ELECTROPHORESIS最新文献

{"title":"Dielectrophoresis in Carcinoma Diagnosis: Recent Developments and Applications.","authors":"Alaleh Vaghef-Koodehi, Blanca H Lapizco-Encinas","doi":"10.1002/elps.8127","DOIUrl":"https://doi.org/10.1002/elps.8127","url":null,"abstract":"<p><p>Accurate cancer cell analysis is critical across a wide range of medical fields, including clinical diagnostics, personalized medicine, drug development, and cancer research. The ability to rapidly analyze and characterize cancer cells is key to understanding tumor characteristics, developing targeted therapies, and improving patient outcomes. Microscale electrokinetic (EK) techniques have demonstrated their effectiveness and reliability as powerful tools for cell analysis, including cancerous cells. The applications of dielectrophoresis (DEP), an EK technique, in cancer cell analysis are discussed here with a focus on carcinomas, cancer that develops in epithelial tissue. In this review article, the working mechanism of DEP is first introduced, followed by an in-depth review of recent studies published between 2015 and 2024. The concluding remarks section provides a summary of the key points discussed in this review and offers insights into potential future advancements in DEP-based systems for analyzing cancerous cells.</p>","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solute Delivery Through a Porous-Walled Microtube With Sinusoidal Roughness by Electroosmotic Pumping.","authors":"Ajay Kumar, Himanshu Gupta, Sirshendu De","doi":"10.1002/elps.8125","DOIUrl":"https://doi.org/10.1002/elps.8125","url":null,"abstract":"&lt;p&gt;&lt;p&gt;This study investigates the delivery of a neutral solute through a porous-walled microtube with sinusoidal roughness under mixed electroosmotic flow pumping, using an external direct current electric field. The effects of various operating conditions, geometries, and properties of the wall, solute, and solvent are investigated. The novelty of this work lies in exploring the impact of sinusoidal roughness on the solute mass flux delivery. It is found that a higher relative roughness amplitude (𝛿 = 0.1) and roughness wavenumber (𝜆 = 12) decrease the average cross-sectional velocity by up to 31% by judiciously tuning the parameters for better solute delivery. The effects of roughness parameters (𝛿, 𝜆), tube length ( &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;L&lt;/mi&gt; &lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$L)$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; , mean tube diameter ( &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;d&lt;/mi&gt; &lt;mi&gt;m&lt;/mi&gt;&lt;/msub&gt; &lt;mrow&gt;&lt;mo&gt;)&lt;/mo&gt; &lt;mo&gt;,&lt;/mo&gt;&lt;/mrow&gt; &lt;/mrow&gt; &lt;annotation&gt;${d_m}), $&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; pump flow rate &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt; &lt;msub&gt;&lt;mi&gt;Q&lt;/mi&gt; &lt;mi&gt;p&lt;/mi&gt;&lt;/msub&gt; &lt;mo&gt;)&lt;/mo&gt; &lt;mo&gt;,&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$({Q_p}),$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; electric field strength ( &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;E&lt;/mi&gt; &lt;mi&gt;z&lt;/mi&gt;&lt;/msub&gt; &lt;mrow&gt;&lt;mo&gt;)&lt;/mo&gt; &lt;mo&gt;,&lt;/mo&gt;&lt;/mrow&gt; &lt;/mrow&gt; &lt;annotation&gt;${E_z}), $&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; wall permeability ( &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;L&lt;/mi&gt; &lt;mi&gt;p&lt;/mi&gt;&lt;/msub&gt; &lt;mrow&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;/mrow&gt; &lt;annotation&gt;${L_p})$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; , trans-wall pressure drop ( &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;Δ&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;P&lt;/mi&gt; &lt;mi&gt;w&lt;/mi&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$Delta {P_w}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ), real retention ( &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;R&lt;/mi&gt; &lt;mi&gt;r&lt;/mi&gt;&lt;/msub&gt; &lt;mrow&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;/mrow&gt; &lt;annotation&gt;${R_r})$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; , solute diffusivity &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt; &lt;mi&gt;D&lt;/mi&gt; &lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$( D )$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; , and osmotic pressure coefficient &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt; &lt;msub&gt;&lt;mi&gt;α&lt;/mi&gt; &lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt; &lt;mspace&gt;&lt;/mspace&gt;&lt;/mrow&gt; &lt;/msub&gt; &lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$({alpha _{1;}})$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; on the solute permeation mass flux are quantified. Among these parameters, the effect of &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;Δ&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;P&lt;/mi&gt; &lt;mi&gt;w&lt;/mi&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$Delta {P_w}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; is the most dominant in increasing the solute permeation flux of the rough-walled microtube, compared to the smooth wall. For example, by changing &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;Δ&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;P&lt;/mi&gt; &lt;mi&gt;w&lt;/mi&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$Delta {P_w}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; from 5 to 20 kPa, the enhancement is about 16% in assisting flow and 19% in opposing flow. It is anticipated that the results of this study will provide valuable design perspectives for customized drug delivery systems using microfluidic channels, as well as enha","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dielectrophoresis Tutorial: Inspired by Hatfield's 1924 Patent and Boltzmann's Theory and Experiments of 1874.","authors":"Ronald Pethig","doi":"10.1002/elps.8114","DOIUrl":"https://doi.org/10.1002/elps.8114","url":null,"abstract":"<p><p>The first patent to describe dielectrophoresis (DEP) as a means and process to separate particles from a mixture was granted by the US Patent Office to Henry Stafford Hatfield in 1924. The novel methods of sample preparation and designs of electrode geometry covered by the patent's disclosures and claims describe the basis for most present-day applications of DEP as a method of particle separation. Hatfield had clearly acquired a deep understanding of DEP, not only from the perspective of the potential energy of the target particle to be separated from others but also from consideration of the conservation of energy of the electrical system. He cites no prior art or supporting theory of what he would have known as the action of the ponderomotive force. There is no record of his publishing this work, but efforts to find the source of his knowledge led to the retrieval of his Ph.D. thesis from the archives of the University of London. It describes innovative applications of DEP to separate impurity particles from powdered mineral ore and refers to the theoretical and experimental studies by Boltzmann of the ponderomotive force acting on small spheroidal samples of insulating material. This early background theory and experimentation by Boltzmann is described here and, together with the rules and methods so clearly and simply described in Hatfield's patent, forms the core of a tutorial for those engaged in DEP but who might lack formal training in physics.</p>","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of the 9-Dye Fluorescent Autosomal and Y Chromosome Multiplex STR Amplification System","authors":"Yu Hao,&nbsp;Zhang Zhe,&nbsp;Cui Yuling,&nbsp;Li Chenjia,&nbsp;Mo Xiaoting,&nbsp;Shang Lei,&nbsp;Song Wen,&nbsp;Jia Lina,&nbsp;Wang Jing,&nbsp;Li Wanshui,&nbsp;Bai Xue","doi":"10.1002/elps.8130","DOIUrl":"10.1002/elps.8130","url":null,"abstract":"<div>\u0000 \u0000 <p>To develop a 9-dye fluorescent autosomal and Y chromosome STR multiplex amplification system and verify its performance. Using the 9-dye fluorescent labeling technology, construct a multiplex amplification system that uses the autosomal and Y chromosome core and preferred loci recommended by GB/T 41009-2021 national standard as candidate loci, then evaluate its accuracy, sensitivity, species specificity, and other system performance index. A 9-dye fluorescent multiplex amplification system containing 70 loci, including Amel, D5S818, D21S11, D7S820, CS1FPO, D2S1338, D19S433, D8S1132, D2S441, VWA, D8S1179, D16S539, D10S1435, PentaD, D3S3045, TPOX, TH01, D22S1045, D18S51, FGA, D19S253, D10S1248, D6S477, D6S1043, D13S317, D12S391, D15S659, PentaE, D1S1656, D3S1358, DYS460, DYS389I, DYS390, DYS533, DYS392, DYS518, DYS557, DYS570, DYS458, DYS437, DYS385, GATA-H4, DYS576, DYS643, DYS508, DYS627, DYS456, DYS391, DYF404S1, DYS438, DYS448, DYF387S1, DYS596, DYS549, DYS399S1, DYS393, DYS635, DYS439, DYS19, DYS444, DYS449, DYS481, DYS527a/b, and DYS447 was successfully constructed. The various loci in this system are well balanced, with a sensitivity of 0.0625 ng and a certain ability to detect mixture samples. This system can obtain rich locus information through a single test and meet the needs of routine testing cases and DNA database construction. It has a good practical significance in forensic medicine.</p>\u0000 </div>","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":"46 7-8","pages":"404-412"},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale Formulation for Assessment of Electroosmotic Flow in Paper-Based Microfluidics.","authors":"Joselynne C Salazar Bove, Sebastian Toro, Pablo A Kler","doi":"10.1002/elps.202400228","DOIUrl":"https://doi.org/10.1002/elps.202400228","url":null,"abstract":"<p><p>In this work, multiscale techniques to model the pressure driven and electroosmotic flows in porous materials with paper-like microstructures are studied and applied. The multiscale technique is based on the definition of a representative volume element (RVE) of the material, where the microstructure is built from connected channels, where the fluid moves inside the void of the porous material. For fluid flow, the velocity is solved under incompressible flow conditions in the Stokes regime at the microscale level, while the homogeneous Darcy problem is solved at the macroscale level. Similarly, for electroosmotic flow, the velocity and pressure are also solved at the microscale under incompressible flow conditions in the Stokes regime. However, in this case a Helmholtz-Smoluchowsky term is considered at the surface of the solid microstructure. Such term is calculated by solving the electric field via the charge conservation equation. Consequently, the electroosmotic velocity is included in the fluid dynamic problem as a boundary condition, significantly reducing the computational demand. Afterward, once the homogenized velocity field of the microscale problem is obtained, an effective pressure-based permeability and an effective electroosmotic permeability are estimated at the macroscale. To validate the results, a comparison is made with experimental data and other numerical studies reported in the literature for common papers used in microfluidics, such as Whatman <math><semantics><mo>#</mo> <annotation>$#$</annotation></semantics> </math> 1 and Munktel 00A, but also through comparisons with direct numerical simulations. Finally, we propose a microcell structure for representing such papers for matching fluid flow and electrical properties. With such topology, electroosmotic and mixed fluid flow are solved in order to demonstrate the capabilities of the multiscale technique for representing different phenomena involved in paper-based microfluidics. With these microcells will be also possible to predict other physicochemical phenomena which are important for paper-based microfluidics such as capillary imbibition or scalar dispersion, among others.</p>","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Self-Assembly Pipette Tip Restricted Access Mesoporous Polypyrrole Solid-Phase Extraction Coupled With Capillary Electrophoresis With Diode Array Detection for the Determination of Enalapril in Urine Samples","authors":"Iara Amorim Carvalho,&nbsp;Camilla Fonseca Silva,&nbsp;Keyller Bastos Borges","doi":"10.1002/elps.8126","DOIUrl":"10.1002/elps.8126","url":null,"abstract":"<p>A miniaturized self-assembly pipette tip with restricted access mesoporous polypyrrole solid-phase extraction, combined with capillary electrophoresis with diode array detection (CE-DAD), was developed to rapidly extract and determine enalapril from urine samples. The CE-DAD technique used 50 mmol L⁻¹ phosphate (pH 7) as the background electrolyte, a voltage of 13 kV, a 30 mbar hydrodynamic injection for 4 s, a capillary temperature of 25°C, and a wavelength of 195 nm to achieve a migration time of 6.3 min with satisfactory peak asymmetry and no interfering and/or baseline noise. The factors that influenced the extraction efficiency were evaluated and optimized: 750 µL sample at pH 7.5, 40 mg adsorbent, 250 µL hexane as a washing solvent, and 750 µL acetonitrile as eluent, resulting in recoveries around 74%. Linearity was acceptable in the 100–3000 ng mL⁻¹ range, and the selectivity and accuracy were also suitable. The limits of detection and quantitation were 30 and 50 ng mL⁻¹, respectively. The adsorbent effectively removed 87% of the proteins and may be reused three times. The analytical approach was successfully verified and used to analyze enalapril in urine samples collected from volunteers. Finally, the greenness of the researched technique was assessed using five measures that showed good eco-friendliness.</p>","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":"46 7-8","pages":"376-387"},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/elps.8126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obituary for Professor Dr. Joachim Klose to be Published in Electrophoresis","authors":"","doi":"10.1002/elps.8118","DOIUrl":"10.1002/elps.8118","url":null,"abstract":"","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":"46 7-8","pages":"478-479"},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dielectrophoresis Low and High Crossover Frequencies of Cancerous Exosomes.","authors":"Michihiko Nakano, Ryu Nakabayashi, Rie Koyama, Masafumi Inaba, Junya Suehiro","doi":"10.1002/elps.8128","DOIUrl":"https://doi.org/10.1002/elps.8128","url":null,"abstract":"<p><p>Exosomes, which constitute a subclass of extracellular vesicles found in various body fluids, play a crucial role in intercellular communication. Exosomes consist of matter derived from their host, such as nucleic acids, proteins, and membrane proteins. Cancer cell-derived exosomes have cancer-specific molecules and are found in the body fluids. As such, they are highly useful in liquid biopsies for cancer diagnosis. For diagnosis, rapid and simple determination of the sampled exosomes is important. Dielectrophoresis (DEP) manipulation has the potential for use in liquid biopsies. DEP behavior based on variations in exosomes has not been well investigated. In this study, the dielectrophoretic characteristics of exosomes derived from four cancer cell lines were investigated: MCF-7, PC-3, HT-29, and COLO 201. The DEP crossover frequencies of these exosomes were determined by directly observing their DEP behaviors at various suspension medium conductivities. Each exosome type exhibited distinct dielectrophoretic characteristics, with significant differences in the lower crossover frequencies linked to variations in the membrane properties and inner conductivity. A single-shell dielectric model was used to estimate the dielectric and physical parameters of the exosomes, aligning with the experimental results. These findings highlight the potential of DEP for specific exosome separation, enabling rapid and simple exosome-based liquid biopsies for cancer diagnosis.</p>","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple and Convenient Three-Electrode Layout for Real-Time Electrorotation Measurement Upon Chemical Stimulation.","authors":"Masato Suzuki, Ryoga Yamada, Yuki Imou, Yushi Isozaki, Tomoyuki Yasukawa","doi":"10.1002/elps.8121","DOIUrl":"https://doi.org/10.1002/elps.8121","url":null,"abstract":"<p><p>We developed a novel electrorotation (ROT) device featuring a microwell array with three electrodes. This device allows to monitor the increase in membrane capacitance of cells subjected to chemical stimulation. The microwell array is integrated into the bottom of a fluidic channel and holds rotating cells during stimulation with a solution containing a chemical agent. Positive dielectrophoresis (p-DEP) effectively traps cells in microwells, whereas negative DEP (n-DEP) facilitates the rapid formation of single-cell presence. Alternating current (AC) voltages with a 120° phase shift applied across the three electrodes enable vertical and simultaneous rotation of cells. We observed a peak in rotation rate as a function of applied frequency, with the frequency spectrum shifting to lower frequencies as membrane capacitance increased. A positive correlation was identified between rotation rate and membrane capacitance, so monitoring in the low-frequency range is advantageous. Although n-DEP at lower frequencies risks removing cells from microwells, the continuous monitoring of the ROT rate during chemical stimulation was achieved by regulating the height of the ROT center of cells. We demonstrated the monitoring of membrane capacitance increase induced by Ca²⁺ influx from ionomycin. This simple configuration facilitates statistical analysis of ROT rates without fluorescent labeling, making it suitable for label-free assessments of white blood cells' responses to stimuli.</p>","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents: Electrophoresis 3–4'25","authors":"","doi":"10.1002/elps.202570022","DOIUrl":"https://doi.org/10.1002/elps.202570022","url":null,"abstract":"","PeriodicalId":11596,"journal":{"name":"ELECTROPHORESIS","volume":"46 3-4","pages":"131-132"},"PeriodicalIF":3.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}