Predictive Value of LncRNA LINC01184 in Papillary Thyroid Cancer Development and Prognosis and Its Regulatory Effect on Cellular Processes.

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2025-08-01 Epub Date: 2025-05-27 DOI:10.1080/07435800.2025.2495274

Yi Sun, Wanping Hu, Jianyuan Huang, Zhi Liu

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引用次数: 0

Abstract

Introduction: This study assessed the potential of lncRNA LINC01184 in predicting PTC progression and prognosis and its regulatory mechanism in PTC cellular processes, aiming to explore a novel biomarker for PTC.

Methods: The study enrolled 111 PTC patients and collected paired tissue samples. Using PCR, the expression of LINC01184 was analyzed, and its association with patients' clinicopathological features and prognosis was evaluated. The regulatory effects of LINC01184 on cell growth and metastasis were assessed by CCK8 and Transwell assays.

Results: LINC01184 was significantly downregulated in PTC, which was closely correlated with poor differentiation, advanced TNM stage, the occurrence of lymph node metastasis, and poor overall survival. In PTC cells, LINC01184 negatively regulated miR-296-3p, and its overexpression suppressed cell growth and metastasis of PTC, which was reversed by overexpressing miR-296-3p.

Conclusion: Downregulated LINC01184 served as a biomarker for PTC. Overexpressing LINC01184 suppressed PTC cell progression via suppressing miR-296-3p.

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LncRNA LINC01184在甲状腺乳头状癌发生、预后中的预测价值及其对细胞过程的调控作用。

本研究评估lncRNA LINC01184在PTC进展和预后预测中的潜力及其在PTC细胞过程中的调控机制，旨在探索一种新的PTC生物标志物。方法：纳入111例PTC患者，收集配对组织样本。采用PCR方法分析LINC01184的表达，并评价其与患者临床病理特征及预后的关系。通过CCK8和Transwell实验评估LINC01184对细胞生长和转移的调节作用。结果：LINC01184在PTC中显著下调，与分化差、TNM分期晚期、发生淋巴结转移、总生存期差密切相关。在PTC细胞中，LINC01184负调控miR-296-3p，其过表达抑制PTC细胞生长和转移，过表达miR-296-3p可逆转这一作用。结论：下调的LINC01184可作为PTC的生物标志物。过表达LINC01184通过抑制miR-296-3p抑制PTC细胞的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.