Hyperuricemia is Associated with the Presence of Metabolically Obese Normal-Weight and Metabolically Healthy Obese Phenotypes.

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2022-08-01 Epub Date: 2022-08-02 DOI:10.1080/07435800.2022.2108049

Fernando Guerrero-Romero, Luis E Simental-Mendía

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引用次数: 2

Abstract

Background: It is well-recognized that hyperuricemia is a common abnormality among individuals with metabolic syndrome.

Aims: The objective of this study was to determine whether hyperuricemia is associated with the metabolically obese normal-weight (MONW) and metabolically healthy obese (MHO) phenotypes.

Methods: Men and women equal or greater than 18 years of age were enrolled in a cross-sectional study. Normal-weight subjects were allocated into the MONW or healthy normal-weight (HNW) groups; while obese individuals were divided into the MHO and metabolically unhealthy obese (MUO) subgroups. MONW phenotype was defined by body mass index (BMI) <25.0 kg/m² accompanied by at least one cardiovascular risk factor (hyperglycemia, elevated blood pressure, hypertriglyceridemia, and low high-density lipoprotein cholesterol), and MHO phenotype was considered in obese subjects (BMI ≥30 kg/m²) without metabolic abnormalities.

Results: A total of 567 individuals were enrolled; of them, normal-weight subjects were allocated into the MONW (n = 101) and control (n = 72) groups, whereas obese individuals into the MHO (n = 61) and MUO (n = 333) groups. The multiple logistic regression analysis adjusted by age, gender, and body mass index revealed that hyperuricemia is significantly associated with MONW (OR = 5.14; 95% CI: 1.37-19.29) and MHO (OR = 0.34; 95% CI: 0.14-0.82) phenotypes.

Conclusion: Results of our study showed that hyperuricemia is associated with both MONW and MHO phenotypes.

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高尿酸血症与代谢肥胖、正常体重和代谢健康肥胖表型的存在有关。

背景:众所周知，高尿酸血症是代谢综合征患者的常见异常。目的:本研究的目的是确定高尿酸血症是否与正常体重代谢肥胖(MONW)和代谢健康肥胖(MHO)表型相关。方法:年龄大于等于18岁的男性和女性被纳入一项横断面研究。正常体重的受试者被分为MONW组和健康正常体重组(HNW);而肥胖个体被分为MHO和代谢不健康肥胖(MUO)亚组。MONW表型定义为体重指数(BMI) 2伴有至少一种心血管危险因素(高血糖、高血压、高甘油三酯血症和低高密度脂蛋白胆固醇)，肥胖受试者(BMI≥30 kg/m2)无代谢异常则考虑MHO表型。结果:共入组567人;其中，体重正常的受试者被分为MONW组(n = 101)和对照组(n = 72)，肥胖者被分为MHO组(n = 61)和MUO组(n = 333)。经年龄、性别和体重指数校正的多元logistic回归分析显示，高尿酸血症与MONW显著相关(OR = 5.14;95% CI: 1.37-19.29)和MHO (OR = 0.34;95% CI: 0.14-0.82)表型。结论:我们的研究结果表明，高尿酸血症与MONW和MHO表型均相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.