Introduction: </strong>This study assessed the potential of lncRNA LINC01184 in predicting PTC progression and prognosis and its regulatory mechanism in PTC cellular processes, aiming to explore a novel biomarker for PTC.</p><p><strong>Methods: </strong>The study enrolled 111 PTC patients and collected paired tissue samples. Using PCR, the expression of LINC01184 was analyzed, and its association with patients' clinicopathological features and prognosis was evaluated. The regulatory effects of LINC01184 on cell growth and metastasis were assessed by CCK8 and Transwell assays.</p><p><strong>Results: </strong>LINC01184 was significantly downregulated in PTC, which was closely correlated with poor differentiation, advanced TNM stage, the occurrence of lymph node metastasis, and poor overall survival. In PTC cells, LINC01184 negatively regulated miR-296-3p, and its overexpression suppressed cell growth and metastasis of PTC, which was reversed by overexpressing miR-296-3p.</p><p><strong>Conclusion: </strong>Downregulated LINC01184 served as a biomarker for PTC. Overexpressing LINC01184 suppressed PTC cell progression via suppressing miR-296-3p.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of hyperprolactinemia and its treatment on oxidative stress.","authors":"Didem Barlak Keti, Mammadhasan Mammadov, Merve Basol Goksuluk, Aysa Hacioglu, Izzet Okcesiz, Zuleyha Karaca, Kursad Unluhizarci","doi":"10.1080/07435800.2025.2511845","DOIUrl":"https://doi.org/10.1080/07435800.2025.2511845","url":null,"abstract":"<p><strong>Introduction: </strong>There are few studies investigating oxidative stress in hyperprolactinemia. We aimed to analyze the associations between hyperprolactinemia, its treatment, and oxidative stress parameters.</p><p><strong>Methods: </strong>Twenty patients who had hyperprolactinemia secondary to a prolactin-secreting pituitary tumor, and 20 age- and BMI-matched healthy controls were prospectively included. Patients were studied at recruitment and six months post-treatment. Markers indicating protein oxidation and antioxidant system were analyzed.</p><p><strong>Results: </strong>Serum prolactin level in the patient group (13 female, 7 male) was significantly higher than controls. Myeloperoxidase (MPO) activity and advanced oxidation protein product (AOPP) levels were comparable between the groups, while pyrrolized protein, and protein carbonyl compound (PCC) levels were significantly higher, and thiol levels lower in the patients at baseline. A decrease in prolactin levels along with improvements in estradiol (in females) and testosterone (in males) levels were observed following treatment. After treatment of hyperprolactinemia a significant decrease in AOPP, PCC, pyrrolized protein, and an increase in thiol levels were observed. MPO activity remained stable.</p><p><strong>Discussion: </strong>In addition to reproductive dysfunctions and altered sex hormones, hyperprolactinemia is associated with oxidative stress, which improves four to six months after cabergoline treatment.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a Lenvatinib Assay: A Pilot Study.","authors":"Monica Majumder, Lucy E Ding, Cameron Wood, Christopher Hodgkins, Eleanor White, Bruce G Robinson, Roderick J Clifton-Bligh, Paul Bonnitcha, Matti L Gild","doi":"10.1080/07435800.2025.2509986","DOIUrl":"https://doi.org/10.1080/07435800.2025.2509986","url":null,"abstract":"<p><strong>Objectives: </strong>Lenvatinib has demonstrated efficacy in improving progression-free and overall survival in patients with radioiodine refractory thyroid cancer. However, treatment-related adverse events (TRAEs) frequently cause dose interruptions and suboptimal dosing, underscoring the importance of monitoring of lenvatinib levels. Currently, there is no validated lenvatinib assay for clinical use. We describe the development of a mass spectrometry assay for accurate quantification of lenvatinib, along with a pilot study reporting peak and trough levels.</p><p><strong>Design, patients and measurements: </strong>A pilot prospective single-center study was conducted at Royal North Shore Hospital, to develop and validate an in-house high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for measuring plasma lenvatinib levels in patients with radioiodine refractory thyroid cancer. Patient data including dosage, TRAEs, and disease progression were recorded.</p><p><strong>Results: </strong>Lenvatinib doses ranged between 4 mg to 14 mg daily. Trough and peak levels were measured in nine and eight patients respectively. Duration of treatment ranged from 7 to 63 months (mean 29 months), with treatment duration at the time of testing ranging from 1 to 14 months. Trough levels ranged from 4.60 to 30.53 µg/L (median 21.74 µg/L). Peak levels for patients receiving 10 mg (<i>n</i> = 3) ranged from 78.50 to 237.72 µg/L (median 129.56 µg/L), while those receiving 14 mg (<i>n</i> = 4) ranged from 65.10 to 263.64 µg/L (median 185.23 µg/L).</p><p><strong>Conclusions: </strong>Our study describes the successful development of a novel LC-MS/MS assay for quantifying plasma lenvatinib levels. Despite consistent dosing, we observed considerable variability in levels in this group. Further research is required to examine the utility of lenvatinib drug monitoring in the setting of thyroid cancer.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Blood Cell-Derived Parameters in the Differential Diagnosis of Subacute Thyroiditis and Graves' Disease and Long-Term Outcomes in Subacute Thyroiditis.","authors":"Ahmet Kursat Soyer, Fatma Neslihan Cuhaci Seyrek, Kubra Durmus Demirel, Abbas Ali Tam, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir","doi":"10.1080/07435800.2025.2505627","DOIUrl":"https://doi.org/10.1080/07435800.2025.2505627","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the utility of blood cell-derived parameters in differentiating subacute thyroiditis (SAT) from Graves' disease (GD) and their association with recurrence and the development of permanent hypothyroidism in the patients with SAT.</p><p><strong>Methods: </strong>The study involved 414 patients with SAT, 415 patients with GD, and 92 healthy controls. Pre-treatment hematological parameters were retrospectively compared, especially in cases where differentiation is challenging, including painless SAT, acute phase reactants negative SAT, and TSI, TRAB (Thyroid Stimulating Immunoglobulin, TSH-receptor-antibodies) negative GD. Factors influencing recurrence and permanent hypothyroidism were also analyzed in SAT group.</p><p><strong>Results: </strong>When compared with the GD group, ratios of neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), systemic inflammatory response index (SIRI), systemic immune inflammatory index (SII) and pan immune inflammation value (PIV) were significantly higher, while large unstained cell percentage (LUC%) and the ratios of eosinophil/monocyte (EMR), eosinophil/lymphocyte (ELR), eosinophil/neutrophil (ENR), eosinophil/platelet (EPR), mean platelet volume/neutrophil (MPV/NEU), MPV/monocyte and MPV/platelets were significantly lower in the SAT group. SII demonstrated the highest diagnostic value, with an optimal cutoff of 652,784. No significant association was observed between these parameters and recurrence or permanent hypothyroidism.</p><p><strong>Conclusion: </strong>Differentiation between SAT and GD can be reliably achieved using blood cell-derived parameters, and that these markers are also applicable in groups where differentiation is challenging. To the best of our knowledge, this is the first study to investigate the LUC%, ELR, ENR, EPR, MPV/NEU, and MPV/monocyte ratios and revealed that they are significantly different between these two diseases.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroglobulin (TG) gene variants in cases with congenital goiter.","authors":"Mahir Cevizoglu, Ozgur Erkal, Doga Turkkahraman","doi":"10.1080/07435800.2025.2503735","DOIUrl":"https://doi.org/10.1080/07435800.2025.2503735","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate TG gene variants and their effects on the clinical course of the disease in children with congenital hypothyroidism (CH) who are suspected to have thyroglobulin synthesis defect.</p><p><strong>Methods: </strong>The study was carried out in patients who were suspected to have thyroglobulin synthesis defect due to low serum thyroglobulin level and goiter at the time of diagnosis of CH. Peripheral blood samples were taken and hypothyroidism gene panel including 344 genes was amplified by PCR and sequenced using next-generation DNA sequencing (NGS) method.</p><p><strong>Results: </strong>A total of four eligible cases were identified for genetic analysis, and variants were detected in all of them. In case 1, a previously reported homozygous c.638 + 5 G>A splice site variant was detected. In case 2, compound heterozygous variants including a previously reported nonsense variant c.7111 C>T, (p.Arg2371Ter) on the first allele and a novel nonsense variant c.5748 C>A, (p.Tyr1916Ter) on the second allele were detected. In case 3, a previously reported homozygous nonsense variant c.1888 C>T, (p.Gln630Ter) was detected. In case 4, a novel homozygous intronic variant c.6200-25T>G was detected.</p><p><strong>Conclusion: </strong>The distinctive phenotypic features of TG gene variants, which are one of the rare causes of dyshormonogenesis, provide an advantage in diagnosis. Therefore, we recommend genetic analysis in cases with low thyroglobulin levels and goiter. Our findings support that TG variants show a heterogeneous distribution over the whole gene. Since the relationship between TG gene variants and thyroid cancer, we suggest that clarification of TG gene variants is important in terms of early diagnosis of thyroid nodule and malignancy.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin attenuates responses to angiotensin II in isolated aortic rings of STZ-induced type 1-like DM rats.","authors":"Nazar M Shareef Mahmood, Almas M R Mahmud, Ismail M Maulood","doi":"10.1080/07435800.2024.2445264","DOIUrl":"10.1080/07435800.2024.2445264","url":null,"abstract":"<p><strong>Background: </strong>In patients with diabetes mellitus (DM), vascular endothelial dysfunction (VED) is the main reason for impaired life expectancy. Melatonin (MEL) demonstrates wide-ranging effects across various organs and exhibits pleiotropic characteristics. The current study aims to investigate the modulatory roles of MEL vascular response to angiotensin II (Ang II) and its receptors including angiotensin type 1 receptor (AT-1 R) and angiotensin type 2 receptor (AT-2 R) in isolated thoracic aorta of non-diabetes (non-DM) and diabetes (DM) rats.</p><p><strong>Methods: </strong>The thoracic aortae were isolated in order to investigate the influence of MEL on AT-1 R, using valsartan (VAL) and MT-2Rusing luzindole (LUZ) <i>via</i> dose-response curve (DRC) measurement of Ang II reactivity. In addition, AT-1 R was involved in this study, under PD123319 with ADInstrument organ bath (Panlab apparatus, Harvard University, USA).</p><p><strong>Results: </strong>The maximum response of Ang II was increased significantly in DM condition. In addition, AT-1 R was completely blocked under VAL, while AT-2 R was upregulated in the DM group. The combination of VAL and PD123319 led to abolishing the Ang II effect dramatically as well. Melatonin alone reduced Ang II in the DM group dramatically. This effect was also observed with MEL, PD1213319, and VAL combination, as well as, with MEL, LUZ, and PD1213319 combination.</p><p><strong>Conclusions: </strong>Melatonin has been demonstrated to modulate both AT-1 R and AT-2 R and has influenced the reactivity of Ang II in the aortas of diabetic rats through highly complex mechanisms.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"96-108"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Diabetes in Patients with Chronic Kidney Disease.","authors":"Jayachidambaram Ambalavanan, Maria Luiza Caramori","doi":"10.1080/07435800.2025.2473896","DOIUrl":"10.1080/07435800.2025.2473896","url":null,"abstract":"<p><strong>Background: </strong>Patients with diabetes and chronic kidney disease (CKD) are at increased risk of kidney disease progression and cardiovascular events.</p><p><strong>Methods: </strong>In this article, we will summarize the 2022 consensus report by the ADA and KDIGO on diabetes management in CKD and include newly available evidence to assist health care professionals in providing optimal care to patients living with diabetes and CKD.</p><p><strong>Results: </strong>Comprehensive care strategies include lifestyle interventions, optimal glycemic, blood pressure, weight, and lipid management, and preferential use of therapies with proven heart and kidney beneficial effects.</p><p><strong>Conclusions: </strong>This article offers a concise overview of the multiple strategies aimed at reducing cardiovascular and kidney risk among people with diabetes and CKD, as recommended by multiple societies.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"65-75"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Weight Loss and Aerobic Exercise on Cortisol and Cortisol Suppression in Postmenopausal Women with Overweight and Obesity.","authors":"Alice S Ryan, Monica C Serra, Galya Bigman, Sausan Jaber","doi":"10.1080/07435800.2024.2439408","DOIUrl":"10.1080/07435800.2024.2439408","url":null,"abstract":"<p><strong>Purpose: </strong>The goal of this study was to explore the complex relationship between obesity, dietary content, weight loss, and cortisol concentrations in postmenopausal women with overweight and obesity.</p><p><strong>Methods: </strong>Women completed basal cortisol testing, a dexamethasone suppression test (DST), DXA scan, 3-hour oral glucose tolerance test (OGTT), and food records before (<i>n</i> = 60) and a subset after 6-months of weight loss (WL; <i>n</i> = 15) or aerobic exercise training+weight loss (AEX+WL, <i>n</i> = 34).</p><p><strong>Results: </strong>At baseline, plasma cortisol concentrations decreased significantly after DST in the entire group, a 54% suppression which was associated with basal glucose. Basal glucose levels and glucose AUC from the OGTT are associated with basal cortisol levels (<i>r</i> = 0.44 and <i>r</i> = 0.29, <i>p</i> < 0.05 respectively). The intervention resulted in significant weight loss (-8%) but no significant changes in basal cortisol or changes in cortisol from basal to DST were observed.</p><p><strong>Conclusion: </strong>Additional research is necessary to better comprehend cortisol regulation in postmenopausal women particularly in response to effective weight reduction interventions.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"87-95"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum Uric Acid and Pregnancy Outcomes: A Study in Chinese Women.","authors":"Yibo Zhou, Xia Gao, Yu An, Jia Liu, Guang Wang","doi":"10.1080/07435800.2024.2427612","DOIUrl":"10.1080/07435800.2024.2427612","url":null,"abstract":"<p><strong>Objective: </strong>The study aims to explore the relationship between serum uric acid (UA) levels in the first trimester and pregnancy outcomes.</p><p><strong>Methods: </strong>The clinical data of 1381 pregnant women who delivered in the Department of Obstetrics and Gynecology of Beijing Chao-Yang Hospital from June 2021 to July 2022 were collected. All patients were categorized into four groups (Q1-Q4) according to quartiles of UA, using the first quartile of UA as the reference group. Logistic regression analysis was used to observe the correlation between UA and pregnancy outcomes. Restricted cubic spline (RCS) was drawn to observe the dose-response relationship between UA and pregnancy outcomes.</p><p><strong>Results: </strong>The numbers of GDM patients in Q1-Q4 were 40 (11.70%), 46 (13.49%), 60 (17.29%) and 83 (23.65%), respectively (<i>p</i> < 0.001). Logistic regression analysis showed that higher quartiles of UA were significantly associated with an increased prevalence of gestational diabetes mellitus (GDM). After adjusting for confounding factors (maternal age, prepregnancy BMI, gestational weight gain, and gestational age), compared with the lowest quartile of UA, the highest quartile of UA had 2.06 times odds of GDM (OR, 2.06; 95% CI, 1.34, 3.18; <i>p</i> = 0.001) in Q4. RCS suggested that the risk of GDM increased slowly until UA levels reached 219.43 µmol/L and then began to increase rapidly afterward (overall <i>p</i> = 0.0037).</p><p><strong>Conclusions: </strong>Increased uric acid concentrations in the first trimester are associated with an increased risk of GDM and gestational hypertension.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"76-86"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Moderate-Intensity Aerobic Exercise on Estrogen Levels and Bone Mineral Density in Ovariectomized Rats.","authors":"Yang Bai","doi":"10.1080/07435800.2025.2484198","DOIUrl":"10.1080/07435800.2025.2484198","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the effects of moderate-intensity aerobic exercise on estrogen levels and bone density density (BMD) in ovariectomized rats.</p><p><strong>Methods: </strong>The sham-operated (SHAM), ovariectomized sedentary (OVX), and ovariectomized exercise (OVX + EX) groups were established. The OVX model was established by bilateral ovariectomy. Bone metabolism indicators, structural mechanical properties of the femur, material mechanical properties of the femur, BMD and bone mineral content were assessed.</p><p><strong>Results: </strong>Compared with the OVX group, the OVX + EX group had lower levels of Ca, P, and STR-ACP, higher BGP levels, increased maximum load, elastic load, maximum stress, and elastic stress of the tibia, elevated serum E2 levels, decreased LH and FSH levels, and higher BMD (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Moderate-intensity aerobic exercise can enhance serum hormone levels, improve bone metabolism and biomechanical properties, and increase bone density in ovariectomized rats.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"118-125"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}