我们只发现了冰山一角吗?一项针对原发性醛固酮增多症的全国性研究，随访长达8年

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2022-04-29 DOI:10.1080/07435800.2022.2068572

Hrafnhildur Gunnarsdóttir, G. Jónsdóttir, G. Birgisson, Jon Gudmundsson, H. Sigurjonsdottir

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引用次数: 1

摘要

背景原发性醛固酮增多症(PA)缺乏长期随访研究。我们的目的是回顾2012-2016年在冰岛诊断的患者的诊断程序和组织病理学结果，比较单侧(UD)和双侧(BD)疾病并评估治疗效果。方法对32例年龄在28 ~ 88岁的患者进行诊断和治疗。结果患者以BD居多，发现病例时均需补充钾。我们观察到收缩压(两组均p < 0.001)、抗高血压药物(p = 0.002 UD和p = 0.04 BD)和钾补充剂(两组均p < 0.001)的降低。结论两组治疗效果相似。低钾血症的比例和病例数表明冰岛严重的PA未被诊断。

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Are We Only Detecting the Tip of the Iceberg? A Nationwide Study on Primary Aldosteronism with up to 8-Year Follow-up

ABSTRACT Background Long-term follow-up studies on primary aldosteronism (PA) are lacking. Objective We aim to review results of diagnostic procedures and histopathology for patients diagnosed during 2012–2016 in Iceland, compare unilateral (UD) and bilateral disease (BD) and assess treatment response. Methods Thirty-two patients aged 28–88 were diagnosed and treated according to guidelines. Results The majority had BD. Everyone needed potassium supplementation at case detection. We saw a reduction in systolic blood pressure (p < .001, both groups), antihypertensive agents (p = .002 UD and p = .04 BD) and potassium supplementation (p < .001, both groups). Conclusion Similar treatment response was seen in both subgroups. Ratio of hypokalemia and number of cases indicates severe PA underdiagnosis in Iceland.

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.