Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study.

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2025-09-08 DOI:10.1080/07435800.2025.2557991

Zixiao Wang, Yifang Hu, Yiren Wei, Cheng Xue, Yanyan Hu, Yifei Wang, Chuyan Wu, Feng Jiang, Fang Wang

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引用次数: 0

Abstract

Background: This Mendelian Randomization (MR) study investigates the causal relationships between mitochondrial proteins and Diabetic polyneuropathy (DPN).

Methods: Using a two-sample MR design with data from FINNGEN (1048 DPN cases, 374,434 controls) and 63 mitochondrial proteins from GWAS datasets. Analyses used the Inverse Variance Weighted (IVW) method, MR-Egger regression, and weighted medians, with extensive sensitivity tests for robustness.

Results: Elevated COA3 levels (OR = 0.5774, 95% CI: 0.4466-0.7465, p < 0.01) decreased DPN risk, while elevated NFU1 (OR: 1.3992, 95% CI: 1.0935-1.7904, p = 0.0075) and SARS2 (OR: 1.3660, 95% CI: 1.0651-1.7520, p = 0.0140) increased risk.

Conclusion: COA3, NFU1, and SARS2 significantly affect DPN risk, with COA3 lowering and NFU1 and SARS2 increasing risk. These findings highlight potential targets for DPN prevention and treatment, suggesting the importance of mitochondrial proteins in DPN pathogenesis, and providing new insights for future therapeutic strategies to effectively combat this debilitating condition.

查看原文本刊更多论文

线粒体蛋白与糖尿病多发神经病变风险之间关系的遗传预测：孟德尔随机研究。

背景：这项孟德尔随机化（MR）研究探讨了线粒体蛋白与糖尿病多发性神经病变（DPN）之间的因果关系。方法：采用来自FINNGEN的数据（1048例DPN病例，374,434例对照）和来自GWAS数据集的63个线粒体蛋白的双样本MR设计。分析使用反方差加权（IVW）方法、MR-Egger回归和加权中位数，并进行了广泛的稳健性敏感性检验。结果：COA3水平升高（OR = 0.5774, 95% CI: 0.4466-0.7465, p p = 0.0075）和SARS2 （OR: 1.3660, 95% CI: 1.0651-1.7520, p = 0.0140）增加了风险。结论：COA3、NFU1和SARS2显著影响DPN风险，COA3降低，NFU1和SARS2升高。这些发现突出了DPN预防和治疗的潜在靶点，提示了线粒体蛋白在DPN发病机制中的重要性，并为未来有效对抗这种衰弱性疾病的治疗策略提供了新的见解。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.