Endocrine Research最新文献

{"title":"Correction.","authors":"","doi":"10.1080/07435800.2026.2626893","DOIUrl":"10.1080/07435800.2026.2626893","url":null,"abstract":"","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"117"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broad-Spectrum Effects of Carbohydrate Reduction on Inflammatory and Immune Mediators in Type 2 Diabetes.","authors":"Shaminie J Athinarayanan, Stephen D Phinney, Rebecca N Adams, Jeff S Volek, Debbie C Thurmond, Amy L McKenzie, Caroline G P Roberts, Robert E Ratner, Ronald M Krauss, Vivian A Fonseca","doi":"10.1080/07435800.2026.2659579","DOIUrl":"10.1080/07435800.2026.2659579","url":null,"abstract":"<p><strong>Background: </strong>Chronic low-grade inflammation contributes to the development and complications of type 2 diabetes (T2D). Nutritional ketosis improves glycemic control and weight, but its broader immunomodulatory effects are less well defined.</p><p><strong>Methods: </strong>In this post-hoc analysis, adults with T2D (<i>n</i> = 195) or prediabetes (<i>n</i> = 89) in a two-year continuous care intervention (CCI) with individualized carbohydrate reduction emphasizing nutritional ketosis were compared with T2D participants receiving usual care (UC, <i>n</i> = 63). Serum was collected at baseline, 1, and 2 years for high-sensitivity CRP, 15 cytokines/adhesion molecules, and comprehensive blood count (CBC)-derived indices. Linear mixed-effects models evaluated longitudinal changes, while regression (including least absolute shrinkage and selection operator, LASSO) examined associations with mean β-hydroxybutyrate (BHB), weight change, HbA1c, and HOMA-IR.</p><p><strong>Results: </strong>Nineteen of 21 markers declined at 1 year in CCI, largely sustained at 2 years; UC showed no changes. Higher BHB predicted reductions in WBC, ICAM-1, VEGF-A, and systemic immune-inflammation index (SII), while weight loss correlated with IL-6, IL-18, IL-1β, and TNF-α.</p><p><strong>Conclusion: </strong>CCI induced broad, durable anti-inflammatory effects, supporting its role in lowering systemic inflammation and cardiometabolic risk.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"100-116"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic ketoacidosis and hyperosmolar hyperglycemic state in patients with end-stage renal disease on dialysis: a review.","authors":"Laurence Aoun, Hadi Itani, Chris Kaspar, Michel Al Achkar, Fares Saliba, Shaza Al Mardini, Erica Abidor, Mohammad Aldalahmeh, Zaid Khamis, Toni Habib, Fadi Haddadin, Waleed Azam, Razan Dankar, Salim Barakat, Sai Shanmukha Sreeram Pannala, Julie Zaidan","doi":"10.1080/07435800.2026.2627210","DOIUrl":"10.1080/07435800.2026.2627210","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to discuss the prevalence, risk factors, and management of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) in patients with end-stage renal disease (ESRD) on hemodialysis.</p><p><strong>Methods: </strong>A comprehensive literature review of retrospective studies, case reports, and clinical guidelines was conducted.</p><p><strong>Results: </strong>DKA and HHS incidence is lower in ESRD patients due to delayed insulin clearance and regular dialysis. Management requires cautious fluid administration, reduced insulin infusion rates, conservative potassium replacement, and gradual correction of hyperosmolarity. Emergency hemodialysis may be necessary for severe acidosis or hyperkalemia.</p><p><strong>Conclusion: </strong>Treatment must be individualized. Emerging strategies, including extended dialysis sessions and closed-loop insulin delivery, require further validation.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"59-67"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the trigeminal system in pancreatic innervation: new concept and challenge - a narrative review.","authors":"Fady M Bou Malhab, Serge A Jabbour, Ralph Defronzo, Rita Nemr","doi":"10.1080/07435800.2026.2631091","DOIUrl":"10.1080/07435800.2026.2631091","url":null,"abstract":"<p><strong>Introduction: </strong>The pancreas is innervated by a complex network including vagal, sympathetic, and spinal sensory pathways but recent studies suggest that the trigeminal system, known for its role in sensory perception, may also contribute to pancreatic innervation.</p><p><strong>Methods: </strong>This review explores the hypothesis that the trigeminal system, via sensory neuropeptides such as calcitonin gene-related peptide and substance P, plays a role in pancreatic sensory innervation. Several hypotheses are proposed to explain this potential role, including embryological development, antidromic activity, and neurotransmitter actions.</p><p><strong>Results: </strong>Neuropeptides, found in pancreatic tissues, may influence blood flow, inflammation, and pain perception, as well as modulate pancreatic functions such as enzyme secretion and insulin release. Understanding the interplay between the trigeminal system and the pancreas could provide insights into the pathophysiology of conditions like pancreatitis and diabetes.</p><p><strong>Discussion: </strong>Targeting these pathways might offer new therapeutic strategies for managing pancreatic disorders, especially pain control and inflammation.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"68-77"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of obstructive sleep apnea and diabetes in Korean adults.","authors":"Mi Ah Han","doi":"10.1080/07435800.2026.2631094","DOIUrl":"10.1080/07435800.2026.2631094","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to determine the relationship between obstructive sleep apnea (OSA) and diabetes in Korean adults.</p><p><strong>Methods: </strong>This study used data from the 8th Korea National Health and Nutrition Examination Survey (2019-2021). A total of 11,439 adults aged ≥40 years were included. The obstructive sleep apnea was evaluated using the Snoring, Tiredness during the daytime, Observed apnea, high blood Pressure, Body mass index, Age, Neck circumference, and Gender (STOP-BANG) criteria.</p><p><strong>Results: </strong>The prevalence of diabetes was 18.3% and a high risk for OSA was 7.3%. The prevalence of diabetes differed depending on the OSA risk, with the high-risk group demonstrating a significantly higher adjusted odds ratio for diabetes (2.78, 95% confidence interval = 2.24-3.44) compared with the low-risk group for OSA. Additionally, we identified a dose-response relationship, where the risk of diabetes increased as the number of risk factors for OSA increased (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>People at high risk for OSA had a higher prevalence of diabetes than those who were not at risk. Given the increasing burden of diabetes and the potential association of OSA with other essential health conditions, further research is needed to evaluate the benefits of diabetes prevention or blood glucose testing in patients with OSA.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"93-99"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ETV4 transcriptionally activates STAT6 to inhibit ferroptosis and promote immune escape in thyroid cancer.","authors":"Wei Zong, Yancang Wang, Bin Xu","doi":"10.1080/07435800.2026.2629919","DOIUrl":"10.1080/07435800.2026.2629919","url":null,"abstract":"<p><strong>Background: </strong>Thyroid cancer (THCA) is one of the most common endocrine malignancies, with a significant increase in incidence over the past few decades. ETS variant transcription factor 4 (ETV4) is a member of the ETS family of transcription factors, which play crucial roles in tumorigenesis. However, the precise mechanisms by which ETV4 contributes to THCA progression remain largely unexplored.</p><p><strong>Methods: </strong>The expression levels of ETV4, programmed death-ligand 1 (PD-L1), signal transducer and activator of transcription 6 (STAT6), and solute carrier family 7 member 11 (SLC7A11) were analyzed using quantitative reverse transcription PCR (qRT-PCR) and western blotting assays. Cell viability was assessed using the Cell Counting Kit-8 (CCK-8) assay. Reactive oxygen species (ROS) levels and apoptosis were evaluated by flow cytometry. Colorimetric assays were employed to measure malondialdehyde (MDA) levels, glutathione (GSH) levels, iron (Fe²⁺) levels, and lactate dehydrogenase (LDH) cytotoxicity. Enzyme-linked immunosorbent assay (ELISA) was used to quantify interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukin-2 (IL-2) levels. The interaction between ETV4 and STAT6 was confirmed using a dual-luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay.</p><p><strong>Results: </strong>ETV4 expression was upregulated in THCA tissues and cells. Its knockdown increased ROS, MDA, and Fe²⁺, decreased GSH and SLC7A11, and reduced PD-L1 expression. Silencing ETV4 enhanced CD8⁺ T cell cytotoxicity and elevated secretion of IFN-γ, TNF-α, and IL-2, while promoting apoptosis. STAT6 expression was upregulated in THCA tissues and positively correlated with ETV4 expression. Mechanistically, ETV4 transcriptionally activated STAT6 in FTC-133 cells, and STAT6 overexpression inhibited ferroptosis and promoted immune escape by interacting with ETV4.</p><p><strong>Conclusion: </strong>ETV4 transcriptionally activated STAT6 to inhibit ferroptosis and promote immune escape in THCA. Targeting the ETV4-STAT6 axis may offer a novel therapeutic strategy, potentially inhibiting ferroptosis and enhancing immune response in THCA patients.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"78-92"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal tissue glycemia is associated with cortisol rise in the morning in young but not in older healthy adults.","authors":"Anika Köhlmoos, Manuela Dittmar","doi":"10.1080/07435800.2026.2664447","DOIUrl":"https://doi.org/10.1080/07435800.2026.2664447","url":null,"abstract":"<p><p>Cortisol and vitamin D are known to influence plasma glucose, but their relationship with glycemia, assessed by continuous glucose monitoring, remains unclear for healthy adults. This study compared these relationships between 32 young (26.0 ± 4.8 years) and 25 older (67.3 ± 4.8 years) healthy volunteers. Cortisol was determined at bedtime, awakening, and 30 min (T30) and 60 min (T60) post-awakening. Older adults had higher fasting glucose but lower cortisol concentration at T30 than young adults. In young adults, night- and daytime mean glucose and fasting glucose correlated negatively with cortisol at T30, while glycemic variability correlated positively with cortisol at T60. Vitamin D correlated negatively with nighttime mean glucose in the young group. In conclusion, glucose concentration and glycemic variability are associated with the cortisol response the following morning. The lack of these associations in older adults could be explained by their higher fasting glucose concentrations resulting in a lower morning cortisol response.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical chaperone TUDCA rescues Insulin-mediated vascular relaxation via ER stress inhibition in diabetic rat model.","authors":"Sagir Mustapha, Ahmad Khusairi Azemi, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar","doi":"10.1080/07435800.2026.2659582","DOIUrl":"https://doi.org/10.1080/07435800.2026.2659582","url":null,"abstract":"<p><strong>Background: </strong>Tauroursodeoxycholic acid (TUDCA) has been shown to improve endothelial dysfunction in type 2 diabetes mellitus (T2DM). However, its role in attenuating endothelial insulin resistance in diabetes is not well understood.</p><p><strong>Objectives: </strong>This study aimed to investigate TUDCA's potential therapeutic effect on endothelial insulin resistance and its underlying mechanisms.</p><p><strong>Methods: </strong>Twenty-seven male Sprague Dawley rats were categorized into control (CON, <i>n</i> = 9), diabetes (DM, <i>n</i> = 9), and diabetes treated with TUDCA (DMT, <i>n</i> = 9). Diabetes was induced using a high-fat diet and low-dose streptozotocin. TUDCA (150 mg/kg) was administered to the DMT group during the last two weeks of a 15-week study. Aortic tissues were analyzed for insulin-mediated relaxation, endoplasmic reticulum (ER) stress markers [inositol-requiring kinase 1 (IRE-1), protein kinase-like ER kinase (PERK), and binding immunoglobulin protein (BIP)], end othelial function markers [endothelial nitric oxide synthase (eNOS), protein kinase B (Akt), and insulinreceptor substrate-1 (IRS-1)], oxidative stress [superoxide dismutase activity (SOD) and malondialdehyde level (MDA)] and inflammation [tumor necrosis factor-alpha (TNF-a)] markers.</p><p><strong>Results: </strong>Insulin-mediated relaxation was impaired in diabetic rats (-56.7%) compared to controls (0%), accompanied by elevated ER stress markers and reduced eNOS, Akt, and IRS-1 expression. TUDCA treatment improved relaxation responses (-6.2%) significantly reduced ER stress markers and restored the expression of endothelial markers.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of serum orexin-A levels in women with polycystic ovary syndrome.","authors":"Yağmur Ağlıç, İbrahim Kale","doi":"10.1080/07435800.2025.2611822","DOIUrl":"10.1080/07435800.2025.2611822","url":null,"abstract":"<p><strong>Objective: </strong>Orexin-A (OXA) is a hypothalamic neuropeptide implicated in glucose regulation and insulin sensitivity. Given the central role of insulin resistance in polycystic ovary syndrome (PCOS), this study evaluated serum OXA levels in women with PCOS.</p><p><strong>Methods: </strong>This cross-sectional case-control study included 88 women with PCOS and 88 age- and body mass index-matched controls. Serum OXA levels were quantified using a commercial ELISA kit.</p><p><strong>Results: </strong>Serum OXA levels were significantly lower in women with PCOS than in controls (321.53 ng/L vs. 385.06 ng/L, <i>p</i> = 0.012). A significant negative correlation was observed between the modified Ferriman-Gallwey score and serum OXA level. In the ROC analysis, a serum OXA level of 369.55 ng/L yielded a sensitivity of 55.7% and a specificity of 55.7% (AUC: 0.610) for detecting PCOS.</p><p><strong>Conclusions: </strong>Serum OXA concentrations were reduced in women with PCOS. Whether this reduction contributes to PCOS pathogenesis or reflects a secondary alteration remains uncertain.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"46-52"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming underutilization of continuous glucose monitoring devices with diabetes among disparate populations.","authors":"Samar A Nasser, Dragana Lovre, Farbod Zahedi Tajrishi, Keith C Ferdinand","doi":"10.1080/07435800.2025.2577643","DOIUrl":"10.1080/07435800.2025.2577643","url":null,"abstract":"<p><strong>Introduction: </strong>Continuous glucose monitoring (CGM) demonstrates significant benefits in glycemic control for both type 1 and type 2 diabetes, including reductions in HbA1c, increased time-in-range, and decreased hypoglycemia.</p><p><strong>Methods: </strong>In this article, we review the recent American Diabetes Association guidelines recommending real-time CGM for adults with type 2 diabetes, including those not using insulin.</p><p><strong>Results: </strong>While acknowledging the documented advantages, CGM remains underutilized, with many barriers, particularly in primary care settings and among racially diverse or lower socioeconomic populations.</p><p><strong>Discussion: </strong>This review outlines positive strategies to address barriers to CGM-adoption, optimize glycemic control and thereby potentially reduce cardiovascular-kidney-metabolic complications.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":" ","pages":"15-26"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145367871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}