{"title":"社区妇女外周血HIF3A DNA甲基化程度与肥胖积累之间的关系:Yakumo研究","authors":"Genki Mizuno, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Ryosuke Fujii, Yoshiki Tsuboi, Atsushi Teshigawara, Itsuki Kageyama, Keisuke Osakabe, Keiko Sugimoto, Hiroaki Ishikawa, Naohiro Ichino, Yoshiji Ohta, Koji Ohashi, Shuji Hashimoto, Koji Suzuki","doi":"10.1080/07435800.2022.2121967","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>DNA methylation in the CpG sites of intron 1 of <i>HIF3A</i> is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of <i>HIF3A</i> and BMI or adiposity parameters in the Japanese population.</p><p><strong>Method: </strong>DNA methylation of <i>HIF3A</i> was quantified via pyrosequencing.</p><p><strong>Result: </strong>DNA methylation of <i>HIF3A</i> differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers.</p><p><strong>Conclusion: </strong>Peripheral blood DNA methylation at the CpG site (cg27146050) of <i>HIF3A</i> correlated with VAT thickness in Japanese women.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between the Extent of Peripheral Blood DNA Methylation of <i>HIF3A</i> and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study.\",\"authors\":\"Genki Mizuno, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Ryosuke Fujii, Yoshiki Tsuboi, Atsushi Teshigawara, Itsuki Kageyama, Keisuke Osakabe, Keiko Sugimoto, Hiroaki Ishikawa, Naohiro Ichino, Yoshiji Ohta, Koji Ohashi, Shuji Hashimoto, Koji Suzuki\",\"doi\":\"10.1080/07435800.2022.2121967\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>DNA methylation in the CpG sites of intron 1 of <i>HIF3A</i> is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of <i>HIF3A</i> and BMI or adiposity parameters in the Japanese population.</p><p><strong>Method: </strong>DNA methylation of <i>HIF3A</i> was quantified via pyrosequencing.</p><p><strong>Result: </strong>DNA methylation of <i>HIF3A</i> differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers.</p><p><strong>Conclusion: </strong>Peripheral blood DNA methylation at the CpG site (cg27146050) of <i>HIF3A</i> correlated with VAT thickness in Japanese women.</p>\",\"PeriodicalId\":11601,\"journal\":{\"name\":\"Endocrine Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2022-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/07435800.2022.2121967\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/9/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07435800.2022.2121967","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/14 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study.
Introduction: DNA methylation in the CpG sites of intron 1 of HIF3A is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of HIF3A and BMI or adiposity parameters in the Japanese population.
Method: DNA methylation of HIF3A was quantified via pyrosequencing.
Result: DNA methylation of HIF3A differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers.
Conclusion: Peripheral blood DNA methylation at the CpG site (cg27146050) of HIF3A correlated with VAT thickness in Japanese women.
期刊介绍:
This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.