Solute Delivery Through a Porous-Walled Microtube With Sinusoidal Roughness by Electroosmotic Pumping.

IF 3 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

ELECTROPHORESIS Pub Date : 2025-03-06 DOI:10.1002/elps.8125

Ajay Kumar, Himanshu Gupta, Sirshendu De

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引用次数: 0

Abstract

This study investigates the delivery of a neutral solute through a porous-walled microtube with sinusoidal roughness under mixed electroosmotic flow pumping, using an external direct current electric field. The effects of various operating conditions, geometries, and properties of the wall, solute, and solvent are investigated. The novelty of this work lies in exploring the impact of sinusoidal roughness on the solute mass flux delivery. It is found that a higher relative roughness amplitude (𝛿 = 0.1) and roughness wavenumber (𝜆 = 12) decrease the average cross-sectional velocity by up to 31% by judiciously tuning the parameters for better solute delivery. The effects of roughness parameters (𝛿, 𝜆), tube length ( $L)$ , mean tube diameter ( $d_{m}),$ pump flow rate $(Q_{p}),$ electric field strength ( $E_{z}),$ wall permeability ( $L_{p})$ , trans-wall pressure drop ( $Δ P_{w}$ ), real retention ( $R_{r})$ , solute diffusivity $(D)$ , and osmotic pressure coefficient $(α_{1})$ on the solute permeation mass flux are quantified. Among these parameters, the effect of $Δ P_{w}$ is the most dominant in increasing the solute permeation flux of the rough-walled microtube, compared to the smooth wall. For example, by changing $Δ P_{w}$ from 5 to 20 kPa, the enhancement is about 16% in assisting flow and 19% in opposing flow. It is anticipated that the results of this study will provide valuable design perspectives for customized drug delivery systems using microfluidic channels, as well as enhance the understanding of nutrient transport in biological systems.

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电渗透泵送溶质通过具有正弦粗糙度的多孔壁微管。

本研究研究了在混合电渗透泵送下，使用外部直流电场，中性溶质通过具有正弦粗糙度的多孔壁微管的输送。研究了各种操作条件、几何形状和壁、溶质和溶剂性质的影响。这项工作的新颖之处在于探索了正弦粗糙度对溶质质量通量传递的影响。研究发现，较高的相对粗糙度幅值（𝛿= 0.1）和粗糙度波数（ = 12）可使平均横截面速度降低31% by judiciously tuning the parameters for better solute delivery. The effects of roughness parameters (𝛿, 𝜆), tube length ( L ) $L)$ , mean tube diameter ( d m ) , ${d_m}), $ pump flow rate ( Q p ) , $({Q_p}),$ electric field strength ( E z ) , ${E_z}), $ wall permeability ( L p ) ${L_p})$ , trans-wall pressure drop ( Δ P w $\Delta {P_w}$ ), real retention ( R r ) ${R_r})$ , solute diffusivity ( D ) $( D )$ , and osmotic pressure coefficient ( α 1 ) $({\alpha _{1\;}})$ on the solute permeation mass flux are quantified. Among these parameters, the effect of Δ P w $\Delta {P_w}$ is the most dominant in increasing the solute permeation flux of the rough-walled microtube, compared to the smooth wall. For example, by changing Δ P w $\Delta {P_w}$ from 5 to 20 kPa, the enhancement is about 16% in assisting flow and 19% in opposing flow. It is anticipated that the results of this study will provide valuable design perspectives for customized drug delivery systems using microfluidic channels, as well as enhance the understanding of nutrient transport in biological systems.

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来源期刊

ELECTROPHORESIS 生物-分析化学

CiteScore

6.30

自引率

13.80%

发文量

244

审稿时长

1.9 months

期刊介绍： ELECTROPHORESIS is an international journal that publishes original manuscripts on all aspects of electrophoresis, and liquid phase separations (e.g., HPLC, micro- and nano-LC, UHPLC, micro- and nano-fluidics, liquid-phase micro-extractions, etc.). Topics include new or improved analytical and preparative methods, sample preparation, development of theory, and innovative applications of electrophoretic and liquid phase separations methods in the study of nucleic acids, proteins, carbohydrates natural products, pharmaceuticals, food analysis, environmental species and other compounds of importance to the life sciences. Papers in the areas of microfluidics and proteomics, which are not limited to electrophoresis-based methods, will also be accepted for publication. Contributions focused on hyphenated and omics techniques are also of interest. Proteomics is within the scope, if related to its fundamentals and new technical approaches. Proteomics applications are only considered in particular cases. Papers describing the application of standard electrophoretic methods will not be considered. Papers on nanoanalysis intended for publication in ELECTROPHORESIS should focus on one or more of the following topics: • Nanoscale electrokinetics and phenomena related to electric double layer and/or confinement in nano-sized geometry • Single cell and subcellular analysis • Nanosensors and ultrasensitive detection aspects (e.g., involving quantum dots, "nanoelectrodes" or nanospray MS) • Nanoscale/nanopore DNA sequencing (next generation sequencing) • Micro- and nanoscale sample preparation • Nanoparticles and cells analyses by dielectrophoresis • Separation-based analysis using nanoparticles, nanotubes and nanowires.